ATE151760T1 - Thiazolidin-derivate - Google Patents

Thiazolidin-derivate

Info

Publication number: ATE151760T1
Authority: AT; Austria
Prior art keywords: group; carbon atom; general formula; atom; single bond
Prior art date: 1987-02-23

Application number

AT91111866T

Other languages

English (en)

Inventor

Masaaki Toda

Shuichi Ohuchida

Hiroyuki Ohno

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-23

Filing date

1988-02-16

Publication date

1997-05-15

1988-02-16 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE151760T1 publication Critical patent/ATE151760T1/de

Links

OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical class C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 11
229910052799 carbon Inorganic materials 0.000 abstract 8
125000002947 alkylene group Chemical group 0.000 abstract 5
125000004450 alkenylene group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000000044 Amnesia Diseases 0.000 abstract 1
208000031091 Amnestic disease Diseases 0.000 abstract 1
102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000006986 amnesia Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
150000003548 thiazolidines Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT91111866T 1987-02-23 1988-02-16 Thiazolidin-derivate ATE151760T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3784487		1987-02-23

Publications (1)

Publication Number	Publication Date
ATE151760T1 true ATE151760T1 (de)	1997-05-15

Family

ID=12508841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91111866T ATE151760T1 (de)	1987-02-23	1988-02-16	Thiazolidin-derivate

Country Status (7)

Country	Link
US (1)	US4857537A (de)
EP (2)	EP0461677B1 (de)
KR (1)	KR960001205B1 (de)
AT (1)	ATE151760T1 (de)
DE (2)	DE3875361T2 (de)
ES (2)	ES2103287T3 (de)
GR (1)	GR3006406T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01250370A (ja) *	1987-12-23	1989-10-05	Zeria Pharmaceut Co Ltd	新規アミノ酸イミド誘導体、製法ならびに用途
JP2515568B2 (ja) *	1987-12-25	1996-07-10	株式会社ヤクルト本社	新規なチアゾリジン誘導体
US5212191A (en) *	1988-04-08	1993-05-18	Ono Pharmaceutical Co., Ltd.	Heterocyclic compounds
US5053414A (en) *	1988-04-08	1991-10-01	Ono Pharmaceutical Co., Ltd.	Heterocyclic compounds
CA2004028C (en) *	1988-12-08	1998-09-22	Motoki Torizuka	Condensed benzene derivative
EP0419683A4 (en) *	1989-04-13	1992-03-11	Japan Tobacco Inc.	New amino acid derivatives having prolylendopeptidase inhibitor activity
US5073549A (en) *	1990-03-22	1991-12-17	Bristol-Myers Squibb Company	BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
US4999349A (en) *	1990-03-22	1991-03-12	Bristol-Myers Squibb Co.	BU-4164E - A and B, prolyl endopeptidase inhibitors
FI925500A7 (fi) *	1990-06-04	1992-12-03	Pfizer	Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja
US5506256A (en) *	1990-07-27	1996-04-09	Yoshitomi Pharmaceutical Industries, Ltd.	Proline derivatives possessing prolyl endopeptidase-inhibitory activity
IT1283782B1 (it) *	1996-08-09	1998-04-30	Ct Lab Farm Srl	Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
US6419857B1 (en) *	1999-12-06	2002-07-16	Baker Hughes Incorporated	Thiazolidines and use thereof for corrosion inhibition
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
AU2004290499C1 (en)	2003-11-03	2011-02-24	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
EP1760076A1 (de)	2005-09-02	2007-03-07	Ferring B.V.	FAP Inhibitoren
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (de)	2007-04-18	2014-12-24	Probiodrug AG	Thioharnstoffderivate als glutaminylcyclaseinhibitoren
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (de)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazolderivate als glutaminylcyclase-hemmer
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60188317A (ja) *	1984-03-09	1985-09-25	Yakult Honsha Co Ltd	抗健忘症剤
JPS6137764A (ja) *	1984-07-31	1986-02-22	Suntory Ltd	抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) *	1985-04-16	1994-03-30	サントリー株式会社	インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
CA1309805C (en) *	1985-04-16	1992-11-03	Naoki Higuchi	Dipeptide derivative and synthesis and use thereof
EP0201743B1 (de) *	1985-04-16	1992-04-01	Suntory Limited	Dipeptid-Derivate von Fettsäure, Verfahren zu ihrer Herstellung, Heilmittel, das sie enthält und Anwendung

1988
- 1988-02-16 DE DE8888102243T patent/DE3875361T2/de not_active Expired - Fee Related
- 1988-02-16 EP EP91111866A patent/EP0461677B1/de not_active Expired - Lifetime
- 1988-02-16 EP EP88102243A patent/EP0280956B1/de not_active Expired - Lifetime
- 1988-02-16 ES ES91111866T patent/ES2103287T3/es not_active Expired - Lifetime
- 1988-02-16 DE DE3855875T patent/DE3855875T2/de not_active Expired - Fee Related
- 1988-02-16 AT AT91111866T patent/ATE151760T1/de not_active IP Right Cessation
- 1988-02-16 ES ES88102243T patent/ES2052619T3/es not_active Expired - Lifetime
- 1988-02-23 US US07/159,073 patent/US4857537A/en not_active Expired - Lifetime
- 1988-02-23 KR KR1019880001849A patent/KR960001205B1/ko not_active Expired - Fee Related
1992
- 1992-12-02 GR GR920402770T patent/GR3006406T3/el unknown

Also Published As

Publication number	Publication date
EP0461677B1 (de)	1997-04-16
ES2103287T3 (es)	1997-09-16
EP0461677A1 (de)	1991-12-18
KR960001205B1 (ko)	1996-01-24
KR880009949A (ko)	1988-10-06
GR3006406T3 (de)	1993-06-21
DE3855875T2 (de)	1997-08-28
EP0280956B1 (de)	1992-10-21
DE3855875D1 (de)	1997-05-22
DE3875361D1 (de)	1992-11-26
US4857537A (en)	1989-08-15
DE3875361T2 (de)	1993-03-25
ES2052619T3 (es)	1994-07-16
EP0280956A1 (de)	1988-09-07

Legal Events

Date	Code	Title	Description
1997-10-15	UEP	Publication of translation of european patent specification
2003-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3855875D1 (de)	1997-05-22	Thiazolidin-Derivate
DE3879522D1 (de)	1993-04-29	Prolinalderivate.
DK0624584T3 (da)	1999-05-25	Piperazinderivater, der er nyttige som calmodulininhibitorer
ATE84787T1 (de)	1993-02-15	Prolin-derivate.
ATE112558T1 (de)	1994-10-15	Glycosidasehemmer.
ES2070135T3 (es)	1995-06-01	Derivados de pirrolidina anti-amnesicos.
DK147588A (da)	1988-09-19	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
BG60285B2 (en)	1994-04-25	Method and herbicide for unwanted vegetation control
SE8203877L (sv)	1982-12-23	Aminosulfonylbensoesyraderivat
ATE137747T1 (de)	1996-05-15	Aminobenzolverbindungen, herstellung und verwendung
GB9016799D0 (en)	1990-09-12	Pesticidal heterocyclic compounds
ATE119523T1 (de)	1995-03-15	Isochinolinderivate und ihre salze als proteasehemmer.
DE69016266D1 (de)	1995-03-09	Aminoketonverbindungen.
DE69734479D1 (de)	2005-12-01	Herstellung von Thiazolen
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus
HUT39173A (en)	1986-08-28	Process for production of derivatives of 3-hydro-amino-2,3-dihydro-benzoxepin