ES2106355T3 - Resolucion enzimatica de una mezcla racemica de inhibidores gaba-t estereoespecificos. - Google Patents

Resolucion enzimatica de una mezcla racemica de inhibidores gaba-t estereoespecificos.

Info

Publication number
ES2106355T3
ES2106355T3 ES93915370T ES93915370T ES2106355T3 ES 2106355 T3 ES2106355 T3 ES 2106355T3 ES 93915370 T ES93915370 T ES 93915370T ES 93915370 T ES93915370 T ES 93915370T ES 2106355 T3 ES2106355 T3 ES 2106355T3
Authority
ES
Spain
Prior art keywords
gaba
inhibitors
stereo
gamma
racemic mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93915370T
Other languages
English (en)
Inventor
Alexey L Margolin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2106355T3 publication Critical patent/ES2106355T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION ES RELATIVA A LA RESOLUCION ENZIMATICA DE UNA MEZCLA RACEMICA DE INHIBIDORES ESTEREOESPECIFICOS DE TRANSAMINASA DE ACIDO GAMMA-AMINOBUTIRICO (GABA-T), USADOS FARMACEUTICAMENTE EN VIVO, ESPECIFICAMENTE GABA GAMMA-ETINILO, GABA GAMMA-VINILO Y GABA GAMMA-ALENILO QUE USA ACILASA DE PENICILINA (PA).
ES93915370T 1992-07-17 1993-06-15 Resolucion enzimatica de una mezcla racemica de inhibidores gaba-t estereoespecificos. Expired - Lifetime ES2106355T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/915,446 US5316944A (en) 1992-07-17 1992-07-17 Enzymatic resolution of a racemic mixture of gamma-amino acids using penicillin acylase

Publications (1)

Publication Number Publication Date
ES2106355T3 true ES2106355T3 (es) 1997-11-01

Family

ID=25435755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93915370T Expired - Lifetime ES2106355T3 (es) 1992-07-17 1993-06-15 Resolucion enzimatica de una mezcla racemica de inhibidores gaba-t estereoespecificos.

Country Status (16)

Country Link
US (1) US5316944A (es)
EP (1) EP0651821B1 (es)
JP (1) JP3213717B2 (es)
KR (1) KR100250100B1 (es)
AT (1) ATE156860T1 (es)
AU (1) AU662998B2 (es)
CA (1) CA2136840C (es)
DE (1) DE69313118T2 (es)
DK (1) DK0651821T3 (es)
ES (1) ES2106355T3 (es)
FI (1) FI106266B (es)
GR (1) GR3024491T3 (es)
HU (1) HU216309B (es)
NO (1) NO318758B1 (es)
NZ (1) NZ253926A (es)
WO (1) WO1994002628A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2287171A1 (en) 1997-05-01 1998-11-12 G.D. Searle & Co. Method and apparatus for preparation of chiral beta amino acids
NL1009814C2 (nl) * 1998-08-06 2000-02-08 Dsm Nv Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
AU2001294378A1 (en) * 2000-09-08 2002-03-22 Dsm N.V. Process for the preparation of enantiomerically enriched amines
EP1315827A1 (en) 2000-09-08 2003-06-04 Dsm N.V. Method for the preparation of enantiomerically enriched amines
FR2853315B1 (fr) * 2003-04-04 2006-07-07 Solvay Procede pour la fabrication de derives d'aminoacides
WO2014060925A2 (en) * 2012-10-15 2014-04-24 Mahesh Kandula Compositions and methods for the treatment of neurological and neurodegenerative diseases
CN105777586A (zh) * 2016-04-14 2016-07-20 安徽省逸欣铭医药科技有限公司 S（+）氨己烯酸酯衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2120244B (en) * 1982-05-17 1985-05-01 Merrell Toraude & Co Aminoalkadiene derivative
DE3247764A1 (de) * 1982-12-23 1984-06-28 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar Fotografische kamera
GB2133002B (en) * 1982-12-30 1986-01-29 Merrell Toraude & Co Process for preparing 4-amino-5-hexenoic acid
US4636470A (en) * 1984-08-17 1987-01-13 Stauffer Chemical Company Resolution of racemates of amino acids

Also Published As

Publication number Publication date
WO1994002628A1 (en) 1994-02-03
DE69313118T2 (de) 1997-12-11
FI106266B (fi) 2000-12-29
CA2136840A1 (en) 1994-02-03
NZ253926A (en) 1996-10-28
KR100250100B1 (ko) 2000-03-15
HU9500129D0 (en) 1995-05-29
AU662998B2 (en) 1995-09-21
HUT70466A (en) 1995-10-30
US5316944A (en) 1994-05-31
NO950157D0 (no) 1995-01-16
HU216309B (hu) 1999-06-28
GR3024491T3 (en) 1997-11-28
JPH07509132A (ja) 1995-10-12
JP3213717B2 (ja) 2001-10-02
KR950702638A (ko) 1995-07-29
DE69313118D1 (de) 1997-09-18
FI950155A0 (fi) 1995-01-13
AU4537793A (en) 1994-02-14
FI950155L (fi) 1995-01-13
EP0651821A1 (en) 1995-05-10
DK0651821T3 (da) 1997-09-01
ATE156860T1 (de) 1997-08-15
NO950157L (no) 1995-01-16
EP0651821B1 (en) 1997-08-13
NO318758B1 (no) 2005-05-02
CA2136840C (en) 1997-01-14

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