ATE153341T1 - 5-o-desosaminylerythronolid derivate - Google Patents

5-o-desosaminylerythronolid derivate

Info

Publication number: ATE153341T1
Authority: AT; Austria
Prior art keywords: moiety; optionally substituted; hydrogen; linkage; desosaminylerythronolide
Prior art date: 1991-12-27

Application number

AT93900447T

Other languages

English (en)

Inventor

Toshifumi Taisho Pharmac Asaka

Yoko Taisho Pharmaceuti Misawa

Masato Taisho Pharma Kashimura

Shigeo Taisho Pharmac Morimoto

Katsuo Taisho Pharmac Hatayama

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-27

Filing date

1992-12-25

Publication date

1997-06-15

1992-12-25 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE153341T1 publication Critical patent/ATE153341T1/de

Links

RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
150000005676 cyclic carbonates Chemical group 0.000 abstract 1
229930193775 erythronolide Natural products 0.000 abstract 1
ZFBRGCCVTUPRFQ-UHFFFAOYSA-N erythronolide-B Natural products CCC1OC(=O)C(C)C(O)C(C)C(O)C(C)(O)CC(C)C(=O)C(C)C(O)C1C ZFBRGCCVTUPRFQ-UHFFFAOYSA-N 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical group O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93900447T 1991-12-27 1992-12-25 5-o-desosaminylerythronolid derivate ATE153341T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34682691		1991-12-27
JP19936892		1992-07-27
JP27986792		1992-10-19

Publications (1)

Publication Number	Publication Date
ATE153341T1 true ATE153341T1 (de)	1997-06-15

Family

ID=27327638

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT93900446T ATE149508T1 (de)	1991-12-27	1992-12-25	5-0-desosaminylerrythronolide-derivate
AT93900447T ATE153341T1 (de)	1991-12-27	1992-12-25	5-o-desosaminylerythronolid derivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT93900446T ATE149508T1 (de)	1991-12-27	1992-12-25	5-0-desosaminylerrythronolide-derivate

Country Status (10)

Country	Link
US (2)	US5523399A (de)
EP (2)	EP0619319B1 (de)
JP (2)	JP3132002B2 (de)
KR (2)	KR100265916B1 (de)
AT (2)	ATE149508T1 (de)
AU (2)	AU667334B2 (de)
CA (2)	CA2126664A1 (de)
DE (2)	DE69217989T2 (de)
ES (2)	ES2101290T3 (de)
WO (2)	WO1993013115A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE135707T1 (de) *	1992-04-22	1996-04-15	Taisho Pharmaceutical Co Ltd	5-0-desosaminylerythronolid a derivate
KR960700258A (ko) *	1993-01-26	1996-01-19	우에하라 아키라	5-0-데소사미닐에리쓰로노라이드 유도체
WO1996004919A1 (en) *	1994-08-12	1996-02-22	Taisho Pharmaceutical Co., Ltd.	Interleukin-5 production inhibitor
FR2738571B1 (fr) *	1995-09-11	1997-10-17	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
USRE38426E1 (en)	1995-10-09	2004-02-10	Aventis Pharma S.A.	5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
FR2739620B1 (fr) *	1995-10-09	1997-12-19	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
ATE259823T1 (de) *	1995-11-08	2004-03-15	Abbott Lab	Tricyclische erythromycinderivate
US6274715B1 (en) *	1995-11-08	2001-08-14	Abbott Laboratories	Tricyclic erythromycin derivatives
DE69626040T2 (de) *	1995-11-08	2004-01-22	Abbott Laboratories, Abbott Park	3-deoxy-3-descladinosederivate von erythromycin a und b
US5747466A (en) *	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
DE69733422T2 (de) *	1996-09-04	2006-05-04	Abbott Laboratories, Abbott Park	6-0-substituierte ketoliden mit antibakteriellen wirkung
US5804565A (en) *	1996-09-24	1998-09-08	Taisho Pharmaceutical Co., Ltd.	Erythromycin A derivatives
US6191118B1 (en)	1996-11-27	2001-02-20	Taisho Pharmaceutical Co., Ltd.	Erythromycin A derivatives
US6140479A (en) *	1997-03-24	2000-10-31	Taisho Pharmaceuticals Co., Ltd.	Erythromycin a derivatives
AU9645998A (en) *	1997-10-29	1999-05-17	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
ZA989830B (en) *	1997-10-29	1999-05-04	Taisho Pharmaceutical Co Ltd	Erythromycin a derivatives
AU9646098A (en)	1997-10-29	1999-05-17	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
EP1044985A4 (de) *	1997-12-11	2001-04-18	Hokuriku Pharmaceutical	Erythromycin
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
FR2777282B1 (fr) *	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
ATE340183T1 (de) *	1999-04-16	2006-10-15	Kosan Biosciences Inc	Antiinfektiöse makrolidderivate
HUP0201516A3 (en) *	1999-05-24	2003-03-28	Pfizer Prod Inc	13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
US6420535B1 (en) *	1999-06-07	2002-07-16	Abbott Laboratories	6-O-carbamate ketolide derivatives
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1146051A3 (de) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A-Derivate
US20020115621A1 (en) *	2000-08-07	2002-08-22	Wei-Gu Su	Macrolide antibiotics
WO2005012322A1 (ja) *	2003-08-05	2005-02-10	Taisho Pharmaceutical Co., Ltd.	エリスロマイシンａ１１，１２−サイクリックカーボネートの製造方法
WO2005030227A1 (en)	2003-09-23	2005-04-07	Enanta Pharmaceuticals, Inc.	9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
EP1781679A1 (de) *	2004-07-28	2007-05-09	Ranbaxy Laboratories Limited	Antibakterielle mittel
US7402568B2 (en)	2004-09-29	2008-07-22	Enanta Pharmaceuticals, Inc.	Bicyclic 9a-azalide derivatives
UA85937C2 (uk)	2004-12-21	2009-03-10	Пфайзер Продактс Інк.	Макроліди
US7271155B2 (en)	2005-01-07	2007-09-18	Enanta Pharmaceuticals, Inc.	9A, 11-2C-bicyclic 9a-azalide derivatives
DE602006004555D1 (de) *	2005-01-13	2009-02-12	Glaxosmithkline Zagreb	Decladinosyl-macrolide mit entzündungshemmender wirkung
JPWO2009019868A1 (ja)	2007-08-06	2010-10-28	大正製薬株式会社	１０ａ、１２位架橋型１０ａ−アザライド化合物
EP2188281A1 (de) *	2007-08-10	2010-05-26	Y's Therapeutics Co, Ltd.	Modulation von immunreaktionen durch verabreichung von roxithromycin oder dessen derivat
US8299035B2 (en)	2008-05-15	2012-10-30	Taisho Pharmaceutucal Co., Ltd.	10a-azalide compound having 4-membered ring structure
US8143369B2 (en)	2009-06-02	2012-03-27	International Business Machines Corporation	Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
CN101863941A (zh) *	2010-06-03	2010-10-20	武汉大学	3-氧-取代的6,11-二-氧-甲基红霉素a的衍生物
CN104961785B (zh) *	2015-06-19	2019-01-11	北京理工大学	一种新型酰内酯衍生物及其制备方法
IL303173A (en)	2023-05-23	2024-12-01	Yeda Res & Dev	Active macrolide antibiotic compounds against pathogens

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3923784A (en) *	1973-09-10	1975-12-02	Hoffmann La Roche	Erythromycin a derivatives
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
AU1204288A (en) *	1987-02-24	1988-08-25	Beecham Group Plc	Erythromycins
JPH0196190A (ja) *	1987-10-07	1989-04-14	Toyo Jozo Co Ltd	６−０−アルキル−エリスロマイシンａ　サイクリック１１，１２−カーボネート
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them

1992
- 1992-12-15 US US08/244,981 patent/US5523399A/en not_active Expired - Fee Related
- 1992-12-25 CA CA002126664A patent/CA2126664A1/en not_active Abandoned
- 1992-12-25 AT AT93900446T patent/ATE149508T1/de not_active IP Right Cessation
- 1992-12-25 ES ES93900446T patent/ES2101290T3/es not_active Expired - Lifetime
- 1992-12-25 AU AU31728/93A patent/AU667334B2/en not_active Ceased
- 1992-12-25 DE DE69217989T patent/DE69217989T2/de not_active Expired - Fee Related
- 1992-12-25 ES ES93900447T patent/ES2104118T3/es not_active Expired - Lifetime
- 1992-12-25 DE DE69219900T patent/DE69219900T2/de not_active Expired - Fee Related
- 1992-12-25 AT AT93900447T patent/ATE153341T1/de not_active IP Right Cessation
- 1992-12-25 JP JP05511558A patent/JP3132002B2/ja not_active Expired - Fee Related
- 1992-12-25 EP EP93900446A patent/EP0619319B1/de not_active Expired - Lifetime
- 1992-12-25 KR KR1019940702223A patent/KR100265916B1/ko not_active Expired - Fee Related
- 1992-12-25 CA CA002126665A patent/CA2126665A1/en not_active Abandoned
- 1992-12-25 WO PCT/JP1992/001713 patent/WO1993013115A1/ja not_active Ceased
- 1992-12-25 KR KR1019940702222A patent/KR100266183B1/ko not_active Expired - Fee Related
- 1992-12-25 AU AU31727/93A patent/AU663145B2/en not_active Ceased
- 1992-12-25 US US08/256,124 patent/US5631354A/en not_active Expired - Fee Related
- 1992-12-25 JP JP05511557A patent/JP3099366B2/ja not_active Expired - Fee Related
- 1992-12-25 EP EP93900447A patent/EP0619320B1/de not_active Expired - Lifetime
- 1992-12-25 WO PCT/JP1992/001714 patent/WO1993013116A1/ja not_active Ceased

Also Published As

Publication number	Publication date
EP0619320A1 (de)	1994-10-12
EP0619320A4 (de)	1994-11-02
ATE149508T1 (de)	1997-03-15
JP3099366B2 (ja)	2000-10-16
KR940703842A (ko)	1994-12-12
WO1993013115A1 (fr)	1993-07-08
DE69219900T2 (de)	1997-09-11
AU667334B2 (en)	1996-03-21
DE69217989D1 (de)	1997-04-10
EP0619319B1 (de)	1997-03-05
AU663145B2 (en)	1995-09-28
DE69219900D1 (de)	1997-06-26
US5631354A (en)	1997-05-20
JP3132002B2 (ja)	2001-02-05
ES2104118T3 (es)	1997-10-01
KR940703841A (ko)	1994-12-12
DE69217989T2 (de)	1997-06-12
AU3172793A (en)	1993-07-28
EP0619319A4 (de)	1994-11-02
KR100265916B1 (ko)	2000-09-15
WO1993013116A1 (fr)	1993-07-08
ES2101290T3 (es)	1997-07-01
EP0619320B1 (de)	1997-05-21
CA2126665A1 (en)	1993-07-08
EP0619319A1 (de)	1994-10-12
AU3172893A (en)	1993-07-28
KR100266183B1 (ko)	2000-09-15
CA2126664A1 (en)	1993-07-08
US5523399A (en)	1996-06-04

Legal Events

Date	Code	Title	Description
1997-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE153341T1 (de)	1997-06-15	5-o-desosaminylerythronolid derivate
ATE135707T1 (de)	1996-04-15	5-0-desosaminylerythronolid a derivate
ATE157368T1 (de)	1997-09-15	6-0-methylerythromycin a-derivat
ES2122472T3 (es)	1998-12-16	Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
FI922561A0 (fi)	1992-06-03	Derivat av 1-metylkarbapenem, deras framstaellning och anvaendning som antibiotika.
ES8704943A1 (es)	1987-04-16	Un procedimiento para la fabricacion de derivados de cefalosporina.
ES2094772T3 (es)	1997-02-01	Derivados de imidazonaftiridinas.
ATE132139T1 (de)	1996-01-15	Diaminoethylen-verbindungen
FI814148L (fi)	1982-06-28	Nya trisubstituerade pyrimido/5,4-d/pyrimidiner deras framstaellning och deras anvaendning saosom laekemedel
DE3888066D1 (de)	1994-04-07	Saccharid-Derivate.
ES2115816T3 (es)	1998-07-01	Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.
GB2104515B (en)	1985-06-05	Sulphimines
ES2096628T3 (es)	1997-03-16	Derivados heterociclicos.
DE3787986D1 (de)	1993-12-09	Macrolid-Derivate.
DE3851190D1 (de)	1994-09-29	Makrolid-Derivate.
DK505188D0 (da)	1988-09-09	Makrolidforbindelser
ES2109936T3 (es)	1998-02-01	Derivados de piperacina.
NO920619L (no)	1992-08-19	Oxazinobenzazolforbindelser
FI811201L (fi)	1981-10-20	4-hydroxi-1,2-benzisotiazol-3(2h)-on-1,1-dioxid deras salter deras framstaellning och anvaendning
DE69130356D1 (de)	1998-11-19	Pyrazoloacridonderivate
FI933468A0 (fi)	1993-08-04	Tetrahydronaftalenderivat, framstaellning av dessa och terapeutisk anvaendning av dessa
ES2068947T3 (es)	1995-05-01	Derivados de angolamicina.
TH3409A (th)	1986-08-01	อนุพันธ์ของซัคคารินที่เติมหมู่เอซิลแล้ว