ES2169375T3 - Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico. - Google Patents

Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico.

Info

Publication number
ES2169375T3
ES2169375T3 ES97917765T ES97917765T ES2169375T3 ES 2169375 T3 ES2169375 T3 ES 2169375T3 ES 97917765 T ES97917765 T ES 97917765T ES 97917765 T ES97917765 T ES 97917765T ES 2169375 T3 ES2169375 T3 ES 2169375T3
Authority
ES
Spain
Prior art keywords
imidazolidin
dioxo
phosphoric acid
pct
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97917765T
Other languages
English (en)
Inventor
Edward Mark Davis
James E Ellis
David A Katonak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2169375T3 publication Critical patent/ES2169375T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

SE DESCRIBE UN PROCESO PERFECCIONADO PARA LA PREPARACION DE UN DIESTER DEL 2,5 - DIOXO - 4,4 - DIFENIL - IMIDAZOLIDIN 1 ILMETIL - ESTER DEL ACIDO FOSFORICO EN EL QUE UN FOSFATO DE METAL ALCALINO SE TRATA CON UNA 3 - (CLOROMETIL) - O UNA 3 (BROMOMETIL) - 5,5 - DIFENIL - 2,4 - IMIDAZOLIDINDIONA PARA OBTENER EL PRODUCTO DESEADO, ASI COMO INTERMEDIOS VALIOSOS USADOS EN EL PROCESO.
ES97917765T 1996-04-30 1997-04-01 Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico. Expired - Lifetime ES2169375T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1651596P 1996-04-30 1996-04-30

Publications (1)

Publication Number Publication Date
ES2169375T3 true ES2169375T3 (es) 2002-07-01

Family

ID=21777523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97917765T Expired - Lifetime ES2169375T3 (es) 1996-04-30 1997-04-01 Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico.

Country Status (15)

Country Link
US (2) US6022975A (es)
EP (1) EP0900227B1 (es)
JP (1) JP4035642B2 (es)
KR (1) KR100453867B1 (es)
AT (1) ATE210670T1 (es)
AU (1) AU708127B2 (es)
BR (1) BR9709198B1 (es)
DE (1) DE69709091T2 (es)
DK (1) DK0900227T3 (es)
ES (1) ES2169375T3 (es)
NZ (1) NZ332115A (es)
PT (1) PT900227E (es)
SI (1) SI0900227T1 (es)
WO (1) WO1997041132A1 (es)
ZA (1) ZA973713B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2169375T3 (es) 1996-04-30 2002-07-01 Warner Lambert Co Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico.
US20070219378A1 (en) * 2004-02-05 2007-09-20 Hartmut Zinser Method for Producing Sodium Fosphenytoin
CH696765A5 (de) * 2004-06-02 2007-11-30 Cilag Ltd Verfahren zur Herstellung von Natrium-fosphenytoin.
DE102004046356A1 (de) * 2004-09-24 2006-03-30 Clariant Gmbh Verfahren zur Herstellung von Alk(en)ylphosphorsäureestersalzen
CA2937222C (en) * 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
ES3031438T3 (en) 2009-06-25 2025-07-08 Alkermes Pharma Ireland Ltd Heterocyclic compounds for the treatment of neurological and psychological disorders
WO2013088255A1 (en) 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
JP6861430B2 (ja) * 2016-09-29 2021-04-21 ノーベルファーマ株式会社 ホスフェニトインナトリウム水和物及びその合成中間体の製法
CA3092335A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE489216A (es) * 1948-06-05 1900-01-01
US3741978A (en) * 1971-04-21 1973-06-26 Hercules Inc Certain o,o-di (c1 and c2 alkyl) phosphorodithioate and phosphorothioate esters useful as insecticides and acaricides
US3925406A (en) * 1972-04-04 1975-12-09 Ciba Geigy Corp Dialkoxyphosphonomethyl derivatives of hydantoins
NL7310784A (es) * 1972-08-10 1974-02-12
CH573948A5 (es) * 1972-12-12 1976-03-31 Ciba Geigy Ag
US4260769A (en) * 1977-04-22 1981-04-07 Interx Research Corporation 5,5-Diphenylhydantoins
DE3126390A1 (de) * 1981-07-03 1983-01-13 Bayer Ag, 5090 Leverkusen S-azolyl-methyl-di(tri)-thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4925860A (en) * 1987-08-05 1990-05-15 E. I. Du Pont De Nemours And Company Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
ES2169375T3 (es) 1996-04-30 2002-07-01 Warner Lambert Co Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico.

Also Published As

Publication number Publication date
SI0900227T1 (en) 2002-04-30
KR20000065111A (ko) 2000-11-06
US6255492B1 (en) 2001-07-03
JP4035642B2 (ja) 2008-01-23
KR100453867B1 (ko) 2005-01-15
EP0900227B1 (en) 2001-12-12
JP2000509071A (ja) 2000-07-18
US6022975A (en) 2000-02-08
ATE210670T1 (de) 2001-12-15
DE69709091T2 (de) 2002-06-20
ZA973713B (en) 1997-12-01
EP0900227A1 (en) 1999-03-10
DK0900227T3 (da) 2002-04-08
PT900227E (pt) 2002-05-31
BR9709198A (pt) 1999-08-10
AU708127B2 (en) 1999-07-29
WO1997041132A1 (en) 1997-11-06
DE69709091D1 (de) 2002-01-24
AU2600997A (en) 1997-11-19
NZ332115A (en) 2000-05-26
BR9709198B1 (pt) 2008-11-18

Similar Documents

Publication Publication Date Title
ATE175194T1 (de) (e)-20(22)-dehydrovitamin-d-verbindungen
PT900227E (pt) Processo melhorado para a sintese de diesteres de ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico do acido fosforicoo
PT84060B (pt) Processo para a preparacao de acidos 2-arilpropionicos
MX9204110A (es) Derivados del acido quinolonacarboxilico y procedimiento para su preparacion.
PT865498E (pt) Processo para a preparacao de ciclodepsipeptideos com 24 atomos no anel substituidos contendo acido aril-lactico
FR2435479A1 (fr) Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3, 7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
MX9604942A (es) Preparacion de purina.
ATE70832T1 (de) Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs|ure.
ES2095080T3 (es) Sintesis regioselectiva del acido 4-cloro-2-tiofencarboxilico.
ES513152A0 (es) "un procedimiento para producir peroxido de hidrogeno y acido 2-ceto-d-gluconico".
AR005878A1 (es) Procedimiento para la elaboracion del ester metilico del acido 2-(2- metilfenil)-3-metoxiacrilico
CO4900052A1 (es) Proceso mejorado para la sintesis de diesteres de 2,5-dioxo- 4,4-difenil-imidazolidin-1-ilmetil ester de acido fosforico
FR2436144A1 (fr) Nouveaux derives d'aurones, leur procede de preparation et leur utilisation comme produits pharmaceutiques
ES8704927A1 (es) Procedimiento para preparar 2(1h)-piridonas
NZ235465A (en) Process for preparing purine derivatives; intermediates
ES2167008T3 (es) Procedimiento de produccion de derivados de diol-1,3 naturales y de derivados de 1,3-dioxano naturales correspondientes.
JPS6474298A (en) Production of fat as substitute for lanolin
ES2119835T3 (es) Procedimiento para la preparacion de esteres alquilicos de acido tetronico.
GR3031546T3 (en) Enzymatic process for producing dihydroxyacetone phosphate from glycerine phosphate and its use in enzymatic aldol additions.
RU95112576A (ru) Способ получения энантиомерно чистого 6-[(4-хлорфенил)-(1h-1,2,4-триазол-1-ил)метил]-1-метил-1н-бензотриазола, промежуточные соединения для их получения и способ их получения
ES2024659B3 (es) Proceso de sintesis de la vitamina a y ciertos de sus derivados
IT7927976A0 (it) Procedimento per la trasformazione di fango di rifiuto ottenuto dalla purificazione dell'acido fosforico ad umido.
ES543102A0 (es) Un procedimiento para la preparacion de un compuesto de qui-nazolinona
JPS54148740A (en) Production of 3-methyl-2-cyclopentene-1-one
US3598843A (en) Glycidamides

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 900227

Country of ref document: ES