ATE153664T1 - Imidazoacridine und ihre antineoplastische anwendung - Google Patents

Imidazoacridine und ihre antineoplastische anwendung

Info

Publication number: ATE153664T1
Authority: AT; Austria
Prior art keywords: alkyl; imidazoacridine; antineoplastic application; antineoplastic; hydrogen
Prior art date: 1991-03-05

Application number

AT92905201T

Other languages

English (en)

Inventor

Wieslaw Marek Cholody

Jerzy Kazimierz Konopa

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-05

Filing date

1992-02-28

Publication date

1997-06-15

1992-02-28 Application filed by British Tech Group filed Critical British Tech Group

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE153664T1 publication Critical patent/ATE153664T1/de

Links

230000000118 anti-neoplastic effect Effects 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT92905201T 1991-03-05 1992-02-28 Imidazoacridine und ihre antineoplastische anwendung ATE153664T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919104548A GB9104548D0 (en)	1991-03-05	1991-03-05	Antineoplastic modified imidazoacridines

Publications (1)

Publication Number	Publication Date
ATE153664T1 true ATE153664T1 (de)	1997-06-15

Family

ID=10690967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92905201T ATE153664T1 (de)	1991-03-05	1992-02-28	Imidazoacridine und ihre antineoplastische anwendung

Country Status (17)

Country	Link
US (1)	US5231100A (de)
EP (2)	EP0502668A1 (de)
JP (1)	JP3176062B2 (de)
AT (1)	ATE153664T1 (de)
AU (1)	AU654700B2 (de)
CA (1)	CA2051356C (de)
DE (1)	DE69220048T2 (de)
DK (1)	DK0579614T3 (de)
ES (1)	ES2103931T3 (de)
GB (2)	GB9104548D0 (de)
GR (1)	GR3024485T3 (de)
IE (1)	IE66260B1 (de)
IL (1)	IL101139A (de)
NO (1)	NO300175B1 (de)
PL (1)	PL167640B1 (de)
WO (1)	WO1992015583A1 (de)
ZA (1)	ZA921615B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0604181A1 (de) *	1992-12-21	1994-06-29	Eli Lilly And Company	Antitumorpräparate und Behandlungsmethoden
US5508289A (en) *	1994-03-14	1996-04-16	The United States America As Represented By The Department Of Health And Human Services	Bis-acridone chemotherapeutic derivatives
AU7456396A (en) *	1995-11-02	1997-05-22	Warner-Lambert Company	Inhibition of amyloidosis by 9-acridinones
PT892801E (pt)	1996-04-12	2002-06-28	Us Gov Health & Human Serv	Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais
GB2317888A (en) *	1996-10-07	1998-04-08	Marek Tadeusz Konieczny	Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale
AU2001240054B2 (en)	2000-03-07	2005-08-11	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	1,8-Naphthalimide Imidazo[4,5,1-de]acridones with Anti-Tumor Activity
CA2596144A1 (en) *	2005-01-28	2006-08-03	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory and demyelinating diseases
WO2007092436A2 (en) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory disorders, demyelinating disorders and cancers
WO2007143096A2 (en) *	2006-06-02	2007-12-13	Xanthus Pharmaceuticals, Inc.	Compounds for treating cancers
WO2008016660A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Imidazoacridine compounds for treating leukemias
US20100016300A1 (en) *	2006-08-02	2010-01-21	Ajami Alfred M	Imidazoacridine Compounds for Treating FLT3-Mediated Disorders
WO2008016700A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	N-oxide compounds for therapeutics uses
US20080118576A1 (en) *	2006-08-28	2008-05-22	Dan Theodorescu	Prediction of an agent's or agents' activity across different cells and tissue types
US8470844B2 (en) *	2008-09-11	2013-06-25	Technion Research & Development Foundation Limited	Imidazoacridinone derivative compounds and methods for their use
PL3070078T3 (pl) *	2015-03-20	2018-02-28	Politechnika Gdańska	Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania
WO2016174674A1 (en)	2015-04-27	2016-11-03	The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center	Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1037377A (en) *	1964-09-02	1966-07-27	Mitsubishi Chem Ind	Naphthoylene-arylimidazole disperse dyestuffs
US4626540A (en) *	1983-11-08	1986-12-02	Warner-Lambert Company	Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
JP2795460B2 (ja) *	1988-06-20	1998-09-10	協和醗酵工業株式会社	ピラゾロアクリドン誘導体

1991
- 1991-03-05 GB GB919104548A patent/GB9104548D0/en active Pending
- 1991-09-16 US US07/760,694 patent/US5231100A/en not_active Expired - Lifetime
- 1991-09-16 CA CA002051356A patent/CA2051356C/en not_active Expired - Fee Related
1992
- 1992-02-28 PL PL92300593A patent/PL167640B1/pl not_active IP Right Cessation
- 1992-02-28 EP EP92301732A patent/EP0502668A1/de active Pending
- 1992-02-28 ES ES92905201T patent/ES2103931T3/es not_active Expired - Lifetime
- 1992-02-28 JP JP50506892A patent/JP3176062B2/ja not_active Expired - Fee Related
- 1992-02-28 AU AU12743/92A patent/AU654700B2/en not_active Ceased
- 1992-02-28 DE DE69220048T patent/DE69220048T2/de not_active Expired - Fee Related
- 1992-02-28 WO PCT/GB1992/000360 patent/WO1992015583A1/en not_active Ceased
- 1992-02-28 DK DK92905201.7T patent/DK0579614T3/da active
- 1992-02-28 AT AT92905201T patent/ATE153664T1/de not_active IP Right Cessation
- 1992-02-28 EP EP92905201A patent/EP0579614B1/de not_active Expired - Lifetime
- 1992-02-28 GB GB9204315A patent/GB2253396B/en not_active Expired - Fee Related
- 1992-03-03 IE IE920677A patent/IE66260B1/en not_active IP Right Cessation
- 1992-03-04 IL IL10113992A patent/IL101139A/en not_active IP Right Cessation
- 1992-03-04 ZA ZA921615A patent/ZA921615B/xx unknown
1993
- 1993-09-03 NO NO933147A patent/NO300175B1/no unknown
1997
- 1997-08-19 GR GR970402124T patent/GR3024485T3/el unknown

Also Published As

Publication number	Publication date
PL167640B1 (pl)	1995-10-31
IE66260B1 (en)	1995-12-27
GB2253396A (en)	1992-09-09
EP0579614B1 (de)	1997-05-28
GR3024485T3 (en)	1997-11-28
IE920677A1 (en)	1992-09-09
EP0502668A1 (de)	1992-09-09
EP0579614A1 (de)	1994-01-26
JPH06508102A (ja)	1994-09-14
CA2051356A1 (en)	1992-09-06
DK0579614T3 (da)	1997-12-15
IL101139A0 (en)	1992-11-15
AU1274392A (en)	1992-10-06
AU654700B2 (en)	1994-11-17
IL101139A (en)	1995-01-24
US5231100A (en)	1993-07-27
WO1992015583A1 (en)	1992-09-17
ZA921615B (en)	1992-11-25
NO933147D0 (no)	1993-09-03
DE69220048D1 (de)	1997-07-03
ES2103931T3 (es)	1997-10-01
GB2253396B (en)	1994-08-10
JP3176062B2 (ja)	2001-06-11
NO933147L (no)	1993-09-03
GB9204315D0 (en)	1992-04-08
GB9104548D0 (en)	1991-04-17
CA2051356C (en)	2002-01-08
DE69220048T2 (de)	1997-10-02
NO300175B1 (no)	1997-04-21

Legal Events

Date	Code	Title	Description
1997-12-15	UEP	Publication of translation of european patent specification
2009-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69220048D1 (de)	1997-07-03	Imidazoacridine und ihre antineoplastische anwendung
ATE132134T1 (de)	1996-01-15	Benzamide
ATE174899T1 (de)	1999-01-15	Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
NO904377D0 (no)	1990-10-10	Tricykliske karbapenemforbindelser.
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
DE69428142D1 (de)	2001-10-11	Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
DK0503537T3 (da)	1997-12-15	6,9-bis(substitueret amino)benzo(g)isoquinolin-5,10-dioner
NO961077D0 (no)	1996-03-15	Substituerte benzoltienylpiperaziner, deres anvendelse som medikamenter og fremgangsmåter for fremstilling
IT1213301B (it)	1989-12-20	Composizioni per il trattamento del le sindromi da ischemia e riperfusione
PH31171A (en)	1998-03-20	Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.
FI954213A0 (fi)	1995-09-08	Kasvainten vastaisia koostumuksia ja hoitomenetelmiä
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
FI903511A0 (fi)	1990-07-11	Pyrrolo (2,1-b) tiazolderivat.
DK1264836T3 (da)	2005-03-07	Fremgangsmåde til fremstilling af indolopyrrolocarbaxolderivater