ATE156860T1 - Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren - Google Patents
Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitorenInfo
- Publication number
- ATE156860T1 ATE156860T1 AT93915370T AT93915370T ATE156860T1 AT E156860 T1 ATE156860 T1 AT E156860T1 AT 93915370 T AT93915370 T AT 93915370T AT 93915370 T AT93915370 T AT 93915370T AT E156860 T1 ATE156860 T1 AT E156860T1
- Authority
- AT
- Austria
- Prior art keywords
- gaba
- inhibitors
- mixture
- razemic
- stereo
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000707 stereoselective effect Effects 0.000 title abstract 2
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 title 1
- 101710115046 4-aminobutyrate aminotransferase, mitochondrial Proteins 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
- 108010073038 Penicillin Amidase Proteins 0.000 abstract 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
- 102000003929 Transaminases Human genes 0.000 abstract 1
- 108090000340 Transaminases Proteins 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/915,446 US5316944A (en) | 1992-07-17 | 1992-07-17 | Enzymatic resolution of a racemic mixture of gamma-amino acids using penicillin acylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE156860T1 true ATE156860T1 (de) | 1997-08-15 |
Family
ID=25435755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93915370T ATE156860T1 (de) | 1992-07-17 | 1993-06-15 | Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5316944A (de) |
| EP (1) | EP0651821B1 (de) |
| JP (1) | JP3213717B2 (de) |
| KR (1) | KR100250100B1 (de) |
| AT (1) | ATE156860T1 (de) |
| AU (1) | AU662998B2 (de) |
| CA (1) | CA2136840C (de) |
| DE (1) | DE69313118T2 (de) |
| DK (1) | DK0651821T3 (de) |
| ES (1) | ES2106355T3 (de) |
| FI (1) | FI106266B (de) |
| GR (1) | GR3024491T3 (de) |
| HU (1) | HU216309B (de) |
| NO (1) | NO318758B1 (de) |
| NZ (1) | NZ253926A (de) |
| WO (1) | WO1994002628A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2287171A1 (en) | 1997-05-01 | 1998-11-12 | G.D. Searle & Co. | Method and apparatus for preparation of chiral beta amino acids |
| NL1009814C2 (nl) * | 1998-08-06 | 2000-02-08 | Dsm Nv | Werkwijze voor de bereiding van een N-geacyleerd aminonitril. |
| AU2001294378A1 (en) * | 2000-09-08 | 2002-03-22 | Dsm N.V. | Process for the preparation of enantiomerically enriched amines |
| EP1315827A1 (de) | 2000-09-08 | 2003-06-04 | Dsm N.V. | Verfahren zur herstellung von angereicherten enantiomen aminen |
| FR2853315B1 (fr) * | 2003-04-04 | 2006-07-07 | Solvay | Procede pour la fabrication de derives d'aminoacides |
| WO2014060925A2 (en) * | 2012-10-15 | 2014-04-24 | Mahesh Kandula | Compositions and methods for the treatment of neurological and neurodegenerative diseases |
| CN105777586A (zh) * | 2016-04-14 | 2016-07-20 | 安徽省逸欣铭医药科技有限公司 | S（+）氨己烯酸酯衍生物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2120244B (en) * | 1982-05-17 | 1985-05-01 | Merrell Toraude & Co | Aminoalkadiene derivative |
| DE3247764A1 (de) * | 1982-12-23 | 1984-06-28 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Fotografische kamera |
| GB2133002B (en) * | 1982-12-30 | 1986-01-29 | Merrell Toraude & Co | Process for preparing 4-amino-5-hexenoic acid |
| US4636470A (en) * | 1984-08-17 | 1987-01-13 | Stauffer Chemical Company | Resolution of racemates of amino acids |
-
1992
- 1992-07-17 US US07/915,446 patent/US5316944A/en not_active Expired - Lifetime
-
1993
- 1993-06-15 CA CA002136840A patent/CA2136840C/en not_active Expired - Lifetime
- 1993-06-15 EP EP93915370A patent/EP0651821B1/de not_active Expired - Lifetime
- 1993-06-15 JP JP50445294A patent/JP3213717B2/ja not_active Expired - Lifetime
- 1993-06-15 KR KR1019950700170A patent/KR100250100B1/ko not_active Expired - Lifetime
- 1993-06-15 DE DE69313118T patent/DE69313118T2/de not_active Expired - Lifetime
- 1993-06-15 ES ES93915370T patent/ES2106355T3/es not_active Expired - Lifetime
- 1993-06-15 DK DK93915370.6T patent/DK0651821T3/da active
- 1993-06-15 HU HU9500129A patent/HU216309B/hu unknown
- 1993-06-15 AU AU45377/93A patent/AU662998B2/en not_active Expired
- 1993-06-15 NZ NZ253926A patent/NZ253926A/en not_active IP Right Cessation
- 1993-06-15 AT AT93915370T patent/ATE156860T1/de active
- 1993-06-15 WO PCT/US1993/005737 patent/WO1994002628A1/en not_active Ceased
-
1995
- 1995-01-13 FI FI950155A patent/FI106266B/fi not_active IP Right Cessation
- 1995-01-16 NO NO19950157A patent/NO318758B1/no not_active IP Right Cessation
-
1997
- 1997-08-21 GR GR970402130T patent/GR3024491T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994002628A1 (en) | 1994-02-03 |
| DE69313118T2 (de) | 1997-12-11 |
| FI106266B (fi) | 2000-12-29 |
| CA2136840A1 (en) | 1994-02-03 |
| NZ253926A (en) | 1996-10-28 |
| KR100250100B1 (ko) | 2000-03-15 |
| HU9500129D0 (en) | 1995-05-29 |
| AU662998B2 (en) | 1995-09-21 |
| HUT70466A (en) | 1995-10-30 |
| US5316944A (en) | 1994-05-31 |
| NO950157D0 (no) | 1995-01-16 |
| HU216309B (hu) | 1999-06-28 |
| GR3024491T3 (en) | 1997-11-28 |
| JPH07509132A (ja) | 1995-10-12 |
| JP3213717B2 (ja) | 2001-10-02 |
| KR950702638A (ko) | 1995-07-29 |
| DE69313118D1 (de) | 1997-09-18 |
| ES2106355T3 (es) | 1997-11-01 |
| FI950155A0 (fi) | 1995-01-13 |
| AU4537793A (en) | 1994-02-14 |
| FI950155L (fi) | 1995-01-13 |
| EP0651821A1 (de) | 1995-05-10 |
| DK0651821T3 (da) | 1997-09-01 |
| NO950157L (no) | 1995-01-16 |
| EP0651821B1 (de) | 1997-08-13 |
| NO318758B1 (no) | 2005-05-02 |
| CA2136840C (en) | 1997-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner |