NO923743L - Nye carboxyalkylderivater anvendbare som inhibitorer av enkefalinase og ace - Google Patents

Nye carboxyalkylderivater anvendbare som inhibitorer av enkefalinase og ace

Info

Publication number: NO923743L
Authority: NO; Norway
Prior art keywords: alkyl; ace; hydrogen; enhibitors; encyphalinase
Prior art date: 1991-09-27

Application number

NO92923743A

Other languages

English (en)

Other versions

NO300844B1 (no

NO923743D0 (no

Inventor

Alan M Warshawsky

Gary Alan Flynn

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-27

Filing date

1992-09-25

Publication date

1993-03-29

1992-09-25 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-09-25 Publication of NO923743D0 publication Critical patent/NO923743D0/no

1993-03-29 Publication of NO923743L publication Critical patent/NO923743L/no

1997-08-04 Publication of NO300844B1 publication Critical patent/NO300844B1/no

Links

238000001816 cooling Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
102000003729 Neprilysin Human genes 0.000 abstract 1
108090000028 Neprilysin Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
-1 methylenedioxy Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO923743A 1991-09-27 1992-09-25 Nye carboxyalkylderivater som er anvendbare som inhibitorer av enkefalinase og ACE NO300844B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76728191A	1991-09-27	1991-09-27

Publications (3)

Publication Number	Publication Date
NO923743D0 NO923743D0 (no)	1992-09-25
NO923743L true NO923743L (no)	1993-03-29
NO300844B1 NO300844B1 (no)	1997-08-04

Family

ID=25079018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO923743A NO300844B1 (no)	1991-09-27	1992-09-25	Nye carboxyalkylderivater som er anvendbare som inhibitorer av enkefalinase og ACE

Country Status (17)

Country	Link
US (1)	US5472959A (no)
EP (1)	EP0534492B1 (no)
JP (1)	JP3173673B2 (no)
KR (1)	KR100273734B1 (no)
AT (1)	ATE146482T1 (no)
AU (1)	AU657794B2 (no)
CA (1)	CA2078759C (no)
DE (1)	DE69216026T2 (no)
DK (1)	DK0534492T3 (no)
ES (1)	ES2097847T3 (no)
FI (1)	FI101304B1 (no)
GR (1)	GR3022654T3 (no)
HU (1)	HU214596B (no)
IL (1)	IL103265A (no)
NO (1)	NO300844B1 (no)
NZ (1)	NZ244442A (no)
ZA (1)	ZA927211B (no)

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US5594106A (en) *	1993-08-23	1997-01-14	Immunex Corporation	Inhibitors of TNF-α secretion
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
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US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US6929953B1 (en) *	1998-03-07	2005-08-16	Robert A. Levine	Apparatus for analyzing biologic fluids
WO1999065500A1 (en)	1998-06-17	1999-12-23	Bristol-Myers Squibb Company	Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
DK1216038T3 (da)	1999-08-30	2005-12-27	Sanofi Aventis Deutschland	Anvendelse af inhibitorer af reninangiotensinsystemet ved forebyggelsen af cardiovaskulære hændelser
EP1443919A4 (en)	2001-11-16	2006-03-22	Bristol Myers Squibb Co	DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7273881B2 (en)	2004-01-16	2007-09-25	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en)	2005-06-14	2011-02-15	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795291B2 (en)	2006-07-07	2010-09-14	Bristol-Myers Squibb Company	Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
US7968577B2 (en)	2006-11-01	2011-06-28	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7994190B2 (en)	2006-11-01	2011-08-09	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010508358A (ja)	2006-11-01	2010-03-18	ブリストル−マイヤーズスクイブカンパニー	グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP2334671A1 (en)	2008-06-24	2011-06-22	Bristol-Myers Squibb Company	Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
CA2763565A1 (en)	2009-05-28	2010-12-02	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
PL2435409T3 (pl)	2009-05-28	2015-01-30	Novartis Ag	Podstawione pochodne aminopropionowe jako inhibitory neprylizyny
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2014126972A1 (en)	2013-02-14	2014-08-21	Novartis Ag	Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
SG11201506018PA (en)	2013-02-14	2015-08-28	Novartis Ag	Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor

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1992
- 1992-09-21 ZA ZA927211A patent/ZA927211B/xx unknown
- 1992-09-21 CA CA002078759A patent/CA2078759C/en not_active Expired - Fee Related
- 1992-09-22 AU AU25247/92A patent/AU657794B2/en not_active Ceased
- 1992-09-22 NZ NZ244442A patent/NZ244442A/xx unknown
- 1992-09-23 IL IL10326592A patent/IL103265A/en not_active IP Right Cessation
- 1992-09-25 NO NO923743A patent/NO300844B1/no not_active IP Right Cessation
- 1992-09-25 HU HU9203076A patent/HU214596B/hu not_active IP Right Cessation
- 1992-09-25 FI FI924312A patent/FI101304B1/fi active
- 1992-09-25 JP JP28066792A patent/JP3173673B2/ja not_active Expired - Fee Related
- 1992-09-26 KR KR1019920017614A patent/KR100273734B1/ko not_active Expired - Fee Related
- 1992-09-28 ES ES92116575T patent/ES2097847T3/es not_active Expired - Lifetime
- 1992-09-28 DK DK92116575.9T patent/DK0534492T3/da active
- 1992-09-28 EP EP92116575A patent/EP0534492B1/en not_active Expired - Lifetime
- 1992-09-28 DE DE69216026T patent/DE69216026T2/de not_active Expired - Fee Related
- 1992-09-28 AT AT92116575T patent/ATE146482T1/de not_active IP Right Cessation
1994
- 1994-12-01 US US08/348,778 patent/US5472959A/en not_active Expired - Fee Related
1997
- 1997-02-26 GR GR970400341T patent/GR3022654T3/el unknown

Also Published As

Publication number	Publication date
KR100273734B1 (ko)	2001-02-01
IL103265A0 (en)	1993-02-21
JPH05213950A (ja)	1993-08-24
US5472959A (en)	1995-12-05
HU214596B (hu)	1998-04-28
ATE146482T1 (de)	1997-01-15
FI101304B (fi)	1998-05-29
ES2097847T3 (es)	1997-04-16
GR3022654T3 (en)	1997-05-31
HUT65174A (en)	1994-05-02
NZ244442A (en)	1995-01-27
AU657794B2 (en)	1995-03-23
NO300844B1 (no)	1997-08-04
HU9203076D0 (en)	1992-12-28
NO923743D0 (no)	1992-09-25
EP0534492B1 (en)	1996-12-18
JP3173673B2 (ja)	2001-06-04
CA2078759C (en)	2003-09-16
IL103265A (en)	1996-09-12
DK0534492T3 (da)	1997-01-06
FI101304B1 (fi)	1998-05-29
ZA927211B (en)	1993-03-24
DE69216026D1 (de)	1997-01-30
CA2078759A1 (en)	1993-03-28
EP0534492A2 (en)	1993-03-31
FI924312A0 (fi)	1992-09-25
DE69216026T2 (de)	1997-07-17
KR930006026A (ko)	1993-04-20
EP0534492A3 (en)	1993-06-09
AU2524792A (en)	1993-04-01
FI924312L (fi)	1993-03-28

Legal Events

Date	Code	Title	Description
2005-06-20	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO923743D0 (no)	1992-09-25	Nye carboxyalkylderivater anvendbare som inhibitorer av enkefalinase og ace
CA2079143A1 (en)	1993-03-28	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
CA2078758A1 (en)	1993-03-28	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0673937T3 (da)	2004-03-22	Bicyclisk heterocyclisk sulfonamid og sulfonsyreesterderivater
PT771794E (pt)	2006-09-29	Compostos heterociclicos contendo oxigenio
MX9300256A (es)	1993-07-01	Derivados de acido acetico y proceso para su preparacion.
NO955023D0 (no)	1995-12-12	Piperidinderivater og fremgangsmåte for fremstilling derav
AU6876894A (en)	1995-02-09	New compositions of matter
MY104376A (en)	1994-03-31	N-imidazolyl deravatives of bicyclic compounds and process for their preparation.
ATE103592T1 (de)	1994-04-15	Carbamoylpyrrolidonderivate, ihre verwendung und herstellung.
SE9701891D0 (sv)	1997-05-21	Stabilisatorblandning för organiska material
EA200200098A1 (ru)	2002-10-31	Ароматические сложные эфиры для маркировки или мечения нефтепродуктов
IS1726B (is)	1999-09-06	Hliðstæðar aðferðir til framleiðslu á andróstenónafleiðu og milliefni notuð í aðferðunum
DE69323090D1 (de)	1999-02-25	4-ALKOXY-2,6-DI-t-BUTYLPHENOLDERIVATE
DE69937045D1 (de)	2007-10-18	Cyclische amidderivate
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