PT97049A - Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados - Google Patents

Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Info

Publication number: PT97049A
Authority: PT; Portugal
Prior art keywords: alpha; methyl ester; derivatives; phenylenanin; aspartil
Prior art date: 1990-03-15

Application number

PT97049A

Other languages

English (en)

Other versions

PT97049B (pt

Inventor

John B Hill

Mark R Johnson

Tse-Lok Ho

Russell Klix

Gayle Webber

Robert A Erickson

Original Assignee

Nutrasweet Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-15

Filing date

1991-03-15

Publication date

1991-12-31

1991-03-15 Application filed by Nutrasweet Co filed Critical Nutrasweet Co

1991-12-31 Publication of PT97049A publication Critical patent/PT97049A/pt

1998-07-31 Publication of PT97049B publication Critical patent/PT97049B/pt

Links

IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
235000010357 aspartame Nutrition 0.000 title 2
FGOJCPKOOGIRPA-UHFFFAOYSA-N 1-o-tert-butyl 4-o-ethyl 5-oxoazepane-1,4-dicarboxylate Chemical compound CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CCC1=O FGOJCPKOOGIRPA-UHFFFAOYSA-N 0.000 title 1
108010011485 Aspartame Proteins 0.000 title 1
229960003438 aspartame Drugs 0.000 title 1
239000000605 aspartame Substances 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT97049A 1990-03-15 1991-03-15 Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados PT97049B (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US49824390A	1990-03-15	1990-03-15
US60665690A	1990-10-31	1990-10-31
US65878491A	1991-02-26	1991-02-26
US66480691A	1991-03-08	1991-03-08

Publications (2)

Publication Number	Publication Date
PT97049A true PT97049A (pt)	1991-12-31
PT97049B PT97049B (pt)	1998-07-31

Family

ID=27504394

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97049A PT97049B (pt)	1990-03-15	1991-03-15	Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Country Status (16)

Country	Link
EP (1)	EP0478729B1 (pt)
CN (1)	CN1057835A (pt)
AT (1)	ATE141613T1 (pt)
AU (1)	AU628257B2 (pt)
CA (1)	CA2060515A1 (pt)
CS (1)	CS70091A2 (pt)
DE (1)	DE69121502T2 (pt)
DK (1)	DK0478729T3 (pt)
ES (1)	ES2091324T3 (pt)
GR (1)	GR3020839T3 (pt)
HU (1)	HUT60712A (pt)
IE (1)	IE910896A1 (pt)
NO (1)	NO920193L (pt)
NZ (1)	NZ237469A (pt)
PT (1)	PT97049B (pt)
WO (1)	WO1991014378A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04234375A (ja) *	1990-12-27	1992-08-24	Ajinomoto Co Inc	新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) *	1990-12-27	1992-08-24	Ajinomoto Co Inc	ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) *	1991-10-23	1993-05-14	Ajinomoto Co Inc	新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en)	1998-11-19	2002-10-15	The Nutrasweet Company	Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) *	2000-04-20	2001-10-25	Degussa	Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
CN100553636C (zh)	2000-08-04	2009-10-28	Dmi生物科学公司	二酮基哌嗪和包含它们的组合物的使用方法
GB2382346B (en) *	2000-08-04	2004-08-11	Dmi Biosciences Inc	Method of synthesizing diketopiperazines
WO2004030522A2 (en)	2002-10-02	2004-04-15	Dmi Biosciences, Inc.	Diagnosis and monitoring of diseases
EP2517718B1 (en)	2003-05-15	2016-03-02	Ampio Pharmaceuticals, Inc.	Treatment of T-cell mediated diseases
JP5856843B2 (ja)	2008-05-27	2016-02-10	アンピオファーマシューティカルズ，インコーポレイテッド	ジケトピペラジンを用いた医薬組成物
EP2613786A4 (en)	2010-09-07	2013-10-23	Dmi Acquisition Corp	TREATMENT OF DISEASES
EA028343B1 (ru)	2011-10-10	2017-11-30	Ампио Фармасьютикалз, Инк.	Лечение дегенеративного заболевания сустава
MY172699A (en)	2011-10-10	2019-12-10	Ampio Pharmaceuticals Inc	Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2771007B1 (en)	2011-10-28	2018-04-04	Ampio Pharmaceuticals, Inc.	Treatment of rhinitis
BR112015020469A2 (pt)	2013-03-15	2020-01-28	Ampio Pharmaceuticals Inc	Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
RU2736513C2 (ru)	2014-08-18	2020-11-17	Ампио Фармасьютикалз, Инк.	Лечение патологических состояний суставов
EP3310375A4 (en)	2015-06-22	2019-02-20	Ampio Pharmaceuticals, Inc.	USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
US11510427B2 (en) *	2016-12-21	2022-11-29	Suntory Holdings Limited	Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose
JPWO2024075813A1 (pt) *	2022-10-07	2024-04-11

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2038106A1 (de) *	1970-07-31	1972-02-10	Henkel & Cie Gmbh	Aktivatoren fuer Perverbindungen
JPS58185545A (ja) *	1982-04-22	1983-10-29	Ajinomoto Co Inc	α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) *	1983-05-13	1988-11-30	Debi Derivati Biologici	Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) *	1984-02-21	1985-09-09	Ajinomoto Co Inc	α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) *	1985-03-29	1989-07-20	Mitsui Toatsu Chemicals Inc.	Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) *	1985-06-04	1994-06-22	味の素株式会社	β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) *	1985-10-31	1987-06-30	Monsanto Company	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) *	1986-01-13	1987-07-16	Green Cross Korea	Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) *	1988-08-31	1991-02-12	Eastman Kodak Company	Process for preparation of amino acids

1991
- 1991-03-12 DK DK91906948.4T patent/DK0478729T3/da active
- 1991-03-12 AU AU75648/91A patent/AU628257B2/en not_active Ceased
- 1991-03-12 EP EP91906948A patent/EP0478729B1/en not_active Expired - Lifetime
- 1991-03-12 HU HU913921A patent/HUT60712A/hu unknown
- 1991-03-12 DE DE69121502T patent/DE69121502T2/de not_active Expired - Fee Related
- 1991-03-12 WO PCT/US1991/001646 patent/WO1991014378A1/en not_active Ceased
- 1991-03-12 AT AT91906948T patent/ATE141613T1/de not_active IP Right Cessation
- 1991-03-12 CA CA002060515A patent/CA2060515A1/en not_active Abandoned
- 1991-03-12 ES ES91906948T patent/ES2091324T3/es not_active Expired - Lifetime
- 1991-03-15 IE IE089691A patent/IE910896A1/en unknown
- 1991-03-15 CN CN91102471.9A patent/CN1057835A/zh active Pending
- 1991-03-15 CS CS91700A patent/CS70091A2/cs unknown
- 1991-03-15 PT PT97049A patent/PT97049B/pt not_active IP Right Cessation
- 1991-03-18 NZ NZ237469A patent/NZ237469A/en unknown
1992
- 1992-01-15 NO NO92920193A patent/NO920193L/no unknown
1996
- 1996-08-22 GR GR960402052T patent/GR3020839T3/el unknown

Also Published As

Publication number	Publication date
NO920193D0 (no)	1992-01-15
DE69121502T2 (de)	1997-01-16
EP0478729A4 (en)	1993-06-16
EP0478729A1 (en)	1992-04-08
IE910896A1 (en)	1991-09-25
EP0478729B1 (en)	1996-08-21
AU7564891A (en)	1991-10-21
ES2091324T3 (es)	1996-11-01
AU628257B2 (en)	1992-09-10
CN1057835A (zh)	1992-01-15
HUT60712A (en)	1992-10-28
WO1991014378A1 (en)	1991-10-03
DE69121502D1 (de)	1996-09-26
NZ237469A (en)	1993-08-26
NO920193L (no)	1992-01-15
CS70091A2 (en)	1991-10-15
DK0478729T3 (da)	1996-09-16
GR3020839T3 (en)	1996-11-30
CA2060515A1 (en)	1991-09-16
PT97049B (pt)	1998-07-31
ATE141613T1 (de)	1996-09-15

Legal Events

Date

Code

Title

Description

1991-12-31

BB1A

Laying open of patent application

Effective date: 19910909

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980414

2000-02-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031

Publication	Publication Date	Title
PT97049A (pt)	1991-12-31	Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados
NO302366B1 (no)	1998-02-23	4-merkaptoacetylamino-£2\|benzazepinon(3)-derivater, og farmasöytisk preparat
FI945776L (fi)	1995-06-11	Yhden astian menetelmä 3-kinolonikarboksyylihaapojohdannaisten valmistamiseksi
FI902435A7 (fi)	1990-11-17	Menetelmä 2-asyylialkonoinihappojen valmistamiseksi
ITMI940726A0 (it)	1994-04-15	Procedimento per la produzione di d-alfa-amminoacidi
FI942581A0 (fi)	1994-06-01	Menetelmä 5-bromi-6-metoksi-1-naftoehappometyyliesterin valmistamiseksi
BR9303969A (pt)	1994-08-02	Processo para produção de ácidos 2-arilbenzimidazol-5-sulfônicos
ITTO930519A0 (it)	1993-07-13	Procedimento di sintesi di acidi cloroacetici.
MX9300026A (es)	1993-12-01	Procedimiento para la preparacion de benzoesteres y benzoacidos.
FI890678A0 (fi)	1989-02-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi
ITPD910141A1 (it)	1993-02-02	Procedimento perfezionato per la realizzazione di calzature
FI905930A7 (fi)	1992-05-31	Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
FI910662A7 (fi)	1991-08-14	Menetelmä 7-amino-3-metoksimetyyli-kef-3-emi-4-karboksyylihapon valmistamiseksi
FI922268L (fi)	1992-05-19	Menetelmä uusien terapeuttisesti käyttökelpoisten N-difenyylialkyylialkoksisubstituoitujen 3-piperidiinikarboksyylihappojohdannaisten valmistamiseksi
IT1137381B (it)	1986-09-10	Processo per la preparazione di derivati esterei di acidi ciclopropancarbossilici
FI953617L (fi)	1995-07-28	Menetelmä substituoitujen 4-hydroksikumariinien valmistamiseksi
IT1172237B (it)	1987-06-18	Derivati di amminoacidi particolarmente utili come medicammenti e procedimento per la loro preparazione
IT1226387B (it)	1991-01-15	Processo per la preparazione di acidi 1,4-diaril-3-pirazol-acetici
IT9019111A0 (it)	1990-01-19	Procedimento perfezionato per la produzione di vanadio areni
PT86666A (pt)	1988-02-01	Process for the preparation of pilocarpine by products
ITMI951297A0 (it)	1995-06-16	Processo per la preparazione di derivati dell'acido-metil-2- tiofeneacetico
FI902157A7 (fi)	1990-10-29	Menetelmä 1,6-hekseenidiohappojen valmistamiseksi
FI930383A7 (fi)	1993-01-29	Menetelmä ja välituote 2-hydroksi-3-sulfido-3-fenyylipropaanihappojen valmistamiseksi
FI945119L (fi)	1994-10-31	Menetelmä 3(S)-metyyliheptaanihapon valmistamiseksi ja välituotteet
PT88578A (pt)	1988-10-01	Process for the manufacture of 2,6-methanopyrrolo-3-benzazocines of intermediates useful for their manufacture and of pharmaceutical compositions containing them