ATE144532T1 - Verfahren zur herstellung von s-acylderivaten des glutathion, und damit hergestellte verbindungen - Google Patents

Verfahren zur herstellung von s-acylderivaten des glutathion, und damit hergestellte verbindungen

Info

Publication number: ATE144532T1
Authority: AT; Austria
Prior art keywords: glutathione; producing; produced therefrom; compounds produced; acyl derivatives
Prior art date: 1990-06-26

Application number

AT91912027T

Other languages

English (en)

Inventor

Lauro Galzigna

Original Assignee

Boehringer Mannheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-26

Filing date

1991-06-21

Publication date

1996-11-15

1991-06-21 Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE144532T1 publication Critical patent/ATE144532T1/de

Links

RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical class OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
108010024636 Glutathione Proteins 0.000 abstract 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
229960003180 glutathione Drugs 0.000 abstract 2
150000001263 acyl chlorides Chemical class 0.000 abstract 1
150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT91912027T 1990-06-26 1991-06-21 Verfahren zur herstellung von s-acylderivaten des glutathion, und damit hergestellte verbindungen ATE144532T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02076090A IT1248994B (it)	1990-06-26	1990-06-26	Processo per la preparazione di s-acil derivati di glutatione composti ottenuti da detto processo e intermedio utile per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE144532T1 true ATE144532T1 (de)	1996-11-15

Family

ID=11171663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91912027T ATE144532T1 (de)	1990-06-26	1991-06-21	Verfahren zur herstellung von s-acylderivaten des glutathion, und damit hergestellte verbindungen

Country Status (10)

Country	Link
US (1)	US5382679A (de)
EP (1)	EP0536231B1 (de)
JP (1)	JPH05508405A (de)
AT (1)	ATE144532T1 (de)
AU (1)	AU8073691A (de)
CA (1)	CA2086107A1 (de)
DE (1)	DE69122867T2 (de)
ES (1)	ES2095940T3 (de)
IT (1)	IT1248994B (de)
WO (1)	WO1992000320A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5679643A (en) *	1987-10-13	1997-10-21	Terrapin Technologies, Inc.	Glutathione analogs and paralog panels comprising glutathione mimics
US5599903A (en) *	1992-04-03	1997-02-04	Terrapin Technologies, Inc.	Glutathione analogs and paralog panels comprising glutathione mimics
US5786336A (en) *	1991-04-29	1998-07-28	Terrapin Technologies, Inc.	Target-selective protocols based on mimics
US5955432A (en) *	1992-04-03	1999-09-21	Terrapin Technologies, Inc.	Metabolic effects of certain glutathione analogs
US5624955A (en) *	1995-05-03	1997-04-29	Regents Of The University Of Minnesota	Compounds that enhance the concentration of glutathione in tissues
US20040229815A1 (en) *	2003-01-03	2004-11-18	Nagasawa Herbert T.	Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug
US7781539B2 (en) *	2003-02-21	2010-08-24	Metabolix Inc.	PHA blends
PT1603987E (pt) *	2003-02-21	2011-11-10	Metabolix Inc	Composições adesivas pha
ES2315737T3 (es) *	2003-12-30	2009-04-01	Metabolix, Inc.	Agentes nucleantes.
US8236533B2 (en)	2005-03-31	2012-08-07	Newsouth Innovations Pty Limited	Process for the production of γ-glutamylcysteine
ITFI20070224A1 (it) *	2007-10-12	2009-04-13	Univ Firenze	Nuovi derivati s-acilici del glutatione, loro sintesi e uso nel trattamento di patologie correlate allo stress ossidativo cellulare
JP5267096B2 (ja) *	2008-12-12	2013-08-21	住友化学株式会社	Ｎ，Ｓ−ジ−ｔｅｒｔ−ブトキシカルボニルグルタチオン蛍光誘導体及びそれを中間体として用いるグルタチオン蛍光誘導体の製造方法
US8609604B2 (en)	2009-12-28	2013-12-17	N.V. Perricone Llc	Methods of improving the appearance of aging skin
US20110160143A1 (en) *	2009-12-28	2011-06-30	Perricone Nicholas V	Topical Acyl Glutathione Psoriasis Compositions
US20110160144A1 (en) *	2009-12-28	2011-06-30	Perricone Nicholas V	Topical Acyl Glutathione Formulations
US8580742B2 (en)	2010-03-05	2013-11-12	N.V. Perricone Llc	Topical glutathione formulations for menopausal skin
CN104755538B (zh)	2012-08-17	2018-08-31	Cj 第一制糖株式会社	用于聚合物共混物的生物基橡胶改性剂
EP3004225A1 (de)	2013-05-30	2016-04-13	Metabolix, Inc.	Rezyklatmischungen
ITMI20131856A1 (it) *	2013-11-08	2015-05-09	Gnosis Spa	Processo per la preparazione di differenti forme cristalline del s-acetil glutatione e loro utilizzi in formulazioni farmaceutiche e nutraceutiche
WO2015149029A1 (en)	2014-03-27	2015-10-01	Metabolix, Inc.	Highly filled polymer systems
CN104072577A (zh) *	2014-07-01	2014-10-01	田州益膳（北京）食品有限公司	S-乙酰-l-谷胱甘肽的制备方法
CN104151396B (zh) *	2014-08-11	2017-12-26	济南大学	混合溶剂中催化合成s‑乙酰基‑l‑谷胱甘肽的方法
IT202200021528A1 (it)	2022-10-19	2024-04-19	Dr Tezza S R L	Procedimento per la preparazione di derivati del glutatione e della cisteina
WO2025262540A1 (en)	2024-06-18	2025-12-26	Dr Tezza S.R.L.	S- and/or n-acylated glutathione derivatives

1990
- 1990-06-26 IT IT02076090A patent/IT1248994B/it active IP Right Grant
1991
- 1991-06-21 DE DE69122867T patent/DE69122867T2/de not_active Expired - Fee Related
- 1991-06-21 EP EP91912027A patent/EP0536231B1/de not_active Expired - Lifetime
- 1991-06-21 AT AT91912027T patent/ATE144532T1/de not_active IP Right Cessation
- 1991-06-21 ES ES91912027T patent/ES2095940T3/es not_active Expired - Lifetime
- 1991-06-21 CA CA002086107A patent/CA2086107A1/en not_active Abandoned
- 1991-06-21 JP JP3511061A patent/JPH05508405A/ja active Pending
- 1991-06-21 AU AU80736/91A patent/AU8073691A/en not_active Abandoned
- 1991-06-21 WO PCT/EP1991/001154 patent/WO1992000320A1/en not_active Ceased
1993
- 1993-02-10 US US07/958,344 patent/US5382679A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IT1248994B (it)	1995-02-11
IT9020760A0 (de)	1990-06-26
ES2095940T3 (es)	1997-03-01
DE69122867T2 (de)	1997-03-06
EP0536231B1 (de)	1996-10-23
DE69122867D1 (de)	1996-11-28
IT9020760A1 (it)	1991-12-26
AU8073691A (en)	1992-01-23
CA2086107A1 (en)	1991-12-27
EP0536231A1 (de)	1993-04-14
JPH05508405A (ja)	1993-11-25
WO1992000320A1 (en)	1992-01-09
US5382679A (en)	1995-01-17

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Legal Events

Date	Code	Title	Description
1997-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties