ES2102405T3 - Procedimiento para la preparacion de peptidos amidados en el extremo c terminal. - Google Patents
Procedimiento para la preparacion de peptidos amidados en el extremo c terminal.Info
- Publication number
- ES2102405T3 ES2102405T3 ES91916824T ES91916824T ES2102405T3 ES 2102405 T3 ES2102405 T3 ES 2102405T3 ES 91916824 T ES91916824 T ES 91916824T ES 91916824 T ES91916824 T ES 91916824T ES 2102405 T3 ES2102405 T3 ES 2102405T3
- Authority
- ES
- Spain
- Prior art keywords
- peptides
- terminally
- preparation
- aralkyl
- cleavage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 239000012038 nucleophile Substances 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- -1 Y is H Chemical group 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000009435 amidation Effects 0.000 abstract 1
- 238000007112 amidation reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000006303 photolysis reaction Methods 0.000 abstract 1
- 230000015843 photosynthesis, light reaction Effects 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011191 terminal modification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE PRESENTA UN METODO PARA LA PREPARACION DE PEPTIDOS CON AMIDO EN EL TERMINAL C P-NH2 MEDIANTE LA REACCION DE UN COMPONENTE DE UN SUSTRATO SELECCIONADO ENTRE A) PEPTIDOS NO BLOQUEADOS EN EL TERMINAL C P-OH, B) PEPTIDOS O DERIVADOS DE PEPTIDOS P-X-Y EN DONDE X ES UN AMINOACIDO O UN RESIDUO PEPTIDO E Y ES OH, OME O UNA MODIFICACION DEL TERMINAL C, Y C) PEPTIDOS ESTERIFICADOS EN EL TERMINAL C P-OR'', EN DONDE R'' ES ALQUIL, ARIL, HETEROARIL, ARALQUIL O UN FRAGMETNO DE AMINO (ALFA)-DES DE UN AMINOACIDO, CON UN COMPONENTE NUCLEOFILO EN LA PRESENCIA DE UNA ENZIMA USANDO COMO COMPUESTO NUCLEOFILO NH2-R CAPAZ DE DIVIDIR EL PRODUCTO DE REACCION P-NH-R EN P-NH2, Y SOPORTAR DICHA DIVISION. LOS NUCLEOFILOS MAS ADECUADOS SE SELECCIONAN ENTRE (I), EN DONDE A-F Y A''-E'' SON ATOMOS DE CARBONO O HASTA 2 ATOMOS HETEROS, Y ES H, ALQUIL, ARIL, ARALQUIL, OXO O CARBOXIDO O UN DERIVADO FUNCIONAL DE LOS MISMOS, X1-X5 SON H O VARIOS SUSTITUYENTES. LA DIVISION PUEDE SER INDUCIDA POR FOTOLISIS, SOLVOLISIS, REDUCCION, ELIMINACION, REORDENAMIENTO U OXIDACION. EL PROCESO ES MUY FLEXIBLE YA QUE PUEDE APATARSE A CUALQUIER TIPO DE SINTESIS ENZIMATICA Y AYUDA EN LA FORMACION DE TERMINALES C DE AMIDO EN TODO LOS TIPOS DE PEPTIDOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK220890A DK220890D0 (da) | 1990-09-14 | 1990-09-14 | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2102405T3 true ES2102405T3 (es) | 1997-08-01 |
Family
ID=8110810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91916824T Expired - Lifetime ES2102405T3 (es) | 1990-09-14 | 1991-09-13 | Procedimiento para la preparacion de peptidos amidados en el extremo c terminal. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0548217B1 (es) |
| JP (1) | JP3329810B2 (es) |
| AT (1) | ATE151463T1 (es) |
| AU (1) | AU660944B2 (es) |
| CA (1) | CA2092721C (es) |
| DE (1) | DE69125614T2 (es) |
| DK (2) | DK220890D0 (es) |
| ES (1) | ES2102405T3 (es) |
| IE (1) | IE913255A1 (es) |
| WO (1) | WO1992005271A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780498A (en) * | 1993-11-01 | 1998-07-14 | Ciba-Geigy Japan Limited | Endothelin receptor antagonists |
| US5801195A (en) * | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
| DK0840804T3 (da) * | 1996-01-23 | 2000-07-17 | Rapigene Inc | Fremgangsmåder og sammensætninger til analyse af nukleinsyremolekyler ved anvendelse af størrelsesseparationsteknikker |
| DE69700902T2 (de) * | 1996-01-23 | 2000-07-20 | Rapigene, Inc. | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
| JP2008502301A (ja) * | 2003-10-10 | 2008-01-31 | ノボ ノルディスク アクティーゼルスカブ | ペプチドの抱合 |
| US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| EP1850878A2 (en) | 2005-02-10 | 2007-11-07 | Novo Nordisk A/S | C-terminally pegylated growth hormones |
| BRPI0610506A2 (pt) | 2005-04-20 | 2010-06-29 | Johnson & Johnson | moduladores de trombina de n-óxidos de piridina fluorados e processo para n-oxidação de heteroarilas contendo nitrogênio |
| DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
| MX2011000847A (es) | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Proteinas conjugadas con eficacia prolongada in vivo. |
| MX2011007736A (es) | 2009-01-22 | 2011-09-06 | Novo Nordisk Healthcare Ag | Compuestos de hormona del crecimiento estables. |
| WO2011015649A1 (en) | 2009-08-06 | 2011-02-10 | Novo Nordisk Health Care Ag | Growth hormones with prolonged in-vivo efficacy |
| RS59459B1 (sr) | 2010-01-22 | 2019-11-29 | Novo Nordisk Healthcare Ag | Hormoni rasta sa produženom in-vivo efikasnošću |
| MX338357B (es) | 2010-01-22 | 2016-04-13 | Novo Nordisk Healthcare Ag | Compuestos estables de la hormona de crecimiento. |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI70597C (fi) * | 1979-04-06 | 1986-09-24 | Carlsberg Biotechnology Ltd | Foerfarande foer enzymatisk framstaellning av peptider |
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| US4708934A (en) * | 1984-09-27 | 1987-11-24 | Unigene Laboratories, Inc. | α-amidation enzyme |
| JPS6229997A (ja) * | 1985-04-08 | 1987-02-07 | Sankyo Co Ltd | Ｃ末端にプロリンアミドを有するペプチドの製法 |
-
1990
- 1990-09-14 DK DK220890A patent/DK220890D0/da not_active Application Discontinuation
-
1991
- 1991-09-13 JP JP51522091A patent/JP3329810B2/ja not_active Expired - Fee Related
- 1991-09-13 DK DK91916824.5T patent/DK0548217T3/da active
- 1991-09-13 AU AU86131/91A patent/AU660944B2/en not_active Ceased
- 1991-09-13 CA CA002092721A patent/CA2092721C/en not_active Expired - Fee Related
- 1991-09-13 ES ES91916824T patent/ES2102405T3/es not_active Expired - Lifetime
- 1991-09-13 WO PCT/DK1991/000268 patent/WO1992005271A1/en not_active Ceased
- 1991-09-13 DE DE69125614T patent/DE69125614T2/de not_active Expired - Fee Related
- 1991-09-13 AT AT91916824T patent/ATE151463T1/de not_active IP Right Cessation
- 1991-09-13 EP EP91916824A patent/EP0548217B1/en not_active Expired - Lifetime
- 1991-09-16 IE IE325591A patent/IE913255A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU660944B2 (en) | 1995-07-13 |
| ATE151463T1 (de) | 1997-04-15 |
| IE913255A1 (en) | 1992-02-25 |
| WO1992005271A1 (en) | 1992-04-02 |
| CA2092721C (en) | 2002-08-13 |
| EP0548217A1 (en) | 1993-06-30 |
| JPH06503471A (ja) | 1994-04-21 |
| DE69125614T2 (de) | 1997-09-11 |
| JP3329810B2 (ja) | 2002-09-30 |
| DE69125614D1 (de) | 1997-05-15 |
| AU8613191A (en) | 1992-04-15 |
| CA2092721A1 (en) | 1992-03-15 |
| DK220890D0 (da) | 1990-09-14 |
| EP0548217B1 (en) | 1997-04-09 |
| DK0548217T3 (da) | 1997-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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