ATE156127T1 - Verfahren zur herstellung von trans-6-(2- (substituierte-pyrrol-1-yl)alkyl>pyran-2-one verwendbar als inhibitoren der cholesterol- synthese - Google Patents

Verfahren zur herstellung von trans-6-(2- (substituierte-pyrrol-1-yl)alkyl>pyran-2-one verwendbar als inhibitoren der cholesterol- synthese

Info

Publication number
ATE156127T1
ATE156127T1 AT94910200T AT94910200T ATE156127T1 AT E156127 T1 ATE156127 T1 AT E156127T1 AT 94910200 T AT94910200 T AT 94910200T AT 94910200 T AT94910200 T AT 94910200T AT E156127 T1 ATE156127 T1 AT E156127T1
Authority
AT
Austria
Prior art keywords
pyran
substituted
alkyl
pyrrol
inhibitors
Prior art date
Application number
AT94910200T
Other languages
English (en)
Inventor
Donald Eugene Butler
Tung Van Le
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE156127T1 publication Critical patent/ATE156127T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94910200T 1993-03-03 1994-02-24 Verfahren zur herstellung von trans-6-(2- (substituierte-pyrrol-1-yl)alkyl>pyran-2-one verwendbar als inhibitoren der cholesterol- synthese ATE156127T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/025,701 US5298627A (en) 1993-03-03 1993-03-03 Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (1)

Publication Number Publication Date
ATE156127T1 true ATE156127T1 (de) 1997-08-15

Family

ID=21827596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94910200T ATE156127T1 (de) 1993-03-03 1994-02-24 Verfahren zur herstellung von trans-6-(2- (substituierte-pyrrol-1-yl)alkyl>pyran-2-one verwendbar als inhibitoren der cholesterol- synthese

Country Status (19)

Country Link
US (8) US5298627A (de)
EP (1) EP0687263B1 (de)
JP (1) JP3510253B2 (de)
KR (1) KR100302431B1 (de)
AT (1) ATE156127T1 (de)
AU (1) AU677047B2 (de)
CA (1) CA2155952C (de)
CZ (4) CZ284365B6 (de)
DE (1) DE69404632T2 (de)
DK (1) DK0687263T3 (de)
ES (1) ES2108435T3 (de)
FI (3) FI109999B (de)
GR (1) GR3024784T3 (de)
HU (1) HU222177B1 (de)
NO (3) NO308529B1 (de)
NZ (1) NZ262830A (de)
RU (1) RU2138497C1 (de)
SK (4) SK281983B6 (de)
WO (1) WO1994020492A1 (de)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
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