ZA921891B - Aminosteroids in a method for inhibiting c17-20 lyase - Google Patents

Aminosteroids in a method for inhibiting c17-20 lyase

Info

Publication number: ZA921891B
Authority: ZA; South Africa
Prior art keywords: alkyl; inhibiting; lyase; aminosteroids; benzoyl
Prior art date: 1991-03-19

Application number

ZA921891A

Other languages

English (en)

Inventor

Philip Marvin Weintraub

Marvin Weintraub Philip

Cynthia Ann Gates

Ann Gates Cynthia

Thomas Robert Blohm

Robert Blohm Thomas

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-19

Filing date

1992-03-13

Publication date

1992-11-25

1992-03-13 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-11-25 Publication of ZA921891B publication Critical patent/ZA921891B/xx

Links

102000004317 Lyases Human genes 0.000 title abstract 2
108090000856 Lyases Proteins 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA921891A 1991-03-19 1992-03-13 Aminosteroids in a method for inhibiting c17-20 lyase ZA921891B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/671,555 US5143909A (en)	1991-03-19	1991-03-19	Aminosteroids in a method for inhibiting c17-20 lyase

Publications (1)

Publication Number	Publication Date
ZA921891B true ZA921891B (en)	1992-11-25

Family

ID=24694981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA921891A ZA921891B (en)	1991-03-19	1992-03-13	Aminosteroids in a method for inhibiting c17-20 lyase

Country Status (13)

Country	Link
US (1)	US5143909A (de)
EP (1)	EP0509259B1 (de)
JP (1)	JP3031585B2 (de)
KR (1)	KR100227717B1 (de)
AT (1)	ATE141507T1 (de)
AU (1)	AU651670B2 (de)
DE (1)	DE69212878T2 (de)
DK (1)	DK0509259T3 (de)
ES (1)	ES2093731T3 (de)
GR (1)	GR3021298T3 (de)
IE (1)	IE73639B1 (de)
TW (1)	TW239076B (de)
ZA (1)	ZA921891B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5318961A (en) *	1990-08-01	1994-06-07	Merrell Dow Pharmaceuticals Inc.	4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
WO1993014762A1 (en) *	1992-01-27	1993-08-05	Merck & Co., Inc.	17β-HYDROXYBENZOYL-4-AZA-5α-ANDROST-1-EN-3-ONES USEFUL TO TREAT BALDNESS
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
DK0758340T3 (da) *	1994-05-02	1999-08-30	Merrell Pharma Inc	Fremgangsmåde til fremstilling af 4-amino-delta 4-3-ketosteroider via 4-nitro-delta 4-3-ketosteroider
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6365597B1 (en)	1996-02-14	2002-04-02	Aventis Pharmaceuticals Inc.	4-aza steroids
CN116874547A (zh) *	2023-06-12	2023-10-13	陕西汉江药业集团股份有限公司	一种黄体酮杂质羧酸物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS
WO1985000519A1 (en) *	1983-07-29	1985-02-14	Duke University	Method of treating androgen-related disorders
GB8503940D0 (en) *	1985-02-15	1985-03-20	Erba Farmitalia	4-substituted androstendione derivatives
GB8622330D0 (en) *	1986-09-17	1986-10-22	Erba Farmitalia	4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) *	1987-05-15	1987-06-17	Erba Farmitalia	4-amino-androstenedione derivatives
ES2189784T3 (es) *	1989-07-07	2003-07-16	Endorech Inc	Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
NZ239142A (en) *	1990-08-01	1994-05-26	Merrell Dow Pharma	4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions

1991
- 1991-03-19 US US07/671,555 patent/US5143909A/en not_active Expired - Fee Related
1992
- 1992-03-13 AU AU12897/92A patent/AU651670B2/en not_active Ceased
- 1992-03-13 ZA ZA921891A patent/ZA921891B/xx unknown
- 1992-03-14 TW TW081101939A patent/TW239076B/zh active
- 1992-03-18 AT AT92104675T patent/ATE141507T1/de not_active IP Right Cessation
- 1992-03-18 DK DK92104675.1T patent/DK0509259T3/da active
- 1992-03-18 IE IE920864A patent/IE73639B1/en not_active IP Right Cessation
- 1992-03-18 ES ES92104675T patent/ES2093731T3/es not_active Expired - Lifetime
- 1992-03-18 DE DE69212878T patent/DE69212878T2/de not_active Expired - Fee Related
- 1992-03-18 KR KR1019920004407A patent/KR100227717B1/ko not_active Expired - Fee Related
- 1992-03-18 EP EP92104675A patent/EP0509259B1/de not_active Expired - Lifetime
- 1992-03-19 JP JP4092468A patent/JP3031585B2/ja not_active Expired - Fee Related
1996
- 1996-10-09 GR GR960402669T patent/GR3021298T3/el unknown

Also Published As

Publication number	Publication date
ES2093731T3 (es)	1997-01-01
EP0509259A1 (de)	1992-10-21
ATE141507T1 (de)	1996-09-15
AU1289792A (en)	1992-09-24
DE69212878T2 (de)	1997-01-23
KR100227717B1 (ko)	1999-11-01
AU651670B2 (en)	1994-07-28
GR3021298T3 (en)	1997-01-31
IE73639B1 (en)	1997-06-18
DK0509259T3 (da)	1996-09-09
JPH05125093A (ja)	1993-05-21
DE69212878D1 (de)	1996-09-26
EP0509259B1 (de)	1996-08-21
JP3031585B2 (ja)	2000-04-10
TW239076B (de)	1995-01-21
US5143909A (en)	1992-09-01
IE920864A1 (en)	1992-09-23

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