ATE138383T1 - Glycolipid-derivate - Google Patents

Glycolipid-derivate

Info

Publication number
ATE138383T1
ATE138383T1 AT93111255T AT93111255T ATE138383T1 AT E138383 T1 ATE138383 T1 AT E138383T1 AT 93111255 T AT93111255 T AT 93111255T AT 93111255 T AT93111255 T AT 93111255T AT E138383 T1 ATE138383 T1 AT E138383T1
Authority
AT
Austria
Prior art keywords
derivatives
glycolipide
chem
agents
metastasis
Prior art date
Application number
AT93111255T
Other languages
English (en)
Inventor
Yutaka Yamada
Kanagawa-Ku Nakamura
Naofumi Takahashi
Keisuke Adachi
Isogo-Ku Mori
Akihiko Kameyama
Original Assignee
Nisshin Oil Mills Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Oil Mills Ltd filed Critical Nisshin Oil Mills Ltd
Application granted granted Critical
Publication of ATE138383T1 publication Critical patent/ATE138383T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93111255T 1992-07-15 1993-07-15 Glycolipid-derivate ATE138383T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18800192 1992-07-15

Publications (1)

Publication Number Publication Date
ATE138383T1 true ATE138383T1 (de) 1996-06-15

Family

ID=16215909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93111255T ATE138383T1 (de) 1992-07-15 1993-07-15 Glycolipid-derivate

Country Status (8)

Country Link
US (1) US5369096A (de)
EP (1) EP0579196B1 (de)
JP (1) JPH0680687A (de)
AT (1) ATE138383T1 (de)
CA (1) CA2100412A1 (de)
DE (1) DE69302767T2 (de)
DK (1) DK0579196T3 (de)
ES (1) ES2090790T3 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors
JPH08500820A (ja) * 1992-06-29 1996-01-30 グライコメッド インコーポレイテッド 細胞接着インヒビターとしての置換されたラクトース誘導体
US5591835A (en) * 1992-06-29 1997-01-07 Glycomed Incorporated Substituted lactose derivatives
DE4408248A1 (de) * 1994-03-11 1995-09-14 Hoechst Ag Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
JPH0899989A (ja) * 1994-09-30 1996-04-16 Akira Hasegawa 新規糖脂質誘導体およびその製造用中間体
WO1996041636A1 (en) * 1995-06-13 1996-12-27 The Nisshin Oil Mills, Ltd. Antiasthmatic agent
HUP9801805A3 (en) * 1995-06-29 2002-01-28 Novartis Ag Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a
AU6485496A (en) * 1995-07-14 1997-02-18 Glycotech Corp. Compounds and methods for treatment of egf receptor associated cancers and purification of the egf receptor
US5876715A (en) * 1995-08-17 1999-03-02 The Biomembrane Institute Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof
CA2316041A1 (en) * 1997-12-30 1999-07-08 Pam Fredman Galactosylceramide, glucosylceramide, lactosylceramide, and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complications
JP2001352982A (ja) * 2000-06-12 2001-12-25 Shimadzu Corp 核酸合成法
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
AU2003245595A1 (en) * 2002-07-03 2004-01-23 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
WO2007021721A2 (en) * 2005-08-09 2007-02-22 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7964569B2 (en) 2006-10-12 2011-06-21 Glycomimetics, Inc. Glycomimetic replacements for hexoses and N-acetyl hexosamines
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8518896B2 (en) 2008-06-13 2013-08-27 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) * 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
EP2794626B3 (de) 2011-12-22 2020-08-05 GlycoMimetics, Inc. E-selectin-antagonistenverbindungen
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (de) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Verfahren zur mobilisierung von knochenmarkinfiltrierenden lymphozyten und deren verwendung
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
US4762800A (en) * 1984-04-26 1988-08-09 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to cell surface antigens of human teratocarcinomas
US5002759A (en) * 1989-07-25 1991-03-26 Colgate-Palmolive Company Oligosaccharide inhibition of Streptococcus pyogenes adhesion
WO1991019501A1 (en) * 1990-06-15 1991-12-26 Cytel Corporation Intercellular adhesion mediators
US5143712A (en) * 1990-07-30 1992-09-01 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US5211937A (en) * 1990-07-30 1993-05-18 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
NZ240316A (en) * 1990-10-25 1996-12-20 Univ Michigan Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells

Also Published As

Publication number Publication date
US5369096A (en) 1994-11-29
DE69302767T2 (de) 1996-11-14
ES2090790T3 (es) 1996-10-16
JPH0680687A (ja) 1994-03-22
EP0579196A1 (de) 1994-01-19
EP0579196B1 (de) 1996-05-22
DE69302767D1 (de) 1996-06-27
DK0579196T3 (da) 1996-07-01
CA2100412A1 (en) 1994-01-16

Similar Documents

Publication Publication Date Title
DE69302767D1 (de) Glycolipid-Derivate
ES2097653T3 (es) Nuevos derivados de desoxigalactonojirimicina.
HUT49860A (en) Process for producing benzamide-type protease inhibitors
ZA971714B (en) Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions
ATE61374T1 (de) Diaminoandrostanderivate.
ZA9710292B (en) Atherosclerosis treatment
MY111305A (en) Wellbore fluid.
ATE203020T1 (de) Schwefel enthaltende heterocyclische verbindungen
DE68922765D1 (de) Substituierte Naphthalen-Verbindungen und diese enthaltende Flüssigkristall-Zusammensetzungen.
HU9400491D0 (en) Acyl-coenzyme-a=cholesterol acyl-transferase (acat) inhibitor tetrazole-carboxamide derivatives
AU2321688A (en) Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes
FI913067A0 (fi) Bisfosfonsyraderivat, deras framstaellning och anvaendning.
SI0668279T1 (en) 6-Azaindole thromboxane synthase inhibitors
MX170732B (es) Composicion de derivados de succinimida y su uso
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
AU4953997A (en) New histidine derivatives, preparation process, and their use as free antiradical agents
NZ240404A (en) Oxysulphonyl (thio)carbamate derivatives and pharmaceutical
DE69103985D1 (de) N-Alkylthiazolidinderivate.
FR2541267B1 (de)
DE69333903D1 (de) Optisch aktive 1-Phenylpyrrolidonderivate