ATE132870T1 - Pyrrolo(2,1-b)thiazol-derivate - Google Patents

Pyrrolo(2,1-b)thiazol-derivate

Info

Publication number: ATE132870T1
Authority: AT; Austria
Prior art keywords: group; substituents; alkyl group; moiety; aryl group
Prior art date: 1989-06-13

Application number

AT90113378T

Other languages

English (en)

Inventor

Norio Suzuki

-Chome Kitakasai

Atsushi Nakayama

Toru Hosokami

Masashi Hasegawa

Shuichi Yokohama

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-13

Filing date

1990-07-12

Publication date

1996-01-15

1990-07-12 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132870T1 publication Critical patent/ATE132870T1/de

Links

MOVFAUAADQBPRE-UHFFFAOYSA-N pyrrolo[2,1-b][1,3]thiazole Chemical class S1C=CN2C=CC=C21 MOVFAUAADQBPRE-UHFFFAOYSA-N 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Hematology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Thiazole And Isothizaole Compounds (AREA)
Detergent Compositions (AREA)
Pyrrole Compounds (AREA)

AT90113378T 1989-06-13 1990-07-12 Pyrrolo(2,1-b)thiazol-derivate ATE132870T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15114189		1989-06-13

Publications (1)

Publication Number	Publication Date
ATE132870T1 true ATE132870T1 (de)	1996-01-15

Family

ID=15512262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90113378T ATE132870T1 (de)	1989-06-13	1990-07-12	Pyrrolo(2,1-b)thiazol-derivate

Country Status (23)

Country	Link
US (1)	US5098919A (de)
EP (1)	EP0410224B1 (de)
JP (1)	JP2875605B2 (de)
KR (1)	KR910002874A (de)
CN (1)	CN1025337C (de)
AT (1)	ATE132870T1 (de)
AU (1)	AU624724B2 (de)
CA (1)	CA2021135A1 (de)
DD (1)	DD296492A5 (de)
DE (1)	DE69024713T2 (de)
DK (1)	DK0410224T3 (de)
ES (1)	ES2084622T3 (de)
FI (1)	FI903511A7 (de)
GR (1)	GR3018798T3 (de)
HU (1)	HU207331B (de)
IE (1)	IE902545A1 (de)
IL (1)	IL95021A (de)
NO (1)	NO903084L (de)
NZ (1)	NZ234450A (de)
PT (1)	PT94688A (de)
RU (2)	RU1836374C (de)
YU (1)	YU136490A (de)
ZA (1)	ZA905407B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0891978T3 (da) *	1997-07-18	2002-07-01	Hoffmann La Roche	5H-Thiazol(3,2-a)pyrimidinderivativer
US20050244892A1 (en) *	2004-02-27	2005-11-03	Lazar Mitchell A	Resistin as a marker and therapeutic target for cardiovascular disease
CN107402307A (zh) *	2008-04-09	2017-11-28	B.R.A.H.M.S 有限公司	用于预测受损峰值耗氧量的内皮素1原

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4193926A (en) *	1974-03-20	1980-03-18	Schering Aktiengesellschaft	4-(Polyalkoxy phenyl)-2-pyrrolidones
US4347186A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein

1990
- 1990-07-10 IL IL9502190A patent/IL95021A/en not_active IP Right Cessation
- 1990-07-10 DD DD90342652A patent/DD296492A5/de not_active IP Right Cessation
- 1990-07-10 ZA ZA905407A patent/ZA905407B/xx unknown
- 1990-07-11 FI FI903511A patent/FI903511A7/fi not_active Application Discontinuation
- 1990-07-11 NO NO90903084A patent/NO903084L/no unknown
- 1990-07-11 AU AU58904/90A patent/AU624724B2/en not_active Ceased
- 1990-07-11 KR KR1019900010442A patent/KR910002874A/ko not_active Ceased
- 1990-07-11 NZ NZ234450A patent/NZ234450A/xx unknown
- 1990-07-12 DK DK90113378.5T patent/DK0410224T3/da active
- 1990-07-12 RU SU904830592A patent/RU1836374C/ru active
- 1990-07-12 DE DE69024713T patent/DE69024713T2/de not_active Expired - Fee Related
- 1990-07-12 ES ES90113378T patent/ES2084622T3/es not_active Expired - Lifetime
- 1990-07-12 PT PT94688A patent/PT94688A/pt not_active Application Discontinuation
- 1990-07-12 IE IE254590A patent/IE902545A1/en unknown
- 1990-07-12 AT AT90113378T patent/ATE132870T1/de not_active IP Right Cessation
- 1990-07-12 YU YU136490A patent/YU136490A/sh unknown
- 1990-07-12 EP EP90113378A patent/EP0410224B1/de not_active Expired - Lifetime
- 1990-07-13 CA CA002021135A patent/CA2021135A1/en not_active Abandoned
- 1990-07-13 US US07/552,031 patent/US5098919A/en not_active Expired - Fee Related
- 1990-07-13 CN CN90107066A patent/CN1025337C/zh not_active Expired - Fee Related
- 1990-07-13 JP JP2186896A patent/JP2875605B2/ja not_active Expired - Fee Related
- 1990-07-13 HU HU904214A patent/HU207331B/hu not_active IP Right Cessation
1991
- 1991-08-22 RU SU915001347A patent/RU2026288C1/ru active
1996
- 1996-01-25 GR GR960400186T patent/GR3018798T3/el unknown

Also Published As

Publication number	Publication date
IE902545A1 (en)	1991-02-27
CN1049350A (zh)	1991-02-20
CN1025337C (zh)	1994-07-06
EP0410224A1 (de)	1991-01-30
AU624724B2 (en)	1992-06-18
HUT57221A (en)	1991-11-28
EP0410224B1 (de)	1996-01-10
DE69024713T2 (de)	1996-06-13
US5098919A (en)	1992-03-24
HU207331B (en)	1993-03-29
GR3018798T3 (en)	1996-04-30
FI903511A0 (fi)	1990-07-11
FI903511A7 (fi)	1991-01-14
RU1836374C (ru)	1993-08-23
AU5890490A (en)	1991-01-17
IL95021A0 (en)	1991-06-10
DD296492A5 (de)	1991-12-05
RU2026288C1 (ru)	1995-01-09
JPH03128385A (ja)	1991-05-31
DE69024713D1 (de)	1996-02-22
JP2875605B2 (ja)	1999-03-31
HU904214D0 (en)	1990-12-28
YU136490A (sh)	1992-09-07
DK0410224T3 (da)	1996-02-05
NZ234450A (en)	1991-10-25
KR910002874A (ko)	1991-02-26
ES2084622T3 (es)	1996-05-16
CA2021135A1 (en)	1991-01-14
NO903084D0 (no)	1990-07-11
NO903084L (no)	1991-01-14
PT94688A (pt)	1991-03-20
ZA905407B (en)	1991-04-24
IL95021A (en)	1994-06-24

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
1998-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO905572L (no)	1991-06-24	Fremgangsmaate for fremstilling av peptidforbindelser.
DE10199003I1 (de)	2003-06-12	Substituierte Thiazolidinionderivate
FI882081A0 (fi)	1988-05-04	2-substituerade e-fusionerade (1,2,4) triazolo(1,5-c) pyrimidiner, farmaceutiska kompositioner och deras anvaendning.
DE68925223D1 (de)	1996-02-08	3-Alkenyl-1-azabicyclo(3.2.0)hept-2-en-2-carbonsäure-Verbindungen
ES474215A1 (es)	1979-04-01	Procedimiento para la preparacion de derivados imidazolile- tiloxialcoxilicos y sus analogos con agrupacion tio
FR2669927B1 (fr)	1994-04-08	Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE68917357D1 (de)	1994-09-15	Derivate der Coffeinsäure und pharmazeutische Zusammensetzungen, die sie enthalten.
DK183789D0 (da)	1989-04-17	2-alkyl-3-benzoylbenzofuraner og laegemidler indeholdende disse
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
IL85768A (en)	1993-02-21	Benzoxazine derivatives, their preparation and pharmaceutical compositions containing them
AU624724B2 (en)	1992-06-18	Pyrrolo(2,1-b)thiazole derivatives
IL75987A0 (en)	1985-12-31	1,6-naphthyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3787844D1 (de)	1993-11-25	Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
NO905245D0 (no)	1990-12-04	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
EP0726269A4 (de)	1997-01-22	Quinolincarbonsäurederivat une seine salze
NZ240272A (en)	1992-10-28	Piperazine derivatives; pharmaceutical compositions and preparatory processes
NO177962C (no)	1995-12-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-oxa-2-oxo-8-azaspiro[4,5Ådecan-derivater
TH9830A (th)	1991-11-01	อนุพันธ์ต่างๆ ของพิร์โรโล (2, 1 - b) ไธอะโซล
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use
ATE1585T1 (de)	1982-10-15	Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische praeparate.