ATE143950T1 - 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator - Google Patents

2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator

Info

Publication number
ATE143950T1
ATE143950T1 AT91902775T AT91902775T ATE143950T1 AT E143950 T1 ATE143950 T1 AT E143950T1 AT 91902775 T AT91902775 T AT 91902775T AT 91902775 T AT91902775 T AT 91902775T AT E143950 T1 ATE143950 T1 AT E143950T1
Authority
AT
Austria
Prior art keywords
active ingredient
production
containing same
nitroimidazole derivative
radiation sensitizer
Prior art date
Application number
AT91902775T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Akira Suzuki
Tomoyuki Mori
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Application granted granted Critical
Publication of ATE143950T1 publication Critical patent/ATE143950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91902775T 1990-01-26 1991-01-24 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator ATE143950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016721A JP2626727B2 (ja) 1990-01-26 1990-01-26 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
ATE143950T1 true ATE143950T1 (de) 1996-10-15

Family

ID=11924130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902775T ATE143950T1 (de) 1990-01-26 1991-01-24 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator

Country Status (10)

Country Link
US (1) US5270330A (de)
EP (1) EP0513351B1 (de)
JP (1) JP2626727B2 (de)
KR (2) KR927003539A (de)
AT (1) ATE143950T1 (de)
CA (1) CA2074533C (de)
DE (1) DE69122605T2 (de)
DK (1) DK0513351T3 (de)
ES (1) ES2094218T3 (de)
WO (1) WO1991011440A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014778A1 (fr) * 1992-12-18 1994-07-07 Pola Chemical Industries, Inc. Derive optiquement actif de 2-nitroimidazole, son procede de production, et intermediaire pour sa production
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1590440A4 (de) * 2003-02-03 2009-03-18 Palo Alto Inst Of Molecular Me Zellabtötende moleküle und vefahren zu deren verwendung
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
CA2567306C (en) * 2004-06-24 2011-06-07 Toyo Suisan Kaisha, Ltd. Radiosensitizer
EP1838305A1 (de) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer-formulierungen mit nitrohistidinderivaten
EP1896040B1 (de) 2005-06-29 2012-08-01 Threshold Pharmaceuticals, Inc. Phosphoramidat-alkylator-prodrugs
ES2884044T3 (es) * 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
US8030338B2 (en) 2007-01-23 2011-10-04 Pola Pharma Inc. Method for producing 2-nitroimidazole derivative
JP5297815B2 (ja) * 2007-01-26 2013-09-25 株式会社ポーラファルマ 医薬組成物
JP5325779B2 (ja) 2007-06-14 2013-10-23 株式会社ポーラファルマ 医薬組成物
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP6082644B2 (ja) * 2013-03-22 2017-02-15 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
WO2019069891A1 (ja) 2017-10-02 2019-04-11 学校法人慶應義塾 癌幹細胞インヒビター

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS6075430A (ja) * 1983-08-31 1985-04-27 Kayaku:Kk 放射線増感剤
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JP3291590B2 (ja) * 1992-08-26 2002-06-10 キヤノン株式会社 カラートナー、カラー現像剤及び画像形成方法

Also Published As

Publication number Publication date
EP0513351B1 (de) 1996-10-09
KR0145333B1 (en) 1998-07-15
KR927003539A (ko) 1992-12-18
WO1991011440A1 (en) 1991-08-08
JP2626727B2 (ja) 1997-07-02
EP0513351A1 (de) 1992-11-19
DE69122605D1 (de) 1996-11-14
CA2074533A1 (en) 1991-07-27
US5270330A (en) 1993-12-14
CA2074533C (en) 2000-10-17
JPH03223258A (ja) 1991-10-02
DE69122605T2 (de) 1997-02-13
EP0513351A4 (en) 1993-11-10
DK0513351T3 (da) 1996-11-25
ES2094218T3 (es) 1997-01-16

Similar Documents

Publication Publication Date Title
ATE143950T1 (de) 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator
DE69232336D1 (de) Stickstoff enthaltende hydrocyclische verbindungen
NZ275647A (en) Tricyclic amide and urea derivatives and medicaments
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
ATE208779T1 (de) Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
HU9300110D0 (en) Method for producing aryl-cycloalkyl derivatives and medical preparatives containing them as active substance
ATE46164T1 (de) 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE205199T1 (de) Quinolin- oder quinazolinderivate, deren herstellung und verwendung
ATE101601T1 (de) Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator.
NO951283L (no) Nye taxanderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene
IT1229569B (it) Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
DK0593766T3 (da) Pyridoncarboxylsyrederivat
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
HUP9801072A2 (hu) Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
GB9715895D0 (en) Heterocyclic compounds
ATE78163T1 (de) Stickstoff enthaltende heterozyklische verbindungen.
ES8303393A1 (es) Un procedimiento para preparar derivados del acido ascorbico.
ES8101589A1 (es) Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos.
ATE42295T1 (de) Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen.
GR3015209T3 (en) Imidazole derivatives, process for their fabrication and pharmaceutical compositions containing them.
ATE254131T1 (de) Benzimidazolderivate
ES8501607A1 (es) Procedimiento para la obtencion de heterociclos nitrogenosos de 5 miembros
DE69031730D1 (de) Neues Antibiotikum, Deoxymulündocandin, Verfahren zu seiner Produktion und Verwendung als Medikament
FI932952A0 (fi) Imidazolylsubstituerade cyklohexanderivat
CA2053705A1 (en) Piperazine derivatives

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time