ATE136021T1 - Verfahren zur herstellung von n1,n4- diethylspermin - Google Patents
Verfahren zur herstellung von n1,n4- diethylsperminInfo
- Publication number
- ATE136021T1 ATE136021T1 AT92203575T AT92203575T ATE136021T1 AT E136021 T1 ATE136021 T1 AT E136021T1 AT 92203575 T AT92203575 T AT 92203575T AT 92203575 T AT92203575 T AT 92203575T AT E136021 T1 ATE136021 T1 AT E136021T1
- Authority
- AT
- Austria
- Prior art keywords
- general formula
- stands
- chem
- pharmaceutically acceptable
- compound
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012021 ethylating agents Substances 0.000 abstract 1
- HCUFAPSHGYTZPM-UHFFFAOYSA-N n,n'-bis(3-aminopropyl)-n,n'-diethylbutane-1,4-diamine Chemical compound NCCCN(CC)CCCCN(CC)CCCN HCUFAPSHGYTZPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940063675 spermine Drugs 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Hematology (AREA)
- Pest Control & Pesticides (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93683586A | 1986-12-02 | 1986-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE136021T1 true ATE136021T1 (de) | 1996-04-15 |
Family
ID=25469139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92203575T ATE136021T1 (de) | 1986-12-02 | 1987-12-01 | Verfahren zur herstellung von n1,n4- diethylspermin |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP0536853B1 (de) |
| JP (1) | JPH0653661B2 (de) |
| AT (1) | ATE136021T1 (de) |
| CA (1) | CA1305425C (de) |
| DE (2) | DE3751764T2 (de) |
| ES (2) | ES2059398T3 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5753714A (en) * | 1987-02-03 | 1998-05-19 | Merrell Pharmaceuticals Inc. | Polyamine derivatives |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
| US5654484A (en) * | 1987-10-08 | 1997-08-05 | Merrell Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
| ATE120447T1 (de) * | 1989-01-10 | 1995-04-15 | Merrell Dow Pharma | Polyamin-derivate als antineoplastische mittel. |
| US5561136A (en) * | 1990-12-13 | 1996-10-01 | Merrell Pharmaceuticals Inc. | Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent |
| GB9105489D0 (en) * | 1991-03-15 | 1991-05-01 | Johnson Matthey Plc | Improvements in chemical compounds |
| FR2714052B1 (fr) * | 1993-12-22 | 1996-02-02 | Synthelabo | Préparation de polyamines substituées sur les deux azotes terminaux. |
| ES2119371T3 (es) * | 1993-12-27 | 1998-10-01 | Novartis Ag | Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico. |
| US5834486A (en) * | 1995-03-15 | 1998-11-10 | Novartis Ag | Piperidinyl-2-alkyl, substituted linear polyamines for the reduction of intracellular, endogenic polyamine levels such as putrescine, spermidine and spermine, and their impact on cell proliferation |
| EP0934249B1 (de) * | 1996-10-18 | 2002-03-27 | Wisconsin Alumni Research Foundation | In ihrer konformation eingeschränkte polyamine und ihre verwendung als antineoplastische mittel |
| US5889061A (en) * | 1997-10-15 | 1999-03-30 | Wisconsin Alumni Research Foundation | Conformationally restricted polyamines |
| US7045550B2 (en) | 2001-08-07 | 2006-05-16 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| RU2017104223A (ru) * | 2014-07-11 | 2018-08-14 | Джензим Корпорейшн | Полиамины с определенной главной цепью |
| WO2018059216A1 (zh) * | 2016-09-29 | 2018-04-05 | 广州君赫生物科技有限公司 | 降低saicar合成酶活性的化合物及应用 |
| CN110678452B (zh) | 2017-04-20 | 2023-02-28 | 广州君赫生物科技有限公司 | 亚精胺及其衍生物的应用 |
| CN110494131B (zh) * | 2017-04-20 | 2022-11-08 | 广州君赫生物科技有限公司 | 精胺及其衍生物在制备抗肿瘤药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS606348B2 (ja) * | 1976-03-31 | 1985-02-18 | 三菱化学株式会社 | 新規ポリアミン類 |
| JPS5998015A (ja) * | 1982-11-27 | 1984-06-06 | Microbial Chem Res Found | 免疫賦活剤 |
-
1987
- 1987-11-26 CA CA000552907A patent/CA1305425C/en not_active Expired - Lifetime
- 1987-12-01 ES ES87310591T patent/ES2059398T3/es not_active Expired - Lifetime
- 1987-12-01 DE DE3751764T patent/DE3751764T2/de not_active Expired - Fee Related
- 1987-12-01 ES ES92203575T patent/ES2088091T3/es not_active Expired - Lifetime
- 1987-12-01 AT AT92203575T patent/ATE136021T1/de not_active IP Right Cessation
- 1987-12-01 DE DE87310591T patent/DE3786896T2/de not_active Expired - Fee Related
- 1987-12-01 EP EP92203575A patent/EP0536853B1/de not_active Expired - Lifetime
- 1987-12-01 EP EP87310591A patent/EP0270349B1/de not_active Expired - Lifetime
- 1987-12-02 JP JP62305487A patent/JPH0653661B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1305425C (en) | 1992-07-21 |
| ES2059398T3 (es) | 1994-11-16 |
| JPS63211225A (ja) | 1988-09-02 |
| EP0270349A2 (de) | 1988-06-08 |
| DE3751764T2 (de) | 1996-10-31 |
| ES2088091T3 (es) | 1996-08-01 |
| EP0270349A3 (en) | 1990-09-12 |
| EP0536853B1 (de) | 1996-03-27 |
| EP0270349B1 (de) | 1993-08-04 |
| DE3786896T2 (de) | 1993-12-23 |
| DE3751764D1 (de) | 1996-05-02 |
| DE3786896D1 (de) | 1993-09-09 |
| EP0536853A2 (de) | 1993-04-14 |
| JPH0653661B2 (ja) | 1994-07-20 |
| EP0536853A3 (en) | 1993-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE136021T1 (de) | Verfahren zur herstellung von n1,n4- diethylspermin | |
| ATE26112T1 (de) | Isochinolin-sulfonamidderivate und verfahren fuer ihre herstellung. | |
| ATE150462T1 (de) | Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung | |
| ES533009A0 (es) | Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina. | |
| DE3762236D1 (de) | Verfahren zur herstellung von (2,2)-paracyclophan und dessen derivaten. | |
| ATE57699T1 (de) | Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung. | |
| AU8004291A (en) | Use of alkyl phospholipids as antiviral drugs, as well as new compounds | |
| DE69108014D1 (de) | Verfahren zur herstellung von nucleosiden und ihre analogen. | |
| DE3768319D1 (de) | Verfahren zur herstellung von o-substituierten hydroxylaminen. | |
| ATE477227T1 (de) | Verfahren zur herstellung eines trans-4-amino-1- cyclohexancarbonsäurederivats | |
| DE3576952D1 (de) | Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten. | |
| ATE277015T1 (de) | Verfahren zur herstellung von 1,4-dihydropyridine sowie in diesem verfahren verwendete verbindungen | |
| DE59306121D1 (de) | Verfahren zur racemattrennung von verapamil | |
| NO166528C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive naftalen- og indanderivater. | |
| NO873248D0 (no) | Fremgangsmaate for fremstilling av kinolincarboxylsyrer. | |
| ATE176783T1 (de) | Verfahren zur herstellung von urethangruppen enthaltende bisoxazolidinen | |
| ATE101391T1 (de) | Verfahren zur herstellung von in stellung 3 durch eine halogenierte gesaettigte kette substituierten cyclopropancarbonsaeurederivaten. | |
| ATE185802T1 (de) | Verfahren zur herstellung von 1-methylindazol-3- carbonsäure | |
| DE69809888D1 (de) | Verfahren zur Herstellung von alpha-Aminoketonen | |
| DE69604642D1 (de) | Verfahren zur herstellung von iodierten kontrastmitteln | |
| ATE21387T1 (de) | Hydrochinonabkoemmlinge, sowie verfahren zu deren herstellung. | |
| ATE77091T1 (de) | Verfahren zur herstellung von alphaaminoalkylphosphons|uren. | |
| DE3750117D1 (de) | Verfahren zur Herstellung von Indolinon-2-Derivaten. | |
| ATE166048T1 (de) | Verfahren zur herstellung von prostaglandin e | |
| ATE127775T1 (de) | Verfahren zur herstellung von alpha-omega- alkandicarbonsäuren. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |