DK10189D0 - Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer - Google Patents

Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer

Info

Publication number: DK10189D0
Authority: DK; Denmark
Prior art keywords: oxidized; guanidine hydrochloride; renated; oxidated; interleukin
Prior art date: 1987-05-11

Application number

DK010189A

Other languages

English (en)

Other versions

DK10189A (da

Inventor

Sidney N Wolfe

Amy Lim

Glenn Dorin

Flint Smith

John T Davis

Original Assignee

Cetus Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-11

Filing date

1989-01-11

Publication date

1989-01-11

1989-01-11 Application filed by Cetus Corp filed Critical Cetus Corp

1989-01-11 Publication of DK10189A publication Critical patent/DK10189A/da

1989-01-11 Publication of DK10189D0 publication Critical patent/DK10189D0/da

Links

108010002350 Interleukin-2 Proteins 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 2
244000005700 microbiome Species 0.000 title abstract 2
102000000588 Interleukin-2 Human genes 0.000 title 1
238000011084 recovery Methods 0.000 title 1
229960000789 guanidine hydrochloride Drugs 0.000 abstract 3
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 abstract 3
238000004255 ion exchange chromatography Methods 0.000 abstract 2
239000003638 chemical reducing agent Substances 0.000 abstract 1
238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK010189A 1987-05-11 1989-01-11 Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer DK10189D0 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4840887A	1987-05-11	1987-05-11
US16714488A	1988-03-25	1988-03-25
PCT/US1988/001043 WO1988008849A1 (en)	1987-05-11	1988-03-31	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms

Publications (2)

Publication Number	Publication Date
DK10189A DK10189A (da)	1989-01-11
DK10189D0 true DK10189D0 (da)	1989-01-11

Family

ID=26726091

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK010189A DK10189D0 (da)	1987-05-11	1989-01-11	Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer

Country Status (9)

Country	Link
EP (1)	EP0368857B1 (da)
JP (1)	JP2955294B2 (da)
AT (1)	ATE156491T1 (da)
AU (1)	AU622860B2 (da)
DE (1)	DE3855986T2 (da)
DK (1)	DK10189D0 (da)
IL (1)	IL86326A (da)
NO (1)	NO176797C (da)
WO (1)	WO1988008849A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4929700A (en) *	1987-04-16	1990-05-29	Cetus Corporation	Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1339757C (en) *	1987-04-16	1998-03-17	Robert F. Halenbeck	Production of purified biologically active, bacterially produced recombinant human csf-1
US4931543A (en) *	1987-05-11	1990-06-05	Cetus Corporation	Process for recovering microbially produced interleukin-2
EP0337243A1 (en) *	1988-04-14	1989-10-18	F. Hoffmann-La Roche Ag	Process for purifying recombinant human interleukin-2
DK580789D0 (da) *	1989-11-20	1989-11-20	Novo Nordisk As	Fremgangsmaade til oprensning af polypeptider
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5258496A (en) *	1990-07-10	1993-11-02	Scios Nova Inc.	Isolation and purification of lung surfactant protein
CA2077906A1 (en) *	1991-01-10	1992-07-11	Kimihiko Matsuzawa	Method for measurement of tissue factor in high sensitivity and measurement kit therefor
US5288931A (en) *	1991-12-06	1994-02-22	Genentech, Inc.	Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
WO1995004823A1 (en) *	1993-08-04	1995-02-16	Ciba-Geigy Ag	High molecular weight desulphatohirudin
US5663304A (en) *	1993-08-20	1997-09-02	Genentech, Inc.	Refolding of misfolded insulin-like growth factor-I
TW517059B (en)	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
JPH11509551A (ja) *	1995-07-21	1999-08-24	アムジエン・インコーポレーテツド	蛋白質を塩から分離することのできる連続静止相を用いてバッファー交換により蛋白質を巻き戻す方法
WO2003097669A2 (en) *	2002-05-17	2003-11-27	Københavns Universitet	Method for purifying denatured proteins having a desired disulfide bond configuration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR79124B (da) *	1982-12-22	1984-10-02	Genentech Inc
US4530787A (en) *	1984-03-28	1985-07-23	Cetus Corporation	Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) *	1984-03-28	1986-02-11	Cetus Corporation	Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4572798A (en) *	1984-12-06	1986-02-25	Cetus Corporation	Method for promoting disulfide bond formation in recombinant proteins
JPH0640832B2 (ja) *	1985-05-10	1994-06-01	味の素株式会社	インタ−ロイキン２ポリペプチドの回収方法
US4748234A (en) *	1985-06-26	1988-05-31	Cetus Corporation	Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4656255A (en) *	1985-09-09	1987-04-07	International Minerals & Chemical Corp.	Protein recovery
US4801686A (en) *	1986-09-04	1989-01-31	Immunex Corporation	Purification of recombinant interleukin-1
US4931543A (en) *	1987-05-11	1990-06-05	Cetus Corporation	Process for recovering microbially produced interleukin-2

1988
- 1988-03-31 AT AT88903676T patent/ATE156491T1/de not_active IP Right Cessation
- 1988-03-31 EP EP88903676A patent/EP0368857B1/en not_active Expired - Lifetime
- 1988-03-31 DE DE3855986T patent/DE3855986T2/de not_active Expired - Lifetime
- 1988-03-31 WO PCT/US1988/001043 patent/WO1988008849A1/en not_active Ceased
- 1988-03-31 AU AU16279/88A patent/AU622860B2/en not_active Expired
- 1988-03-31 JP JP63503562A patent/JP2955294B2/ja not_active Expired - Lifetime
- 1988-05-10 IL IL8632688A patent/IL86326A/xx not_active IP Right Cessation
- 1988-12-21 NO NO885678A patent/NO176797C/no not_active IP Right Cessation
1989
- 1989-01-11 DK DK010189A patent/DK10189D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU1627988A (en)	1988-12-06
EP0368857A1 (en)	1990-05-23
IL86326A (en)	1997-02-18
DK10189A (da)	1989-01-11
DE3855986T2 (de)	1998-02-05
IL86326A0 (en)	1988-11-15
WO1988008849A1 (en)	1988-11-17
ATE156491T1 (de)	1997-08-15
AU622860B2 (en)	1992-04-30
EP0368857B1 (en)	1997-08-06
NO885678D0 (no)	1988-12-21
NO176797C (no)	1995-05-31
NO885678L (no)	1988-12-21
DE3855986D1 (de)	1997-09-11
NO176797B (no)	1995-02-20
JPH02503384A (ja)	1990-10-18
JP2955294B2 (ja)	1999-10-04

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Legal Events

Date	Code	Title	Description
2001-06-05	AHS	Application shelved for other reasons than non-payment