ATE141613T1 - Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür - Google Patents

Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür

Info

Publication number: ATE141613T1
Authority: AT; Austria
Prior art keywords: diketopiperazine; intermediate products; dkp; new intermediate; derivatives
Prior art date: 1990-03-15

Application number

AT91906948T

Other languages

English (en)

Inventor

John B Hill

Tse-Lok Ho

Mark R Johnson

Russell Klix

Gayle Webber

Robert A Erickson

Original Assignee

Nutrasweet Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-15

Filing date

1991-03-12

Publication date

1996-09-15

1991-03-12 Application filed by Nutrasweet Co filed Critical Nutrasweet Co

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141613T1 publication Critical patent/ATE141613T1/de

Links

IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
108010011485 Aspartame Proteins 0.000 title 1
229960003438 aspartame Drugs 0.000 title 1
235000010357 aspartame Nutrition 0.000 title 1
239000000605 aspartame Substances 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT91906948T 1990-03-15 1991-03-12 Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür ATE141613T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US49824390A	1990-03-15	1990-03-15
US60665690A	1990-10-31	1990-10-31
US65878491A	1991-02-26	1991-02-26
US66480691A	1991-03-08	1991-03-08

Publications (1)

Publication Number	Publication Date
ATE141613T1 true ATE141613T1 (de)	1996-09-15

Family

ID=27504394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91906948T ATE141613T1 (de)	1990-03-15	1991-03-12	Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür

Country Status (16)

Country	Link
EP (1)	EP0478729B1 (de)
CN (1)	CN1057835A (de)
AT (1)	ATE141613T1 (de)
AU (1)	AU628257B2 (de)
CA (1)	CA2060515A1 (de)
CS (1)	CS70091A2 (de)
DE (1)	DE69121502T2 (de)
DK (1)	DK0478729T3 (de)
ES (1)	ES2091324T3 (de)
GR (1)	GR3020839T3 (de)
HU (1)	HUT60712A (de)
IE (1)	IE910896A1 (de)
NO (1)	NO920193L (de)
NZ (1)	NZ237469A (de)
PT (1)	PT97049B (de)
WO (1)	WO1991014378A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04234375A (ja) *	1990-12-27	1992-08-24	Ajinomoto Co Inc	新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) *	1990-12-27	1992-08-24	Ajinomoto Co Inc	ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) *	1991-10-23	1993-05-14	Ajinomoto Co Inc	新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en)	1998-11-19	2002-10-15	The Nutrasweet Company	Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) *	2000-04-20	2001-10-25	Degussa	Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
CN100553636C (zh)	2000-08-04	2009-10-28	Dmi生物科学公司	二酮基哌嗪和包含它们的组合物的使用方法
GB2382346B (en) *	2000-08-04	2004-08-11	Dmi Biosciences Inc	Method of synthesizing diketopiperazines
WO2004030522A2 (en)	2002-10-02	2004-04-15	Dmi Biosciences, Inc.	Diagnosis and monitoring of diseases
EP2517718B1 (de)	2003-05-15	2016-03-02	Ampio Pharmaceuticals, Inc.	Behandlung von T-Zell-vermittelten Krankheiten
JP5856843B2 (ja)	2008-05-27	2016-02-10	アンピオファーマシューティカルズ，インコーポレイテッド	ジケトピペラジンを用いた医薬組成物
EP2613786A4 (de)	2010-09-07	2013-10-23	Dmi Acquisition Corp	Behandlung von erkrankungen
EA028343B1 (ru)	2011-10-10	2017-11-30	Ампио Фармасьютикалз, Инк.	Лечение дегенеративного заболевания сустава
MY172699A (en)	2011-10-10	2019-12-10	Ampio Pharmaceuticals Inc	Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2771007B1 (de)	2011-10-28	2018-04-04	Ampio Pharmaceuticals, Inc.	Behandlung von rhinitis
BR112015020469A2 (pt)	2013-03-15	2020-01-28	Ampio Pharmaceuticals Inc	Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
RU2736513C2 (ru)	2014-08-18	2020-11-17	Ампио Фармасьютикалз, Инк.	Лечение патологических состояний суставов
EP3310375A4 (de)	2015-06-22	2019-02-20	Ampio Pharmaceuticals, Inc.	Verwendung von niedermolekularen fraktionen von humanem serumalbumin bei der behandlung von erkrankungen
US11510427B2 (en) *	2016-12-21	2022-11-29	Suntory Holdings Limited	Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose
JPWO2024075813A1 (de) *	2022-10-07	2024-04-11

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2038106A1 (de) *	1970-07-31	1972-02-10	Henkel & Cie Gmbh	Aktivatoren fuer Perverbindungen
JPS58185545A (ja) *	1982-04-22	1983-10-29	Ajinomoto Co Inc	α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) *	1983-05-13	1988-11-30	Debi Derivati Biologici	Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) *	1984-02-21	1985-09-09	Ajinomoto Co Inc	α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) *	1985-03-29	1989-07-20	Mitsui Toatsu Chemicals Inc.	Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) *	1985-06-04	1994-06-22	味の素株式会社	β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) *	1985-10-31	1987-06-30	Monsanto Company	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) *	1986-01-13	1987-07-16	Green Cross Korea	Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) *	1988-08-31	1991-02-12	Eastman Kodak Company	Process for preparation of amino acids

1991
- 1991-03-12 DK DK91906948.4T patent/DK0478729T3/da active
- 1991-03-12 AU AU75648/91A patent/AU628257B2/en not_active Ceased
- 1991-03-12 EP EP91906948A patent/EP0478729B1/de not_active Expired - Lifetime
- 1991-03-12 HU HU913921A patent/HUT60712A/hu unknown
- 1991-03-12 DE DE69121502T patent/DE69121502T2/de not_active Expired - Fee Related
- 1991-03-12 WO PCT/US1991/001646 patent/WO1991014378A1/en not_active Ceased
- 1991-03-12 AT AT91906948T patent/ATE141613T1/de not_active IP Right Cessation
- 1991-03-12 CA CA002060515A patent/CA2060515A1/en not_active Abandoned
- 1991-03-12 ES ES91906948T patent/ES2091324T3/es not_active Expired - Lifetime
- 1991-03-15 IE IE089691A patent/IE910896A1/en unknown
- 1991-03-15 CN CN91102471.9A patent/CN1057835A/zh active Pending
- 1991-03-15 CS CS91700A patent/CS70091A2/cs unknown
- 1991-03-15 PT PT97049A patent/PT97049B/pt not_active IP Right Cessation
- 1991-03-18 NZ NZ237469A patent/NZ237469A/en unknown
1992
- 1992-01-15 NO NO92920193A patent/NO920193L/no unknown
1996
- 1996-08-22 GR GR960402052T patent/GR3020839T3/el unknown

Also Published As

Publication number	Publication date
NO920193D0 (no)	1992-01-15
DE69121502T2 (de)	1997-01-16
EP0478729A4 (en)	1993-06-16
EP0478729A1 (de)	1992-04-08
IE910896A1 (en)	1991-09-25
EP0478729B1 (de)	1996-08-21
AU7564891A (en)	1991-10-21
ES2091324T3 (es)	1996-11-01
AU628257B2 (en)	1992-09-10
CN1057835A (zh)	1992-01-15
HUT60712A (en)	1992-10-28
WO1991014378A1 (en)	1991-10-03
DE69121502D1 (de)	1996-09-26
NZ237469A (en)	1993-08-26
NO920193L (no)	1992-01-15
CS70091A2 (en)	1991-10-15
DK0478729T3 (da)	1996-09-16
GR3020839T3 (en)	1996-11-30
PT97049A (pt)	1991-12-31
CA2060515A1 (en)	1991-09-16
PT97049B (pt)	1998-07-31

Legal Events

Date	Code	Title	Description
1997-02-15	UEP	Publication of translation of european patent specification
2002-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE141613T1 (de)	1996-09-15	Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür
DE69316405D1 (de)	1998-02-26	Verfahren zur fermentativen Herstellung von Aminosäuren
DE69132176D1 (de)	2000-06-08	Verfahren zur Herstellung von Elektroden
DE69832209D1 (de)	2005-12-08	Verfahren zur Herstellung von 3,3-Dimethylbutyraldehyd durch Oxidation von 3,3-Dimethylbutanol
DE68919246D1 (de)	1994-12-15	Verfahren zur Herstellung von Aminosäuren.
DE69611957D1 (de)	2001-04-12	Verfahren zur Herstellung von Goldpulver durch Aerosolzersetzungen
DE69328761D1 (de)	2000-07-06	Verfahren zur Herstellung von L-Tryptophan, L-Tyrosin oder L-Phenylalanin
DE68913394D1 (de)	1994-04-07	Verfahren zur Herstellung von substituierten Phenoxyethylaminen sowie Zwischenverbindungen.
DE69531308D1 (de)	2003-08-21	Verfahren zur Herstellung von gereinigten papillomavirus Proteinen
DE3583220D1 (de)	1991-07-18	Verwendung von dipeptidderivaten fuer die herstellung von arzneimitteln zur behandlung von an amyotropher lateralsklerose erkrankten.
IL98647A0 (en)	1992-07-15	Anti-inflammatory factor,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE70067T1 (de)	1991-12-15	Peptidaminoalkoholderivate, welche ein tetrasubstituiertes kohlenstoffatom besitzen, hemmungsstoffe von renin und proteasesaeuren, verfahren zur herstellung und pharmazeutische zusammensetzungen.
DE69220113D1 (de)	1997-07-10	Verfahren zur Herstellung von menschlichem Serum Albumin
DE69306016D1 (de)	1997-01-02	Verfahren zur Herstellung von Acrolein
DE69607524D1 (de)	2000-05-11	Verfahren zur Herstellung von einem Bicyclohexanderivat
DE69611120D1 (de)	2001-01-11	Verfahren zur Herstellung von "grüner-Tee-Eiern"
DE59007794D1 (de)	1995-01-12	Verfahren zur Herstellung von 2-Chlor-5-chlormethyl-pyridin und neue Zwischenprodukte.
DE69530176T2 (de)	2004-01-29	Verfahren zur Herstellung von Protein
DE69113323D1 (de)	1995-11-02	Verfahren zur Herstellung von alpha-Hydroxycarbonsäure amiden.
DE59309922D1 (de)	2000-02-17	Verfahren zur Herstellung von substituierten 2,3-Difluorpyridinen
DE59510265D1 (de)	2002-08-08	Verfahren zur Herstellung von 2,6-Dichlor-3-fluor-benzonitril und neue Zwischen-produkte
FR2625651B1 (fr)	1994-01-21	Procede d'elimination de l'amertume d'hydrolysats de proteines et produit obtenu
DE59107146D1 (de)	1996-02-08	Verfahren zur Herstellung von T-Gate-Elektroden
DE69500362D1 (de)	1997-07-24	Verfahren zur Herstellung 5,6-dihydroxyindol-Derivate ausgehend von Dopa
DE59300584D1 (de)	1995-10-19	Verfahren zur Herstellung von 5-Cyanvaleriansäureamid.