NO821616L - 1-substituert-spiro(piperidin-oksobenzoksazin)er og fremgangsmaate for deres fremstilling - Google Patents

1-substituert-spiro(piperidin-oksobenzoksazin)er og fremgangsmaate for deres fremstilling

Info

Publication number
NO821616L
NO821616L NO821616A NO821616A NO821616L NO 821616 L NO821616 L NO 821616L NO 821616 A NO821616 A NO 821616A NO 821616 A NO821616 A NO 821616A NO 821616 L NO821616 L NO 821616L
Authority
NO
Norway
Prior art keywords
hydrogen
pharmaceutically acceptable
formula
acid addition
acceptable acid
Prior art date
Application number
NO821616A
Other languages
English (en)
Norwegian (no)
Inventor
Adolph Peter Roszkowski
Robin Douglas Clark
Arthur Frederick Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO821616L publication Critical patent/NO821616L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO821616A 1981-05-18 1982-05-14 1-substituert-spiro(piperidin-oksobenzoksazin)er og fremgangsmaate for deres fremstilling NO821616L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/264,779 US4349549A (en) 1981-05-18 1981-05-18 Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s

Publications (1)

Publication Number Publication Date
NO821616L true NO821616L (no) 1982-11-19

Family

ID=23007572

Family Applications (1)

Application Number Title Priority Date Filing Date
NO821616A NO821616L (no) 1981-05-18 1982-05-14 1-substituert-spiro(piperidin-oksobenzoksazin)er og fremgangsmaate for deres fremstilling

Country Status (20)

Country Link
US (1) US4349549A (de)
EP (1) EP0065864B1 (de)
JP (1) JPS57193485A (de)
KR (1) KR830010115A (de)
AT (1) ATE15198T1 (de)
AU (1) AU8376982A (de)
BR (1) BR8202861A (de)
DE (1) DE3265802D1 (de)
DK (1) DK221882A (de)
ES (3) ES512275A0 (de)
FI (1) FI821733A7 (de)
HU (1) HU186933B (de)
IE (1) IE53034B1 (de)
IL (1) IL65801A (de)
NO (1) NO821616L (de)
NZ (1) NZ200631A (de)
PH (1) PH20072A (de)
PL (2) PL236472A1 (de)
PT (1) PT74912B (de)
ZA (1) ZA823414B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
GB2131021B (en) * 1982-11-24 1985-12-18 Erba Farmitalia Antipsychotic benzoxazines
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
WO2001045707A1 (en) * 1999-12-21 2001-06-28 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001230537A1 (en) * 2000-02-01 2001-08-14 Daiichi Pharmaceutical Co., Ltd. Pyridoxazine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
EP2374455A3 (de) 2004-08-19 2012-03-28 Vertex Pharmaceuticals Incorporated Modulatoren von muskarinischen Rezeptoren
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
AU2006330866A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
AU2007221214A1 (en) 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
KR20080098070A (ko) * 2006-02-22 2008-11-06 버텍스 파마슈티칼스 인코포레이티드 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
AU2007284548A1 (en) * 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CA2660974A1 (en) * 2006-08-18 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP2010540640A (ja) * 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン作用性レセプターのモジュレーター
CN113264949B (zh) * 2021-05-31 2022-04-05 西南大学 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments

Also Published As

Publication number Publication date
IE821179L (en) 1982-11-18
US4349549A (en) 1982-09-14
FI821733A0 (fi) 1982-05-17
NZ200631A (en) 1985-10-11
IL65801A (en) 1985-09-29
JPS57193485A (en) 1982-11-27
IE53034B1 (en) 1988-05-11
BR8202861A (pt) 1983-04-26
FI821733A7 (fi) 1982-11-19
AU8376982A (en) 1982-11-25
ES8401075A1 (es) 1983-12-01
ES512275A0 (es) 1983-12-01
PT74912A (en) 1982-06-01
EP0065864A1 (de) 1982-12-01
EP0065864B1 (de) 1985-08-28
ES8404790A1 (es) 1984-06-01
KR830010115A (ko) 1983-12-26
PH20072A (en) 1986-09-18
HU186933B (en) 1985-10-28
PL246771A1 (en) 1984-10-22
IL65801A0 (en) 1982-08-31
DK221882A (da) 1982-11-19
ES521124A0 (es) 1984-06-01
ES521125A0 (es) 1984-06-01
PT74912B (en) 1983-12-07
ATE15198T1 (de) 1985-09-15
ZA823414B (en) 1983-12-28
PL236472A1 (en) 1984-07-30
ES8404791A1 (es) 1984-06-01
DE3265802D1 (en) 1985-10-03

Similar Documents

Publication Publication Date Title
NO821616L (no) 1-substituert-spiro(piperidin-oksobenzoksazin)er og fremgangsmaate for deres fremstilling
KR910006863B1 (ko) 인돌-3-카르복사미드 유도체의 제조방법
SK282406B6 (sk) N-(4-Piperidinyl) (dihydrobenzofurán alebo dihydro-2H-benzopyrán) karboxamidové deriváty, spôsob a medziprodukty na ich výrobu a farmaceutické prípravky na ich báze
NO303174B1 (no) Nye azaheterocyklylmetyl-kromaner, og anvendelse av disse for fremstilling av legemidler
DK155327B (da) Analogifremgangsmaade til fremstilling af 5h-2,3-benzodiazepinderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf
JPH0587506B2 (de)
HU198931B (en) Process for producing 2-square brackets open /piperidin-4-yl/-methyl square brackets closed -1,2,3,4-tetradihydro-9h-pyrido/3,4-b/indole derivatives and pharma ceutical compositions comprising same
NO820937L (no) 9-(2-(3-indolyl)etyl)-1-oksa-4,9-diazaspiro(5,5)-undekan-3-oner og fremgangsmaate for deres fremstilling
JPS61155358A (ja) ジアリール酪酸誘導体
US5708174A (en) Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
CA1115703A (en) Piperidinopropyl derivatives
US4420485A (en) 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
NO313238B1 (no) N-substituerte piperidinyl bisykliske benzoatderivater
JPH0699420B2 (ja) 水素添加された１−ベンゾオキサシクロアルキルピリジンカルボン酸化合物，その製造方法及び該化合物を含む医薬製剤
EP0412822B1 (de) 4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
NO171786B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater
CA3245085A1 (en) HETEROCYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
NO124724B (de)
NO164899B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolylindolforbindelser.
NO167863B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive, kondenserte, heterocykliske tetrahydroaminokinolinoler.
KR870001681B1 (ko) 히단토인 유도체의 제조방법
WO1993003031A1 (fr) Derive de pyrroloazepine
CS248020B2 (en) Production method of the (+)-enantiomere or (+-)-racemical 4a,9b-trans-hexahydro-1h-pyridoindole derivatives
US7202360B2 (en) Method for preparing risperidone
NO148747B (no) Analogifremgangsmaate til fremstilling av n-fenyl-n-(4-piperidinyl)lavere alkyl-tetrazolamider