ATE148630T1 - Stabilisierte derivate von vitamin d2 und d3 enthaltende pharmazeutische zusammensetzungen - Google Patents
Stabilisierte derivate von vitamin d2 und d3 enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE148630T1 ATE148630T1 AT93306978T AT93306978T ATE148630T1 AT E148630 T1 ATE148630 T1 AT E148630T1 AT 93306978 T AT93306978 T AT 93306978T AT 93306978 T AT93306978 T AT 93306978T AT E148630 T1 ATE148630 T1 AT E148630T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- pharmaceutical compositions
- compositions containing
- containing stabilized
- stabilized derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title abstract 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 abstract 3
- 239000004615 ingredient Substances 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL10322492A IL103224A (en) | 1992-09-18 | 1992-09-18 | Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE148630T1 true ATE148630T1 (de) | 1997-02-15 |
Family
ID=11064050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93306978T ATE148630T1 (de) | 1992-09-18 | 1993-09-03 | Stabilisierte derivate von vitamin d2 und d3 enthaltende pharmazeutische zusammensetzungen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5565442A (de) |
| EP (1) | EP0588539B1 (de) |
| JP (1) | JP3464691B2 (de) |
| AT (1) | ATE148630T1 (de) |
| AU (1) | AU667742B2 (de) |
| CA (1) | CA2106423C (de) |
| DE (1) | DE69307977T2 (de) |
| DK (1) | DK0588539T3 (de) |
| ES (1) | ES2098672T3 (de) |
| GR (1) | GR3023127T3 (de) |
| IL (1) | IL103224A (de) |
| ZA (1) | ZA936835B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
| JP2656448B2 (ja) * | 1994-07-25 | 1997-09-24 | マイクロアルジェコーポレーション株式会社 | カルシウムを主成分とする健康食品 |
| DE19710054A1 (de) * | 1997-03-12 | 1998-09-17 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| ITFI970184A1 (it) * | 1997-07-30 | 1999-01-30 | Menarini Farma Ind | Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico |
| AU7895601A (en) * | 2000-07-18 | 2002-01-30 | Bone Care Int Inc | Stabilized 1alpha-hydroxy vitamin d |
| US6475526B1 (en) | 2001-06-05 | 2002-11-05 | Jeffrey B. Smith | Zinc containing compositions for anti-viral use |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| JP4698950B2 (ja) * | 2002-04-09 | 2011-06-08 | フラメル・テクノロジー | アモキシシリンの改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤 |
| EP1492511B3 (de) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US20080274209A1 (en) * | 2002-11-04 | 2008-11-06 | Integritas Pharma, Inc. | Methods of treating inflammation |
| US6855341B2 (en) * | 2002-11-04 | 2005-02-15 | Jeffrey B. Smith | Anti-viral compositions and methods of making and using the anti-viral compositions |
| US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2563533C (en) | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| US7700365B2 (en) * | 2004-10-29 | 2010-04-20 | Mayo Foundation For Medical Education And Research | Vitamin D deficiencies |
| FR2889810A1 (fr) * | 2005-05-24 | 2007-02-23 | Flamel Technologies Sa | Forme medicamenteuse orale, microparticulaire, anti-mesurage |
| EP2262765B1 (de) * | 2008-03-12 | 2016-03-09 | OPKO Ireland Global Holdings, Limited | Stabilisiertes 1,25-dihydroxyvitamin d2 und verfahren zu dessen herstellung |
| US20110212534A1 (en) * | 2008-08-11 | 2011-09-01 | Taylor Robert L | Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3 |
| KR101814186B1 (ko) | 2008-09-17 | 2018-03-14 | 키아스마 인코포레이티드 | 약제학적 조성물 및 연관된 투여방법 |
| CA2981549A1 (en) | 2009-01-27 | 2010-08-05 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| CN106265695B (zh) | 2009-08-14 | 2021-05-07 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| EP2468265A3 (de) * | 2010-12-04 | 2013-01-02 | DEEF Pharmaceutical Industries Co. | Homogene Zubereitungen mit Vitamin D |
| EP2978431A4 (de) | 2013-03-27 | 2016-08-24 | Psm Healthcare Ltd | Stabilisierte vitamin-d-formulierungen |
| CN112156097A (zh) | 2013-05-29 | 2021-01-01 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
| US11071743B1 (en) * | 2015-01-16 | 2021-07-27 | Gregory M. Fahy | Effective, non-toxic treatments for brain cancer |
| WO2016126830A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932634A (en) * | 1973-06-28 | 1976-01-13 | Pfizer Inc. | High potency vitamin water dispersible formulations |
| JPS58206533A (ja) * | 1982-05-27 | 1983-12-01 | Teijin Ltd | 活性型ビタミンｄ↓３誘導体組成物及びそれを活性成分とする薬剤 |
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| CA1272953A (en) * | 1984-10-08 | 1990-08-21 | Yuji Makino | Pharmaceutical composition for external use containing active-type vitamin d.sub.3 |
| CA1317546C (en) * | 1985-07-01 | 1993-05-11 | Werner Meier | Pharmaceutical preparations containing mixtures of hydroxy derivatives of vitamin d |
| JPS62149619A (ja) * | 1985-09-05 | 1987-07-03 | Teijin Ltd | 活性型ビタミンｄ３類注射用組成物 |
| DD266099A1 (de) * | 1987-09-28 | 1989-03-22 | Jenapharm Veb | Verfahren zur herstellung von stabilen waessrigen vitamin-d-loesungen |
| JPH0331257Y2 (de) * | 1987-10-31 | 1991-07-02 | ||
| JP2525478B2 (ja) * | 1989-03-01 | 1996-08-21 | 帝人株式会社 | 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤 |
| JPH02240024A (ja) * | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類製剤用組成物 |
| DK0398217T3 (da) * | 1989-05-18 | 1994-02-14 | Hoffmann La Roche | Dehydrocholecalciferolderivater |
| DK0437225T3 (da) * | 1990-01-10 | 1994-06-27 | Hoffmann La Roche | Topiske præparater |
| JP2963718B2 (ja) * | 1990-03-06 | 1999-10-18 | グレラン製薬株式会社 | ビタミンｄ▲下３▼類含有製剤 |
| JP2787364B2 (ja) * | 1990-03-29 | 1998-08-13 | 大塚製薬株式会社 | 脂溶性ビタミン注射液 |
| JP2845342B2 (ja) * | 1990-04-28 | 1999-01-13 | 大正製薬株式会社 | ビタミンｄ▲下３▼誘導体含有固形製剤組成物 |
| JP2974734B2 (ja) * | 1990-07-12 | 1999-11-10 | 中外製薬株式会社 | 安定な活性型ビタミンｄ▲下３▼類製剤 |
| JPH04198129A (ja) * | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類含有組成物 |
-
1992
- 1992-09-18 IL IL10322492A patent/IL103224A/en not_active IP Right Cessation
-
1993
- 1993-09-03 DK DK93306978.3T patent/DK0588539T3/da active
- 1993-09-03 EP EP93306978A patent/EP0588539B1/de not_active Expired - Lifetime
- 1993-09-03 AT AT93306978T patent/ATE148630T1/de not_active IP Right Cessation
- 1993-09-03 DE DE69307977T patent/DE69307977T2/de not_active Expired - Lifetime
- 1993-09-03 ES ES93306978T patent/ES2098672T3/es not_active Expired - Lifetime
- 1993-09-13 US US08/120,210 patent/US5565442A/en not_active Expired - Lifetime
- 1993-09-16 ZA ZA936835A patent/ZA936835B/xx unknown
- 1993-09-16 AU AU47408/93A patent/AU667742B2/en not_active Ceased
- 1993-09-17 CA CA002106423A patent/CA2106423C/en not_active Expired - Fee Related
- 1993-09-20 JP JP23389093A patent/JP3464691B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-31 US US08/657,676 patent/US5804573A/en not_active Expired - Lifetime
-
1997
- 1997-04-14 GR GR970400788T patent/GR3023127T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69307977T2 (de) | 1997-08-28 |
| IL103224A0 (en) | 1993-02-21 |
| EP0588539A1 (de) | 1994-03-23 |
| DK0588539T3 (da) | 1997-03-10 |
| EP0588539B1 (de) | 1997-02-05 |
| GR3023127T3 (en) | 1997-07-30 |
| AU4740893A (en) | 1994-03-24 |
| CA2106423A1 (en) | 1994-03-19 |
| DE69307977D1 (de) | 1997-03-20 |
| ES2098672T3 (es) | 1997-05-01 |
| AU667742B2 (en) | 1996-04-04 |
| US5565442A (en) | 1996-10-15 |
| ZA936835B (en) | 1994-04-14 |
| JPH06219952A (ja) | 1994-08-09 |
| IL103224A (en) | 1998-08-16 |
| US5804573A (en) | 1998-09-08 |
| CA2106423C (en) | 2005-02-22 |
| JP3464691B2 (ja) | 2003-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |