NO991833L - Bis (acridincarboksamid) og bis (fenazincarboksamid) som antitumormidler - Google Patents

Bis (acridincarboksamid) og bis (fenazincarboksamid) som antitumormidler

Info

Publication number: NO991833L
Authority: NO; Norway
Prior art keywords: bis; carboxamide; pct; alkyl; different
Prior art date: 1996-10-18

Application number

NO991833A

Other languages

English (en)

Other versions

NO313381B1 (no

NO991833D0 (no

Inventor

William Alexander Denny

Swarnalatha Akuritaya Gamage

Julie Ann Spicer

Bruce Charles Baguley

Graeme John Finlay

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-18

Filing date

1999-04-16

Publication date

1999-06-03

1999-04-16 Application filed by Xenova Ltd filed Critical Xenova Ltd

1999-04-16 Publication of NO991833D0 publication Critical patent/NO991833D0/no

1999-06-03 Publication of NO991833L publication Critical patent/NO991833L/no

2002-09-23 Publication of NO313381B1 publication Critical patent/NO313381B1/no

Links

229940125665 acridine carboxamide Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
XBGNERSKEKDZDS-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]acridine-4-carboxamide Chemical compound C1=CC=C2N=C3C(C(=O)NCCN(C)C)=CC=CC3=CC2=C1 XBGNERSKEKDZDS-UHFFFAOYSA-N 0.000 title abstract 2
KPZYYKDXZKFBQU-UHFFFAOYSA-N phenazine-1-carboxamide Chemical compound C1=CC=C2N=C3C(C(=O)N)=CC=CC3=NC2=C1 KPZYYKDXZKFBQU-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
-1 methylenedioxy group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polishing Bodies And Polishing Tools (AREA)
Multicomponent Fibers (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO19991833A 1996-10-18 1999-04-16 Bis (akridinkarboksamid) og bis (fenazinkarboksamid), derivat derav, deres fremstilling, farmasöytiske blandinger og anvendelsederav NO313381B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9621795.5A GB9621795D0 (en)	1996-10-18	1996-10-18	Pharmaceutical compounds
PCT/GB1997/002886 WO1998017650A1 (en)	1996-10-18	1997-10-17	Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents

Publications (3)

Publication Number	Publication Date
NO991833D0 NO991833D0 (no)	1999-04-16
NO991833L true NO991833L (no)	1999-06-03
NO313381B1 NO313381B1 (no)	2002-09-23

Family

ID=10801674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19991833A NO313381B1 (no)	1996-10-18	1999-04-16	Bis (akridinkarboksamid) og bis (fenazinkarboksamid), derivat derav, deres fremstilling, farmasöytiske blandinger og anvendelsederav

Country Status (29)

Country	Link
US (1)	US6114332A (no)
EP (1)	EP0934278B1 (no)
JP (1)	JP2001503399A (no)
KR (1)	KR20000049252A (no)
CN (1)	CN1116285C (no)
AT (1)	ATE223381T1 (no)
AU (1)	AU717724B2 (no)
BG (1)	BG64555B1 (no)
BR (1)	BR9711948A (no)
CA (1)	CA2268411C (no)
CZ (1)	CZ295302B6 (no)
DE (1)	DE69715230T2 (no)
DK (1)	DK0934278T3 (no)
ES (1)	ES2183142T3 (no)
GB (2)	GB9621795D0 (no)
HU (1)	HU221953B1 (no)
ID (1)	ID22444A (no)
MY (1)	MY122017A (no)
NO (1)	NO313381B1 (no)
NZ (1)	NZ335055A (no)
PL (1)	PL193669B1 (no)
PT (1)	PT934278E (no)
RO (1)	RO120636B1 (no)
RU (1)	RU2179972C2 (no)
SK (1)	SK285121B6 (no)
TW (1)	TW432060B (no)
UA (1)	UA67729C2 (no)
WO (1)	WO1998017650A1 (no)
ZA (2)	ZA979328B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6974878B2 (en)	2001-03-21	2005-12-13	Symyx Technologies, Inc.	Catalyst ligands, catalytic metal complexes and processes using same
EP1131283A1 (en) *	1999-09-10	2001-09-12	Symyx Technologies	Catalyst ligands, catalytic metal complexes and processes using and methods of making same
JP4718328B2 (ja) *	2003-12-31	2011-07-06	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	Ｃ８連結したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アクリドン／アクリジン・ハイブリッド
JP2017500368A (ja) *	2013-12-24	2017-01-05	ユニバーシティーオブフロリダリサーチファンデーション，インク．	抗微生物剤としてのフェナジン誘導体
CN104961801B (zh) *	2015-07-13	2018-01-19	兰州大学	一种具有多靶点的抗菌多肽偶联物及其二聚物的合成和应用
CN106554321B (zh) *	2015-09-25	2019-05-28	陆源	一种吩嗪类物质、其制备方法及其应用
US20240279204A1 (en) *	2021-12-09	2024-08-22	Korea Institute Of Ocean Science & Technology	Novel diphenazine compound, and use thereof for preventing or treating cancer or neuroinflammatory diseases
WO2025043616A1 (zh) *	2023-08-31	2025-03-06	侯明宏	吖啶类衍生物用于抗癌的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ201084A (en) *	1982-06-25	1985-10-11	New Zealand Dev Finance	4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
JPS61112061A (ja) *	1984-08-16	1986-05-30	デベロツプメント　フアイナンス　コ−ポレ−シヨン　オブニユ−ジ−ランド	新規なフエナジン誘導体
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale

1996
- 1996-10-18 GB GBGB9621795.5A patent/GB9621795D0/en active Pending
1997
- 1997-10-17 DK DK97909456T patent/DK0934278T3/da active
- 1997-10-17 CA CA002268411A patent/CA2268411C/en not_active Expired - Fee Related
- 1997-10-17 ZA ZA979328A patent/ZA979328B/xx unknown
- 1997-10-17 JP JP51910998A patent/JP2001503399A/ja not_active Ceased
- 1997-10-17 RO RO99-00433A patent/RO120636B1/ro unknown
- 1997-10-17 KR KR1019990703357A patent/KR20000049252A/ko not_active Ceased
- 1997-10-17 SK SK504-99A patent/SK285121B6/sk unknown
- 1997-10-17 MY MYPI97004914A patent/MY122017A/en unknown
- 1997-10-17 ZA ZA9709331A patent/ZA979331B/xx unknown
- 1997-10-17 UA UA99042117A patent/UA67729C2/uk unknown
- 1997-10-17 AT AT97909456T patent/ATE223381T1/de not_active IP Right Cessation
- 1997-10-17 EP EP97909456A patent/EP0934278B1/en not_active Expired - Lifetime
- 1997-10-17 ID IDW990196A patent/ID22444A/id unknown
- 1997-10-17 ES ES97909456T patent/ES2183142T3/es not_active Expired - Lifetime
- 1997-10-17 CZ CZ19991271A patent/CZ295302B6/cs not_active IP Right Cessation
- 1997-10-17 RU RU99109978/04A patent/RU2179972C2/ru not_active IP Right Cessation
- 1997-10-17 US US09/284,623 patent/US6114332A/en not_active Expired - Fee Related
- 1997-10-17 HU HU9902883A patent/HU221953B1/hu not_active IP Right Cessation
- 1997-10-17 NZ NZ335055A patent/NZ335055A/xx unknown
- 1997-10-17 PL PL97332877A patent/PL193669B1/pl not_active IP Right Cessation
- 1997-10-17 DE DE69715230T patent/DE69715230T2/de not_active Expired - Fee Related
- 1997-10-17 BR BR9711948A patent/BR9711948A/pt not_active Application Discontinuation
- 1997-10-17 PT PT97909456T patent/PT934278E/pt unknown
- 1997-10-17 GB GB9908192A patent/GB2334032B/en not_active Expired - Lifetime
- 1997-10-17 WO PCT/GB1997/002886 patent/WO1998017650A1/en not_active Ceased
- 1997-10-17 AU AU47137/97A patent/AU717724B2/en not_active Ceased
- 1997-10-17 CN CN97180614A patent/CN1116285C/zh not_active Expired - Fee Related
- 1997-10-18 TW TW086115404A patent/TW432060B/zh not_active IP Right Cessation
1999
- 1999-04-13 BG BG103329A patent/BG64555B1/bg unknown
- 1999-04-16 NO NO19991833A patent/NO313381B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1998017650A1 (en)	1998-04-30
BR9711948A (pt)	1999-08-24
CZ295302B6 (cs)	2005-07-13
DE69715230D1 (de)	2002-10-10
SK285121B6 (sk)	2006-06-01
CA2268411C (en)	2008-07-22
NZ335055A (en)	2000-09-29
TW432060B (en)	2001-05-01
PL193669B1 (pl)	2007-03-30
EP0934278B1 (en)	2002-09-04
AU717724B2 (en)	2000-03-30
ZA979331B (en)	1998-05-21
CN1240430A (zh)	2000-01-05
ID22444A (id)	1999-10-14
GB9621795D0 (en)	1996-12-11
UA67729C2 (uk)	2004-07-15
ZA979328B (en)	1998-07-06
HUP9902883A3 (en)	2001-01-29
KR20000049252A (ko)	2000-07-25
ATE223381T1 (de)	2002-09-15
NO313381B1 (no)	2002-09-23
PT934278E (pt)	2003-01-31
EP0934278A1 (en)	1999-08-11
GB9908192D0 (en)	1999-06-02
JP2001503399A (ja)	2001-03-13
BG103329A (en)	2000-11-30
GB2334032B (en)	2000-11-08
CZ127199A3 (cs)	1999-09-15
PL332877A1 (en)	1999-10-25
CA2268411A1 (en)	1998-04-30
NO991833D0 (no)	1999-04-16
MY122017A (en)	2006-03-31
HK1018773A1 (en)	2000-01-07
BG64555B1 (bg)	2005-07-29
GB2334032A (en)	1999-08-11
HU221953B1 (hu)	2003-03-28
AU4713797A (en)	1998-05-15
CN1116285C (zh)	2003-07-30
SK50499A3 (en)	2000-05-16
DE69715230T2 (de)	2009-09-17
ES2183142T3 (es)	2003-03-16
RO120636B1 (ro)	2006-05-30
US6114332A (en)	2000-09-05
RU2179972C2 (ru)	2002-02-27
DK0934278T3 (da)	2003-01-06

Legal Events

Date	Code	Title	Description
2010-05-31	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NZ239425A (en)	1993-10-26	Sulphonamide derivatives and pharmaceutical compositions
RU2000113595A (ru)	2004-02-20	Производные пиридонкарбоновой кислоты или его соль
MXPA02006329A (es)	2004-05-14	8-arilquinolinas sustituidas que son inhibidores de fosfodiesterasa-4.
DE50204780D1 (de)	2005-12-08	Arylsulfonamide als antivirale mittel
DK0934278T3 (da)	2003-01-06	Bis(acridincarboxamid) og bis(phenazincarboxamid) som antitumormidler
CA2045857A1 (en)	1992-01-11	Diaminotrifluoromethylpyridine Derivatives, Process for Their Production and Phospholipase A2 Inhibitor Containing Them
ATE173727T1 (de)	1998-12-15	Substituierte chinoline für die behandlung von leismaniosen
MX9701949A (es)	1997-06-28	Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.
YU5893A (sh)	1996-07-24	Sulfonilkarbamid i postupak za njegovo dobijanje
NO955197L (no)	1996-02-16	Nye carbosykliske nukleoside midler som er anvendbare som selektive inhibitorer av pro-inflammatoriske cytokiner
KR960702463A (ko)	1996-04-27	Dc-89 유도체[dc-89 derivative]
DE60221251D1 (de)	2007-08-30	Bis(2-aryl-5-pyridyl)derivate
PL366894A1 (en)	2005-02-07	Variolin derivatives and their use as antitumor agents
ATE367377T1 (de)	2007-08-15	Bis(5-aryl-2-pyridyl)derivate
CO4940468A1 (es)	2000-07-24	Nuevos derivados de naftilpiperacina