ATE160875T1 - Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe - Google Patents

Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe

Info

Publication number: ATE160875T1
Authority: AT; Austria
Prior art keywords: apoptotic cells; pct; high affinity; phosphatidyl serine; sample
Prior art date: 1994-04-11

Application number

AT95913946T

Other languages

English (en)

Inventor

Christiaan Pe Reutelingsperger

Original Assignee

Nexins Research B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-11

Filing date

1995-04-11

Publication date

1997-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE160875(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-04-11 Application filed by Nexins Research B V filed Critical Nexins Research B V

1997-12-15 Application granted granted Critical

1997-12-15 Publication of ATE160875T1 publication Critical patent/ATE160875T1/de

Links

230000001640 apoptogenic effect Effects 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 4
239000003153 chemical reaction reagent Substances 0.000 abstract 5
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 4
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 4
102000000412 Annexin Human genes 0.000 abstract 1
108050008874 Annexin Proteins 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
238000003759 clinical diagnosis Methods 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
230000004987 nonapoptotic effect Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
230000035479 physiological effects, processes and functions Effects 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Zoology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

AT95913946T 1994-04-11 1995-04-11 Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe ATE160875T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94200968		1994-04-11

Publications (1)

Publication Number	Publication Date
ATE160875T1 true ATE160875T1 (de)	1997-12-15

Family

ID=8216787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95913946T ATE160875T1 (de)	1994-04-11	1995-04-11	Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe

Country Status (12)

Country	Link
US (1)	US5834196A (de)
EP (1)	EP0755516B1 (de)
JP (1)	JP2824155B2 (de)
AT (1)	ATE160875T1 (de)
AU (1)	AU689248B2 (de)
CA (1)	CA2185535C (de)
DE (1)	DE69501161T2 (de)
DK (1)	DK0755516T3 (de)
ES (1)	ES2112057T3 (de)
NO (1)	NO303513B1 (de)
NZ (1)	NZ283171A (de)
WO (1)	WO1995027903A1 (de)

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US6558916B2 (en) *	1996-08-02	2003-05-06	Axiom Biotechnologies, Inc.	Cell flow apparatus and method for real-time measurements of patient cellular responses
US6280967B1 (en) *	1996-08-02	2001-08-28	Axiom Biotechnologies, Inc.	Cell flow apparatus and method for real-time of cellular responses
US5804436A (en)	1996-08-02	1998-09-08	Axiom Biotechnologies, Inc.	Apparatus and method for real-time measurement of cellular response
KR20010020443A (ko)	1997-04-30	2001-03-15	캐서린 구	생체내 세포 치사를 이미지화시키는 방법
US6270980B1 (en) *	1997-06-05	2001-08-07	Idun Pharmaceuticals, Inc.	Rapid methods for identifying modifiers of cellular apoptosis activity
US6511829B1 (en) *	1997-10-09	2003-01-28	The Regents Of The University Of California	GFP-annexin fusion proteins
EP0928968A1 (de) *	1998-01-12	1999-07-14	Universität Basel	Verfahren zum Screening der Apoptosis und Necrose
IL123429A0 (en)	1998-02-24	1998-09-24	Nst Neurosurvival Technologies	Peptides and pharmaceutical compositions comprising same
US7067109B1 (en)	1998-07-13	2006-06-27	Board Of Regents, The University Of Texas System	Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en)	1998-07-13	2004-11-16	Board Of Regents, The University Of Texas System	Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6406693B1 (en)	1998-07-13	2002-06-18	Board Of Regents, The University Of Texas System	Cancer treatment methods using antibodies to aminophospholipids
CA2333147C (en)	1998-07-13	2012-02-07	Board Of Regents, The University Of Texas System	Cancer treatment methods using antibodies to aminophospholipids
EP1520588B1 (de)	1998-07-13	2014-12-24	Board Of Regents, The University Of Texas System	Verwendung von Antikörper gegen Aminophospholipide zur Krebsbehandlung
IL125908A (en)	1998-08-24	2005-05-17	Nst Neurosurvival Technologies	Peptides and pharmaceutical compositions comprising same
IL131266A0 (en)	1999-08-05	2001-01-28	N S T Neurosurvival Technologi	Peptides and pharmaceutical compositions comprising same
WO2000010673A1 (en) *	1998-08-24	2000-03-02	Nst Neurosurvival Technologies Ltd.	Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids
US6063580A (en) *	1998-08-31	2000-05-16	Wayne State University	Methods for the temporal analysis of programmed cell death in living cells
US5939267A (en) *	1998-08-31	1999-08-17	Wayne State University	Methods for the temporal analysis of programmed cell death in living cells
EP1283904A2 (de) *	1999-11-03	2003-02-19	Oncotech, Inc.	Diagnose von krebs mit zellsortierung und genexpressionsprofilen
EP1118334A1 (de) *	2000-01-11	2001-07-25	Aventis Behring Gesellschaft mit beschränkter Haftung	Verfahren zur Herstellung von Konjugate zur Behändlung von Allergien und Autoimmunkrankheiten
FR2809181B1 (fr) *	2000-05-16	2002-10-25	Biocytex	Monoreactif pour le dosage des microparticules plaquettaires
EP1223429A1 (de) *	2001-01-13	2002-07-17	Dentognostics GmbH	Verfahren zum Nachweis von lebenden Mikroorganismen
WO2002080754A2 (en)	2001-04-03	2002-10-17	Theseus Imaging Corporation	Methods for using annexin for detecting cell death in vivo and treating associated conditions
CA2443314C (en)	2001-04-03	2006-03-21	The Board Of Trustees Of The Leland Stanford Junior University	Method of imaging cell death in vivo
US20050013778A1 (en) *	2001-04-03	2005-01-20	Theseus Imaging Corporation	Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death
EP1472238B1 (de)	2002-02-01	2012-07-04	Promega Corporation	Biolumineszenz protease assay
US20050266405A1 (en) *	2002-03-08	2005-12-01	Kopreski Michael S	Analysis of apoptotic bodies in bodily fluids
US7179616B1 (en)	2002-10-07	2007-02-20	University Of Notre Dame Du Lac	Method for detecting phosphatidylserine on the surface of cells
WO2004072296A2 (en) *	2003-01-30	2004-08-26	The General Hospital Corporation	Compositions for modulating immune cell activity and methods for detection thereof
US20040203069A1 (en) *	2003-04-10	2004-10-14	Chris Reutelingsperger	Method for determining and/or isolating lipid-binding compounds
WO2005014801A1 (en) *	2003-08-04	2005-02-17	University Court Of The University Of Edinburgh	Improvements in cell culture productivity
US7416854B2 (en) *	2004-01-22	2008-08-26	Promega Corporation	Luminogenic and nonluminogenic multiplex assay
US7553632B2 (en)	2004-01-22	2009-06-30	Promega Corporation	Luminogenic and nonluminogenic multiplex assay
US7511016B2 (en) *	2004-07-07	2009-03-31	Mosamedix B.V.	Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
ES2315889T3 (es) *	2004-07-14	2009-04-01	Janssen Pharmaceutica Nv	Ensayo de deteccion de p75ntr para identificar moduladores de la apoptosis.
GB0425324D0 (en) *	2004-11-17	2004-12-22	Univ Edinburgh	Assay method
US7687243B1 (en)	2005-06-06	2010-03-30	Crook Tonia M	Automated method for detecting apoptosis in cells
JP2009506772A (ja) *	2005-09-01	2009-02-19	プロメガコーポレイション	細胞ベースの発光及び非発光プロテアソームアッセイ
WO2007053654A2 (en) *	2005-10-31	2007-05-10	Cedars-Sinai Medical Center	Agglutination-based method for fast detection, isolation and quantification of apoptotic cells
KR100987547B1 (ko) *	2006-06-01	2010-10-12	가톨릭대학교 산학협력단	냉동보관된 제대혈 줄기세포로부터 초기 세포사를 측정하는조성물, 키트 및 그 방법
US20070293893A1 (en) *	2006-06-14	2007-12-20	Craig Stolen	Method and apparatus for preconditioning of cells
AU2008239654A1 (en)	2007-04-13	2008-10-23	Promega Corporation	Luminescent live and dead cell assay
EP2349321B1 (de)	2008-10-17	2020-04-22	London Health Sciences Centre Research Inc.	Annexin und seine verwendung zur behandlung von entzündungserkrankungen
WO2013044099A1 (en)	2011-09-23	2013-03-28	Siemens Healthcare Diagnostics Inc.	Cell response assay for cancer and methods of producing and using same
WO2019129646A1 (en)	2017-12-29	2019-07-04	F. Hoffmann-La Roche Ag	Tissue sample preparation system
CN116773805A (zh) *	2022-03-10	2023-09-19	南方科技大学	一种试剂盒、以及细胞损伤程度的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2070647C (en) *	1989-12-27	2001-04-10	Christiaan Reutelingsperger	Use of an anticoagulant as a diagnostic agent
US5627036A (en) *	1989-12-27	1997-05-06	Boehringer Ingelheim International Gmbh	Use of an anticoagulant as a diagnostic agent

1995
- 1995-04-11 CA CA002185535A patent/CA2185535C/en not_active Expired - Lifetime
- 1995-04-11 AT AT95913946T patent/ATE160875T1/de not_active IP Right Cessation
- 1995-04-11 EP EP95913946A patent/EP0755516B1/de not_active Revoked
- 1995-04-11 US US08/727,506 patent/US5834196A/en not_active Expired - Lifetime
- 1995-04-11 AU AU21141/95A patent/AU689248B2/en not_active Expired
- 1995-04-11 ES ES95913946T patent/ES2112057T3/es not_active Expired - Lifetime
- 1995-04-11 DK DK95913946T patent/DK0755516T3/da active
- 1995-04-11 WO PCT/NL1995/000134 patent/WO1995027903A1/en not_active Ceased
- 1995-04-11 DE DE69501161T patent/DE69501161T2/de not_active Revoked
- 1995-04-11 NZ NZ283171A patent/NZ283171A/en not_active IP Right Cessation
- 1995-04-11 JP JP7526263A patent/JP2824155B2/ja not_active Expired - Lifetime
1996
- 1996-10-10 NO NO964308A patent/NO303513B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ283171A (en)	1998-02-26
NO964308D0 (no)	1996-10-10
AU689248B2 (en)	1998-03-26
EP0755516B1 (de)	1997-12-03
JPH09505894A (ja)	1997-06-10
CA2185535C (en)	2000-10-24
CA2185535A1 (en)	1995-10-19
DK0755516T3 (da)	1998-08-10
US5834196A (en)	1998-11-10
DE69501161D1 (de)	1998-01-15
EP0755516A1 (de)	1997-01-29
JP2824155B2 (ja)	1998-11-11
ES2112057T3 (es)	1998-03-16
AU2114195A (en)	1995-10-30
DE69501161T2 (de)	1998-03-19
NO303513B1 (no)	1998-07-20
NO964308L (no)	1996-12-11
WO1995027903A1 (en)	1995-10-19

Legal Events

Date	Code	Title	Description
2003-04-15	RZN	Patent revoked

Publication	Publication Date	Title
ATE160875T1 (de)	1997-12-15	Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe
DE69939121D1 (de)	2008-08-28	Verfahren und materialien zum nachweis und zur messung von durch freie radikale verursachten schäden
BR9711869B1 (pt)	2008-11-18	mÉtodo e kit para coletar amostras de espÉcimes lÍquidas para teste analÍtico.
IT1190152B (it)	1988-02-16	Provino per la valutazione dei risultati di esami non distruttivi di materiali,nonche' elementi di difetto e procedimento per preparare provini
MX9801687A (es)	1998-11-29	Compuestos y metodos para el diagnostico de tuberculosis.
BG104275A (en)	2000-08-31	Method and device for express analysis of tested parameters in biological samples
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DE69941627D1 (de)	2009-12-17	Für krebs
ATE258310T1 (de)	2004-02-15	Testverfahren für collagenpeptid
JPS61228351A (ja)	1986-10-11	糞便中のヘモグロビンの検出方法
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SIDDIQUI et al.	1990	Evaluation of creatine kinase in the cerebrospinal fluid of patients with various neurological diseases
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