DK0651821T3 - Enzymatisk resolvering af en racemisk blanding af stereospecifikke GABA-T-inhibitorer. - Google Patents

Enzymatisk resolvering af en racemisk blanding af stereospecifikke GABA-T-inhibitorer.

Info

Publication number: DK0651821T3
Authority: DK; Denmark
Prior art keywords: gaba; stereospecific; racemic mixture; inhibitors; gamma
Prior art date: 1992-07-17

Application number

DK93915370.6T

Other languages

English (en)

Inventor

Alexey L Margolin

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-17

Filing date

1993-06-15

Publication date

1997-09-01

1993-06-15 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-09-01 Application granted granted Critical

1997-09-01 Publication of DK0651821T3 publication Critical patent/DK0651821T3/da

Links

230000002255 enzymatic effect Effects 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
230000000707 stereoselective effect Effects 0.000 title abstract 2
102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 title 1
101710115046 4-aminobutyrate aminotransferase, mitochondrial Proteins 0.000 title 1
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
108010073038 Penicillin Amidase Proteins 0.000 abstract 2
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
102000003929 Transaminases Human genes 0.000 abstract 1
108090000340 Transaminases Proteins 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK93915370.6T 1992-07-17 1993-06-15 Enzymatisk resolvering af en racemisk blanding af stereospecifikke GABA-T-inhibitorer. DK0651821T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/915,446 US5316944A (en)	1992-07-17	1992-07-17	Enzymatic resolution of a racemic mixture of gamma-amino acids using penicillin acylase

Publications (1)

Publication Number	Publication Date
DK0651821T3 true DK0651821T3 (da)	1997-09-01

Family

ID=25435755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93915370.6T DK0651821T3 (da)	1992-07-17	1993-06-15	Enzymatisk resolvering af en racemisk blanding af stereospecifikke GABA-T-inhibitorer.

Country Status (16)

Country	Link
US (1)	US5316944A (da)
EP (1)	EP0651821B1 (da)
JP (1)	JP3213717B2 (da)
KR (1)	KR100250100B1 (da)
AT (1)	ATE156860T1 (da)
AU (1)	AU662998B2 (da)
CA (1)	CA2136840C (da)
DE (1)	DE69313118T2 (da)
DK (1)	DK0651821T3 (da)
ES (1)	ES2106355T3 (da)
FI (1)	FI106266B (da)
GR (1)	GR3024491T3 (da)
HU (1)	HU216309B (da)
NO (1)	NO318758B1 (da)
NZ (1)	NZ253926A (da)
WO (1)	WO1994002628A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2287171A1 (en)	1997-05-01	1998-11-12	G.D. Searle & Co.	Method and apparatus for preparation of chiral beta amino acids
NL1009814C2 (nl) *	1998-08-06	2000-02-08	Dsm Nv	Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
AU2001294378A1 (en) *	2000-09-08	2002-03-22	Dsm N.V.	Process for the preparation of enantiomerically enriched amines
EP1315827A1 (en)	2000-09-08	2003-06-04	Dsm N.V.	Method for the preparation of enantiomerically enriched amines
FR2853315B1 (fr) *	2003-04-04	2006-07-07	Solvay	Procede pour la fabrication de derives d'aminoacides
WO2014060925A2 (en) *	2012-10-15	2014-04-24	Mahesh Kandula	Compositions and methods for the treatment of neurological and neurodegenerative diseases
CN105777586A (zh) *	2016-04-14	2016-07-20	安徽省逸欣铭医药科技有限公司	S（+）氨己烯酸酯衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2120244B (en) *	1982-05-17	1985-05-01	Merrell Toraude & Co	Aminoalkadiene derivative
DE3247764A1 (de) *	1982-12-23	1984-06-28	Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar	Fotografische kamera
GB2133002B (en) *	1982-12-30	1986-01-29	Merrell Toraude & Co	Process for preparing 4-amino-5-hexenoic acid
US4636470A (en) *	1984-08-17	1987-01-13	Stauffer Chemical Company	Resolution of racemates of amino acids

1992
- 1992-07-17 US US07/915,446 patent/US5316944A/en not_active Expired - Lifetime
1993
- 1993-06-15 CA CA002136840A patent/CA2136840C/en not_active Expired - Lifetime
- 1993-06-15 EP EP93915370A patent/EP0651821B1/en not_active Expired - Lifetime
- 1993-06-15 JP JP50445294A patent/JP3213717B2/ja not_active Expired - Lifetime
- 1993-06-15 KR KR1019950700170A patent/KR100250100B1/ko not_active Expired - Lifetime
- 1993-06-15 DE DE69313118T patent/DE69313118T2/de not_active Expired - Lifetime
- 1993-06-15 ES ES93915370T patent/ES2106355T3/es not_active Expired - Lifetime
- 1993-06-15 DK DK93915370.6T patent/DK0651821T3/da active
- 1993-06-15 HU HU9500129A patent/HU216309B/hu unknown
- 1993-06-15 AU AU45377/93A patent/AU662998B2/en not_active Expired
- 1993-06-15 NZ NZ253926A patent/NZ253926A/en not_active IP Right Cessation
- 1993-06-15 AT AT93915370T patent/ATE156860T1/de active
- 1993-06-15 WO PCT/US1993/005737 patent/WO1994002628A1/en not_active Ceased
1995
- 1995-01-13 FI FI950155A patent/FI106266B/fi not_active IP Right Cessation
- 1995-01-16 NO NO19950157A patent/NO318758B1/no not_active IP Right Cessation
1997
- 1997-08-21 GR GR970402130T patent/GR3024491T3/el unknown

Also Published As

Publication number	Publication date
WO1994002628A1 (en)	1994-02-03
DE69313118T2 (de)	1997-12-11
FI106266B (fi)	2000-12-29
CA2136840A1 (en)	1994-02-03
NZ253926A (en)	1996-10-28
KR100250100B1 (ko)	2000-03-15
HU9500129D0 (en)	1995-05-29
AU662998B2 (en)	1995-09-21
HUT70466A (en)	1995-10-30
US5316944A (en)	1994-05-31
NO950157D0 (no)	1995-01-16
HU216309B (hu)	1999-06-28
GR3024491T3 (en)	1997-11-28
JPH07509132A (ja)	1995-10-12
JP3213717B2 (ja)	2001-10-02
KR950702638A (ko)	1995-07-29
DE69313118D1 (de)	1997-09-18
ES2106355T3 (es)	1997-11-01
FI950155A0 (fi)	1995-01-13
AU4537793A (en)	1994-02-14
FI950155L (fi)	1995-01-13
EP0651821A1 (en)	1995-05-10
ATE156860T1 (de)	1997-08-15
NO950157L (no)	1995-01-16
EP0651821B1 (en)	1997-08-13
NO318758B1 (no)	2005-05-02
CA2136840C (en)	1997-01-14

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MX9803377A (es)	1998-11-30	Metodo de transmision de informacion y aparato de codificiacion/descodificacion y aparato de codificicacion-multiplexion/descodificacion-desmultiplexion en sistema de transmision de informacion al cual se aplica el metodo de transmision de informacio
DK0870051T3 (da)	2002-02-25	Fremstilling af ammoniumacrylat
DK0651821T3 (da)	1997-09-01	Enzymatisk resolvering af en racemisk blanding af stereospecifikke GABA-T-inhibitorer.
DK166986D0 (da)	1986-04-11	Fremgangsmaade til racemisering af et optisk aktivt n-benzylidenamimosyreamid
NZ503169A (en)	2001-12-21	Synthesis of clasto-lactacystin beta-lactone whereupon the process relies upon a stereoselective addition of a formyl amide to an oxazoline
DK0904348T3 (da)	2005-02-14	Fremgangsmåde til fremstilling af aminoalkoholer og derivater deraf
NO990155D0 (no)	1999-01-14	Biooppl°sning av N-acylazetidin-2-karboksylsyrer
GB1527346A (en)	1978-10-04	Method for the determination of enzyme activities
ES8406415A1 (es)	1984-08-16	Procedimiento analogo para preparar acido (r,s)-5-amino-hepta-5,6-dienoico,acido (s)-4-amino-hepta-5,6-dienoico o sus sales farmaceuticamente aceptables.
RU94015601A (ru)	1996-07-10	Способ получения энантиомеров арилалкановых кислот
AU8388891A (en)	1992-01-23	Acaricidal agents based on azomethines of 2,3-diaminomaleic acid nitrile
GR3026123T3 (en)	1998-05-29	Novel processes for preparing (s)-4-amino-hepta-5,6-dienoic acid and intermediates thereof
HUP0101025A1 (hu)	2001-08-28	1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formája
CA2332931A1 (en)	2000-01-20	The treatment of renal colic with gaba analogs
ES2019166A6 (es)	1991-06-01	Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos.