ATE151463T1 - Verfahren zur herstellung c-terminal amidierter peptide - Google Patents

Verfahren zur herstellung c-terminal amidierter peptide

Info

Publication number: ATE151463T1
Authority: AT; Austria
Prior art keywords: peptides; terminally; aralkyl; cleavage; aryl
Prior art date: 1990-09-14

Application number

AT91916824T

Other languages

English (en)

Inventor

Ole Buchardt

Klaus Breddam

Dennis Henriksen

Original Assignee

Ole Buchardt

Klaus Breddam

Dennis Henriksen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-14

Filing date

1991-09-13

Publication date

1997-04-15

1991-09-13 Application filed by Ole Buchardt, Klaus Breddam, Dennis Henriksen filed Critical Ole Buchardt

1997-04-15 Application granted granted Critical

1997-04-15 Publication of ATE151463T1 publication Critical patent/ATE151463T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
210000004899 c-terminal region Anatomy 0.000 abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 2
239000012038 nucleophile Substances 0.000 abstract 2
230000007017 scission Effects 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
-1 Y is H Chemical group 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000009435 amidation Effects 0.000 abstract 1
238000007112 amidation reaction Methods 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
238000006303 photolysis reaction Methods 0.000 abstract 1
230000015843 photosynthesis, light reaction Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000008707 rearrangement Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
238000003797 solvolysis reaction Methods 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
238000011191 terminal modification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT91916824T 1990-09-14 1991-09-13 Verfahren zur herstellung c-terminal amidierter peptide ATE151463T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK220890A DK220890D0 (da)	1990-09-14	1990-09-14	Fremgangsmaade til fremstilling af c-terminalt amiderede peptider

Publications (1)

Publication Number	Publication Date
ATE151463T1 true ATE151463T1 (de)	1997-04-15

Family

ID=8110810

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91916824T ATE151463T1 (de)	1990-09-14	1991-09-13	Verfahren zur herstellung c-terminal amidierter peptide

Country Status (10)

Country	Link
EP (1)	EP0548217B1 (de)
JP (1)	JP3329810B2 (de)
AT (1)	ATE151463T1 (de)
AU (1)	AU660944B2 (de)
CA (1)	CA2092721C (de)
DE (1)	DE69125614T2 (de)
DK (2)	DK220890D0 (de)
ES (1)	ES2102405T3 (de)
IE (1)	IE913255A1 (de)
WO (1)	WO1992005271A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5780498A (en) *	1993-11-01	1998-07-14	Ciba-Geigy Japan Limited	Endothelin receptor antagonists
US5801195A (en) *	1994-12-30	1998-09-01	Celgene Corporation	Immunotherapeutic aryl amides
DK0840804T3 (da) *	1996-01-23	2000-07-17	Rapigene Inc	Fremgangsmåder og sammensætninger til analyse af nukleinsyremolekyler ved anvendelse af størrelsesseparationsteknikker
DE69700902T2 (de) *	1996-01-23	2000-07-20	Rapigene, Inc.	Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
JP2008502301A (ja) *	2003-10-10	2008-01-31	ノボ　ノルディスク　アクティーゼルスカブ	ペプチドの抱合
US7524813B2 (en)	2003-10-10	2009-04-28	Novo Nordisk Health Care Ag	Selectively conjugated peptides and methods of making the same
EP1850878A2 (de)	2005-02-10	2007-11-07	Novo Nordisk A/S	C-terminal-pegylierte wachstumshormone
BRPI0610506A2 (pt)	2005-04-20	2010-06-29	Johnson & Johnson	moduladores de trombina de n-óxidos de piridina fluorados e processo para n-oxidação de heteroarilas contendo nitrogênio
DE102005046113A1 (de) *	2005-09-27	2007-03-29	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen
MX2011000847A (es)	2008-08-06	2011-02-25	Novo Nordisk Healthcare Ag	Proteinas conjugadas con eficacia prolongada in vivo.
MX2011007736A (es)	2009-01-22	2011-09-06	Novo Nordisk Healthcare Ag	Compuestos de hormona del crecimiento estables.
WO2011015649A1 (en)	2009-08-06	2011-02-10	Novo Nordisk Health Care Ag	Growth hormones with prolonged in-vivo efficacy
RS59459B1 (sr)	2010-01-22	2019-11-29	Novo Nordisk Healthcare Ag	Hormoni rasta sa produženom in-vivo efikasnošću
MX338357B (es)	2010-01-22	2016-04-13	Novo Nordisk Healthcare Ag	Compuestos estables de la hormona de crecimiento.
US11045523B2 (en)	2013-04-05	2021-06-29	Novo Nordisk Healthcare Ag	Formulation of growth hormone albumin-binder conjugate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI70597C (fi) *	1979-04-06	1986-09-24	Carlsberg Biotechnology Ltd	Foerfarande foer enzymatisk framstaellning av peptider
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
US4708934A (en) *	1984-09-27	1987-11-24	Unigene Laboratories, Inc.	α-amidation enzyme
JPS6229997A (ja) *	1985-04-08	1987-02-07	Sankyo Co Ltd	Ｃ末端にプロリンアミドを有するペプチドの製法

1990
- 1990-09-14 DK DK220890A patent/DK220890D0/da not_active Application Discontinuation
1991
- 1991-09-13 JP JP51522091A patent/JP3329810B2/ja not_active Expired - Fee Related
- 1991-09-13 DK DK91916824.5T patent/DK0548217T3/da active
- 1991-09-13 AU AU86131/91A patent/AU660944B2/en not_active Ceased
- 1991-09-13 CA CA002092721A patent/CA2092721C/en not_active Expired - Fee Related
- 1991-09-13 ES ES91916824T patent/ES2102405T3/es not_active Expired - Lifetime
- 1991-09-13 WO PCT/DK1991/000268 patent/WO1992005271A1/en not_active Ceased
- 1991-09-13 DE DE69125614T patent/DE69125614T2/de not_active Expired - Fee Related
- 1991-09-13 AT AT91916824T patent/ATE151463T1/de not_active IP Right Cessation
- 1991-09-13 EP EP91916824A patent/EP0548217B1/de not_active Expired - Lifetime
- 1991-09-16 IE IE325591A patent/IE913255A1/en unknown

Also Published As

Publication number	Publication date
AU660944B2 (en)	1995-07-13
IE913255A1 (en)	1992-02-25
WO1992005271A1 (en)	1992-04-02
CA2092721C (en)	2002-08-13
EP0548217A1 (de)	1993-06-30
JPH06503471A (ja)	1994-04-21
DE69125614T2 (de)	1997-09-11
JP3329810B2 (ja)	2002-09-30
DE69125614D1 (de)	1997-05-15
AU8613191A (en)	1992-04-15
CA2092721A1 (en)	1992-03-15
DK220890D0 (da)	1990-09-14
ES2102405T3 (es)	1997-08-01
EP0548217B1 (de)	1997-04-09
DK0548217T3 (da)	1997-07-28

Legal Events

Date	Code	Title	Description
1998-12-15	UEP	Publication of translation of european patent specification
2003-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69125614D1 (de)	1997-05-15	Verfahren zur herstellung c-terminal amidierter peptide
DE69512851D1 (de)	1999-11-25	Verfahren zur Herstellung von N-Acyl-5-Fluorocytidinderivaten
ATE282020T1 (de)	2004-11-15	Verfahren zur herstellung von 2-aminomalonsäure- derivaten
DE60012349D1 (de)	2004-08-26	Verfahren zur herstellung einer katalysatorkomponente für olefinpolymerisation
DE69400496D1 (de)	1996-10-17	Verfahren zur Herstellung von Alkylpolyglucosiden
US6251625B1 (en)	2001-06-26	Process for preparing peptides and N-carbamoyl-protected peptides
DE59209313D1 (de)	1998-06-10	Verfahren zur enzymatischen Herstellung geschützter und ungeschützter Di- und Oligopeptide in wässrigen Lösungen
ATE140443T1 (de)	1996-08-15	Verfahren zur herstellung von ketendimeren
DE69814635D1 (de)	2003-06-18	Verfahren zur herstellung von 2-hydroxybenzamidderivaten
SE9300583L (sv)	1994-08-23	Förfarande för framställning av ketendimerer
IN185844B (de)	2001-05-12
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AU7337598A (en)	1998-11-27	Process for preparing and purifying complex esters
KR920702341A (ko)	1992-09-03	순수분리된 N-포밀-L-아스파라틱 무수물을 사용하여 α-L-아스파르틸-L-페닐 알라닌 메틸에스테르 염산 제조공정
ATE360016T1 (de)	2007-05-15	Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
DE69830518D1 (de)	2005-07-14	Verfahren zur herstellung von hochreinen fettsäure-niedrigalkylestern
US5286903A (en)	1994-02-15	Process for the preparation of cyclohexanedicarboxylic acids
ATE251135T1 (de)	2003-10-15	Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
DE69108192D1 (de)	1995-04-20	Verfahren zur enzymatischen Herstellung von GRF(1-44)NH2.
ATE258547T1 (de)	2004-02-15	Verfahren zur herstellung von 2-hydroxy-6- trifluormethylpyridin
DE602004021814D1 (de)	2009-08-13	Verfahren zur peptidsynthese
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ATE245149T1 (de)	2003-08-15	Verfahren zur herstellung von alkoxytriazolinonen
EP0155165A2 (de)	1985-09-18	Verfahren zur Einführung von Phospinoylgruppen in Aminogruppen
ATE319722T1 (de)	2006-03-15	Verfahren zur herstellung von vitamin-d analogen