ATE149508T1 - 5-0-desosaminylerrythronolide-derivate - Google Patents

5-0-desosaminylerrythronolide-derivate

Info

Publication number: ATE149508T1
Authority: AT; Austria
Prior art keywords: moiety; optionally substituted; hydrogen; desosaminylerrythronolide; derivatives
Prior art date: 1991-12-27

Application number

AT93900446T

Other languages

English (en)

Inventor

Toshifumi Asaka

Yoko Misawa

Masato Kashimura

Shigeo Morimoto

Katsuo Hatayama

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-27

Filing date

1992-12-25

Publication date

1997-03-15

1992-12-25 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149508T1 publication Critical patent/ATE149508T1/de

Links

RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
150000005676 cyclic carbonates Chemical group 0.000 abstract 1
229930193775 erythronolide Natural products 0.000 abstract 1
ZFBRGCCVTUPRFQ-UHFFFAOYSA-N erythronolide-B Natural products CCC1OC(=O)C(C)C(O)C(C)C(O)C(C)(O)CC(C)C(=O)C(C)C(O)C1C ZFBRGCCVTUPRFQ-UHFFFAOYSA-N 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical group O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93900446T 1991-12-27 1992-12-25 5-0-desosaminylerrythronolide-derivate ATE149508T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34682691		1991-12-27
JP19936892		1992-07-27
JP27986792		1992-10-19

Publications (1)

Publication Number	Publication Date
ATE149508T1 true ATE149508T1 (de)	1997-03-15

Family

ID=27327638

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT93900446T ATE149508T1 (de)	1991-12-27	1992-12-25	5-0-desosaminylerrythronolide-derivate
AT93900447T ATE153341T1 (de)	1991-12-27	1992-12-25	5-o-desosaminylerythronolid derivate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT93900447T ATE153341T1 (de)	1991-12-27	1992-12-25	5-o-desosaminylerythronolid derivate

Country Status (10)

Country	Link
US (2)	US5523399A (de)
EP (2)	EP0619319B1 (de)
JP (2)	JP3099366B2 (de)
KR (2)	KR100265916B1 (de)
AT (2)	ATE149508T1 (de)
AU (2)	AU667334B2 (de)
CA (2)	CA2126664A1 (de)
DE (2)	DE69219900T2 (de)
ES (2)	ES2104118T3 (de)
WO (2)	WO1993013116A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69301916T2 (de) *	1992-04-22	1996-08-08	Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo	5-0-desosaminylerythronolid a derivate
US5602239A (en) *	1993-01-26	1997-02-11	Taisho Pharmaceutical Co., Ltd.	5-O-desosaminylerythronolide derivatives
CA2196879A1 (en) *	1994-08-12	1996-02-22	Akihiko Hoshino	Interleukin-5 production inhibitor
FR2738571B1 (fr) *	1995-09-11	1997-10-17	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2739620B1 (fr) *	1995-10-09	1997-12-19	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
USRE38426E1 (en)	1995-10-09	2004-02-10	Aventis Pharma S.A.	5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
CA2235681A1 (en) *	1995-11-08	1997-05-15	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins a and b
EP0876388B1 (de) *	1995-11-08	2004-02-18	Abbott Laboratories	Tricyclische erythromycinderivate
US5747466A (en) *	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
US6274715B1 (en) *	1995-11-08	2001-08-14	Abbott Laboratories	Tricyclic erythromycin derivatives
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ATE296831T1 (de) *	1996-09-04	2005-06-15	Abbott Lab	6-0-substituierte ketoliden mit antibakteriellen wirkung
US5804565A (en) *	1996-09-24	1998-09-08	Taisho Pharmaceutical Co., Ltd.	Erythromycin A derivatives
CN1238777A (zh) *	1996-11-27	1999-12-15	大正制药株式会社	红霉素a衍生物
WO1998042720A1 (fr) *	1997-03-24	1998-10-01	Taisho Pharmaceutical Co., Ltd.	Derives d'erythromycine a
ZA989830B (en) *	1997-10-29	1999-05-04	Taisho Pharmaceutical Co Ltd	Erythromycin a derivatives
AU9646098A (en)	1997-10-29	1999-05-17	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
AU9645998A (en) *	1997-10-29	1999-05-17	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
EP1044985A4 (de) *	1997-12-11	2001-04-18	Hokuriku Pharmaceutical	Erythromycin
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
FR2777282B1 (fr) *	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
AU775637B2 (en) *	1999-04-16	2004-08-12	Kosan Biosciences, Inc.	Macrolide antiinfective agents
TR200103395T2 (tr) *	1999-05-24	2002-04-22	Pfizer Products Inc.	13-metil eritromisin türevleri.
US6420535B1 (en) *	1999-06-07	2002-07-16	Abbott Laboratories	6-O-carbamate ketolide derivatives
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1146051A3 (de) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A-Derivate
US20020115621A1 (en) *	2000-08-07	2002-08-22	Wei-Gu Su	Macrolide antibiotics
WO2005012322A1 (ja) *	2003-08-05	2005-02-10	Taisho Pharmaceutical Co., Ltd.	エリスロマイシンａ１１，１２−サイクリックカーボネートの製造方法
US7276487B2 (en)	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
EP1781679A1 (de) *	2004-07-28	2007-05-09	Ranbaxy Laboratories Limited	Antibakterielle mittel
US7402568B2 (en)	2004-09-29	2008-07-22	Enanta Pharmaceuticals, Inc.	Bicyclic 9a-azalide derivatives
EA011281B1 (ru)	2004-12-21	2009-02-27	Пфайзер Продактс Инк.	Макролиды
US7271155B2 (en)	2005-01-07	2007-09-18	Enanta Pharmaceuticals, Inc.	9A, 11-2C-bicyclic 9a-azalide derivatives
WO2006077501A2 (en) *	2005-01-13	2006-07-27	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Decladinosyl-macrolides with anti-inflammatory activity
US8293715B2 (en) *	2007-08-06	2012-10-23	Taisho Pharmaceutical Co., Ltd.	10a-Azalide compound crosslinked at 10a- and 12-positions
EP2188281A1 (de) *	2007-08-10	2010-05-26	Y's Therapeutics Co, Ltd.	Modulation von immunreaktionen durch verabreichung von roxithromycin oder dessen derivat
JPWO2009139181A1 (ja)	2008-05-15	2011-09-15	大正製薬株式会社	４員環構造を有する１０ａ−アザライド化合物
US8143369B2 (en)	2009-06-02	2012-03-27	International Business Machines Corporation	Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
CN101863941A (zh) *	2010-06-03	2010-10-20	武汉大学	3-氧-取代的6,11-二-氧-甲基红霉素a的衍生物
CN104961785B (zh) *	2015-06-19	2019-01-11	北京理工大学	一种新型酰内酯衍生物及其制备方法
IL303173A (en)	2023-05-23	2024-12-01	Yeda Res & Dev	Active macrolide antibiotic compounds against pathogens

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3923784A (en) *	1973-09-10	1975-12-02	Hoffmann La Roche	Erythromycin a derivatives
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
PT86800B (pt) *	1987-02-24	1992-05-29	Beecham Group Plc	Processo para a preparacao de derivados de eritromicina
JPH0196190A (ja) *	1987-10-07	1989-04-14	Toyo Jozo Co Ltd	６−０−アルキル−エリスロマイシンａ　サイクリック１１，１２−カーボネート
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them

1992
- 1992-12-15 US US08/244,981 patent/US5523399A/en not_active Expired - Fee Related
- 1992-12-25 JP JP05511557A patent/JP3099366B2/ja not_active Expired - Fee Related
- 1992-12-25 AT AT93900446T patent/ATE149508T1/de not_active IP Right Cessation
- 1992-12-25 EP EP93900446A patent/EP0619319B1/de not_active Expired - Lifetime
- 1992-12-25 DE DE69219900T patent/DE69219900T2/de not_active Expired - Fee Related
- 1992-12-25 US US08/256,124 patent/US5631354A/en not_active Expired - Fee Related
- 1992-12-25 EP EP93900447A patent/EP0619320B1/de not_active Expired - Lifetime
- 1992-12-25 CA CA002126664A patent/CA2126664A1/en not_active Abandoned
- 1992-12-25 AU AU31728/93A patent/AU667334B2/en not_active Ceased
- 1992-12-25 DE DE69217989T patent/DE69217989T2/de not_active Expired - Fee Related
- 1992-12-25 KR KR1019940702223A patent/KR100265916B1/ko not_active Expired - Fee Related
- 1992-12-25 ES ES93900447T patent/ES2104118T3/es not_active Expired - Lifetime
- 1992-12-25 JP JP05511558A patent/JP3132002B2/ja not_active Expired - Fee Related
- 1992-12-25 AT AT93900447T patent/ATE153341T1/de not_active IP Right Cessation
- 1992-12-25 AU AU31727/93A patent/AU663145B2/en not_active Ceased
- 1992-12-25 WO PCT/JP1992/001714 patent/WO1993013116A1/ja not_active Ceased
- 1992-12-25 ES ES93900446T patent/ES2101290T3/es not_active Expired - Lifetime
- 1992-12-25 WO PCT/JP1992/001713 patent/WO1993013115A1/ja not_active Ceased
- 1992-12-25 KR KR1019940702222A patent/KR100266183B1/ko not_active Expired - Fee Related
- 1992-12-25 CA CA002126665A patent/CA2126665A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1993013116A1 (fr)	1993-07-08
DE69219900T2 (de)	1997-09-11
ES2104118T3 (es)	1997-10-01
US5631354A (en)	1997-05-20
AU3172793A (en)	1993-07-28
AU667334B2 (en)	1996-03-21
DE69217989T2 (de)	1997-06-12
EP0619320A4 (de)	1994-11-02
EP0619320A1 (de)	1994-10-12
KR100266183B1 (ko)	2000-09-15
ATE153341T1 (de)	1997-06-15
AU3172893A (en)	1993-07-28
EP0619319B1 (de)	1997-03-05
KR940703841A (ko)	1994-12-12
EP0619319A1 (de)	1994-10-12
WO1993013115A1 (fr)	1993-07-08
ES2101290T3 (es)	1997-07-01
DE69217989D1 (de)	1997-04-10
CA2126664A1 (en)	1993-07-08
KR940703842A (ko)	1994-12-12
DE69219900D1 (de)	1997-06-26
EP0619320B1 (de)	1997-05-21
JP3099366B2 (ja)	2000-10-16
US5523399A (en)	1996-06-04
JP3132002B2 (ja)	2001-02-05
EP0619319A4 (de)	1994-11-02
AU663145B2 (en)	1995-09-28
CA2126665A1 (en)	1993-07-08
KR100265916B1 (ko)	2000-09-15

Legal Events

Date	Code	Title	Description
1997-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE149508T1 (de)	1997-03-15	5-0-desosaminylerrythronolide-derivate
DK0638585T3 (da)	1996-12-02	5-O-desosaminylerythronolid-A-derivater
ATE157368T1 (de)	1997-09-15	6-0-methylerythromycin a-derivat
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
ATE162796T1 (de)	1998-02-15	4-a-substutierte avermectinderivate
FI922561A0 (fi)	1992-06-03	Derivat av 1-metylkarbapenem, deras framstaellning och anvaendning som antibiotika.
ATE132139T1 (de)	1996-01-15	Diaminoethylen-verbindungen
ATE144778T1 (de)	1996-11-15	9a-n-(n'-carbamoyl)-und 9a-n-(n'thiocarbamoyl)- derivate von 9-deoxo-9a-aza-9a-homoerythromycin a
ES2188481T3 (es)	2003-07-01	Derivados de polinalbufina.
FI814148L (fi)	1982-06-28	Nya trisubstituerade pyrimido/5,4-d/pyrimidiner deras framstaellning och deras anvaendning saosom laekemedel
DE3888066D1 (de)	1994-04-07	Saccharid-Derivate.
ES2115816T3 (es)	1998-07-01	Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.
DE3787986D1 (de)	1993-12-09	Macrolid-Derivate.
IE821782L (en)	1983-01-25	Sulphimines
ES2096628T3 (es)	1997-03-16	Derivados heterociclicos.
DE3851190D1 (de)	1994-09-29	Makrolid-Derivate.
DE3851189D1 (de)	1994-09-29	Makrolid-Derivate.
NO920619L (no)	1992-08-19	Oxazinobenzazolforbindelser
NO993124L (no)	1999-08-20	Nye erytromycinderivater, fremgangsmåte for fremstilling av disse samt deres anvendelse som medisiner
DE69130356D1 (de)	1998-11-19	Pyrazoloacridonderivate