ATE135041T1 - Verfahren zur herstellung von faktorabhängigen menschlichen b-zellinien - Google Patents

Verfahren zur herstellung von faktorabhängigen menschlichen b-zellinien

Info

Publication number: ATE135041T1
Authority: AT; Austria
Prior art keywords: cell lines; cross; factor dependent; dependent human; producing factor
Prior art date: 1989-12-14

Application number

AT91900209T

Other languages

English (en)

Inventor

Jacques Banchereau

Francoise Rousset

Original Assignee

Schering Plough Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-14

Filing date

1990-12-13

Publication date

1996-03-15

1990-12-13 Application filed by Schering Plough Corp filed Critical Schering Plough Corp

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE135041T1 publication Critical patent/ATE135041T1/de

Links

230000001419 dependent effect Effects 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
210000003719 b-lymphocyte Anatomy 0.000 abstract 2
239000003431 cross linking reagent Substances 0.000 abstract 2
238000012258 culturing Methods 0.000 abstract 2
230000007774 longterm Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108010063916 CD40 Antigens Proteins 0.000 abstract 1
101150013553 CD40 gene Proteins 0.000 abstract 1
108060003951 Immunoglobulin Proteins 0.000 abstract 1
102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000004132 cross linking Methods 0.000 abstract 1
102000018358 immunoglobulin Human genes 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
230000003362 replicative effect Effects 0.000 abstract 1
230000000284 resting effect Effects 0.000 abstract 1
230000003248 secreting effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Microbiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Control Of El Displays (AREA)
Photosensitive Polymer And Photoresist Processing (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Materials For Medical Uses (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Silicon Polymers (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Light Receiving Elements (AREA)
Peptides Or Proteins (AREA)

AT91900209T 1989-12-14 1990-12-13 Verfahren zur herstellung von faktorabhängigen menschlichen b-zellinien ATE135041T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP19890403491 EP0434879A1 (de)	1989-12-14	1989-12-14	Verfahren zur Herstellung von faktorabhÀ¤ngigen menschlichen B-Zellinien

Publications (1)

Publication Number	Publication Date
ATE135041T1 true ATE135041T1 (de)	1996-03-15

Family

ID=8203014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91900209T ATE135041T1 (de)	1989-12-14	1990-12-13	Verfahren zur herstellung von faktorabhängigen menschlichen b-zellinien

Country Status (16)

Country	Link
EP (2)	EP0434879A1 (de)
JP (1)	JPH0789910B2 (de)
AT (1)	ATE135041T1 (de)
AU (1)	AU655759B2 (de)
CA (1)	CA2071886A1 (de)
DE (1)	DE69025772T2 (de)
ES (1)	ES2084146T3 (de)
FI (1)	FI922655A7 (de)
IE (1)	IE904498A1 (de)
IL (1)	IL96639A0 (de)
MY (1)	MY106561A (de)
NO (1)	NO922332L (de)
NZ (1)	NZ236425A (de)
OA (1)	OA09701A (de)
WO (1)	WO1991009115A1 (de)
ZA (1)	ZA909778B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5874082A (en) *	1992-07-09	1999-02-23	Chiron Corporation	Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
US5397703A (en)	1992-07-09	1995-03-14	Cetus Oncology Corporation	Method for generation of antibodies to cell surface molecules
AU5098493A (en) *	1992-08-21	1994-03-15	Schering Corporation	Cd40 ligand, anti cd40 antibodies, and soluble cd40
EP0619323A1 (de) *	1993-04-09	1994-10-12	Schering-Plough	Menschliche monoklonale Antikörper und Verfahren und Material zu deren Herstellung
EP0659766A1 (de) *	1993-11-23	1995-06-28	Schering-Plough	Menschliche Monoklonalantikörper gegen menschliche Cytokine und Verfahren zur Herstellung dieser Antikörper
US5959085A (en) *	1993-11-23	1999-09-28	Schering Corporation	Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
ATE309267T1 (de)	1994-04-28	2005-11-15	Boehringer Ingelheim Pharma	Methode zur proliferation und differenzierung von b-zellen und verwendungen dafür
US6465251B1 (en)	1996-11-13	2002-10-15	Dana-Farber Cancer Institute, Inc.	Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin
WO1999022008A1 (en) *	1997-10-27	1999-05-06	Sumitomo Electric Industries, Ltd.	Inducer for production of antigen-specific antibody, expression vector containing gene therefor, and method of inducing production of antigen-specific antibody
US7063845B2 (en)	2000-04-28	2006-06-20	Gemini Science, Inc.	Human anti-CD40 antibodies
EP1322383B9 (de)	2000-10-02	2006-09-06	Chiron Corporation	Verfahren zur therapie von b-zellmalignitäten unter verwendung von antagonistischen antikörpern gegen cd40
CA2658221C (en)	2001-04-27	2012-11-27	Kyowa Kirin Co., Ltd.	Anti-cd40 monoclonal antibody
GB2398783A (en)	2003-02-26	2004-09-01	Antonio Lanzavecchia	A method for producing immortalised human B memory lymphocytes
AU2004215125B2 (en)	2003-02-26	2011-01-06	Institute For Research In Biomedicine	Monoclonal antibody production by EBV transformation of B cells
CA2617637C (en)	2005-08-02	2017-07-18	Xbiotech Inc.	Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies
JP5762408B2 (ja)	2009-08-13	2015-08-12	クルセルホランドベーヴェー	ヒト呼吸器合胞体ウイルス（ｒｓｖ）に対する抗体および使用方法
EP2316920A1 (de) *	2009-10-30	2011-05-04	BioNTech AG	Klonale Expansion von B-Zellen
BR112012031638B1 (pt)	2010-07-09	2021-01-12	Janssen Vaccines & Prevention B.V.	anticorpo anti-rsv ou fragmento de ligação de antígeno do mesmo, anticorpo multivalente, composição farmacêutica, uso de anticorpo ou fragmento de ligação de antígeno, método de detectar infecção por rsv, e, ácido nucleico isolado
EP2724157B1 (de)	2011-06-27	2017-03-08	Valneva	Screening-verfahren für zellen

1989
- 1989-12-14 EP EP19890403491 patent/EP0434879A1/de not_active Withdrawn
1990
- 1990-12-05 ZA ZA909778A patent/ZA909778B/xx unknown
- 1990-12-11 MY MYPI90002163A patent/MY106561A/en unknown
- 1990-12-11 NZ NZ236425A patent/NZ236425A/xx unknown
- 1990-12-12 IL IL96639A patent/IL96639A0/xx unknown
- 1990-12-13 DE DE69025772T patent/DE69025772T2/de not_active Expired - Fee Related
- 1990-12-13 ES ES91900209T patent/ES2084146T3/es not_active Expired - Lifetime
- 1990-12-13 FI FI922655A patent/FI922655A7/fi not_active Application Discontinuation
- 1990-12-13 AT AT91900209T patent/ATE135041T1/de not_active IP Right Cessation
- 1990-12-13 CA CA002071886A patent/CA2071886A1/en not_active Abandoned
- 1990-12-13 AU AU69017/91A patent/AU655759B2/en not_active Ceased
- 1990-12-13 JP JP3500964A patent/JPH0789910B2/ja not_active Expired - Lifetime
- 1990-12-13 WO PCT/EP1990/002195 patent/WO1991009115A1/en not_active Ceased
- 1990-12-13 EP EP91900209A patent/EP0505397B1/de not_active Expired - Lifetime
- 1990-12-13 IE IE449890A patent/IE904498A1/en unknown
1992
- 1992-06-04 OA OA60226A patent/OA09701A/en unknown
- 1992-06-12 NO NO92922332A patent/NO922332L/no unknown

Also Published As

Publication number	Publication date
AU6901791A (en)	1991-07-18
JPH0789910B2 (ja)	1995-10-04
OA09701A (en)	1993-08-30
MY106561A (en)	1995-06-30
DE69025772D1 (de)	1996-04-11
FI922655A0 (fi)	1992-06-09
ES2084146T3 (es)	1996-05-01
NO922332D0 (no)	1992-06-12
EP0434879A1 (de)	1991-07-03
EP0505397B1 (de)	1996-03-06
AU655759B2 (en)	1995-01-12
WO1991009115A1 (en)	1991-06-27
FI922655A7 (fi)	1992-06-09
NZ236425A (en)	1993-02-25
CA2071886A1 (en)	1991-06-15
IE904498A1 (en)	1991-06-19
DE69025772T2 (de)	1997-02-06
EP0505397A1 (de)	1992-09-30
NO922332L (no)	1992-06-12
ZA909778B (en)	1991-10-30
IL96639A0 (en)	1991-09-16
JPH05503214A (ja)	1993-06-03

Legal Events

Date	Code	Title	Description
1996-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE135041T1 (de)	1996-03-15	Verfahren zur herstellung von faktorabhängigen menschlichen b-zellinien
DK0920505T3 (da)	2008-09-08	Pattedyrcelleoverfladeantigener og tilhörende reagenser
AU2508492A (en)	1993-03-16	Sirs vaccine and diagnosis method
WO1998027114A3 (en)	1998-10-22	Mammalian cell surface antigens; related reagents
KR880006357A (ko)	1988-07-22	인터류킨-i에 대한 항체
BR9714401A (pt)	2000-04-18	Antìgenos de supefìcie de célula de mamìfero; regentes relacionados
DE3587268D1 (de)	1993-05-19	Verfahren zur isolierung des mycobakteriellen antigens-a60 und die verwendung dieses antigens zur herstellung von immunologischen reagenzien und in immunologischen testverfahren.
ATE71411T1 (de)	1992-01-15	Monoklonale antikoerper mit spezifitaet fuer membran-assoziierte antigene.
ATE48037T1 (de)	1989-12-15	Verfahren und reagenz zur verwendung zur bestimmung von pivka-ii.
AU564575B2 (en)	1987-08-20	Polyvalent endotoxin specific antibodies
DE69430975D1 (de)	2002-08-22	Verfahren zur Herstellung von Proteinen
ATE137864T1 (de)	1996-05-15	Immunobestimmung von menschlichem osteocalcin, reagenz und satz dafür
JPS6488367A (en)	1989-04-03	Immobilized antibody
ATE80467T1 (de)	1992-09-15	Immuntestverfahren.
DE3580524D1 (de)	1990-12-20	Monoklonaler antikoerper geeignet zur spezifischen unterscheidung von humanen hepatokarzinomzellen.
EP1867720A3 (de)	2008-01-09	Für Zelloberflächenantigene von Säugetieren kodierende gereinigte Gene; Proteine und Antikörper
ATE132896T1 (de)	1996-01-15	Methoden zur verwendung von an humanen klasse-ii- histokompatibilitätsantigenen mangelnden zellinien
ES2047946T3 (es)	1994-03-01	Metodos de cultivos celulares para producir proteina c activada.
IT8821547A0 (it)	1988-07-29	Metodo immunologico per la determinazione di anticorpi anti antigeni di microorganismi, mediante anticorpi antiidiotipo e mezzi adatti allo scopo.
ATE1387T1 (de)	1982-08-15	Verfahren zur gewinnung von immunglobulin-eantik\rpern der maus, die hierfuer verwendbaren hybridzellinien und deren herstellung; verwendung der so erhaltenen immunglobulin-e-antikoerper.