ATE146482T1 - Karboxyalkylsubstituierte enkephalinase und ace- hemmer - Google Patents

Karboxyalkylsubstituierte enkephalinase und ace- hemmer

Info

Publication number: ATE146482T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; enkephalinase; carboxyalkyl; substituted
Prior art date: 1991-09-27

Application number

AT92116575T

Other languages

English (en)

Inventor

Alan M Warshawsky

Gary A Flynn

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-27

Filing date

1992-09-28

Publication date

1997-01-15

1992-09-28 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE146482T1 publication Critical patent/ATE146482T1/de

Links

102000003729 Neprilysin Human genes 0.000 title abstract 2
108090000028 Neprilysin Proteins 0.000 title abstract 2
239000005541 ACE inhibitor Substances 0.000 title 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 1
239000002792 enkephalinase inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
-1 methylenedioxy Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92116575T 1991-09-27 1992-09-28 Karboxyalkylsubstituierte enkephalinase und ace- hemmer ATE146482T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76728191A	1991-09-27	1991-09-27

Publications (1)

Publication Number	Publication Date
ATE146482T1 true ATE146482T1 (de)	1997-01-15

Family

ID=25079018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92116575T ATE146482T1 (de)	1991-09-27	1992-09-28	Karboxyalkylsubstituierte enkephalinase und ace- hemmer

Country Status (17)

Country	Link
US (1)	US5472959A (de)
EP (1)	EP0534492B1 (de)
JP (1)	JP3173673B2 (de)
KR (1)	KR100273734B1 (de)
AT (1)	ATE146482T1 (de)
AU (1)	AU657794B2 (de)
CA (1)	CA2078759C (de)
DE (1)	DE69216026T2 (de)
DK (1)	DK0534492T3 (de)
ES (1)	ES2097847T3 (de)
FI (1)	FI101304B1 (de)
GR (1)	GR3022654T3 (de)
HU (1)	HU214596B (de)
IL (1)	IL103265A (de)
NO (1)	NO300844B1 (de)
NZ (1)	NZ244442A (de)
ZA (1)	ZA927211B (de)

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ATE155143T1 (de) *	1991-09-27	1997-07-15	Merrell Pharma Inc	2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
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US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7273881B2 (en)	2004-01-16	2007-09-25	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795291B2 (en)	2006-07-07	2010-09-14	Bristol-Myers Squibb Company	Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
CN101573340A (zh)	2006-11-01	2009-11-04	百时美施贵宝公司	糖皮质激素受体AP-1和/或NF-κB活性的调节剂及其用途
EP2089355A2 (de)	2006-11-01	2009-08-19	Brystol-Myers Squibb Company	Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kappa-b-aktivität und deren verwendung
WO2008057855A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (de)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
WO2009158380A1 (en)	2008-06-24	2009-12-30	Bristol-Myers Squibb Company	Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP5420761B2 (ja)	2009-05-28	2014-02-19	ノバルティスアーゲー	ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
SG176010A1 (en)	2009-05-28	2011-12-29	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2014126972A1 (en)	2013-02-14	2014-08-21	Novartis Ag	Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
NZ710574A (en)	2013-02-14	2017-11-24	Novartis Ag	Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
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1992
- 1992-09-21 CA CA002078759A patent/CA2078759C/en not_active Expired - Fee Related
- 1992-09-21 ZA ZA927211A patent/ZA927211B/xx unknown
- 1992-09-22 AU AU25247/92A patent/AU657794B2/en not_active Ceased
- 1992-09-22 NZ NZ244442A patent/NZ244442A/xx unknown
- 1992-09-23 IL IL10326592A patent/IL103265A/en not_active IP Right Cessation
- 1992-09-25 HU HU9203076A patent/HU214596B/hu not_active IP Right Cessation
- 1992-09-25 FI FI924312A patent/FI101304B1/fi active
- 1992-09-25 NO NO923743A patent/NO300844B1/no not_active IP Right Cessation
- 1992-09-25 JP JP28066792A patent/JP3173673B2/ja not_active Expired - Fee Related
- 1992-09-26 KR KR1019920017614A patent/KR100273734B1/ko not_active Expired - Fee Related
- 1992-09-28 DK DK92116575.9T patent/DK0534492T3/da active
- 1992-09-28 AT AT92116575T patent/ATE146482T1/de not_active IP Right Cessation
- 1992-09-28 ES ES92116575T patent/ES2097847T3/es not_active Expired - Lifetime
- 1992-09-28 DE DE69216026T patent/DE69216026T2/de not_active Expired - Fee Related
- 1992-09-28 EP EP92116575A patent/EP0534492B1/de not_active Expired - Lifetime
1994
- 1994-12-01 US US08/348,778 patent/US5472959A/en not_active Expired - Fee Related
1997
- 1997-02-26 GR GR970400341T patent/GR3022654T3/el unknown

Also Published As

Publication number	Publication date
IL103265A (en)	1996-09-12
FI101304B (fi)	1998-05-29
NO300844B1 (no)	1997-08-04
GR3022654T3 (en)	1997-05-31
HU9203076D0 (en)	1992-12-28
ES2097847T3 (es)	1997-04-16
HU214596B (hu)	1998-04-28
DE69216026T2 (de)	1997-07-17
NO923743D0 (no)	1992-09-25
US5472959A (en)	1995-12-05
CA2078759A1 (en)	1993-03-28
KR100273734B1 (ko)	2001-02-01
EP0534492B1 (de)	1996-12-18
HUT65174A (en)	1994-05-02
CA2078759C (en)	2003-09-16
AU2524792A (en)	1993-04-01
FI924312L (fi)	1993-03-28
FI101304B1 (fi)	1998-05-29
JPH05213950A (ja)	1993-08-24
EP0534492A3 (en)	1993-06-09
AU657794B2 (en)	1995-03-23
FI924312A0 (fi)	1992-09-25
DK0534492T3 (da)	1997-01-06
KR930006026A (ko)	1993-04-20
NZ244442A (en)	1995-01-27
EP0534492A2 (de)	1993-03-31
NO923743L (no)	1993-03-29
JP3173673B2 (ja)	2001-06-04
ZA927211B (en)	1993-03-24
IL103265A0 (en)	1993-02-21
DE69216026D1 (de)	1997-01-30

Legal Events

Date	Code	Title	Description
2005-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69216026D1 (de)	1997-01-30	Karboxyalkylsubstituierte Enkephalinase und ACE-Hemmer
CA2079143A1 (en)	1993-03-28	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
CA2078758A1 (en)	1993-03-28	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
PT771794E (pt)	2006-09-29	Compostos heterociclicos contendo oxigenio
FI943561A0 (fi)	1994-07-29	Uudet ainekoostumukset
SE9701891D0 (sv)	1997-05-21	Stabilisatorblandning för organiska material
IS4206A (is)	1995-03-18	Hliðstæðar aðferðir til framleiðslu á andróstenónafleiðu og milliefni notuð í aðferðunum
DE69323090D1 (de)	1999-02-25	4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE
DE69937045D1 (de)	2007-10-18	Cyclische amidderivate
ATE97410T1 (de)	1993-12-15	6-amino-6-desoxyfumagillole, ihre herstellung und ihre verwendung.
SE8802402D0 (sv)	1988-06-28	Novel esters
AU7733491A (en)	1991-11-28	Isochromane derivatives
DK681487A (da)	1988-06-23	Kemisk forbindelse og anvendelse af samme som tilsaetningsmiddel til destillatbraendsel
MX9101270A (es)	1992-07-08	Compuesto,preparacion y uso
WO2003075928A3 (en)	2003-12-04	Stable pharmaceutical compositions
IL78625A0 (en)	1986-08-31	Furanone derivatives and their preparation