ZA929792B - A process for preparing 2-chloro-2'-deoxyadenosine - Google Patents
A process for preparing 2-chloro-2'-deoxyadenosineInfo
- Publication number
- ZA929792B ZA929792B ZA929792A ZA929792A ZA929792B ZA 929792 B ZA929792 B ZA 929792B ZA 929792 A ZA929792 A ZA 929792A ZA 929792 A ZA929792 A ZA 929792A ZA 929792 B ZA929792 B ZA 929792B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparing
- deoxyadenosine
- chloro
- cda
- chem
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- UENGBOCGGKLVJJ-UHFFFAOYSA-N 2-chloro-1-(2,4-difluorophenyl)ethanone Chemical compound FC1=CC=C(C(=O)CCl)C(F)=C1 UENGBOCGGKLVJJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000063 antileukemic agent Substances 0.000 abstract 1
- 201000009277 hairy cell leukemia Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81099291A | 1991-12-18 | 1991-12-18 | |
| US07/869,689 US5208327A (en) | 1991-12-18 | 1992-04-16 | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA929792B true ZA929792B (en) | 1994-06-17 |
Family
ID=27123419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA929792A ZA929792B (en) | 1991-12-18 | 1992-12-17 | A process for preparing 2-chloro-2'-deoxyadenosine |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5208327A (de) |
| EP (1) | EP0547910B1 (de) |
| JP (1) | JPH05255378A (de) |
| AT (1) | ATE149509T1 (de) |
| AU (1) | AU653457B2 (de) |
| CA (1) | CA2085503C (de) |
| DE (1) | DE69217873T2 (de) |
| DK (1) | DK0547910T3 (de) |
| ES (1) | ES2101053T3 (de) |
| GR (1) | GR3023317T3 (de) |
| ZA (1) | ZA929792B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641757A (en) * | 1994-12-21 | 1997-06-24 | Ortho Pharmaceutical Corporation | Stable 2-chloro-2'-deoxyadenosine formulations |
| ES2182920T3 (es) * | 1994-12-22 | 2003-03-16 | Ortho Pharma Corp | Formulaciones solubles de 2-cloro02'-deoxiadenosina. |
| US6252061B1 (en) * | 1998-03-23 | 2001-06-26 | Reliable Biopharmaceutical, Inc. | Process for the production of 2-halo-6-aminopurine derivatives |
| US6274725B1 (en) * | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
| WO2000064918A1 (en) * | 1999-04-28 | 2000-11-02 | Sterrenbeld Biotechnologie North America, Inc. | METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE |
| JP2002193967A (ja) * | 2000-07-10 | 2002-07-10 | Sumika Fine Chemicals Co Ltd | ２，６−ジクロロプリンの製造方法 |
| ES2405825T3 (es) * | 2002-09-25 | 2013-06-03 | Brigham Young University | Método para la preparación de compuestos 2-halo-2'-desoxiadenosina a partir de 2'-desoxiguanosina |
| AU2004288182A1 (en) * | 2003-10-28 | 2005-05-19 | 3M Innovative Properties Company | Improved designs for filtration systems within appliances |
| JP2008524310A (ja) * | 2004-12-22 | 2008-07-10 | ラボラトワール セローノ ソシエテ アノニム | 多発性硬化症の組み合せ治療 |
| EP3332789B1 (de) | 2004-12-22 | 2022-04-06 | Merck Serono SA | Cladribinkur zur behandlung von multipler sklerose |
| AU2007253254B2 (en) | 2006-05-24 | 2013-01-17 | Merck Serono Sa | Cladribine regimen for treating multiple sclerosis |
| DE602006009282D1 (de) * | 2006-12-15 | 2009-10-29 | Explora Lab Sa | Verfahren zur Herstellung von Cladribin |
| RU2324699C1 (ru) * | 2007-02-05 | 2008-05-20 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук | СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА |
| RU2324698C1 (ru) * | 2007-02-05 | 2008-05-20 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | Способ получения 2-хлораденозина |
| EP2343074A1 (de) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen |
| WO2011113476A2 (en) | 2010-03-16 | 2011-09-22 | Cilag Ag | Method for producing 2'-deoxyadenosine compounds |
| GB201401465D0 (en) | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
| CN106397516B (zh) * | 2016-08-30 | 2019-09-27 | 北京沣瑞医药科技有限公司 | 坎格雷洛中间体及其制备方法和应用 |
| TWI767937B (zh) | 2016-09-09 | 2022-06-21 | 美商卡利泰拉生物科技公司 | 外核苷酸酶抑制劑及其使用方法 |
| GB2564717A (en) | 2017-07-21 | 2019-01-23 | Chord Therapeutics S A R L | Use of cladribine for treating autoimmune neuromuscular disease |
| EP3713582A1 (de) | 2017-11-24 | 2020-09-30 | Merck Patent GmbH | Cladribin-dosierungsplan zur verwendung bei der behandlung progressiver formen von multipler sklerose |
| CA3194812A1 (en) | 2020-09-10 | 2022-03-17 | Merck Patent Gmbh | Novel treatment regimen for the treatment of autoimmune disorders |
| GB2601786A (en) | 2020-12-10 | 2022-06-15 | Chord Therapeutics S A R L | Use of cladribine for treating immune brain disease |
| US20240077481A1 (en) | 2021-03-03 | 2024-03-07 | Ares Trading S.A. | Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods |
| TW202541818A (zh) | 2023-12-14 | 2025-11-01 | 瑞士商亞利斯貿易公司 | 用於治療重症肌無力之克拉屈濱(cladribine)療程 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4760137A (en) * | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| CA1269659A (en) * | 1984-08-06 | 1990-05-29 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| AU651569B2 (en) * | 1990-01-11 | 1994-07-28 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating RNA activity and gene expression |
-
1992
- 1992-04-16 US US07/869,689 patent/US5208327A/en not_active Expired - Lifetime
- 1992-12-11 AU AU30122/92A patent/AU653457B2/en not_active Expired
- 1992-12-16 CA CA002085503A patent/CA2085503C/en not_active Expired - Lifetime
- 1992-12-16 JP JP4353918A patent/JPH05255378A/ja active Pending
- 1992-12-17 EP EP92311564A patent/EP0547910B1/de not_active Expired - Lifetime
- 1992-12-17 AT AT92311564T patent/ATE149509T1/de active
- 1992-12-17 ZA ZA929792A patent/ZA929792B/xx unknown
- 1992-12-17 DK DK92311564.6T patent/DK0547910T3/da active
- 1992-12-17 ES ES92311564T patent/ES2101053T3/es not_active Expired - Lifetime
- 1992-12-17 DE DE69217873T patent/DE69217873T2/de not_active Expired - Lifetime
-
1997
- 1997-05-02 GR GR970400975T patent/GR3023317T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU653457B2 (en) | 1994-09-29 |
| DE69217873T2 (de) | 1997-06-12 |
| US5208327A (en) | 1993-05-04 |
| CA2085503C (en) | 1997-08-19 |
| AU3012292A (en) | 1993-07-01 |
| JPH05255378A (ja) | 1993-10-05 |
| EP0547910B1 (de) | 1997-03-05 |
| ES2101053T3 (es) | 1997-07-01 |
| EP0547910A1 (de) | 1993-06-23 |
| GR3023317T3 (en) | 1997-08-29 |
| DE69217873D1 (de) | 1997-04-10 |
| DK0547910T3 (da) | 1997-03-24 |
| CA2085503A1 (en) | 1993-06-19 |
| ATE149509T1 (de) | 1997-03-15 |
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