DK0687263T3 - Fremgangsmåde til fremstilling af trans-6-(2-(substitueret pyrrol-1-yl)-alkyl)-pyran-2-on-inhibitorer af cholesterolsyntese - Google Patents

Fremgangsmåde til fremstilling af trans-6-(2-(substitueret pyrrol-1-yl)-alkyl)-pyran-2-on-inhibitorer af cholesterolsyntese

Info

Publication number
DK0687263T3
DK0687263T3 DK94910200.8T DK94910200T DK0687263T3 DK 0687263 T3 DK0687263 T3 DK 0687263T3 DK 94910200 T DK94910200 T DK 94910200T DK 0687263 T3 DK0687263 T3 DK 0687263T3
Authority
DK
Denmark
Prior art keywords
pyran
trans
alkyl
preparation
inhibitors
Prior art date
Application number
DK94910200.8T
Other languages
Danish (da)
English (en)
Inventor
Donald Eugene Butler
Tung Van Le
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0687263T3 publication Critical patent/DK0687263T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94910200.8T 1993-03-03 1994-02-24 Fremgangsmåde til fremstilling af trans-6-(2-(substitueret pyrrol-1-yl)-alkyl)-pyran-2-on-inhibitorer af cholesterolsyntese DK0687263T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/025,701 US5298627A (en) 1993-03-03 1993-03-03 Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (1)

Publication Number Publication Date
DK0687263T3 true DK0687263T3 (da) 1998-02-16

Family

ID=21827596

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94910200.8T DK0687263T3 (da) 1993-03-03 1994-02-24 Fremgangsmåde til fremstilling af trans-6-(2-(substitueret pyrrol-1-yl)-alkyl)-pyran-2-on-inhibitorer af cholesterolsyntese

Country Status (19)

Country Link
US (8) US5298627A (de)
EP (1) EP0687263B1 (de)
JP (1) JP3510253B2 (de)
KR (1) KR100302431B1 (de)
AT (1) ATE156127T1 (de)
AU (1) AU677047B2 (de)
CA (1) CA2155952C (de)
CZ (4) CZ284365B6 (de)
DE (1) DE69404632T2 (de)
DK (1) DK0687263T3 (de)
ES (1) ES2108435T3 (de)
FI (3) FI109999B (de)
GR (1) GR3024784T3 (de)
HU (1) HU222177B1 (de)
NO (3) NO308529B1 (de)
NZ (1) NZ262830A (de)
RU (1) RU2138497C1 (de)
SK (4) SK281983B6 (de)
WO (1) WO1994020492A1 (de)

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* Cited by examiner, † Cited by third party
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