ATE146464T1 - Alkoxy-substituierte taxane als antitumormittel - Google Patents

Alkoxy-substituierte taxane als antitumormittel

Info

Publication number: ATE146464T1
Authority: AT; Austria
Prior art keywords: alkoxy; tumor agents; substituted taxanes; hydrogen; taxane derivative
Prior art date: 1991-09-23

Application number

AT92308607T

Other languages

English (en)

Inventor

Robert A Holton

Ronald J Biediger

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-23

Filing date

1992-09-22

Publication date

1997-01-15

1992-09-22 Application filed by Univ Florida State filed Critical Univ Florida State

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE146464T1 publication Critical patent/ATE146464T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
229940123237 Taxane Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Polyethers (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT92308607T 1991-09-23 1992-09-22 Alkoxy-substituierte taxane als antitumormittel ATE146464T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76380591A	1991-09-23	1991-09-23
US07/863,198 US5243045A (en)	1991-09-23	1992-04-03	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
ATE146464T1 true ATE146464T1 (de)	1997-01-15

Family

ID=27117341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308607T ATE146464T1 (de)	1991-09-23	1992-09-22	Alkoxy-substituierte taxane als antitumormittel

Country Status (15)

Country	Link
US (1)	US5243045A (de)
EP (1)	EP0534707B1 (de)
JP (1)	JP3217155B2 (de)
AT (1)	ATE146464T1 (de)
AU (1)	AU653247B2 (de)
CA (1)	CA2077598C (de)
DE (1)	DE69216028T2 (de)
DK (1)	DK0534707T3 (de)
ES (1)	ES2101044T3 (de)
FI (1)	FI112478B (de)
GR (1)	GR3022853T3 (de)
HU (1)	HU218283B (de)
MX (1)	MX9205310A (de)
NO (1)	NO303633B1 (de)
NZ (1)	NZ244456A (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6028205A (en) *	1991-09-23	2000-02-22	Florida State University	C2 tricyclic taxanes
US5654447A (en) *	1991-09-23	1997-08-05	Florida State University	Process for the preparation of 10-desacetoxybaccatin III
US5998656A (en)	1991-09-23	1999-12-07	Florida State University	C10 tricyclic taxanes
US6011056A (en)	1991-09-23	2000-01-04	Florida State University	C9 taxane derivatives and pharmaceutical compositions containing them
US5714513A (en) *	1991-09-23	1998-02-03	Florida State University	C10 taxane derivatives and pharmaceutical compositions
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
ZA926828B (en) *	1991-09-23	1993-03-15	Univ Florida State	Novel alkoxy substituted taxanes and pharmaceutical compositions containing them.
US6335362B1 (en)	1991-09-23	2002-01-01	Florida State University	Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) *	1991-09-23	1998-04-14	Florida State University	Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) *	1991-09-23	1999-12-21	Florida State University	Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5710287A (en) *	1991-09-23	1998-01-20	Florida State University	Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) *	1991-09-23	1998-03-17	Florida State University	C2 taxane derivaties and pharmaceutical compositions containing them
US5489601A (en) *	1991-09-23	1996-02-06	Florida State University	Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en)	1991-09-23	1998-02-24	Florida State University	C7 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en)	1991-09-23	2002-12-17	Florida State University	9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5728850A (en) *	1991-09-23	1998-03-17	Florida State University	Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) *	1991-09-23	2000-01-25	Florida State University	Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
PT1001036E (pt) *	1992-01-15	2005-01-31	Squibb & Sons Inc	Processos enzimaticos para o desdobramento de misturas enantiomericas de compostos uteis como intermediarios na preparacao de taxanos
US5272171A (en) *	1992-02-13	1993-12-21	Bristol-Myers Squibb Company	Phosphonooxy and carbonate derivatives of taxol
US5451392A (en) *	1992-03-03	1995-09-19	The Research And Development Institute At Montana State University	Production of taxol
US5445809A (en) *	1992-03-03	1995-08-29	Research And Development Institute At Montana State University	Production of taxol from the yew tree
US5294637A (en) *	1992-07-01	1994-03-15	Bristol-Myers Squibb Company	Fluoro taxols
US5254580A (en) *	1993-01-19	1993-10-19	Bristol-Myers Squibb Company	7,8-cyclopropataxanes
FR2696461B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
FR2698871B1 (fr)	1992-12-09	1995-02-24	Rhone Poulenc Rorer Sa	Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en)	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) *	1992-12-24	1997-07-08	Bristol-Myers Squibb Company	Phosphonooxymethyl ethers of taxane derivatives
AU682173B2 (en) *	1993-01-15	1997-09-25	Florida State University	Process for the preparation of 10-desacetoxybaccatin III
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
WO1994020485A1 (en) *	1993-03-05	1994-09-15	Florida State University	Process for the preparation of 9-desoxotaxanes
US6710191B2 (en)	1993-03-05	2004-03-23	Florida State University	9β-hydroxytetracyclic taxanes
TW467896B (en)	1993-03-19	2001-12-11	Bristol Myers Squibb Co	Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
DE69434190T2 (de) *	1993-03-22	2005-05-25	Florida State University, Tallahassee	Pharmazeutische Zusammenstellungen enthaltende eine furyl oder thienyl substituierte Seitenkette
IT1261667B (it) *	1993-05-20	1996-05-29		Tassano ad attivita' antitumorale.
TW397866B (en)	1993-07-14	2000-07-11	Bristol Myers Squibb Co	Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5965566A (en) *	1993-10-20	1999-10-12	Enzon, Inc.	High molecular weight polymer-based prodrugs
US6201140B1 (en)	1994-07-28	2001-03-13	Bristol-Myers Squibb Company	7-0-ethers of taxane derivatives
US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6177456B1 (en)	1995-10-02	2001-01-23	Xechem International, Inc.	Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5840748A (en) *	1995-10-02	1998-11-24	Xechem International, Inc.	Dihalocephalomannine and methods of use therefor
US5807888A (en) *	1995-12-13	1998-09-15	Xechem International, Inc.	Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5854278A (en) *	1995-12-13	1998-12-29	Xechem International, Inc.	Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) *	1995-10-02	1997-08-05	Xechem International, Inc.	Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
EP0927175A4 (de) *	1996-05-06	2002-05-22	Univ Florida State	1-deoxybaccatin iii, 1-deoxytaxol und 1-deoxytaxol-analoge und verfahren zu ihrer herstellung
US6017935A (en) *	1997-04-24	2000-01-25	Bristol-Myers Squibb Company	7-sulfur substituted paclitaxels
JPH1192468A (ja) *	1997-09-17	1999-04-06	Yakult Honsha Co Ltd	新規なタキサン誘導体
US6156789A (en) *	1998-03-17	2000-12-05	Rhone-Poulenc Rorer S.A.	Method for treating abnormal cell proliferation in the brain
US6136988A (en)	1998-04-10	2000-10-24	Hauser, Inc.	7-hexanoyltaxol and methods for preparing the same
ATE342260T1 (de)	1999-05-28	2006-11-15	Bristol Myers Squibb Co	Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6649632B2 (en) *	2000-02-02	2003-11-18	Fsu Research Foundation, Inc.	C10 ester substituted taxanes
JP2003521545A (ja) *	2000-02-02	2003-07-15	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	改良された溶解性を有するタキサン製剤
MXPA01009921A (es) *	2000-02-02	2003-08-01	Univ Florida State Res Found	Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales.
CZ20013429A3 (cs) *	2000-02-02	2002-04-17	Florida State University Research Foundation, Inc.	Taxany substituované v poloze C7 karbonátem jako protinádorová činidla
CA2368274C (en) *	2000-02-02	2009-10-13	Florida State University Research Foundation, Inc.	C10 ester substituted taxanes as antitumor agents
BR0104358A (pt) *	2000-02-02	2002-01-02	Univ Florida State Res Found	Formulações de taxana tendo solubilidade aperfeiçoada
NZ514406A (en) *	2000-02-02	2005-01-28	Univ Florida State Res Found	C10 heterosubstituted acetate taxanes as antitumor agents
DE60136430D1 (de) *	2000-02-02	2008-12-18	Univ Florida State Res Found	Heterosubstituierte c7-taxanacetate als antitumormittel
CO5280224A1 (es) *	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
EP1165549B1 (de)	2000-02-02	2008-04-16	Florida State University Research Foundation, Inc.	C7-carbamoyloxysubstituierte taxane als antitumormittel
IL145636A0 (en)	2000-02-02	2002-06-30	Univ Florida State Res Found	C10 carbonate substituted taxanes as antitumor agents
US6638742B1 (en)	2000-07-07	2003-10-28	University Of Portland	Methods for obtaining taxanes
AU2001288805A1 (en) *	2000-09-22	2002-04-02	Bristol-Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
SG129990A1 (en) *	2001-08-01	2007-03-20	Univ Florida State Res Found	C10 ester substituted taxanes
US7063977B2 (en) *	2001-08-21	2006-06-20	Bristol-Myers Squibb Company	Enzymatic resolution of t-butyl taxane derivatives
PL368945A1 (en) *	2001-11-30	2005-04-04	Bristol-Myers Squibb Company	Paclitaxel solvates
US7064980B2 (en) *	2003-09-17	2006-06-20	Sandisk Corporation	Non-volatile memory and method with bit line coupled compensation
HN2005000054A (es) *	2004-02-13	2009-02-18	Florida State University Foundation Inc	Taxanos sustituidos con esteres de ciclopentilo en c10
EP1737444A4 (de)	2004-03-05	2008-05-21	Univ Florida State Res Found	C7-lactyloxa-substituierte taxane
AU2006214498A1 (en) *	2005-02-14	2006-08-24	Florida State University Research Foundation, Inc.	C10 cyclopropyl ester substituted taxane compositions
CA2718567A1 (en) *	2008-03-31	2009-12-03	Florida State University Research Foundation, Inc.	C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them

1992
- 1992-04-03 US US07/863,198 patent/US5243045A/en not_active Expired - Lifetime
- 1992-09-04 AU AU22123/92A patent/AU653247B2/en not_active Ceased
- 1992-09-04 CA CA002077598A patent/CA2077598C/en not_active Expired - Fee Related
- 1992-09-18 MX MX9205310A patent/MX9205310A/es unknown
- 1992-09-21 FI FI924227A patent/FI112478B/fi active
- 1992-09-22 HU HU9203016A patent/HU218283B/hu not_active IP Right Cessation
- 1992-09-22 DE DE69216028T patent/DE69216028T2/de not_active Expired - Fee Related
- 1992-09-22 NO NO923678A patent/NO303633B1/no not_active IP Right Cessation
- 1992-09-22 AT AT92308607T patent/ATE146464T1/de not_active IP Right Cessation
- 1992-09-22 JP JP27676392A patent/JP3217155B2/ja not_active Expired - Fee Related
- 1992-09-22 ES ES92308607T patent/ES2101044T3/es not_active Expired - Lifetime
- 1992-09-22 EP EP92308607A patent/EP0534707B1/de not_active Expired - Lifetime
- 1992-09-22 DK DK92308607.8T patent/DK0534707T3/da active
- 1992-09-23 NZ NZ244456A patent/NZ244456A/en not_active IP Right Cessation
1997
- 1997-03-17 GR GR970400528T patent/GR3022853T3/el unknown

Also Published As

Publication number	Publication date
JP3217155B2 (ja)	2001-10-09
DE69216028D1 (de)	1997-01-30
NO303633B1 (no)	1998-08-10
JPH05239044A (ja)	1993-09-17
HU9203016D0 (en)	1992-12-28
NZ244456A (en)	1995-04-27
EP0534707A1 (de)	1993-03-31
NO923678D0 (no)	1992-09-22
DK0534707T3 (da)	1997-06-09
ES2101044T3 (es)	1997-07-01
HU218283B (en)	2000-07-28
AU653247B2 (en)	1994-09-22
CA2077598C (en)	1997-11-25
FI924227L (fi)	1993-03-24
EP0534707B1 (de)	1996-12-18
DE69216028T2 (de)	1997-07-03
NO923678L (no)	1993-03-24
FI924227A0 (fi)	1992-09-21
FI112478B (fi)	2003-12-15
HUT62873A (en)	1993-06-28
US5243045A (en)	1993-09-07
GR3022853T3 (en)	1997-06-30
MX9205310A (es)	1993-07-01
AU2212392A (en)	1993-03-25
CA2077598A1 (en)	1993-03-24

Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
2010-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69216028D1 (de)	1997-01-30	Alkoxy-substituierte Taxane als Antitumormittel
ATE128134T1 (de)	1995-10-15	Furyl- und thienyl-substituierte taxane als antitumormittel.
DE69232895D1 (de)	2003-02-20	Substituierte Taxane als Antitumormittel
DK0669918T3 (da)	1999-09-20	Furyl- eller thienylcarbonyl-substituerede taxaner og farmaceutiske præparater indeholdende disse
FR2696458B1 (fr)	1994-11-10	Procédé de préparation de dérivés du taxane.
FI940075A0 (fi)	1994-01-07	Menetelmä bakkatiini-III- ja 10-desasetyylibakkatiini-III-johdannaisten valmistamiseksi
MX9306606A (es)	1994-04-29	Procedimiento para la preparacion de derivados de taxano.
DE69731005D1 (de)	2004-11-04	Verfahren zu Herstellung von Taxol