ATE135747T1 - Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids - Google Patents

Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids

Info

Publication number
ATE135747T1
ATE135747T1 AT87905848T AT87905848T ATE135747T1 AT E135747 T1 ATE135747 T1 AT E135747T1 AT 87905848 T AT87905848 T AT 87905848T AT 87905848 T AT87905848 T AT 87905848T AT E135747 T1 ATE135747 T1 AT E135747T1
Authority
AT
Austria
Prior art keywords
amino acid
glycoprotein
immunodeficiency virus
human immunodeficiency
acid sequences
Prior art date
Application number
AT87905848T
Other languages
English (en)
Inventor
Paul J Maddon
Dan R Littman
Leonard Chess
Richard Axel
Robin Weiss
J Steven Mcdougal
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of ATE135747T1 publication Critical patent/ATE135747T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT87905848T 1986-08-21 1987-08-20 Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids ATE135747T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89858786A 1986-08-21 1986-08-21

Publications (1)

Publication Number Publication Date
ATE135747T1 true ATE135747T1 (de) 1996-04-15

Family

ID=25409679

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87905848T ATE135747T1 (de) 1986-08-21 1987-08-20 Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids

Country Status (9)

Country Link
US (2) US5871913A (de)
EP (1) EP0280710B1 (de)
JP (1) JP3134874B2 (de)
AT (1) ATE135747T1 (de)
AU (1) AU616639B2 (de)
CA (1) CA1340627C (de)
DE (1) DE3751751T2 (de)
DK (1) DK175520B1 (de)
WO (1) WO1988001304A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292636A (en) * 1986-03-31 1994-03-08 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using soluble T cell surface molecules
US5110906A (en) * 1986-08-21 1992-05-05 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
US6673896B1 (en) 1986-08-21 2004-01-06 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
US5958678A (en) * 1986-08-21 1999-09-28 The Trustees Of Columbia University In The City Of New York DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
WO1988001304A1 (en) 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
AU609447B2 (en) * 1987-02-19 1991-05-02 Nissin Shokuhin Kabushiki Kaisha Methods and materials for hiv detection and therapy
US5140105A (en) * 1987-02-19 1992-08-18 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
US5169752A (en) * 1987-02-19 1992-12-08 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
US5217895A (en) * 1987-02-19 1993-06-08 Nissin Shokuhin Kabushiki Kaisha Monoclonal anti-idiotypic antibodies specific for anti-T4 antibodies and cross-reactive with HIV
US5180660A (en) * 1987-02-19 1993-01-19 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
AU1484688A (en) * 1987-02-20 1988-09-14 Imclone Systems, Inc. Monoclonal antibodies in vaccine formulations
IL83687A (en) * 1987-08-30 1995-03-30 Yeda Res & Dev Pharmaceutical compositions comprising molecular decays and their use in the manufacture of said compositions
EP0347435A4 (en) * 1987-09-04 1991-11-21 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
AU618969B2 (en) * 1987-10-02 1992-01-16 Genentech Inc. Adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
NZ226414A (en) * 1987-10-02 1992-07-28 Genentech Inc Cd4 peptide adhesion variants and their preparation and use
IL87902A0 (en) * 1987-10-08 1989-03-31 Dana Farber Cancer Inst Inc Soluble human cd4 fragments and applications thereof
PT88783B (pt) * 1987-10-23 1993-01-29 Smithkline Beckman Corp Processo de purificacao de proteina t4 soluvel e de producao da mesma
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
AU3006789A (en) * 1988-02-24 1989-08-24 Smithkline Beckman Corporation Expression of hiv binding proteins
EP0346091A3 (de) * 1988-06-10 1990-09-12 Dana Farber Cancer Institute Verfahren zur Diagnose von natürlich vorkommenden Antikörpern gegen cd4
WO1989011860A1 (en) * 1988-06-10 1989-12-14 Biogen, Inc. Combinations of soluble t4 proteins and anti-retroviral agents and methods for treating or preventing aids, arc and hiv infection
WO1990001870A1 (en) * 1988-08-22 1990-03-08 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Retroviral vectors expressing soluble cd4; a gene therapy for aids
DE3828582A1 (de) * 1988-08-23 1990-03-01 Max Planck Gesellschaft Monoklonaler antikoerper zur inhibierung der infektion von zellen durch hiv-viren
WO1990004414A1 (en) * 1988-10-18 1990-05-03 Biogen, Inc. Conjugates of soluble t4 proteins and toxins and methods for treating or preventing aids, arc and hiv infection
AU4660789A (en) * 1988-11-23 1990-06-12 Genentech Inc. Polypeptide derivatives
JPH04504842A (ja) * 1989-01-18 1992-08-27 プレジデント アンド フェローズ オブ ハーバード カレッジ Ａｉｄｓ、ａｒｃおよびｈｉｖ感染の治療または予防のための組成物および方法
AU5437190A (en) * 1989-04-05 1990-11-05 Upjohn Company, The Soluble cd4 produced in (e. coli)
EP0408372A1 (de) * 1989-07-13 1991-01-16 Smithkline Beecham Corporation Antivirale Therapie
JPH0353894A (ja) * 1989-07-21 1991-03-07 Calpis Food Ind Co Ltd:The 抗ヒトｃｄ４ペプチドに対するモノクローナル抗体
JPH05500611A (ja) * 1989-08-23 1993-02-12 ザ・ジェネラル・ホスピタル・コーポレーション 非ヒト霊長類ｃｄ４ポリペプチド、グリコシル化可能なヒトｃｄ４分子、その断片、その融合タンパク質、その遺伝子配列および使用
EP0432693A1 (de) * 1989-12-11 1991-06-19 Sumitomo Chemical Company, Limited Für virusinfizierte Zellen cytotoxische Liposomen
JPH03254693A (ja) * 1990-03-06 1991-11-13 Calpis Food Ind Co Ltd:The 抗イデオタイプ抗体作製用抗原、抗イデオタイプ抗体、及びその製法
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
DE69233480T2 (de) 1991-02-08 2006-01-05 Progenics Pharmaceuticals, Inc. CD4-gamma2- und CD4-IgG2-Chimären
AU1438592A (en) * 1991-02-08 1992-09-07 Progenics Pharmaceuticals, Inc. Cd4-gamma1 and cd4-igg1 chimeras
US5789152A (en) * 1991-04-30 1998-08-04 Basil T. Hone Composition and method for detecting HIV with baculovirus derived vesicles
AU3662293A (en) * 1992-02-10 1993-09-03 Progenics Pharmaceuticals, Inc. A method of using cd4-containing molecules to substantially reduce the risk of occupational hiv transmission
EP0664710A4 (de) 1992-08-07 1998-09-30 Progenics Pharm Inc IMMUNOKONJUGATE BESTEHEND AUS EINEM NICHT-PEPTIDYLEN TEIL UND EINEM CD4-GAMMA2- ODER CD4-IgG2 TEIL, UND VERWENDUNGEN DAVON.
US5817767A (en) * 1993-02-24 1998-10-06 Progenics Pharmaceuticals, Inc. Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same
CA2223088A1 (en) 1995-06-07 1996-12-19 Bob Dale Brown Novel carbamate-based cationic lipids
US6342586B1 (en) 1996-06-10 2002-01-29 Progenics Pharmaceuticals, Inc. Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates and uses thereof
EP0900841A1 (de) * 1997-06-18 1999-03-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Spleissvarianten von LAG-3
US7311920B1 (en) 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US6908612B2 (en) 1999-10-08 2005-06-21 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US20030157063A1 (en) * 2001-12-21 2003-08-21 Jean-Louis Touraine Gene therapy using anti-gp41 antibody and CD4 immunoadhesin
CN1747970A (zh) * 2003-02-06 2006-03-15 三肽公司 抗原/抗体或配体/受体糖基化的特异性交换剂
JP4038679B2 (ja) * 2003-05-13 2008-01-30 住友電気工業株式会社 半導体レーザーバーの固定用治具
US20080146495A1 (en) * 2005-03-11 2008-06-19 The Regents Of The University Of California Methods for Treating Hiv by Inhibiting Cd4 Down-Modulation
US20130158339A1 (en) 2011-12-16 2013-06-20 General Electric Company System and Method of Infant Care Control and Workflow
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US621054A (en) * 1899-03-14 Horatio frederick forrest
JPS57144983A (en) 1981-02-27 1982-09-07 Otsuka Pharmaceut Factory Inc Preparation of physiologically active substance
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4520113A (en) * 1984-04-23 1985-05-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions
US4663436A (en) * 1984-04-24 1987-05-05 Scripps Clinic And Research Foundation Leukemia-associated virus immunogen, vaccine and assay
US4761371A (en) 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US4629783A (en) * 1985-04-29 1986-12-16 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
US5110906A (en) 1986-08-21 1992-05-05 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
US5126433A (en) 1986-08-21 1992-06-30 The Trustees Of Columbia University In The City Of New York Soluble forms of the t cell surface protein cd4
WO1988001304A1 (en) 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
EP0347435A4 (en) 1987-09-04 1991-11-21 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
PT88783B (pt) * 1987-10-23 1993-01-29 Smithkline Beckman Corp Processo de purificacao de proteina t4 soluvel e de producao da mesma

Also Published As

Publication number Publication date
JPH01500879A (ja) 1989-03-30
WO1988001304A1 (en) 1988-02-25
DK217288D0 (da) 1988-04-21
DE3751751D1 (de) 1996-04-25
US6570000B1 (en) 2003-05-27
US5871913A (en) 1999-02-16
DE3751751T2 (de) 1996-10-17
EP0280710A4 (de) 1989-03-14
DK217288A (da) 1988-06-16
AU7879287A (en) 1988-03-08
JP3134874B2 (ja) 2001-02-13
EP0280710A1 (de) 1988-09-07
DK175520B1 (da) 2004-11-22
CA1340627C (en) 1999-07-06
AU616639B2 (en) 1991-11-07
EP0280710B1 (de) 1996-03-20

Similar Documents

Publication Publication Date Title
DE3751751D1 (de) Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids
DE3588254D1 (de) Gag-Antigen und dessen Verwendung zum Nachweis von LAV-Infektion, sowie in immunogenen Zusammensetzungen
ES2013346A6 (es) Metodos para producir secuencias y moleculas de adn recombinante, asi como proteinas t4 solubles.
EA200400376A1 (ru) Пептиды, полученные из казеина, и их использование в терапии
ATE163195T1 (de) Lösliche liganden für cd40
SE8703225L (sv) Monoklonala antikroppar och peptider anvendbara vid behandling och diagnostisering av hiv-infektioner
ATE106748T1 (de) Vakzine zum schutz vor hiv-virusinfektionen, verfahren zu ihrer herstellung und ihre verwendung als diagnostikum und immuntherapeutikum.
ATE134195T1 (de) Peptidfragmente von hiv
ITRM920350A1 (it) Epitopi immunologicamente omologhi di hla e proteine del virus hiv.
EP0236977A3 (de) Impfstoffe gegen Rindervirus-Diarrhoe und Schweine-Cholera
DK0426314T3 (da) HIV-relaterede peptider
BE1000167A4 (fr) Antigene du virus de l'hepatite b et procede pour sa production.
EP0218431A3 (en) Novel polypeptides, dnas that code for the same and method of preparing said polypeptides and dnas
DE3856592D1 (de) Adhäsionsvarianten
FR2792639B1 (fr) Nouveaux immunogenes anti-vih (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time