ATE153535T1 - Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum - Google Patents

Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum

Info

Publication number: ATE153535T1
Authority: AT; Austria
Prior art keywords: induring; tgf; bone growth; beta composition; beta
Prior art date: 1993-01-12

Application number

AT94906606T

Other languages

English (en)

Inventor

Arthur J Ammann

Steven L Beck

Tue H Nguyen

Boonsri Ongpipattanakul

Christopher G Rudman

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-12

Filing date

1994-01-11

Publication date

1997-06-15

1994-01-11 Application filed by Genentech Inc filed Critical Genentech Inc

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE153535T1 publication Critical patent/ATE153535T1/de

Links

239000000203 mixture Substances 0.000 title abstract 4
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 2
230000008468 bone growth Effects 0.000 title 1
238000009472 formulation Methods 0.000 abstract 3
229920000945 Amylopectin Polymers 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
239000001506 calcium phosphate Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
239000008187 granular material Substances 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
229940078499 tricalcium phosphate Drugs 0.000 abstract 1
229910000391 tricalcium phosphate Inorganic materials 0.000 abstract 1
235000019731 tricalcium phosphate Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Dermatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)

AT94906606T 1993-01-12 1994-01-11 Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum ATE153535T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US336593A	1993-01-12	1993-01-12

Publications (1)

Publication Number	Publication Date
ATE153535T1 true ATE153535T1 (de)	1997-06-15

Family

ID=21705523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94906606T ATE153535T1 (de)	1993-01-12	1994-01-11	Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum

Country Status (10)

Country	Link
EP (1)	EP0679097B1 (de)
JP (1)	JP3347144B2 (de)
AT (1)	ATE153535T1 (de)
AU (1)	AU671721B2 (de)
CA (1)	CA2151486A1 (de)
DE (1)	DE69403439T2 (de)
DK (1)	DK0679097T3 (de)
ES (1)	ES2105641T3 (de)
GR (1)	GR3024277T3 (de)
WO (1)	WO1994015653A1 (de)

Families Citing this family (34)

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US5503558A (en) *	1993-11-12	1996-04-02	Mcgill University	Osseointegration promoting implant composition, implant assembly and method therefor
DE19529223A1 (de) *	1995-08-09	1997-02-13	Boehringer Mannheim Gmbh	Verwendung von Plasminogenaktivatoren zum lokalen Knochenaufbau
US6902584B2 (en)	1995-10-16	2005-06-07	Depuy Spine, Inc.	Bone grafting matrix
US5776193A (en)	1995-10-16	1998-07-07	Orquest, Inc.	Bone grafting matrix
JP4388602B2 (ja) †	1997-02-07	2009-12-24	ストライカーコーポレイション	マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US20010016646A1 (en)	1998-03-20	2001-08-23	David C. Rueger	Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en)	1997-03-20	2006-05-09	Stryker Corporation	Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
NL1008582C2 (nl) *	1998-01-05	1999-07-06	Vrije Universiteit	Botmateriaal.
US20030147860A1 (en)	2002-02-07	2003-08-07	Marchosky J. Alexander	Compositions and methods for forming and strengthening bone
DE69903732T2 (de) *	1998-07-02	2003-07-03	Stichting Skeletal Tissue Engineering Group Amsterdam, Amsterdam	Knochenzement mit antimikrobiellen peptiden
EP0992251A1 (de) *	1998-10-07	2000-04-12	Isotis B.V.	Vorrichtung zur Knochenbehandlung eines Knochersatzmaterials
IT1302534B1 (it)	1998-12-21	2000-09-05	Fidia Advanced Biopolymers Srl	Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
JP2002539172A (ja) *	1999-03-17	2002-11-19	ノバルティスアクチエンゲゼルシャフト	Ｔｇｆ−ベータを含む医薬組成物
CA2377435A1 (en)	1999-06-29	2001-01-04	J. Alexander Marchosky	Compositions and methods for forming and strengthening bone
US20020114795A1 (en) *	2000-12-22	2002-08-22	Thorne Kevin J.	Composition and process for bone growth and repair
US6949251B2 (en)	2001-03-02	2005-09-27	Stryker Corporation	Porous β-tricalcium phosphate granules for regeneration of bone tissue
ES2247423T5 (es)	2001-11-19	2015-12-30	Scil Technology Gmbh	Método de producción de un dispositivo recubierto homogéneamente que tiene propiedades osteoinductoras y osteoconductoras
TW200400062A (en)	2002-04-03	2004-01-01	Mathys Medizinaltechnik Ag	Kneadable, pliable bone replacement material
US7166133B2 (en)	2002-06-13	2007-01-23	Kensey Nash Corporation	Devices and methods for treating defects in the tissue of a living being
US7018361B2 (en)	2002-06-14	2006-03-28	Baxter International Inc.	Infusion pump
US7384652B2 (en)	2002-06-24	2008-06-10	New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery	Complexed-acidic-phospholipid-collagen composites for bone induction
JP5449638B2 (ja) *	2002-07-31	2014-03-19	デンツプライインターナショナルインコーポレーテッド	多孔性粒子およびキャリアゲルを含む骨修復パテ
US8876532B2 (en)	2002-07-31	2014-11-04	Dentsply International Inc.	Bone repair putty
ATE322916T1 (de)	2002-09-10	2006-04-15	Scil Technology Gmbh	Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat
EP1462126A1 (de) *	2003-03-28	2004-09-29	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Verbesserte osteoinduktive Materialien
US7534264B2 (en)	2004-01-28	2009-05-19	Ultradent Products, Inc.	Delivery system for bone growth promoting material
ATE478008T1 (de)	2004-03-10	2010-09-15	Scil Technology Gmbh	Überzogene implantate, ihre herstellung und verwendung davon
EP1880731A1 (de) *	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Menschlicher Wachstums und Differenzierungsfaktor GDF-5
EP3345607B1 (de) *	2006-12-29	2022-10-26	Ossifi-Mab LLC	Verfahren zur veränderung des knochenwachstums durch verabreichung von sost- oder wise-antagonisten oder agonisten
WO2010001578A1 (ja) *	2008-06-30	2010-01-07	国立大学法人東京大学	骨成長因子を吸着し，その活性を阻害しない骨補填剤
AU2011250934B2 (en)	2010-05-11	2016-02-25	Howmedica Osteonics Corp.,	Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
EP2529764A1 (de)	2011-05-31	2012-12-05	Curasan AG	Biologisch degradierbares kompositmaterial
US20140066837A1 (en)	2012-07-26	2014-03-06	Ronald L. Moy	Skin care compositions and methods
US10688222B2 (en)	2016-11-21	2020-06-23	Warsaw Orthopedic, Inc.	Lyophilized moldable implants containing an oxysterol

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5108436A (en) *	1988-09-29	1992-04-28	Collagen Corporation	Implant fixation
IE61346B1 (en) *	1988-11-02	1994-11-02	Genentech Inc	A permeable material to fit around the teeth or gums of a mammal
US4976736A (en) *	1989-04-28	1990-12-11	Interpore International	Coated biomaterials and methods for making same
US5158934A (en) *	1989-09-01	1992-10-27	Genentech, Inc.	Method of inducing bone growth using TGF-β
US5071655A (en) *	1990-01-12	1991-12-10	Baylink David J	Pharmaceutical combination for treatment of bone-wasting diseases
US5208219A (en)	1991-02-14	1993-05-04	Celtrix Pharmaceuticals Inc.	Method for inducing bone growth
DE4121043A1 (de) *	1991-06-26	1993-01-07	Merck Patent Gmbh	Knochenersatzmaterial mit fgf
US5270300A (en) *	1991-09-06	1993-12-14	Robert Francis Shaw	Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone

1994
- 1994-01-11 AU AU60262/94A patent/AU671721B2/en not_active Expired
- 1994-01-11 WO PCT/US1994/000409 patent/WO1994015653A1/en not_active Ceased
- 1994-01-11 ES ES94906606T patent/ES2105641T3/es not_active Expired - Lifetime
- 1994-01-11 JP JP51630794A patent/JP3347144B2/ja not_active Expired - Lifetime
- 1994-01-11 EP EP94906606A patent/EP0679097B1/de not_active Expired - Lifetime
- 1994-01-11 DE DE69403439T patent/DE69403439T2/de not_active Expired - Lifetime
- 1994-01-11 AT AT94906606T patent/ATE153535T1/de active
- 1994-01-11 DK DK94906606.2T patent/DK0679097T3/da active
- 1994-01-11 CA CA002151486A patent/CA2151486A1/en not_active Abandoned
1997
- 1997-07-30 GR GR970401926T patent/GR3024277T3/el unknown

Also Published As

Publication number	Publication date
EP0679097A1 (de)	1995-11-02
DK0679097T3 (da)	1997-12-22
JP3347144B2 (ja)	2002-11-20
DE69403439T2 (de)	1997-10-23
AU671721B2 (en)	1996-09-05
GR3024277T3 (en)	1997-10-31
DE69403439D1 (de)	1997-07-03
JPH08505548A (ja)	1996-06-18
EP0679097B1 (de)	1997-05-28
ES2105641T3 (es)	1997-10-16
CA2151486A1 (en)	1994-07-21
AU6026294A (en)	1994-08-15
WO1994015653A1 (en)	1994-07-21

Legal Events

Date	Code	Title	Description
1997-12-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE153535T1 (de)	1997-06-15	Tgf-beta zusammensetzung zum herbeiführen von knochenwachstum
AR034347A1 (es)	2004-02-18	Vehiculo para la liberacion de fosfato de calcio para proteinas osteoinductivas
AU2841099A (en)	1999-10-18	Method for preparing a biomaterial based on hydroxyapatite, resulting biomaterial and surgical or dental use
ATE279950T1 (de)	2004-11-15	Zusammensetzung zur implantation in den menschlichen und tierischen körper
ATE183382T1 (de)	1999-09-15	Kalzium phosphat als hydroxyapatit-vorläufer und verfahren zur herstellung und verwendung derselben
ATE296642T1 (de)	2005-06-15	Reverse-phase zusamensetzung zur bindegewebsreparatur
ATE174872T1 (de)	1999-01-15	Carbonierte hydroxyapatit-zusammensetzungen und ihre verwendungen
CA2172538A1 (en)	1995-03-30	Self-setting calcium phosphate cements and methods for preparing and using them
ATE9866T1 (de)	1984-11-15	Knochenzement und verfahren zu seiner herstellung.
ATE57616T1 (de)	1990-11-15	Material zum ausfuellen von periodontalen knochendefekten.
DE69128621D1 (de)	1998-02-12	Biokeramisches system zur abgabe von bioaktiven stoffen
AU4950099A (en)	2000-02-14	Material for bone reconstruction
ATE243049T1 (de)	2003-07-15	Mineral-polymer hybrid-zusammensetzung
WO2001054746A3 (en)	2002-03-07	Composite biomaterial including anisometric calcium phosphate reinforcement particles
IL143266A0 (en)	2002-04-21	Transforming growth factor-beta binding proteins and pharmaceutical compositions for increasing bone mineral content utilizing the same
DK0692986T3 (da)	2000-09-18	Biomaterialepræparat samt fremgangsmåde til fremstilling heraf
AU2003229615A1 (en)	2003-11-17	Method of preparing porous calcium phosphate granules
AU8452891A (en)	1992-03-26	Calcium uptake inhibitors
IL142747A (en)	2005-05-17	Compositions containing glutamic acid and glycolic acid and a method of treating plants utilizing the same
DE58904841D1 (de)	1993-08-05	Praeparat zum vorbeugen gegen knochenschwund und zur behandlung von knochenschwund.
UA49201A (uk)	2002-09-16	Замінник кісткового борошна
ATE188129T1 (de)	2000-01-15	Ipriflavone enthaltende pharmazeutische zubereitungen und deren verwendung zur ersetzung von knochendefekten
RU92016566A (ru)	1997-01-10	Биокерамическая система для ввода биологически активных соединений, способ ее получения, фармацевтическое средство, способ применения биокерамической системы
IT1293087B1 (it)	1999-02-11	Microparticelle a base di materiali polimerici ibridi per il rilascio controllato di molecole biologicamente attive, procedimento per la
TW221964B (en)	1994-04-01	Cultivating material for gardening