ATE157012T1 - Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen - Google Patents

Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen

Info

Publication number
ATE157012T1
ATE157012T1 AT90916560T AT90916560T ATE157012T1 AT E157012 T1 ATE157012 T1 AT E157012T1 AT 90916560 T AT90916560 T AT 90916560T AT 90916560 T AT90916560 T AT 90916560T AT E157012 T1 ATE157012 T1 AT E157012T1
Authority
AT
Austria
Prior art keywords
genetic material
cells
foreign genes
vivo administration
functional foreign
Prior art date
Application number
AT90916560T
Other languages
English (en)
Inventor
Kenneth L Brigham
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23712442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE157012(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Application granted granted Critical
Publication of ATE157012T1 publication Critical patent/ATE157012T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT90916560T 1989-11-03 1990-10-18 Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen ATE157012T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43155289A 1989-11-03 1989-11-03

Publications (1)

Publication Number Publication Date
ATE157012T1 true ATE157012T1 (de) 1997-09-15

Family

ID=23712442

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90916560T ATE157012T1 (de) 1989-11-03 1990-10-18 Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen

Country Status (8)

Country Link
EP (2) EP0452457B1 (de)
JP (1) JP3056782B2 (de)
AT (1) ATE157012T1 (de)
AU (1) AU625013B2 (de)
CA (1) CA2044593C (de)
DE (1) DE69031305T2 (de)
DK (1) DK0452457T3 (de)
WO (1) WO1991006309A1 (de)

Families Citing this family (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585254A (en) * 1987-08-21 1996-12-17 University Of Colorado Foundation, Inc. Autonomous parvovirus gene delivery vehicles and expression vectors
US7238673B2 (en) 1989-03-31 2007-07-03 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5698531A (en) 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5643567A (en) * 1990-12-04 1997-07-01 Board Of Regents, The University Of Texas System Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen
EP0625207A1 (de) * 1991-12-17 1994-11-23 The Regents Of The University Of California Gentherapie zur behandlung der regulatoraktivität der transmembranen leitfähigkeit bei der zytischen fibrose (cftr)
US6627615B1 (en) 1991-12-17 2003-09-30 The Regents Of The University Of California Methods and compositions for in vivo gene therapy
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
CA2134773A1 (en) * 1992-06-04 1993-12-09 Robert J. Debs Methods and compositions for in vivo gene therapy
US6806084B1 (en) 1992-06-04 2004-10-19 The Regents Of The University Of California Methods for compositions for in vivo gene delivery
US5821234A (en) * 1992-09-10 1998-10-13 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of proliferation of vascular smooth muscle cell
WO1994005782A1 (en) * 1992-09-10 1994-03-17 Trustees Of Tufts College In vivo production of transgenic organ by introducing the transgene via lumen
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US5645829A (en) * 1993-06-18 1997-07-08 Beth Israel Hospital Association Mesothelial cell gene therapy
US6197553B1 (en) 1994-07-15 2001-03-06 Merck & Co., Inc. Method for large scale plasmid purification
CA2192342A1 (en) * 1994-07-15 1996-02-01 Ann L. Lee A method for large scale plasmid purification
EA001616B1 (ru) 1995-02-28 2001-06-25 Зе Риджентс Оф Зи Юнивесити Оф Кэлифоньэ Способ лечения болезни сердца, способ лечения недостаточности периферических сосудов и способ ограничения доставки и экспрессии трансгенной конструкции в определенном органе или структуре
US6752987B1 (en) 1995-02-28 2004-06-22 The Regents Of The University Of California Adenovirus encoding human adenylylcyclase (AC) VI
US5885971A (en) * 1995-03-24 1999-03-23 The Regents Of The University Of California Gene therapy by secretory gland expression
US6531455B1 (en) 1995-03-24 2003-03-11 The Regents Of The University Of California Delivery of polynucleotides by secretory gland expression
AR003122A1 (es) * 1995-05-19 1998-07-08 Merck & Co Inc Un proceso para aislacion y purificacion de plasmidos en fermentadores de gran escala y el adn aislado y purificado obtenido mediante dicho proceso.
KR100725199B1 (ko) 1995-08-29 2007-08-16 안제스에무지 가부시키가이샤 에이치지에프유전자를함유하는약제
IL115199A (en) * 1995-09-07 2005-05-17 Opperbas Holding Bv Composition comprising a polynucleic acid molecule in a liposome and method using said composition
JP2765814B2 (ja) * 1995-11-24 1998-06-18 コナミ株式会社 ビデオゲーム装置及びビデオゲームのプレイキャラクタ成長制御方法
US5783566A (en) * 1996-05-10 1998-07-21 California Institute Of Technology Method for increasing or decreasing transfection efficiency
US6225290B1 (en) 1996-09-19 2001-05-01 The Regents Of The University Of California Systemic gene therapy by intestinal cell transformation
US7112338B2 (en) 1997-03-12 2006-09-26 The Regents Of The University Of California Cationic liposome delivery of taxanes to angiogenic blood vessels
US5837283A (en) 1997-03-12 1998-11-17 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells
CA2304983A1 (en) 1997-09-24 1999-04-01 The Regents Of The University Of California Non-primate lentiviral vectors and packaging systems
WO1999034806A1 (en) 1998-01-08 1999-07-15 The Regents Of The University Of California KINESIN MOTOR MODULATORS DERIVED FROM THE MARINE SPONGE $i(ADOCIA)
US6410328B1 (en) 1998-02-03 2002-06-25 Protiva Biotherapeutics Inc. Sensitizing cells to compounds using lipid-mediated gene and compound delivery
JP2002502831A (ja) 1998-02-03 2002-01-29 イネックス ファーマシューティカルズ コーポレイション 癌の治療に用いる血清に対して安定なプラスミド脂質粒子の全身供与
CA2330824A1 (en) 1998-06-17 1999-12-23 Epimmune Inc. Hla binding peptides and their uses
AU767066B2 (en) 1999-03-03 2003-10-30 Curis, Inc. Methods of modulating lipid metabolism and storage
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
EP1194449B1 (de) 1999-06-28 2010-09-22 Oklahoma Medical Research Foundation Inhibitoren des memapsin 2 und ihre verwendung
US6989374B1 (en) 1999-10-08 2006-01-24 Anges Mg, Inc. Gene therapy for cardiomyopathy
JP4776131B2 (ja) 1999-11-18 2011-09-21 エピミューン インコーポレイテッド ヘテロクリティックアナログおよび関連方法
EP1255822A2 (de) 1999-12-27 2002-11-13 The Regents Of The University Of California Modifizierte adenylylcyclase vom typ vi für gentheraphie bei congestiven herzkrankheiten
JP2003530838A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
CA2705366A1 (en) 2000-08-28 2002-03-07 Agensys, Inc. Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
WO2002077012A2 (en) 2001-03-23 2002-10-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Human papilloma virus immunoreative peptides
US7541512B2 (en) 2001-03-30 2009-06-02 Synageva Biopharma Corp. Avians containing a lysozyme promoter transgene
WO2002079447A2 (en) 2001-03-30 2002-10-10 Avigenics, Inc. Avian lysozyme promoter
US7176300B2 (en) 2001-03-30 2007-02-13 Avigenics, Inc. Avian lysozyme promoter
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
EP2280030A3 (de) 2001-04-10 2011-06-15 Agensys, Inc. Nukleinsäuren und zugehörige Proteine für die Behandlung und den Nachweis von Krebs
IL159756A0 (en) 2001-07-12 2004-06-20 Univ Massachusetts IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
EP1900815B1 (de) 2001-07-12 2016-09-07 University of Massachusetts In-vivo-Herstellung kleiner interferierender und Genverstummung vermittelnder RNAs
EP2287186B1 (de) 2001-09-06 2014-12-31 Agensys, Inc. Nucleinsäure und entsprechendes Protein, STEAP-1, bei der Behandlung und zum Nachweis von Krebs
US7745418B2 (en) 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
AU2003225791A1 (en) 2002-03-15 2003-09-29 Department Of Veterans Affairs, Rehabilitation R And D Service Methods and compositions for directing cells to target organs
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
CA2500715A1 (en) 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
JP2006508163A (ja) 2002-11-27 2006-03-09 アジェンシス， インコーポレイテッド 癌の処置および検出において有用な２４ｐ４ｃ１２と称される、核酸および対応タンパク質
EP1903056A3 (de) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon
EP1587923B1 (de) 2003-01-22 2011-08-24 Duke University Verbesserte konstrukte zur expression lysosomaler polypeptide
CA2860151A1 (en) 2003-02-10 2004-08-26 Agensys, Inc. Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
CA2526274C (en) 2003-05-30 2015-12-01 Agensys, Inc. Prostate stem cell antigen (psca) variants and subsequences thereof
ATE485394T1 (de) 2003-06-02 2010-11-15 Univ Massachusetts Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
US7459547B2 (en) 2003-06-02 2008-12-02 University Of Massachusetts Methods and compositions for controlling efficacy of RNA silencing
EP1633770B1 (de) 2003-06-13 2015-04-29 Alnylam Europe AG Doppelsträngige ribonukleinsäure mit verbesserter wirksamkeit in einem organismus
EP1677735B1 (de) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Verfahren und zusammensetzungen zur modulierung der adipozyten-funktion
US7608699B2 (en) 2003-12-29 2009-10-27 Rockefeller University Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof
WO2005077091A2 (en) 2004-02-10 2005-08-25 Trustees Of Dartmouth College Nicotinamide riboside kinase compositions and methods for using the same
AU2005247509C1 (en) 2004-05-27 2012-09-20 Alnylam Pharmaceuticals, Inc. Nuclease resistant double-stranded ribonucleic acid
EP1753871B1 (de) 2004-05-28 2015-07-15 Agensys, Inc. An psca-proteine bindende antikörper und verwandte moleküle
EP1789070B1 (de) 2004-08-03 2012-10-24 Biogen Idec MA Inc. Taj in der neuronalen funktion
WO2006081331A2 (en) 2005-01-25 2006-08-03 Prolexys Pharmaceuticals, Inc. Quinoxaline derivatives as antitumor agents
EP3300739A3 (de) 2005-03-31 2018-07-18 Agensys, Inc. An 161p2f10b-proteine bindende antikörper und zugehörige moleküle
UA95446C2 (ru) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
EP1896605A4 (de) 2005-06-07 2010-09-01 Univ Rockefeller Stimulierung der proliferation pankreatischer b-zellen
EP1907533A4 (de) 2005-06-30 2008-09-03 Whitehead Biomedical Inst Vorläuferzellen und verwendungen dafür
US7943134B2 (en) 2005-08-31 2011-05-17 Academia Sinica Compositions and methods for identifying response targets and treating flavivirus infection responses
CN101365801B (zh) 2005-10-28 2013-03-27 阿尔尼拉姆医药品有限公司 抑制亨廷顿基因表达的组合物和方法
CA2626690A1 (en) 2005-11-09 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of factor v leiden mutant gene
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
EP3360965A1 (de) 2006-01-20 2018-08-15 Cell Signaling Technology, Inc. Translokation und mutante ros-kinase in humanem nichtkleinzelligem bronchialkarzinom
EP3266867A1 (de) 2006-04-14 2018-01-10 Cell Signaling Technology, Inc. Gendefekte und mutante alk-kinase in festen menschlichen tumoren
EP1920775B1 (de) 2006-10-10 2012-12-19 Gunther Prof. Dr. Hartmann 5' Triphosphat -oligonukleotid induziert eine antivirale Reaktion
EP4082551A1 (de) 2006-08-08 2022-11-02 Rheinische Friedrich-Wilhelms-Universität Bonn Struktur und verwendung von 5'-phosphat-oligonukleotiden
EP2629094A1 (de) 2007-01-24 2013-08-21 Carnegie Mellon University Optische Biosensoren
WO2008116347A1 (en) 2007-03-26 2008-10-02 General Regeneratives Limited Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies
EP2203558B1 (de) 2007-10-18 2016-05-04 Cell Signaling Technology, Inc. Translokation und mutations-ros-kinase bei menschlichem nicht-kleinzelligem bronchialkarzinom
CN101998965B (zh) 2007-11-01 2014-03-12 安斯泰来制药有限公司 免疫抑制性多肽与核酸
WO2009059011A2 (en) 2007-11-01 2009-05-07 Mayo Foundation For Medical Education And Research Hla-dr binding peptides and their uses
EP2297323A1 (de) 2008-05-21 2011-03-23 Hartmann, Gunther 5 -triphosphat-oligonukleotid mit stumpfem ende und verwendugen davon
EP3587434A1 (de) 2008-09-23 2020-01-01 Alnylam Pharmaceuticals Inc. Chemische modifikationen von monomeren und oligonukleotiden mit click komponenten um liganden zu konjugieren
AU2010211133A1 (en) 2009-02-03 2011-07-21 F. Hoffmann-La Roche Ag Compositions and methods for inhibiting expression of PTP1B genes
DK2881402T3 (en) 2009-02-12 2017-08-28 Cell Signaling Technology Inc Mutant ROS expression in human liver cancer
US9249306B2 (en) 2009-02-18 2016-02-02 Carnegie Mellon University Quenched dendrimeric dyes for florescence detection
WO2011005496A2 (en) 2009-06-22 2011-01-13 Massachusetts Eye & Ear Infirmary Islet1 (isl1) and hearing loss
WO2011005799A2 (en) 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
PL3178490T3 (pl) 2009-07-15 2022-08-01 Glaxosmithkline Biologicals S.A. Kompozycje białka f rsv i sposoby ich wytwarzania
AR078921A1 (es) 2009-11-09 2011-12-14 Hoffmann La Roche Composiciones y metodos para inhibir la expresion de genes de la superfamilia de quinesinas, kif10
WO2011064750A1 (en) 2009-11-27 2011-06-03 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
AU2010325549B2 (en) 2009-11-27 2017-04-20 Basf Plant Science Company Gmbh Optimized endonucleases and uses thereof
JP2013511979A (ja) 2009-11-27 2013-04-11 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー キメラエンドヌクレアーゼおよびその使用
US20110152349A1 (en) 2009-12-18 2011-06-23 Anke Geick Compositions and methods for inhibiting expression of il-18 genes
WO2011088435A1 (en) 2010-01-15 2011-07-21 Cornell University Methods for reducing protein levels in a cell
WO2011100131A2 (en) 2010-01-28 2011-08-18 Alnylam Pharmacuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
TW201129365A (en) 2010-02-05 2011-09-01 Hoffmann La Roche Compositions and methods for inhibiting expression of IKK2 genes
EP2569633B1 (de) 2010-05-14 2016-02-10 The General Hospital Corporation Zusammensetzungen und verfahren zur identifikation tumorspezifischer neoantigene
US9995679B2 (en) 2010-05-25 2018-06-12 Carnegie Mellon University Targeted probes of cellular physiology
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
EP3520813B1 (de) 2010-10-11 2023-04-19 GlaxoSmithKline Biologicals S.A. Antigenfreisetzungsplattformen
EP2851426B1 (de) 2010-10-18 2018-08-22 Arrowhead Pharmaceuticals, Inc. Zusammensetzungen und Verfahren zur Hemmung der Expression von RRM2-Genen
CA2823194A1 (en) 2010-12-27 2012-07-05 Brown University Therapeutic and diagnostic methods involving biglycan and utrophin
PL2667892T3 (pl) 2011-01-26 2019-09-30 Glaxosmithkline Biologicals Sa Schemat szczepień przeciwko rsv
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
ES2651143T3 (es) 2011-05-13 2018-01-24 Glaxosmithkline Biologicals Sa Antígenos de F de prefusión del VRS
SG194751A1 (en) 2011-06-30 2013-12-30 Arrowhead Res Corp Compositions and methods for inhibiting gene expression of hepatitis b virus
PL2760463T3 (pl) 2011-09-20 2019-05-31 Univ North Carolina Chapel Hill Regulacja kanałów sodowych przez białka PLUNC
AU2012322704B2 (en) 2011-10-11 2017-09-07 Novartis Ag Recombinant self-replicating polycistronic RNA molecules
US20140348863A1 (en) 2011-10-12 2014-11-27 Alessia Bianchi Cmv antigens and uses thereof
ES2894724T3 (es) 2011-12-02 2022-02-15 Rhode Island Hospital Vacuna contra la malaria falciparum
EP2612918A1 (de) 2012-01-06 2013-07-10 BASF Plant Science Company GmbH In planta-Rekombination
DK2838998T3 (en) 2012-04-18 2018-01-15 Cell Signaling Technology Inc EGFR AND ROS1 IN CANCER
US9921221B2 (en) 2012-07-26 2018-03-20 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
EP2851086A1 (de) 2013-09-20 2015-03-25 Sanofi Serpine: Verfahren zur therapeutischen ß-Zellen-Regeneration und Funktion
EP2769732A1 (de) 2013-02-22 2014-08-27 Sanofi Serpine: Verfahren zur therapeutischen Beta-Zellen-Regeneration und Funktion
WO2014128257A1 (en) 2013-02-22 2014-08-28 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
WO2014165349A1 (en) 2013-04-04 2014-10-09 Trustees Of Dartmouth College Compositions and methods for in vivo excision of hiv-1 proviral dna
AU2014251207B2 (en) 2013-04-07 2019-06-13 Dana-Farber Cancer Institute, Inc. Compositions and methods for personalized neoplasia vaccines
EP3052464B1 (de) 2013-10-04 2020-04-15 Novartis AG 3 endkappen für rnai-mittel zur verwendung in der rna-interferenz
CN105792832B (zh) 2013-10-04 2021-03-23 诺华股份有限公司 用于治疗乙肝病毒的有机化合物
WO2015051366A2 (en) 2013-10-04 2015-04-09 Novartis Ag Novel formats for organic compounds for use in rna interference
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド ネオ抗原ワクチンによる併用療法
KR20160138494A (ko) 2014-03-31 2016-12-05 데비오팜 인터네셔날 에스 에이 Fgfr 융합물
EP4372091A3 (de) 2014-12-12 2024-07-31 Tod M. Woolf Zusammensetzungen und verfahren zur bearbeitung von nukleinsäuren in zellen unter verwendung von oligonukleotiden
EP4636401A2 (de) 2014-12-19 2025-10-22 The Broad Institute, Inc. Verfahren zur profilierung des t-zell-rezeptor-repertoirs
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
PT3265568T (pt) 2015-03-06 2020-08-20 Massachusetts Eye & Ear Infirmary Terapias de aumento de genes para a degeneração hereditária da retina causada por mutações no gene prpf31
US20180140626A1 (en) 2015-05-14 2018-05-24 Joslin Diabetes Center, Inc. Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
MX2017014700A (es) 2015-05-20 2018-08-15 Broad Inst Inc Neoantigenos compartidos.
TW202241500A (zh) 2015-06-09 2022-11-01 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
WO2017027350A2 (en) 2015-08-07 2017-02-16 Arrowhead Pharmaceuticals, Inc. Rnai therapy for hepatitis b virus infection
WO2017066796A2 (en) 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulators of telomere disease
WO2017066712A2 (en) 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulators of telomere disease
WO2017087708A1 (en) 2015-11-19 2017-05-26 The Brigham And Women's Hospital, Inc. Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
US20170199961A1 (en) 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
EP3405576A4 (de) 2016-01-19 2019-09-18 The University of North Carolina at Chapel Hill Verfahren und zusammensetzungen mit rna-interferenz zur kras-hemmung
BR112018017144A2 (pt) 2016-02-22 2019-01-15 Univ North Carolina Chapel Hill inibidores de peptídeo de canais de cálcio
CN109310739A (zh) 2016-03-31 2019-02-05 内恩疗法公司 新抗原及其使用方法
EP3446119A1 (de) 2016-04-18 2019-02-27 The Broad Institute Inc. Verbesserte hla-epitopvorhersage
EP4023228A1 (de) 2016-05-06 2022-07-06 Tod M. Woolf Genomändernde oligonukleotide ohne programmierbare nukleasen
JOP20190015A1 (ar) 2016-08-04 2019-02-04 Arrowhead Pharmaceuticals Inc عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
CN118370809A (zh) 2017-04-03 2024-07-23 百欧恩泰美国公司 蛋白质抗原及其用途
EP3609577B1 (de) 2017-04-14 2024-09-11 University of Massachusetts Braune fettselektive adipokine
MX2019013259A (es) 2017-05-08 2020-01-13 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus.
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
AU2018279627B2 (en) 2017-06-09 2023-08-10 Seattle Project Corp. Neoantigen identification, manufacture, and use
ES3029080T3 (en) 2017-10-10 2025-06-23 Seattle Project Corp Neoantigen identification using hotspots
US11885815B2 (en) 2017-11-22 2024-01-30 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
EP4495597A3 (de) 2018-01-04 2025-04-30 Iconic Therapeutics LLC Antikörper gegen den gewebefaktor, antikörper-wirkstoff-konjugate und zugehörige verfahren
EP3790893A4 (de) 2018-05-11 2022-03-16 University Of Massachusetts Verfahren zur verbesserung der leptinempfindlichkeit zur behandlung von fettleibigkeit und diabetes
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
JP7457733B2 (ja) 2019-05-30 2024-03-28 グリットストーン バイオ インコーポレイテッド 改変アデノウイルス
US20220305117A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
CA3143679A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
CN114746109A (zh) 2019-09-02 2022-07-12 居里研究所 靶向肿瘤新抗原性肽的免疫疗法
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
WO2021078910A1 (en) 2019-10-22 2021-04-29 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
JP2023519101A (ja) 2020-02-12 2023-05-10 マサチューセッツ アイ アンド イヤー インファーマリー Ｒｐ１関連網膜変性症のハプロタイプに基づく処置
EP4149952A1 (de) 2020-05-12 2023-03-22 Institut Curie Neoantigene epitope in zusammenhang mit sf3b1-mutationen
EP4192496A4 (de) 2020-08-06 2025-01-01 Gritstone bio, Inc. Multiepitop-impfstoffkassetten
WO2022079083A1 (en) 2020-10-15 2022-04-21 F. Hoffmann-La Roche Ag Nucleic acid constructs for va rna transcription
WO2022079082A1 (en) 2020-10-15 2022-04-21 F. Hoffmann-La Roche Ag Nucleic acid constructs for simultaneous gene activation
MX2023007003A (es) 2020-12-14 2023-08-18 Biontech Us Inc Antigenos especificos de tejidos para la inmunoterapia del cancer.
CN116981697A (zh) 2021-01-14 2023-10-31 森迪生物科学公司 可分泌有效载荷调节
MX2023010640A (es) 2021-03-11 2024-02-07 Inst Curie Péptidos neoantigénicos transmembranales.
CA3212964A1 (en) 2021-03-11 2022-09-15 Mnemo Therapeutics Tumor neoantigenic peptides
AU2022242811A1 (en) 2021-03-22 2023-09-28 The University Of North Carolina At Chapel Hill Modified peptidomimetics and methods of use
EP4499134A1 (de) 2022-03-24 2025-02-05 Institut Curie Gegen tumortransponierbare elementabgeleitete neoantigene peptide in glioblastomen gerichtete immuntherapie
WO2023220693A1 (en) 2022-05-12 2023-11-16 SunVax mRNA Therapeutics Inc. Synthetic self-amplifying mrna molecules with secretion antigen and immunomodulator
IL316504A (en) 2022-05-25 2024-12-01 BioNTech SE RNA compositions for the delivery of monkeypox antigens and related methods
CN114958912B (zh) * 2022-05-30 2023-11-10 新乡医学院 一种hek293细胞瞬时表达转染用试剂和瞬时表达系统转染方法
AU2024316307A1 (en) 2023-08-03 2026-02-26 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
WO2025064470A1 (en) 2023-09-19 2025-03-27 Regeneron Pharmaceuticals, Inc. Viral peptides and uses thereof
WO2025088117A1 (en) 2023-10-25 2025-05-01 Rheinische Friedrich-Wilhelms-Universität Bonn Ribonucleic acid construct capable of inducing an immune response, as well as pharmaceutical composition and kit comprising same
WO2025136809A2 (en) 2023-12-19 2025-06-26 Regeneron Pharmaceuticals, Inc. Foxp3 peptides and uses thereof
WO2025158069A1 (en) 2024-01-25 2025-07-31 Rheinische Friedrich-Wilhelms-Universität Bonn CONSTRUCT COMPRISING mRNA-STRAND AND RETINOIC ACID-INDUCIBLE GENE I (RIG-I)-LIGAND(S), PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME
WO2025178991A1 (en) 2024-02-21 2025-08-28 Regeneron Pharmaceuticals, Inc. Splicing factor gene mutation-associated neoantigenic peptides and uses thereof
WO2025189168A1 (en) 2024-03-08 2025-09-12 SunVax mRNA Therapeutics Inc. Methods for cascade amplifications of therapeutic payloads (catp) & compositions for cancer immunotherapies and gene therapy
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
WO2026047025A1 (en) 2024-08-27 2026-03-05 Rheinische Friedrich-Wilhelms-Universität Bonn Photocontrollable conjugate, pharmaceutical composition and kit comprising the same, and uses thereof
EP4702988A1 (de) 2024-08-28 2026-03-04 Biotechnology Assets S.A. Kombinationsprodukt zur behandlung von leishmaniose

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2942780A1 (de) * 1979-10-23 1981-05-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Eukaryotische zellen, eukaryotische protoplasten und vielzellige eukaryotische lebende organismen mit einem gehalt an durch lipidvesikel eingebrachter dna, verfahren zu ihrer herstellung von gen-produkten, zur immunisierung und zur behebung genetisch bedingter defekte
US4579821A (en) * 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4789633A (en) * 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
NZ219392A (en) * 1986-02-28 1989-05-29 Smithkline Beckman Corp Production of an immortalised primary cell line
EP0386185A1 (de) * 1988-07-29 1990-09-12 IntraCel Corporation Verfahren zur genexpression von heterologischen proteinen durch in-vivo-zelltransfektion
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates

Also Published As

Publication number Publication date
EP0800830A2 (de) 1997-10-15
DE69031305D1 (de) 1997-09-25
CA2044593C (en) 2004-04-20
EP0452457B1 (de) 1997-08-20
EP0800830A3 (de) 1999-03-17
DK0452457T3 (da) 1998-03-02
DE69031305T2 (de) 1998-03-26
AU6645690A (en) 1991-05-31
CA2044593A1 (en) 1991-05-04
JPH04502772A (ja) 1992-05-21
AU625013B2 (en) 1992-06-25
JP3056782B2 (ja) 2000-06-26
EP0452457A4 (en) 1993-02-17
EP0452457A1 (de) 1991-10-23
WO1991006309A1 (en) 1991-05-16

Similar Documents

Publication Publication Date Title
ATE157012T1 (de) Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen
ATE195551T1 (de) System und verfahren zur transplantation von zellen
DE3856505D1 (de) Proteine mit Faktor VIII Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende Zusammensetzungen
DE69426328D1 (de) Verwendung von mesothelialen zellen in der gentherapie
ATE110108T1 (de) Genetische modifizierung von endothelialen zellen.
DE3280479D1 (de) Rekombinante DNS-Mittel und Verfahren
ATE270323T1 (de) Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo
EP0279582A3 (de) DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
IL68366A (en) Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
ATE211166T1 (de) Zellkulturmatrix und biologisch abbaubare dreidimensionale matrix auf hyaluronsäurederivatbasis
ATE69241T1 (de) Herstellung von polypeptiden mit humangammainterferon-aktivitaet.
NO890833L (no) Fremstilling av kallikrein.
ATE243741T1 (de) Zufuhr von genprodukten mittels mesangium-zellen
DE69833264D1 (de) Verfahren und zusammensetzungen für die krebstherapie unter verwendung von interferon-beta codierenden genen
FI913266A7 (fi) Menetelmä ulkosyntyisen DNA:n viemiseksi eläinten somaattisten ja itur adan solujen sisään
HUP9800520A2 (hu) Génexpresszió emlős sejtekben
ATE82319T1 (de) Verfahren zur herstellung von aktivierten toetenden zellen.
Taichman et al. Maturation of human gingival keratinocytes cultured with fibroblasts from keratinizing and non-keratinizing epithelia
ES2058274T3 (es) Un metodo para expresar un producto genico heterologo no bacteriano.
IL83622A0 (en) In vivo administration of genetic material to animals
ITRM940345A0 (it) "metodo per la amplificazione in vitro e l'espressione in cellule di mammifero di sequenza esogene di acidi nucleici"
FI884845A7 (fi) Menetelmä geenin monistamiseksi tarkoituksena lisätä proteiinin tuotantoa viljellyissa eläinsoluissa
IL79913A0 (en) In vivo administration of genetic material to animals
TH9321A (th) ผลิตภัณฑ์ปรากฎการณ์ใหม่สำหรับการรักษามะเร็ง

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
RZN Patent revoked