IL103224A - Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3 - Google Patents

Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3

Info

Publication number: IL103224A
Authority: IL; Israel
Prior art keywords: pharmaceutical composition; ingredient; composition according; ingredients; vitamin
Prior art date: 1992-09-18

Application number

IL10322492A

Other languages

English (en)

Other versions

IL103224A0 (en

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-18

Filing date

1992-09-18

Publication date

1998-08-16

1992-09-18 Priority to IL10322492A priority Critical patent/IL103224A/en

1992-09-18 Application filed by Teva Pharma filed Critical Teva Pharma

1993-02-21 Publication of IL103224A0 publication Critical patent/IL103224A0/xx

1993-09-03 Priority to AT93306978T priority patent/ATE148630T1/de

1993-09-03 Priority to ES93306978T priority patent/ES2098672T3/es

1993-09-03 Priority to EP93306978A priority patent/EP0588539B1/de

1993-09-03 Priority to DK93306978.3T priority patent/DK0588539T3/da

1993-09-03 Priority to DE69307977T priority patent/DE69307977T2/de

1993-09-13 Priority to US08/120,210 priority patent/US5565442A/en

1993-09-16 Priority to AU47408/93A priority patent/AU667742B2/en

1993-09-16 Priority to ZA936835A priority patent/ZA936835B/xx

1993-09-17 Priority to CA002106423A priority patent/CA2106423C/en

1993-09-20 Priority to JP23389093A priority patent/JP3464691B2/ja

1996-05-31 Priority to US08/657,676 priority patent/US5804573A/en

1997-04-14 Priority to GR970400788T priority patent/GR3023127T3/el

1998-08-16 Publication of IL103224A publication Critical patent/IL103224A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 27
229940088594 vitamin Drugs 0.000 title claims description 9
229930003231 vitamin Natural products 0.000 title claims description 9
239000011782 vitamin Substances 0.000 title claims description 9
235000013343 vitamin Nutrition 0.000 title claims description 9
239000004615 ingredient Substances 0.000 claims abstract description 39
239000007787 solid Substances 0.000 claims abstract description 18
239000000203 mixture Substances 0.000 claims abstract description 14
239000003963 antioxidant agent Substances 0.000 claims abstract description 7
230000003078 antioxidant effect Effects 0.000 claims abstract description 7
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
239000003381 stabilizer Substances 0.000 claims abstract description 5
239000003937 drug carrier Substances 0.000 claims abstract description 4
229940124531 pharmaceutical excipient Drugs 0.000 claims abstract description 4
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 18
239000004359 castor oil Substances 0.000 claims description 10
235000019438 castor oil Nutrition 0.000 claims description 10
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 10
235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 9
235000019359 magnesium stearate Nutrition 0.000 claims description 9
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
239000000600 sorbitol Substances 0.000 claims description 8
150000003722 vitamin derivatives Chemical class 0.000 claims description 7
239000004322 Butylated hydroxytoluene Substances 0.000 claims description 6
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 6
235000006708 antioxidants Nutrition 0.000 claims description 6
235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 6
229940095259 butylated hydroxytoluene Drugs 0.000 claims description 6
-1 fatty acid esters Chemical class 0.000 claims description 6
229920001223 polyethylene glycol Polymers 0.000 claims description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
239000002552 dosage form Substances 0.000 claims description 5
239000008101 lactose Substances 0.000 claims description 5
239000000314 lubricant Substances 0.000 claims description 5
239000002904 solvent Substances 0.000 claims description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
239000002202 Polyethylene glycol Substances 0.000 claims description 4
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 4
235000014113 dietary fatty acids Nutrition 0.000 claims description 4
239000000194 fatty acid Substances 0.000 claims description 4
229930195729 fatty acid Natural products 0.000 claims description 4
239000007903 gelatin capsule Substances 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
FCKJYANJHNLEEP-SRLFHJKTSA-N 24,25-dihydroxycholecalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCC(O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C FCKJYANJHNLEEP-SRLFHJKTSA-N 0.000 claims description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
WFZKUWGUJVKMHC-QPGHTDHKSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5,6-dihydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCC(O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C WFZKUWGUJVKMHC-QPGHTDHKSA-N 0.000 claims description 2
SNOXQOOPUCMFPS-ZLNGONTQSA-N (1s,3z)-3-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C SNOXQOOPUCMFPS-ZLNGONTQSA-N 0.000 claims description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Polymers OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
JNYAEWCLZODPBN-UHFFFAOYSA-N 2-(1,2-dihydroxyethyl)oxolane-3,4-diol Polymers OCC(O)C1OCC(O)C1O JNYAEWCLZODPBN-UHFFFAOYSA-N 0.000 claims description 2
239000004040 24-hydroxy-cholecalciferol Substances 0.000 claims description 2
JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims description 2
239000003872 25-hydroxy-cholecalciferol Substances 0.000 claims description 2
235000021318 Calcifediol Nutrition 0.000 claims description 2
229930003427 Vitamin E Natural products 0.000 claims description 2
235000010323 ascorbic acid Nutrition 0.000 claims description 2
239000011668 ascorbic acid Substances 0.000 claims description 2
229960005070 ascorbic acid Drugs 0.000 claims description 2
JWUBBDSIWDLEOM-DTOXIADCSA-N calcidiol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DTOXIADCSA-N 0.000 claims description 2
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims description 2
239000001506 calcium phosphate Substances 0.000 claims description 2
229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
235000011010 calcium phosphates Nutrition 0.000 claims description 2
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
235000013539 calcium stearate Nutrition 0.000 claims description 2
239000008116 calcium stearate Substances 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
150000002170 ethers Chemical class 0.000 claims description 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
150000002314 glycerols Polymers 0.000 claims description 2
238000002156 mixing Methods 0.000 claims description 2
229940068917 polyethylene glycols Drugs 0.000 claims description 2
235000010388 propyl gallate Nutrition 0.000 claims description 2
239000000473 propyl gallate Substances 0.000 claims description 2
229940075579 propyl gallate Drugs 0.000 claims description 2
JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 claims description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
235000019165 vitamin E Nutrition 0.000 claims description 2
229940046009 vitamin E Drugs 0.000 claims description 2
239000011709 vitamin E Substances 0.000 claims description 2
229930003316 Vitamin D Natural products 0.000 claims 1
235000019166 vitamin D Nutrition 0.000 claims 1
239000011710 vitamin D Substances 0.000 claims 1
150000003710 vitamin D derivatives Chemical class 0.000 claims 1
229940046008 vitamin d Drugs 0.000 claims 1
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract description 5
235000005282 vitamin D3 Nutrition 0.000 abstract 1
239000011647 vitamin D3 Substances 0.000 abstract 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
229940021056 vitamin d3 Drugs 0.000 abstract 1
239000004255 Butylated hydroxyanisole Substances 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 6
229940043253 butylated hydroxyanisole Drugs 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
238000003556 assay Methods 0.000 description 4
239000008187 granular material Substances 0.000 description 3
238000013112 stability test Methods 0.000 description 3
239000007791 liquid phase Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
208000000038 Hypoparathyroidism Diseases 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
102000003982 Parathyroid hormone Human genes 0.000 description 1
108090000445 Parathyroid hormone Proteins 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
201000006035 X-linked dominant hypophosphatemic rickets Diseases 0.000 description 1
MMSSTFYJXGKFHL-RJMJUYIDSA-N [Mg].O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O Chemical compound [Mg].O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O MMSSTFYJXGKFHL-RJMJUYIDSA-N 0.000 description 1
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
238000013459 approach Methods 0.000 description 1
235000013734 beta-carotene Nutrition 0.000 description 1
239000011648 beta-carotene Substances 0.000 description 1
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
229960002747 betacarotene Drugs 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000020832 chronic kidney disease Diseases 0.000 description 1
208000022831 chronic renal failure syndrome Diseases 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
CRVGKGJPQYZRPT-UHFFFAOYSA-N diethylamino acetate Chemical compound CCN(CC)OC(C)=O CRVGKGJPQYZRPT-UHFFFAOYSA-N 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
208000011111 hypophosphatemic rickets Diseases 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000011164 ossification Effects 0.000 description 1
208000005368 osteomalacia Diseases 0.000 description 1
239000000199 parathyroid hormone Substances 0.000 description 1
229960001319 parathyroid hormone Drugs 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000002028 premature Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000001185 psoriatic effect Effects 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
231100000916 relative toxicity Toxicity 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000032349 type 2B vitamin D-dependent rickets Diseases 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Biophysics (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL10322492A 1992-09-18 1992-09-18 Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3 IL103224A (en)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
IL10322492A IL103224A (en)	1992-09-18	1992-09-18	Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
AT93306978T ATE148630T1 (de)	1992-09-18	1993-09-03	Stabilisierte derivate von vitamin d2 und d3 enthaltende pharmazeutische zusammensetzungen
ES93306978T ES2098672T3 (es)	1992-09-18	1993-09-03	Composiciones farmaceuticas estabilizadas que contienen derivados de vitaminas d2 y d3.
EP93306978A EP0588539B1 (de)	1992-09-18	1993-09-03	Stabilisierte Derivate von Vitamin D2 und D3 enthaltende pharmazeutische Zusammensetzungen
DK93306978.3T DK0588539T3 (da)	1992-09-18	1993-09-03	Stabiliserede farmaceutiske præparater indeholdende derivater af vitamin D2 og D3
DE69307977T DE69307977T2 (de)	1992-09-18	1993-09-03	Stabilisierte Derivate von Vitamin D2 und D3 enthaltende pharmazeutische Zusammensetzungen
US08/120,210 US5565442A (en)	1992-09-18	1993-09-13	Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3
AU47408/93A AU667742B2 (en)	1992-09-18	1993-09-16	Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3
ZA936835A ZA936835B (en)	1992-09-18	1993-09-16	Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3
CA002106423A CA2106423C (en)	1992-09-18	1993-09-17	Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
JP23389093A JP3464691B2 (ja)	1992-09-18	1993-09-20	固型製薬組成物
US08/657,676 US5804573A (en)	1992-09-18	1996-05-31	Stabilized pharmaceutical composition containing derivative of vitamins D2 and D3
GR970400788T GR3023127T3 (en)	1992-09-18	1997-04-14	Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL10322492A IL103224A (en)	1992-09-18	1992-09-18	Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3

Publications (2)

Publication Number	Publication Date
IL103224A0 IL103224A0 (en)	1993-02-21
IL103224A true IL103224A (en)	1998-08-16

Family

ID=11064050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10322492A IL103224A (en)	1992-09-18	1992-09-18	Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3

Country Status (12)

Country	Link
US (2)	US5565442A (de)
EP (1)	EP0588539B1 (de)
JP (1)	JP3464691B2 (de)
AT (1)	ATE148630T1 (de)
AU (1)	AU667742B2 (de)
CA (1)	CA2106423C (de)
DE (1)	DE69307977T2 (de)
DK (1)	DK0588539T3 (de)
ES (1)	ES2098672T3 (de)
GR (1)	GR3023127T3 (de)
IL (1)	IL103224A (de)
ZA (1)	ZA936835B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9325445D0 (en)	1993-12-13	1994-02-16	Cortecs Ltd	Pharmaceutical formulations
JP2656448B2 (ja) *	1994-07-25	1997-09-24	マイクロアルジェコーポレーション株式会社	カルシウムを主成分とする健康食品
DE19710054A1 (de) *	1997-03-12	1998-09-17	Merck Patent Gmbh	Pharmazeutische Zubereitung
ITFI970184A1 (it) *	1997-07-30	1999-01-30	Menarini Farma Ind	Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
AU7895601A (en) *	2000-07-18	2002-01-30	Bone Care Int Inc	Stabilized 1alpha-hydroxy vitamin d
US6475526B1 (en)	2001-06-05	2002-11-05	Jeffrey B. Smith	Zinc containing compositions for anti-viral use
US8101209B2 (en)	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
JP4698950B2 (ja) *	2002-04-09	2011-06-08	フラメル・テクノロジー	アモキシシリンの改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
EP1492511B3 (de)	2002-04-09	2012-05-02	Flamel Technologies	Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
US7148211B2 (en) *	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US20040053895A1 (en) *	2002-09-18	2004-03-18	Bone Care International, Inc.	Multi-use vessels for vitamin D formulations
US20040058895A1 (en) *	2002-09-18	2004-03-25	Bone Care International, Inc.	Multi-use vessels for vitamin D formulations
US20080274209A1 (en) *	2002-11-04	2008-11-06	Integritas Pharma, Inc.	Methods of treating inflammation
US6855341B2 (en) *	2002-11-04	2005-02-15	Jeffrey B. Smith	Anti-viral compositions and methods of making and using the anti-viral compositions
US20060189586A1 (en) *	2003-06-11	2006-08-24	Cleland Jeffrey L	Pharmaceutical compositions comprising active vitamin D compounds
CA2563533C (en)	2004-04-15	2013-10-01	Shmuel A. Ben-Sasson	Compositions capable of facilitating penetration across a biological barrier
US7700365B2 (en) *	2004-10-29	2010-04-20	Mayo Foundation For Medical Education And Research	Vitamin D deficiencies
FR2889810A1 (fr) *	2005-05-24	2007-02-23	Flamel Technologies Sa	Forme medicamenteuse orale, microparticulaire, anti-mesurage
EP2262765B1 (de) *	2008-03-12	2016-03-09	OPKO Ireland Global Holdings, Limited	Stabilisiertes 1,25-dihydroxyvitamin d2 und verfahren zu dessen herstellung
US20110212534A1 (en) *	2008-08-11	2011-09-01	Taylor Robert L	Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3
KR101814186B1 (ko)	2008-09-17	2018-03-14	키아스마 인코포레이티드	약제학적 조성물 및 연관된 투여방법
CA2981549A1 (en)	2009-01-27	2010-08-05	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
EP2468265A3 (de) *	2010-12-04	2013-01-02	DEEF Pharmaceutical Industries Co.	Homogene Zubereitungen mit Vitamin D
EP2978431A4 (de)	2013-03-27	2016-08-24	Psm Healthcare Ltd	Stabilisierte vitamin-d-formulierungen
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发
US11071743B1 (en) *	2015-01-16	2021-07-27	Gregory M. Fahy	Effective, non-toxic treatments for brain cancer
WO2016126830A1 (en)	2015-02-03	2016-08-11	Chiasma Inc.	Method of treating diseases
US11141457B1 (en)	2020-12-28	2021-10-12	Amryt Endo, Inc.	Oral octreotide therapy and contraceptive methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932634A (en) *	1973-06-28	1976-01-13	Pfizer Inc.	High potency vitamin water dispersible formulations
JPS58206533A (ja) *	1982-05-27	1983-12-01	Teijin Ltd	活性型ビタミンｄ↓３誘導体組成物及びそれを活性成分とする薬剤
JPS59155309A (ja) *	1983-02-22	1984-09-04	Teijin Ltd	活性型ビタミンｄ↓３類組成物
CA1272953A (en) *	1984-10-08	1990-08-21	Yuji Makino	Pharmaceutical composition for external use containing active-type vitamin d.sub.3
CA1317546C (en) *	1985-07-01	1993-05-11	Werner Meier	Pharmaceutical preparations containing mixtures of hydroxy derivatives of vitamin d
JPS62149619A (ja) *	1985-09-05	1987-07-03	Teijin Ltd	活性型ビタミンｄ３類注射用組成物
DD266099A1 (de) *	1987-09-28	1989-03-22	Jenapharm Veb	Verfahren zur herstellung von stabilen waessrigen vitamin-d-loesungen
JPH0331257Y2 (de) *	1987-10-31	1991-07-02
JP2525478B2 (ja) *	1989-03-01	1996-08-21	帝人株式会社	安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JPH02240024A (ja) *	1989-03-13	1990-09-25	Ss Pharmaceut Co Ltd	活性型ビタミンｄ↓３類製剤用組成物
DK0398217T3 (da) *	1989-05-18	1994-02-14	Hoffmann La Roche	Dehydrocholecalciferolderivater
DK0437225T3 (da) *	1990-01-10	1994-06-27	Hoffmann La Roche	Topiske præparater
JP2963718B2 (ja) *	1990-03-06	1999-10-18	グレラン製薬株式会社	ビタミンｄ▲下３▼類含有製剤
JP2787364B2 (ja) *	1990-03-29	1998-08-13	大塚製薬株式会社	脂溶性ビタミン注射液
JP2845342B2 (ja) *	1990-04-28	1999-01-13	大正製薬株式会社	ビタミンｄ▲下３▼誘導体含有固形製剤組成物
JP2974734B2 (ja) *	1990-07-12	1999-11-10	中外製薬株式会社	安定な活性型ビタミンｄ▲下３▼類製剤
JPH04198129A (ja) *	1990-11-28	1992-07-17	Sumitomo Pharmaceut Co Ltd	活性型ビタミンｄ↓３類含有組成物

1992
- 1992-09-18 IL IL10322492A patent/IL103224A/en not_active IP Right Cessation
1993
- 1993-09-03 DK DK93306978.3T patent/DK0588539T3/da active
- 1993-09-03 EP EP93306978A patent/EP0588539B1/de not_active Expired - Lifetime
- 1993-09-03 AT AT93306978T patent/ATE148630T1/de not_active IP Right Cessation
- 1993-09-03 DE DE69307977T patent/DE69307977T2/de not_active Expired - Lifetime
- 1993-09-03 ES ES93306978T patent/ES2098672T3/es not_active Expired - Lifetime
- 1993-09-13 US US08/120,210 patent/US5565442A/en not_active Expired - Lifetime
- 1993-09-16 ZA ZA936835A patent/ZA936835B/xx unknown
- 1993-09-16 AU AU47408/93A patent/AU667742B2/en not_active Ceased
- 1993-09-17 CA CA002106423A patent/CA2106423C/en not_active Expired - Fee Related
- 1993-09-20 JP JP23389093A patent/JP3464691B2/ja not_active Expired - Fee Related
1996
- 1996-05-31 US US08/657,676 patent/US5804573A/en not_active Expired - Lifetime
1997
- 1997-04-14 GR GR970400788T patent/GR3023127T3/el unknown

Also Published As

Publication number	Publication date
DE69307977T2 (de)	1997-08-28
IL103224A0 (en)	1993-02-21
EP0588539A1 (de)	1994-03-23
DK0588539T3 (da)	1997-03-10
EP0588539B1 (de)	1997-02-05
GR3023127T3 (en)	1997-07-30
AU4740893A (en)	1994-03-24
CA2106423A1 (en)	1994-03-19
DE69307977D1 (de)	1997-03-20
ES2098672T3 (es)	1997-05-01
AU667742B2 (en)	1996-04-04
ATE148630T1 (de)	1997-02-15
US5565442A (en)	1996-10-15
ZA936835B (en)	1994-04-14
JPH06219952A (ja)	1994-08-09
US5804573A (en)	1998-09-08
CA2106423C (en)	2005-02-22
JP3464691B2 (ja)	2003-11-10

Legal Events

Date	Code	Title
1998-12-27	FF	Patent granted
1999-06-20	KB	Patent renewed
2002-12-01	KB	Patent renewed
2006-12-07	KB	Patent renewed
2011-04-28	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5804573A (en)	1998-09-08	Stabilized pharmaceutical composition containing derivative of vitamins D2 and D3
US4729895A (en)	1988-03-08	Composition for solid pharmaceutical preparations of active vitamins D.sub.3
EP0229652B1 (de)	1991-10-30	Stabilisiertes Tocopherol in trockenener freifliessender Partikelform
US4869900A (en)	1989-09-26	Pharamaceutical composition containing ubidecarenone
CA2065603C (en)	2007-04-03	Stabilized vitamin d preparation
EP0387808B1 (de)	1993-05-12	Zusammensetzungen zur Herstellung von in Dosisformen aktiven Vitaminen D3 sowie Verfahren zur Herstellung stabiler, in Dosisformen aktiver Vitamine D3 unter deren Verwendung
AU751575B2 (en)	2002-08-22	Pharmaceutical levothyroxine preparation
US3136695A (en)	1964-06-09	Anhydrous thixotropic gel sustained release therapeutic compositions and method of preparation
EP0416773B1 (de)	1993-03-03	Vitamin-B12-Zusammensetzung
US5004651A (en)	1991-04-02	Stabilizing system for solid dosage forms
US2857313A (en)	1958-10-21	Self-lubricating granulation
US4666919A (en)	1987-05-19	Stabilized pharmaceutical composition containing an isocarbostyril derivative
JP2891744B2 (ja)	1999-05-17	パントテン酸カルシウム組成物およびその製造方法
US3564097A (en)	1971-02-16	Stable multivitamin tablets containing tricalcium phosphate
EP0688565B1 (de)	2003-11-26	Desogestrel enthaltende Tablette, Kapsel oder Granulat und Verfahren zu deren Herstellung
JP2914690B2 (ja)	1999-07-05	安定なビタミンｄ▲下３▼類含有製剤
JP2963718B2 (ja)	1999-10-18	ビタミンｄ▲下３▼類含有製剤
US5258375A (en)	1993-11-02	Composition for the preparation of dosage-form active vitamins D3 containing polyvinylacetal diethylaminoacetate
HK1001996B (en)	2004-03-19	Tablet, capsule, or granule comprising desogestrel and process for making them
HK1023508A1 (en)	2000-09-15	Stabilized tibolone compositions
HK1023508B (en)	2005-03-24	Stabilized tibolone compositions