ATE148122T1 - Optisch aktive thienotriazolodiazepin- verbindungen - Google Patents

Optisch aktive thienotriazolodiazepin- verbindungen

Info

Publication number: ATE148122T1
Authority: AT; Austria
Prior art keywords: carbon atoms; alkyl; optically active; hydrogen; active thienotriazolodiazepine
Prior art date: 1990-10-12

Application number

AT91117375T

Other languages

English (en)

Inventor

Minoru Moriwaki

Syuji Yuasa

Hiroyuki Kitani

Michio Terasawa

Original Assignee

Yoshitomi Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-12

Filing date

1991-10-11

Publication date

1997-02-15

1991-10-11 Application filed by Yoshitomi Pharmaceutical filed Critical Yoshitomi Pharmaceutical

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE148122T1 publication Critical patent/ATE148122T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
-1 2-morpholinocarbonylethyl Chemical group 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 abstract 1
125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000001953 recrystallisation Methods 0.000 abstract 1
238000009877 rendering Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT91117375T 1990-10-12 1991-10-11 Optisch aktive thienotriazolodiazepin- verbindungen ATE148122T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP27445190		1990-10-12
JP21451291		1991-07-31

Publications (1)

Publication Number	Publication Date
ATE148122T1 true ATE148122T1 (de)	1997-02-15

Family

ID=26520357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91117375T ATE148122T1 (de)	1990-10-12	1991-10-11	Optisch aktive thienotriazolodiazepin- verbindungen

Country Status (9)

Country	Link
US (1)	US5286858A (de)
EP (1)	EP0480455B1 (de)
JP (1)	JP2959598B2 (de)
KR (1)	KR940006633B1 (de)
AT (1)	ATE148122T1 (de)
CA (1)	CA2053123A1 (de)
DE (1)	DE69124330T2 (de)
DK (1)	DK0480455T3 (de)
ES (1)	ES2099114T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0638560A4 (de) *	1991-10-11	1995-03-29	Yoshitomi Pharmaceutical	Heilmittel für osteoporose und diazepinverbindung*.
CN1984887B (zh) *	2004-07-13	2010-07-28	大鹏药品工业株式会社	甲磺司特结晶的均匀性评价方法、均匀的结晶及其制造方法
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
WO2012075456A1 (en)	2010-12-02	2012-06-07	Constellation Pharmaceuticals	Bromodomain inhibitors and uses thereof
WO2012151512A2 (en)	2011-05-04	2012-11-08	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2721031B1 (de)	2011-06-17	2016-01-20	Constellation Pharmaceuticals, Inc.	Bromodomainhemmer und ihre verwendungen
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
EP2864336B1 (de)	2012-06-06	2016-11-23	Constellation Pharmaceuticals, Inc.	Benzo[b]isoxazolazepinbromdomänenhemmer und verwendungen davon
TR201906788T4 (tr)	2014-06-20	2019-05-21	Constellation Pharmaceuticals Inc	2-((4s)-6-(4-klorofenil)-1-metil-4h-benzo[c]izoksazolo[4,5-e]azepın-4-il)asetamidin kristal formları.
JP2025501761A (ja)	2021-12-22	2025-01-23	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2039408T3 (es) *	1986-11-17	1993-10-01	Yoshitomi Pharmaceutical Industries, Ltd.	Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
DE3878833T2 (de) *	1987-05-28	1993-06-09	Yoshitomi Pharmaceutical	Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
MC1999A1 (fr) *	1987-12-18	1990-01-26	Hoffmann La Roche	Composes tricycliques
CA1324863C (en) *	1988-01-30	1993-11-30	Welfide Corporation	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
DE4010528A1 (de) *	1990-04-02	1991-10-17	Boehringer Ingelheim Kg	Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine

1991
- 1991-10-09 JP JP3290665A patent/JP2959598B2/ja not_active Expired - Lifetime
- 1991-10-10 CA CA002053123A patent/CA2053123A1/en not_active Abandoned
- 1991-10-11 ES ES91117375T patent/ES2099114T3/es not_active Expired - Lifetime
- 1991-10-11 EP EP91117375A patent/EP0480455B1/de not_active Expired - Lifetime
- 1991-10-11 DE DE69124330T patent/DE69124330T2/de not_active Expired - Fee Related
- 1991-10-11 US US07/774,945 patent/US5286858A/en not_active Expired - Lifetime
- 1991-10-11 AT AT91117375T patent/ATE148122T1/de not_active IP Right Cessation
- 1991-10-11 DK DK91117375.5T patent/DK0480455T3/da active
- 1991-10-12 KR KR1019910017987A patent/KR940006633B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5286858A (en)	1994-02-15
ES2099114T3 (es)	1997-05-16
JP2959598B2 (ja)	1999-10-06
EP0480455A1 (de)	1992-04-15
DE69124330T2 (de)	1997-07-03
KR920008048A (ko)	1992-05-27
DK0480455T3 (da)	1997-02-10
KR940006633B1 (ko)	1994-07-23
DE69124330D1 (de)	1997-03-06
CA2053123A1 (en)	1992-04-13
JPH0586067A (ja)	1993-04-06
EP0480455B1 (de)	1997-01-22

Legal Events

Date	Code	Title
1997-07-15	UEP	Publication of translation of european patent specification
2001-06-15	EEFA	Change of the company name
2003-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NL300396I1 (nl)	2009-10-01	Nieuwe derivaten met naftalinestructuren, werkwijze voor de bereiding ervan en de farmaceutische preparaten die deze bevatten
ES8105705A1 (es)	1981-06-16	Un procedimiento para la preparacion de sulfonamidas.
HUT68721A (en)	1995-07-28	Benzofuran and benzizoxazole derivatives, pharmaceutical composition containing said compounds as active agent and process for preparing them
DE69124330D1 (de)	1997-03-06	Optisch aktive Thienotriazolodiazepin-Verbindungen
DK0402752T3 (da)	1996-01-15	N-Heteroaryl-purin-6-aminer, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
HUP0101230A2 (hu)	2001-10-28	Eljárás 2-[(2-piridil)-metilszulfinil]-1H-benzimidazol-származékok előállítására
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
DE3069173D1 (en)	1984-10-18	Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
ATE70842T1 (de)	1992-01-15	Bakterizide pyridobenzothiazinderivate mit langer wirkungsdauer.
ATE109475T1 (de)	1994-08-15	Benzothiazolinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE22081T1 (de)	1986-09-15	Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
PT87310A (pt)	1988-05-01	Process for the preparation of thiadiazole guanidines
TH20764A (th)	1996-09-24	อนุพันธ์เฮเทอโรไซคลิคของแอไซโลน
TH14567A (de)	1994-08-26
TH15829A (th)	1995-04-18	อนุพันธ์คาร์โบสไทริล
DE69419083D1 (de)	1999-07-22	Salmycine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
TH6256A (th)	1989-07-03	อนุพันธ์ แอริล สารต่อต้านการอักเสบ
TH4616B (th)	1995-07-13	อนุพันธ์ของควิโนลีน-3-คาร์บอกซิลิค แอซิตการเตรียมและการใช้สารเหล่านี้
TH36106A (th)	1999-12-03	สารประกอบตัวใหม่ที่มีผลทำให้ไม่รู้สึกเจ็บปวด