ATE160779T1 - Antipsychotische indazolderivate - Google Patents
Antipsychotische indazolderivateInfo
- Publication number
- ATE160779T1 ATE160779T1 AT94909210T AT94909210T ATE160779T1 AT E160779 T1 ATE160779 T1 AT E160779T1 AT 94909210 T AT94909210 T AT 94909210T AT 94909210 T AT94909210 T AT 94909210T AT E160779 T1 ATE160779 T1 AT E160779T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- indazole derivatives
- sec
- dopamine
- antipsychotic
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 title 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 2
- 108050004812 Dopamine receptor Proteins 0.000 abstract 2
- 102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- -1 piperazinylmethyl moiety Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305623A GB9305623D0 (en) | 1993-03-18 | 1993-03-18 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE160779T1 true ATE160779T1 (de) | 1997-12-15 |
Family
ID=10732311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909210T ATE160779T1 (de) | 1993-03-18 | 1994-03-14 | Antipsychotische indazolderivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5780475A (de) |
| EP (1) | EP0689539B1 (de) |
| JP (1) | JPH08512284A (de) |
| AT (1) | ATE160779T1 (de) |
| AU (1) | AU685090B2 (de) |
| CA (1) | CA2156838A1 (de) |
| DE (1) | DE69407174T2 (de) |
| ES (1) | ES2110225T3 (de) |
| GB (1) | GB9305623D0 (de) |
| WO (1) | WO1994021630A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9324244D0 (en) * | 1993-11-25 | 1994-01-12 | Merck Sharp & Dohme | Therapeutic agents |
| ATE201016T1 (de) * | 1995-06-09 | 2001-05-15 | Hoffmann La Roche | Pyrimidindion-, pyrimidintrion-, triazindion- derivate als alpha-1-adrenergische rezeptorantagonisten |
| JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体 |
| US5998415A (en) * | 1995-11-02 | 1999-12-07 | Merck Sharp & Dohme Ltd. | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors |
| GB9524356D0 (en) * | 1995-11-29 | 1996-01-31 | Merck Sharp & Dohme | Therapeutic agents |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| DE19637237A1 (de) | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
| AU6246198A (en) * | 1997-02-18 | 1998-09-08 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| US5872144A (en) * | 1997-02-18 | 1999-02-16 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| IL126745A (en) * | 1997-11-04 | 2003-09-17 | Pfizer Prod Inc | Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors |
| AU6242999A (en) * | 1998-09-02 | 2000-03-21 | Neurogen Corporation | 2-aryl-4-(1-(4-heteroaryl)piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
| US6355801B1 (en) | 1999-11-08 | 2002-03-12 | Schering Corporation | Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine |
| IL150337A0 (en) * | 1999-12-30 | 2002-12-01 | Lundbeck & Co As H | Phenylpiperazinyl derivatives |
| AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
| EP1531822B1 (de) * | 2002-06-12 | 2009-08-05 | ChemoCentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로［３,４-ｂ］피리딘 및 인다졸 |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| GB2497476B (en) | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
| KR102314286B1 (ko) | 2016-12-16 | 2021-10-21 | 화이자 인코포레이티드 | Glp-1 수용체 작용제 및 이의 용도 |
| PT4408840T (pt) | 2021-09-27 | 2025-10-07 | Terns Pharmaceuticals Inc | Ácidos benzimidazolocarboxílicos como agonistas de glp-1r |
| CN118401519A (zh) | 2021-10-25 | 2024-07-26 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| CN119095843A (zh) | 2022-02-23 | 2024-12-06 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| EP4568664B1 (de) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Kombination aus einem thr-beta-agonisten und einem glp-1r-agonisten zur verwendung bei der behandlung von fettleibigkeit |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| US3678059A (en) * | 1969-10-07 | 1972-07-18 | Ciba Geigy Corp | 3-aminoalkylidene-indazoles |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| HU225047B1 (en) * | 1991-03-28 | 2006-05-29 | Eisai Co Ltd | Heterocyclic-piperidin-derivatives, pharmaceutical compositions containing them and process for their production |
| BR9406128A (pt) * | 1993-03-01 | 1996-02-27 | Merck Sharp & Dohme | Uso de um composto processo para o tratamento e/ou prevençao de distúrbios psicóticos composto composiçao farmacêutica processos para a preparaçao de um composto e de uma composiçao farmacêutica |
| GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
-
1993
- 1993-03-18 GB GB939305623A patent/GB9305623D0/en active Pending
-
1994
- 1994-03-14 ES ES94909210T patent/ES2110225T3/es not_active Expired - Lifetime
- 1994-03-14 AU AU62140/94A patent/AU685090B2/en not_active Ceased
- 1994-03-14 AT AT94909210T patent/ATE160779T1/de active
- 1994-03-14 WO PCT/GB1994/000504 patent/WO1994021630A1/en not_active Ceased
- 1994-03-14 CA CA002156838A patent/CA2156838A1/en not_active Abandoned
- 1994-03-14 EP EP94909210A patent/EP0689539B1/de not_active Expired - Lifetime
- 1994-03-14 US US08/525,629 patent/US5780475A/en not_active Expired - Fee Related
- 1994-03-14 DE DE69407174T patent/DE69407174T2/de not_active Expired - Fee Related
- 1994-03-14 JP JP6520766A patent/JPH08512284A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US5780475A (en) | 1998-07-14 |
| WO1994021630A1 (en) | 1994-09-29 |
| DE69407174D1 (de) | 1998-01-15 |
| AU685090B2 (en) | 1998-01-15 |
| AU6214094A (en) | 1994-10-11 |
| GB9305623D0 (en) | 1993-05-05 |
| CA2156838A1 (en) | 1994-09-29 |
| JPH08512284A (ja) | 1996-12-24 |
| DE69407174T2 (de) | 1998-07-02 |
| ES2110225T3 (es) | 1998-02-01 |
| EP0689539A1 (de) | 1996-01-03 |
| EP0689539B1 (de) | 1997-12-03 |
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