NO914171L - Fremgangsmaate for fremstilling av peptidforbindelser - Google Patents

Fremgangsmaate for fremstilling av peptidforbindelser

Info

Publication number: NO914171L
Authority: NO; Norway
Prior art keywords: alkyl; substituents; preparation; pyridyl; hydrogen
Prior art date: 1990-10-24

Application number

NO91914171A

Other languages

English (en)

Norwegian (no)

Other versions

NO914171D0 (no

Inventor

Masaaki Matsuo

Daijiro Hagiwara

Hiroshi Miyake

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-24

Filing date

1991-10-23

Publication date

1992-04-27

1991-10-23 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1991-10-23 Publication of NO914171D0 publication Critical patent/NO914171D0/no

1992-04-27 Publication of NO914171L publication Critical patent/NO914171L/no

Links

125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
102000003141 Tachykinin Human genes 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 pyrazolopyridyl Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108060008037 tachykinin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Crystallography & Structural Chemistry (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyridine Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Electroluminescent Light Sources (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO91914171A 1990-10-24 1991-10-23 Fremgangsmaate for fremstilling av peptidforbindelser NO914171L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909023116A GB9023116D0 (en)	1990-10-24	1990-10-24	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Publications (2)

Publication Number	Publication Date
NO914171D0 NO914171D0 (no)	1991-10-23
NO914171L true NO914171L (no)	1992-04-27

Family

ID=10684270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91914171A NO914171L (no)	1990-10-24	1991-10-23	Fremgangsmaate for fremstilling av peptidforbindelser

Country Status (19)

Country	Link
EP (1)	EP0482539B1 (de)
JP (1)	JP3206764B2 (de)
KR (1)	KR920008065A (de)
CN (2)	CN1038939C (de)
AT (1)	ATE146480T1 (de)
AU (1)	AU647534B2 (de)
CA (1)	CA2054097A1 (de)
DE (1)	DE69123697T2 (de)
DK (1)	DK0482539T3 (de)
ES (1)	ES2095283T3 (de)
FI (1)	FI914961A7 (de)
GB (1)	GB9023116D0 (de)
GR (1)	GR3022137T3 (de)
HU (2)	HUT59163A (de)
IE (1)	IE913599A1 (de)
NO (1)	NO914171L (de)
PT (1)	PT99317B (de)
RU (1)	RU2073683C1 (de)
ZA (1)	ZA918011B (de)

Families Citing this family (64)

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US5420297A (en) *	1990-10-24	1995-05-30	Fujisawa Pharmaceutical Co., Ltd.	Peptides having substance P antagonistic activity
ATE195867T1 (de)	1991-09-20	2000-09-15	Glaxo Group Ltd	Neue medizinische indikation für tachykinin- antagonisten
US5328927A (en) *	1992-03-03	1994-07-12	Merck Sharpe & Dohme, Ltd.	Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
DE4243496A1 (de) *	1992-09-03	1994-03-10	Boehringer Ingelheim Kg	Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP0610487B1 (de) *	1992-09-03	1999-11-10	Boehringer Ingelheim Pharma KG	Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
IT1256623B (it) *	1992-12-04	1995-12-12	Federico Arcamone	Antagonisti delle tachichinine, procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
US5674889A (en) *	1993-02-22	1997-10-07	Merck, Sharp & Dohme, Ltd.	Aromatic compounds, compositions containing them and their use in therapy
WO1994020126A1 (en) *	1993-03-03	1994-09-15	Fujisawa Pharmaceutical Co., Ltd.	Use of peptides for the manufacture of a medicament
US5635510A (en) *	1993-05-06	1997-06-03	Merrell Pharmaceuticals Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines
WO1995000536A1 (en) *	1993-06-22	1995-01-05	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds
US5455262A (en) *	1993-10-06	1995-10-03	Florida State University	Mercaptosulfide metalloproteinase inhibitors
EE9600186A (et) *	1994-05-07	1997-08-15	Boehringer Ingelheim Kg	Neurokiniini (tahhüülkiniini) antagonistid
DE69508093T2 (de)	1994-08-25	1999-07-15	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Substituierte piperidine für die behandlung von allergischen krankheiten
US5830868A (en) *	1994-09-13	1998-11-03	Warner-Lambert Company	Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
AU700693B2 (en) *	1995-04-13	1999-01-14	Aventis Pharmaceuticals Inc.	Novel substituted piperazine derivatives having tachykinin receptor antagonists activity
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) *	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US6423689B1 (en)	1997-12-22	2002-07-23	Warner-Lambert Company	Peptidyl calcium channel blockers
ID27998A (id) *	1998-07-23	2001-05-03	Akzo Nobel Nv	Peptida baru untuk penggunaan dalam imunoterapi pada penyakit atau atoimun
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100885986B1 (ko)	1999-11-03	2009-03-03	에이엠알 테크놀로지, 인크.	노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
CA2415532C (en)	2000-07-11	2010-05-11	Albany Molecular Research, Inc.	Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
KR101389246B1 (ko)	2004-07-15	2014-04-24	브리스톨-마이어스스퀴브컴파니	아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
EP1888050B1 (de)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	Cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropansäure zur Behandlug von Krebs
ZA200800440B (en)	2005-07-15	2009-12-30	Amr Technology Inc	Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (de)	2007-01-10	2019-04-03	MSD Italia S.r.l.	Amidsubstituierte Indazole als Poly-(ADP-Ribose)-Polymerase (PARP)-Hemmer
JP2010516734A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物
US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
CN102638982B (zh)	2009-05-12	2015-07-08	百时美施贵宝公司	(S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
EP2429295B1 (de)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl-, heteroaryl- und heterocyclen-substituierte tetrahydroisochinoline und ihre verwendung
KR101830447B1 (ko)	2009-05-12	2018-02-20	알바니 몰레큘라 리써치, 인크.	7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
EP2488028B1 (de)	2009-10-14	2020-08-19	Merck Sharp & Dohme Corp.	Substituierte piperidine zur erhöhung der p53-aktivität und ihre verwendung
US9446029B2 (en)	2010-07-27	2016-09-20	Colorado State University Research Foundation	Use of NK-1 receptor antagonists in management of visceral pain
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JP2013537423A (ja)	2010-08-17	2013-10-03	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en)	2010-09-01	2012-03-08	Schering Corporation	Indazole derivatives useful as erk inhibitors
EP2615916B1 (de)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Kondensierte pyrazolderivate als neue erk-hemmer
DK2632472T3 (en)	2010-10-29	2018-03-19	Sirna Therapeutics Inc	RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
EP2699568A1 (de)	2011-04-21	2014-02-26	Piramal Enterprises Limited	Kristalline form eines morpholinsulfonylindolderivat-salzes und verfahren zu seiner herstellung
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (de)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	Sina-zusammensetzungen
CN105050598B (zh)	2012-09-28	2018-04-27	默沙东公司	作为erk抑制剂的新型化合物
RS56680B1 (sr)	2012-11-28	2018-03-30	Merck Sharp & Dohme	Kompozicije i postupci za lečenje kancera
US8846657B2 (en)	2012-12-20	2014-09-30	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (de)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Kreisförmige polynukleotide
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3706742B1 (de)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
EP3833668B1 (de)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
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EP3833667B1 (de)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5-inhibitoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4395401A (en) *	1981-09-09	1983-07-26	Smithkline Beckman Corporation	Renally active dipeptides
US5187156A (en) *	1988-03-16	1993-02-16	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) *	1989-04-28	1992-11-17	Fujisawa Pharmaceutical Company, Ltd.	Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same

1990
- 1990-10-24 GB GB909023116A patent/GB9023116D0/en active Pending
1991
- 1991-10-07 ZA ZA918011A patent/ZA918011B/xx unknown
- 1991-10-16 IE IE359991A patent/IE913599A1/en not_active Application Discontinuation
- 1991-10-18 AU AU85925/91A patent/AU647534B2/en not_active Ceased
- 1991-10-20 DE DE69123697T patent/DE69123697T2/de not_active Expired - Fee Related
- 1991-10-20 DK DK91117889.5T patent/DK0482539T3/da active
- 1991-10-20 AT AT91117889T patent/ATE146480T1/de not_active IP Right Cessation
- 1991-10-20 EP EP91117889A patent/EP0482539B1/de not_active Expired - Lifetime
- 1991-10-20 ES ES91117889T patent/ES2095283T3/es not_active Expired - Lifetime
- 1991-10-22 HU HU913331A patent/HUT59163A/hu unknown
- 1991-10-22 KR KR1019910018577A patent/KR920008065A/ko not_active Ceased
- 1991-10-22 FI FI914961A patent/FI914961A7/fi not_active Application Discontinuation
- 1991-10-23 CA CA002054097A patent/CA2054097A1/en not_active Abandoned
- 1991-10-23 NO NO91914171A patent/NO914171L/no unknown
- 1991-10-23 CN CN91109851A patent/CN1038939C/zh not_active Expired - Lifetime
- 1991-10-23 PT PT99317A patent/PT99317B/pt not_active IP Right Cessation
- 1991-10-23 RU SU915010105A patent/RU2073683C1/ru active
- 1991-10-24 JP JP34387291A patent/JP3206764B2/ja not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00392P patent/HU211611A9/hu unknown
1996
- 1996-08-14 CN CN96111367A patent/CN1148503A/zh active Pending
- 1996-12-23 GR GR960403576T patent/GR3022137T3/el unknown

Also Published As

Publication number	Publication date
DE69123697T2 (de)	1997-04-17
GB9023116D0 (en)	1990-12-05
HU211611A9 (en)	1995-12-28
CN1148503A (zh)	1997-04-30
HU913331D0 (en)	1992-01-28
PT99317A (pt)	1992-09-30
DE69123697D1 (de)	1997-01-30
NO914171D0 (no)	1991-10-23
FI914961A0 (fi)	1991-10-22
RU2073683C1 (ru)	1997-02-20
EP0482539A3 (en)	1992-08-26
CN1038939C (zh)	1998-07-01
JPH04297492A (ja)	1992-10-21
KR920008065A (ko)	1992-05-27
CA2054097A1 (en)	1992-04-25
DK0482539T3 (da)	1997-01-06
CN1060848A (zh)	1992-05-06
EP0482539A2 (de)	1992-04-29
FI914961A7 (fi)	1992-04-25
ES2095283T3 (es)	1997-02-16
JP3206764B2 (ja)	2001-09-10
GR3022137T3 (en)	1997-03-31
IE913599A1 (en)	1992-05-22
EP0482539B1 (de)	1996-12-18
PT99317B (pt)	1999-04-30
HUT59163A (en)	1992-04-28
AU647534B2 (en)	1994-03-24
AU8592591A (en)	1992-04-30
ZA918011B (en)	1992-07-29
ATE146480T1 (de)	1997-01-15

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