ATE146480T1 - Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate - Google Patents

Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate

Info

Publication number: ATE146480T1
Authority: AT; Austria
Prior art keywords: suitable substituent; alkyl; production; pharmaceutical preparations; preparations containing
Prior art date: 1990-10-24

Application number

AT91117889T

Other languages

English (en)

Inventor

Masaaki Matsuo

Daijiro Hagiwara

Hiroshi Miyake

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-24

Filing date

1991-10-20

Publication date

1997-01-15

1991-10-20 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE146480T1 publication Critical patent/ATE146480T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
-1 pyrazolopyridyl Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Crystallography & Structural Chemistry (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Electroluminescent Light Sources (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyridine Compounds (AREA)

AT91117889T 1990-10-24 1991-10-20 Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate ATE146480T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909023116A GB9023116D0 (en)	1990-10-24	1990-10-24	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number	Publication Date
ATE146480T1 true ATE146480T1 (de)	1997-01-15

Family

ID=10684270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91117889T ATE146480T1 (de)	1990-10-24	1991-10-20	Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate

Country Status (19)

Country	Link
EP (1)	EP0482539B1 (de)
JP (1)	JP3206764B2 (de)
KR (1)	KR920008065A (de)
CN (2)	CN1038939C (de)
AT (1)	ATE146480T1 (de)
AU (1)	AU647534B2 (de)
CA (1)	CA2054097A1 (de)
DE (1)	DE69123697T2 (de)
DK (1)	DK0482539T3 (de)
ES (1)	ES2095283T3 (de)
FI (1)	FI914961A7 (de)
GB (1)	GB9023116D0 (de)
GR (1)	GR3022137T3 (de)
HU (2)	HUT59163A (de)
IE (1)	IE913599A1 (de)
NO (1)	NO914171L (de)
PT (1)	PT99317B (de)
RU (1)	RU2073683C1 (de)
ZA (1)	ZA918011B (de)

Families Citing this family (64)

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US5420297A (en) *	1990-10-24	1995-05-30	Fujisawa Pharmaceutical Co., Ltd.	Peptides having substance P antagonistic activity
DE69231395T3 (de)	1991-09-20	2005-07-21	Glaxo Group Ltd., Greenford	Neue medizinische Indikation für Tachykinin-Antagonisten
US5328927A (en) *	1992-03-03	1994-07-12	Merck Sharpe & Dohme, Ltd.	Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
DE4243496A1 (de) *	1992-09-03	1994-03-10	Boehringer Ingelheim Kg	Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DK0610487T3 (da) *	1992-09-03	2000-05-15	Boehringer Ingelheim Pharma	Nye aminosyrederivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
IT1256623B (it) *	1992-12-04	1995-12-12	Federico Arcamone	Antagonisti delle tachichinine, procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
US5674889A (en) *	1993-02-22	1997-10-07	Merck, Sharp & Dohme, Ltd.	Aromatic compounds, compositions containing them and their use in therapy
WO1994020126A1 (en) *	1993-03-03	1994-09-15	Fujisawa Pharmaceutical Co., Ltd.	Use of peptides for the manufacture of a medicament
US5635510A (en) *	1993-05-06	1997-06-03	Merrell Pharmaceuticals Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines
WO1995000536A1 (en) *	1993-06-22	1995-01-05	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds
US5455262A (en) *	1993-10-06	1995-10-03	Florida State University	Mercaptosulfide metalloproteinase inhibitors
AU690275B2 (en) *	1994-05-07	1998-04-23	Boehringer Ingelheim International Gmbh	Neurokinine (tachykinine) antagonists
CA2198084C (en)	1994-08-25	2000-03-28	Timothy P. Burkholder	Novel substituted piperidines useful for the treatment of allergic diseases
US5830868A (en) *	1994-09-13	1998-11-03	Warner-Lambert Company	Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
JP3950170B2 (ja) *	1995-04-13	2007-07-25	アベンティス・ファーマスーティカルズ・インコーポレイテッド	タキキニン受容体アンタゴニスト活性を有する新規な置換されたピペラジン誘導体
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en)	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US6423689B1 (en)	1997-12-22	2002-07-23	Warner-Lambert Company	Peptidyl calcium channel blockers
BR9912378A (pt) *	1998-07-23	2001-04-17	Akzo Nobel Nv	Peptìdeo, composição farmacêutica, uso de um ou mais dos peptìdeos, e, composição para diagnóstico.
MXPA02004330A (es)	1999-11-03	2004-07-30	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100821410B1 (ko)	2000-07-11	2008-04-10	에이엠알 테크놀로지, 인크.	4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도
NZ552397A (en)	2004-07-15	2011-04-29	Amr Technology Inc	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ES2382814T3 (es)	2005-05-17	2012-06-13	Merck Sharp & Dohme Ltd.	Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
KR101594898B1 (ko)	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP4611444B2 (ja)	2007-01-10	2011-01-12	イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー	ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
EP2117538A1 (de)	2007-01-24	2009-11-18	Glaxo Group Limited	Pharmazeutische zusammensetzungen mit 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
AU2008269154B2 (en)	2007-06-27	2014-06-12	Merck Sharp & Dohme Llc	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
WO2010132437A1 (en)	2009-05-12	2010-11-18	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
AU2010247735B2 (en)	2009-05-12	2015-07-16	Albany Molecular Research, Inc.	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
AU2010247763B2 (en)	2009-05-12	2015-12-24	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
PE20121172A1 (es)	2009-10-14	2012-09-05	Merck Sharp & Dohme	Piperidinas sustituidas con actividad en la hdm2
US9446029B2 (en)	2010-07-27	2016-09-20	Colorado State University Research Foundation	Use of NK-1 receptor antagonists in management of visceral pain
EP3330377A1 (de)	2010-08-02	2018-06-06	Sirna Therapeutics, Inc.	Durch rna-interferenz vermittelte hemmung der catenin (cadherin-assoziiertes protein)-beta-1 (ctnnb1)- genexpression mittels kurzer interferierender nukleinsäuren (sina)
US9029341B2 (en)	2010-08-17	2015-05-12	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (de)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
AU2012245971A1 (en)	2011-04-21	2013-10-17	Piramal Enterprises Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (de)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Neue verbindungen als erk-hemmer
US20150299696A1 (en)	2012-05-02	2015-10-22	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
RU2660429C2 (ru)	2012-09-28	2018-07-06	Мерк Шарп И Доум Корп.	Новые соединения, которые являются ингибиторами erk
RS56680B1 (sr)	2012-11-28	2018-03-30	Merck Sharp & Dohme	Kompozicije i postupci za lečenje kancera
KR102196882B1 (ko)	2012-12-20	2020-12-30	머크 샤프 앤드 돔 코포레이션	Hdm2 억제제로서의 치환된 이미다조피리딘
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785B1 (de)	2016-10-12	2025-08-27	Merck Sharp & Dohme LLC	Kdm5-inhibitoren
EP3706747B1 (de)	2017-11-08	2025-09-03	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
US11981701B2 (en)	2018-08-07	2024-05-14	Merck Sharp & Dohme Llc	PRMT5 inhibitors
US12173026B2 (en)	2018-08-07	2024-12-24	Merck Sharp & Dohme Llc	PRMT5 inhibitors
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4395401A (en) *	1981-09-09	1983-07-26	Smithkline Beckman Corporation	Renally active dipeptides
US5187156A (en) *	1988-03-16	1993-02-16	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) *	1989-04-28	1992-11-17	Fujisawa Pharmaceutical Company, Ltd.	Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same

1990
- 1990-10-24 GB GB909023116A patent/GB9023116D0/en active Pending
1991
- 1991-10-07 ZA ZA918011A patent/ZA918011B/xx unknown
- 1991-10-16 IE IE359991A patent/IE913599A1/en not_active Application Discontinuation
- 1991-10-18 AU AU85925/91A patent/AU647534B2/en not_active Ceased
- 1991-10-20 AT AT91117889T patent/ATE146480T1/de not_active IP Right Cessation
- 1991-10-20 ES ES91117889T patent/ES2095283T3/es not_active Expired - Lifetime
- 1991-10-20 DK DK91117889.5T patent/DK0482539T3/da active
- 1991-10-20 EP EP91117889A patent/EP0482539B1/de not_active Expired - Lifetime
- 1991-10-20 DE DE69123697T patent/DE69123697T2/de not_active Expired - Fee Related
- 1991-10-22 HU HU913331A patent/HUT59163A/hu unknown
- 1991-10-22 FI FI914961A patent/FI914961A7/fi not_active Application Discontinuation
- 1991-10-22 KR KR1019910018577A patent/KR920008065A/ko not_active Ceased
- 1991-10-23 NO NO91914171A patent/NO914171L/no unknown
- 1991-10-23 CN CN91109851A patent/CN1038939C/zh not_active Expired - Lifetime
- 1991-10-23 RU SU915010105A patent/RU2073683C1/ru active
- 1991-10-23 PT PT99317A patent/PT99317B/pt not_active IP Right Cessation
- 1991-10-23 CA CA002054097A patent/CA2054097A1/en not_active Abandoned
- 1991-10-24 JP JP34387291A patent/JP3206764B2/ja not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00392P patent/HU211611A9/hu unknown
1996
- 1996-08-14 CN CN96111367A patent/CN1148503A/zh active Pending
- 1996-12-23 GR GR960403576T patent/GR3022137T3/el unknown

Also Published As

Publication number	Publication date
CN1148503A (zh)	1997-04-30
PT99317B (pt)	1999-04-30
NO914171D0 (no)	1991-10-23
GB9023116D0 (en)	1990-12-05
FI914961A7 (fi)	1992-04-25
KR920008065A (ko)	1992-05-27
HU211611A9 (en)	1995-12-28
DK0482539T3 (da)	1997-01-06
NO914171L (no)	1992-04-27
HU913331D0 (en)	1992-01-28
AU647534B2 (en)	1994-03-24
CN1038939C (zh)	1998-07-01
ZA918011B (en)	1992-07-29
HUT59163A (en)	1992-04-28
CA2054097A1 (en)	1992-04-25
RU2073683C1 (ru)	1997-02-20
EP0482539A3 (en)	1992-08-26
JP3206764B2 (ja)	2001-09-10
DE69123697D1 (de)	1997-01-30
ES2095283T3 (es)	1997-02-16
FI914961A0 (fi)	1991-10-22
EP0482539B1 (de)	1996-12-18
JPH04297492A (ja)	1992-10-21
CN1060848A (zh)	1992-05-06
PT99317A (pt)	1992-09-30
DE69123697T2 (de)	1997-04-17
AU8592591A (en)	1992-04-30
EP0482539A2 (de)	1992-04-29
GR3022137T3 (en)	1997-03-31
IE913599A1 (en)	1992-05-22

Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
1999-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE146480T1 (de)	1997-01-15	Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate
ATE115961T1 (de)	1995-01-15	Peptidverbindungen, verfahren zu deren herstellung und pharmazeutische präparate, die diese enthalten.
ATE98651T1 (de)	1994-01-15	Peptide mit tachykininantagonistischer aktivitaet, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
ATE137763T1 (de)	1996-05-15	Peptid-verbindungen, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzung
ATE172731T1 (de)	1998-11-15	Pyrazolopyridinverbindung und verfahren zu ihrer herstellung
KR870003130A (ko)	1987-04-15	테이코플라닌 화합물의 아미드
ATE63124T1 (de)	1991-05-15	Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
ATE61340T1 (de)	1991-03-15	Aminosaeurederivate und deren verfahren zur herstellung.
DE68926981D1 (de)	1996-09-26	Cephemverbindungen und Verfahren zu ihrer Herstellung
ATE48001T1 (de)	1989-12-15	Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
ATE195521T1 (de)	2000-09-15	Indolizinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69024154D1 (de)	1996-01-25	Pyrimidoindolderivate und Verfahren zu ihrer Herstellung
FR2699536B1 (fr)	1995-03-03	Nouveaux dérivés de p-[di(2-chloroéthyl)amino]phénylalanine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.