ATE135706T1 - Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln - Google Patents

Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln

Info

Publication number: ATE135706T1
Authority: AT; Austria
Prior art keywords: radical; representing; production; medicinal products; erythromycin derivatives
Prior art date: 1992-11-05

Application number

AT93402704T

Other languages

English (en)

Inventor

Constantin Agouridas

Alain Bonnefoy

Jean-Francois Chantot

Martret Odile Le

Alexis Denis

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-05

Filing date

1993-11-04

Publication date

1996-04-15

1992-11-05 Priority claimed from FR9213320A external-priority patent/FR2697523B1/fr

1993-07-02 Priority claimed from FR9308109A external-priority patent/FR2707088B1/fr

1993-11-04 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE135706T1 publication Critical patent/ATE135706T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
-1 carbocyclic aryl radical Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
150000003254 radicals Chemical group 0.000 abstract 2
101100293593 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) nar-1 gene Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT93402704T 1992-11-05 1993-11-04 Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln ATE135706T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9213320A FR2697523B1 (fr)	1992-11-05	1992-11-05	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR9308109A FR2707088B1 (fr)	1993-07-02	1993-07-02	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number	Publication Date
ATE135706T1 true ATE135706T1 (de)	1996-04-15

Family

ID=26229842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93402704T ATE135706T1 (de)	1992-11-05	1993-11-04	Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln

Country Status (16)

Country	Link
US (2)	US5527780A (de)
EP (1)	EP0596802B1 (de)
JP (2)	JP3000022B2 (de)
KR (1)	KR100317149B1 (de)
CN (1)	CN1040876C (de)
AT (1)	ATE135706T1 (de)
AU (1)	AU670329B2 (de)
BR (1)	BR9304481A (de)
CA (1)	CA2102457C (de)
DE (1)	DE69301897T2 (de)
DK (1)	DK0596802T3 (de)
ES (1)	ES2085130T3 (de)
GR (1)	GR3019385T3 (de)
HU (3)	HU221978B1 (de)
MA (1)	MA23018A1 (de)
RU (1)	RU2126416C1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2718450B1 (fr) *	1994-04-08	1997-01-10	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) *	1994-05-03	1996-07-12	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) *	1994-12-09	1997-01-17	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732023B1 (fr) *	1995-03-22	1997-04-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) *	1995-04-06	1997-04-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5747466A (en) *	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2742757B1 (fr)	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2751656B1 (fr) *	1996-07-24	1998-10-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ATE296831T1 (de) *	1996-09-04	2005-06-15	Abbott Lab	6-0-substituierte ketoliden mit antibakteriellen wirkung
FR2757168B1 (fr) *	1996-12-12	1999-06-11	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) *	1997-02-27	1999-04-30	Hoechst Marion Roussel Inc	Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5922683A (en) *	1997-05-29	1999-07-13	Abbott Laboratories	Multicyclic erythromycin derivatives
EP0988308A1 (de) *	1997-06-11	2000-03-29	Pfizer Products Inc.	9-oximderivate von erythromycin
US5780604A (en) *	1997-09-26	1998-07-14	Abbott Laboratories	11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
US6034069A (en) *	1997-09-30	2000-03-07	Abbott Laboratories	3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
US6046171A (en) *	1997-10-29	2000-04-04	Abbott Laboratories	6,11-bridged erythromycin derivatives
WO1999021869A1 (en) *	1997-10-29	1999-05-06	Taisho Pharmaceutical Co., Ltd.	Erythromycin a, 11,12-carbamate derivatives
US6124269A (en) *	1997-10-29	2000-09-26	Abbott Laboratories	2-Halo-6-O-substituted ketolide derivatives
ZA989830B (en) *	1997-10-29	1999-05-04	Taisho Pharmaceutical Co Ltd	Erythromycin a derivatives
HRP980189B1 (en) *	1998-04-06	2004-04-30	Pliva Pharm & Chem Works	Novel 15-membered lactams ketolides
FR2777282B1 (fr) *	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
JP4573925B2 (ja) *	1998-07-09	2010-11-04	アベンティス・ファーマ・ソシエテ・アノニム	新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) *	1998-07-21	2001-08-10	Hoechst Marion Roussel Inc	Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
AU5299499A (en)	1998-09-22	2000-04-10	Pfizer Products Inc.	Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) *	1998-11-10	2000-05-12	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CZ20011512A3 (cs)	1998-11-03	2001-09-12	Pfizer Products Inc.	Nová makrolidová antibiotika
FR2786188B1 (fr) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1137654A1 (de)	1998-12-10	2001-10-04	Pfizer Products Inc.	Carbamat- und carbazat-ketolide antibiotika
AP2001002222A0 (en)	1999-01-27	2001-09-30	Pfizer Prod Inc	Ketolide antibiotics.
FR2789392B1 (fr) *	1999-02-04	2001-10-05	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
US6939861B2 (en) *	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
AU775637B2 (en)	1999-04-16	2004-08-12	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
HRP990116B1 (en) *	1999-04-20	2007-10-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
TR200103395T2 (tr) *	1999-05-24	2002-04-22	Pfizer Products Inc.	13-metil eritromisin türevleri.
US6420535B1 (en)	1999-06-07	2002-07-16	Abbott Laboratories	6-O-carbamate ketolide derivatives
EP1146051A3 (de) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A-Derivate
US8063021B2 (en) *	2002-01-17	2011-11-22	Kosan Biosciences Incorporated	Ketolide anti-infective compounds
US6753318B1 (en)	2002-07-25	2004-06-22	Enanta Pharmaceuticals, Inc.	6,11-4-carbon bridged erythromycin derivatives
US7910558B2 (en) *	2002-05-13	2011-03-22	Enanta Pharmaceuticals, Inc.	Bridged macrocyclic compounds and processes for the preparation thereof
US7064110B2 (en) *	2002-05-13	2006-06-20	Enanta Pharmaceuticals, Inc.	6-11 bicycle ketolide derivatives
US6878691B2 (en) *	2002-05-13	2005-04-12	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US6841664B2 (en) *	2002-07-25	2005-01-11	Enanra Pharmaceuticals, Inc.	6,11-4-carbon bridged ketolides
WO2005070918A1 (en) *	2002-05-13	2005-08-04	Enanta Pharmaceuticals, Inc.	Process for the preparation of t-11 bicyclic erythromycin derivatives
US7273853B2 (en) *	2002-05-13	2007-09-25	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
KR100661973B1 (ko) *	2002-05-13	2006-12-28	이난타 파마슈티칼스, 인코포레이티드	6,11 바이사이클릭 에리스로마이신 유도체
US6764998B1 (en)	2003-06-18	2004-07-20	Enanta Pharmaceuticals, Inc.	6,11-4C-bicyclic 9a-azalide derivatives
US7135573B2 (en) *	2002-05-13	2006-11-14	Enanta Pharmaceuticals, Inc.	Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
TW200420573A (en) *	2002-09-26	2004-10-16	Rib X Pharmaceuticals Inc	Bifunctional heterocyclic compounds and methods of making and using same
HRP20020779A2 (en)	2002-09-27	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
CN1780846A (zh) *	2003-03-05	2006-05-31	Rib－X医药品有限公司	双官能杂环化合物及其制备和使用方法
EP3738591A3 (de)	2003-03-10	2021-03-24	Merck Sharp & Dohme Corp.	Neuartige antibakterielle wirkstoffe
US6645941B1 (en)	2003-03-26	2003-11-11	Enanta Pharmaceuticals, Inc.	6,11-3C-bicyclic 9a-azalide derivatives
WO2005007143A2 (en) *	2003-07-14	2005-01-27	The Board Of Trustees Of The University Of Illinois	Use of makrolides and ketolides for the treatment of tuberculosis
US7276487B2 (en) *	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005042554A1 (en) *	2003-10-30	2005-05-12	Rib-X Pharmaceuticals, Inc.	Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US20070270357A1 (en) *	2003-11-18	2007-11-22	Farmer Jay J	Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same
US7414030B2 (en) *	2004-01-07	2008-08-19	Enanta Pharmaceuticals, Inc.	6-11 Bicyclic erythromycin derivatives
US7265094B2 (en) *	2004-01-09	2007-09-04	Enanta Pharmaceuticals, Inc.	9N-substituted 6-11 bicyclic erythromycin derivatives
US8202843B2 (en)	2004-02-27	2012-06-19	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
EA011281B1 (ru)	2004-12-21	2009-02-27	Пфайзер Продактс Инк.	Макролиды
US20100035832A1 (en) *	2005-01-12	2010-02-11	Alpharma Aps	Macrolides
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
WO2006129257A2 (en) *	2005-05-30	2006-12-07	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
EP1779849A1 (de) *	2005-10-28	2007-05-02	Nikem Research S.R.L.	V-ATPase Inhibitoren zur Behandlung von septischem Schock
CN100424089C (zh) *	2006-01-18	2008-10-08	中国药科大学	一种制备大环内酯类半合成抗生素泰利霉素的方法
EP2203435B1 (de) *	2007-09-17	2018-07-18	Enanta Pharmaceuticals, Inc.	6, 11-gebrückte biaryl-makrolide
US8354383B2 (en) *	2007-09-17	2013-01-15	Enanta Pharmaceuticals, Inc.	6,11-bridged biaryl macrolides
US8273720B2 (en) *	2007-09-17	2012-09-25	Enanta Pharmaceuticals, Inc.	6,11-bicyclolides: bridged biaryl macrolide derivatives
CN101917850B (zh)	2007-10-25	2016-01-13	森普拉制药公司	大环内酯类抗菌剂的制备方法
EP2220104A1 (de) *	2007-10-25	2010-08-25	Sandoz AG	Verfahren zur herstellung von telithromycin
TW200946109A (en) *	2008-05-09	2009-11-16	Enanta Pharm Inc	Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
DK2358379T3 (en) *	2008-10-24	2016-03-07	Cempra Pharmaceuticals Inc	BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
EP2475253B1 (de)	2009-09-10	2016-10-26	Cempra Pharmaceuticals, Inc.	Verfahren zur behandlung von malaria, tuberkulose und mac-erkrankungen
BR112012023950A2 (pt)	2010-03-22	2016-07-05	Cempra Pharmaceuticals Inc	formas cristalinas de um macrolídeo, e usos dos mesmos
PL2571506T3 (pl)	2010-05-20	2017-10-31	Cempra Pharmaceuticals Inc	Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US9815863B2 (en) *	2010-09-10	2017-11-14	Cempra Pharmaceuticals, Inc.	Hydrogen bond forming fluoro ketolides for treating diseases
DE102010055322A1 (de) *	2010-12-21	2012-06-21	Christian-Albrechts-Universität Zu Kiel	Antibakteriell und antimykotisch wirkende Substanzen
MX2014011537A (es)	2012-03-27	2015-02-10	Cempra Pharmaceuticals Inc	Formulaciones parenterales para la administracion de antibioticos macrolidos.
WO2014152326A1 (en)	2013-03-14	2014-09-25	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
BR112015023670A2 (pt)	2013-03-15	2017-07-18	Cempra Pharmaceuticals Inc	processo para preparar um composto

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT342770B (de) *	1975-04-07	1978-04-25	Thomae Gmbh Dr K	Verfahren zur herstellung neuer erythromycinderivate
DE2936865A1 (de) *	1979-09-12	1981-04-02	Bayer Ag, 5090 Leverkusen	Verwendung von pikromycin-derivaten als nutritiva
GR77556B (de) *	1982-11-15	1984-09-24	Pfizer
JPS6229595A (ja) *	1985-07-31	1987-02-07	Toyo Jozo Co Ltd	５−ｏ−マイカミノシル−ナルボノライド誘導体およびその製法
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
US5075289A (en) *	1988-06-07	1991-12-24	Abbott Laboratories	9-r-azacyclic erythromycin antibiotics
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
ES2104889T3 (es) *	1990-11-28	1997-10-16	Taisho Pharmaceutical Co Ltd	Derivado de 6-o-metileritromicina a.
FR2692579B1 (fr) *	1992-06-19	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2702480B1 (fr) *	1993-03-09	1995-04-28	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

1993
- 1993-11-01 US US08/146,697 patent/US5527780A/en not_active Expired - Lifetime
- 1993-11-02 MA MA23324A patent/MA23018A1/fr unknown
- 1993-11-04 BR BR9304481A patent/BR9304481A/pt not_active Application Discontinuation
- 1993-11-04 JP JP5297603A patent/JP3000022B2/ja not_active Expired - Lifetime
- 1993-11-04 EP EP93402704A patent/EP0596802B1/de not_active Expired - Lifetime
- 1993-11-04 DK DK93402704.6T patent/DK0596802T3/da active
- 1993-11-04 ES ES93402704T patent/ES2085130T3/es not_active Expired - Lifetime
- 1993-11-04 AT AT93402704T patent/ATE135706T1/de active
- 1993-11-04 CA CA002102457A patent/CA2102457C/fr not_active Expired - Lifetime
- 1993-11-04 DE DE69301897T patent/DE69301897T2/de not_active Expired - Lifetime
- 1993-11-04 RU RU93050129A patent/RU2126416C1/ru active
- 1993-11-05 HU HU0003975A patent/HU221978B1/hu active IP Right Grant
- 1993-11-05 HU HU0200629D patent/HU222113B1/hu active IP Right Grant
- 1993-11-05 CN CN93114229A patent/CN1040876C/zh not_active Expired - Lifetime
- 1993-11-05 HU HU9303148A patent/HU220048B/hu unknown
- 1993-11-05 AU AU50477/93A patent/AU670329B2/en not_active Expired
- 1993-11-05 KR KR1019930023371A patent/KR100317149B1/ko not_active Expired - Lifetime
1995
- 1995-02-21 US US08/391,959 patent/US5614614A/en not_active Expired - Lifetime
1996
- 1996-03-21 GR GR950403179T patent/GR3019385T3/el unknown
1998
- 1998-09-03 JP JP26389698A patent/JP3151188B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR100317149B1 (ko)	2002-06-20
HU0003975D0 (de)	2000-12-28
JPH06220082A (ja)	1994-08-09
EP0596802A1 (de)	1994-05-11
CA2102457C (fr)	2002-01-22
DE69301897T2 (de)	1996-11-07
CA2102457A1 (fr)	1994-05-06
BR9304481A (pt)	1994-06-21
MA23018A1 (fr)	1994-07-01
HU222113B1 (hu)	2003-04-28
RU2126416C1 (ru)	1999-02-20
HU221978B1 (hu)	2003-03-28
CN1040876C (zh)	1998-11-25
JPH11180994A (ja)	1999-07-06
GR3019385T3 (en)	1996-06-30
HUT66446A (en)	1994-11-28
JP3151188B2 (ja)	2001-04-03
KR940011474A (ko)	1994-06-21
AU670329B2 (en)	1996-07-11
DK0596802T3 (da)	1996-06-03
EP0596802B1 (de)	1996-03-20
US5527780A (en)	1996-06-18
HU220048B (hu)	2001-10-28
AU5047793A (en)	1994-05-19
US5614614A (en)	1997-03-25
ES2085130T3 (es)	1996-05-16
JP3000022B2 (ja)	2000-01-17
CN1090581A (zh)	1994-08-10
DE69301897D1 (de)	1996-04-25

Legal Events

Date	Code	Title	Description
1996-09-15	UEP	Publication of translation of european patent specification
2005-05-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
ATE135706T1 (de)	1996-04-15	Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln
BG100951A (en)	1997-08-29	Novel erythromycin derivatives, method for their preparation and their use as drugs
DE3785315D1 (de)	1993-05-13	Erythromycin-a-derivate und verfahren zu ihrer herstellung.
ATE124696T1 (de)	1995-07-15	Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung.
EA199800768A1 (ru)	1999-02-25	Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
FI933903A0 (fi)	1993-09-07	Substituerade cyklohexanderivat, foerfarande foer framstaellning daerav och anvaendning av foereningar foer behandling av sjukdomar
HUT59394A (en)	1992-05-28	Process for producing piperazine derivatives and pharmaceutical compositions comprising same
FI101376B1 (fi)	1998-06-15	Menetelmä 3-bentsyyliamino-2-fenyylipiperidiinijohdannaisten valmistamiseksi
ATE25677T1 (de)	1987-03-15	Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung.
DE3576955D1 (de)	1990-05-10	Beta-carbolin-3-oxadiazolylderivate, verfahren zu ihrer herstellung und ihre verwendung.
NZ218243A (en)	1990-03-27	B-carboline derivatives and pharmaceutical compositions
ATE134623T1 (de)	1996-03-15	Salicyl(thio)etherderivate, verfahren und zwischenprodukte zu ihrer herstellung
ATE53583T1 (de)	1990-06-15	Beta-carbolin-3-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung.
ATE183190T1 (de)	1999-08-15	Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimittel
EA199900156A1 (ru)	1999-08-26	Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
ATE122339T1 (de)	1995-05-15	9-halogen-11(beta)-hydroxy-prostaglandinderivat , verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EA199900528A1 (ru)	1999-12-29	Новые производные эритромицина, способ их получения и применения в качетве медикаментов
DE69311999D1 (de)	1997-08-14	Verfahren zur Herstellung von Amino-Thiadiazolylacetylhaliden
ATE231161T1 (de)	2003-02-15	6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln
DE3860117D1 (de)	1990-06-07	2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
EA199800767A1 (ru)	1999-02-25	Производные 1(2h)хинолинкарбоновой кислоты, способ их получения и их применение в синтезе веществ, обладающих антибиотическими свойствами