ATE162201T1 - Cnp-gen und vorläuferprotein aus schwein - Google Patents

Cnp-gen und vorläuferprotein aus schwein

Info

Publication number: ATE162201T1
Authority: AT; Austria
Prior art keywords: leu; gly; lys; ala; pro
Prior art date: 1990-07-13

Application number

AT91111630T

Other languages

English (en)

Inventor

Hisayuki Matsuo

Kenji Kangawa

Naoto Minamino

Shoji Tanaka

Kayoko Kawashima

Yasunori Tawaragi

Original Assignee

Suntory Ltd

Hisayuki Matsuo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-13

Filing date

1991-07-12

Publication date

1998-01-15

1991-07-12 Application filed by Suntory Ltd, Hisayuki Matsuo filed Critical Suntory Ltd

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE162201T1 publication Critical patent/ATE162201T1/de

Links

239000002243 precursor Substances 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
102000004169 proteins and genes Human genes 0.000 title abstract 2
101150017692 cnp gene Proteins 0.000 title 1
235000015277 pork Nutrition 0.000 title 1
102000012421 C-Type Natriuretic Peptide Human genes 0.000 abstract 4
101800000060 C-type natriuretic peptide Proteins 0.000 abstract 4
YUAXTFMFMOIMAM-QWRGUYRKSA-N Lys-Lys-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O YUAXTFMFMOIMAM-QWRGUYRKSA-N 0.000 abstract 2
XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 abstract 2
108010050848 glycylleucine Proteins 0.000 abstract 2
RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 abstract 1
KQFRUSHJPKXBMB-BHDSKKPTSA-N Ala-Ala-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)C)C(O)=O)=CNC2=C1 KQFRUSHJPKXBMB-BHDSKKPTSA-N 0.000 abstract 1
OLVCTPPSXNRGKV-GUBZILKMSA-N Ala-Pro-Pro Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 OLVCTPPSXNRGKV-GUBZILKMSA-N 0.000 abstract 1
ZJBUILVYSXQNSW-YTWAJWBKSA-N Arg-Thr-Pro Chemical compound C[C@H]([C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N)O ZJBUILVYSXQNSW-YTWAJWBKSA-N 0.000 abstract 1
PFOYSEIHFVKHNF-FXQIFTODSA-N Asn-Ala-Arg Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O PFOYSEIHFVKHNF-FXQIFTODSA-N 0.000 abstract 1
YVXRYLVELQYAEQ-SRVKXCTJSA-N Asn-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(=O)N)N YVXRYLVELQYAEQ-SRVKXCTJSA-N 0.000 abstract 1
DONWIPDSZZJHHK-HJGDQZAQSA-N Asp-Lys-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)N)O DONWIPDSZZJHHK-HJGDQZAQSA-N 0.000 abstract 1
VGOFRWOTSXVPAU-SDDRHHMPSA-N Glu-His-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CCC(=O)O)N)C(=O)O VGOFRWOTSXVPAU-SDDRHHMPSA-N 0.000 abstract 1
AAJHGGDRKHYSDH-GUBZILKMSA-N Glu-Pro-Gln Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CCC(=O)O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O AAJHGGDRKHYSDH-GUBZILKMSA-N 0.000 abstract 1
KIEICAOUSNYOLM-NRPADANISA-N Glu-Val-Ala Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(O)=O KIEICAOUSNYOLM-NRPADANISA-N 0.000 abstract 1
IWAXHBCACVWNHT-BQBZGAKWSA-N Gly-Asp-Arg Chemical compound NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCCN=C(N)N IWAXHBCACVWNHT-BQBZGAKWSA-N 0.000 abstract 1
SABZDFAAOJATBR-QWRGUYRKSA-N Gly-Cys-Phe Chemical compound [H]NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O SABZDFAAOJATBR-QWRGUYRKSA-N 0.000 abstract 1
CCQOOWAONKGYKQ-BYPYZUCNSA-N Gly-Gly-Ala Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)CN CCQOOWAONKGYKQ-BYPYZUCNSA-N 0.000 abstract 1
KMSGYZQRXPUKGI-BYPYZUCNSA-N Gly-Gly-Asn Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CC(N)=O KMSGYZQRXPUKGI-BYPYZUCNSA-N 0.000 abstract 1
QPTNELDXWKRIFX-YFKPBYRVSA-N Gly-Gly-Gln Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CCC(N)=O QPTNELDXWKRIFX-YFKPBYRVSA-N 0.000 abstract 1
LLZXNUUIBOALNY-QWRGUYRKSA-N Gly-Leu-Lys Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CCCCN LLZXNUUIBOALNY-QWRGUYRKSA-N 0.000 abstract 1
LBRCLQMZAHRTLV-ZKWXMUAHSA-N Ile-Gly-Ser Chemical compound CC[C@H](C)[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O LBRCLQMZAHRTLV-ZKWXMUAHSA-N 0.000 abstract 1
IBMVEYRWAWIOTN-UHFFFAOYSA-N L-Leucyl-L-Arginyl-L-Proline Natural products CC(C)CC(N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(O)=O IBMVEYRWAWIOTN-UHFFFAOYSA-N 0.000 abstract 1
KVRKAGGMEWNURO-CIUDSAMLSA-N Leu-Ala-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(C)C)N KVRKAGGMEWNURO-CIUDSAMLSA-N 0.000 abstract 1
REPPKAMYTOJTFC-DCAQKATOSA-N Leu-Arg-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O REPPKAMYTOJTFC-DCAQKATOSA-N 0.000 abstract 1
IBMVEYRWAWIOTN-RWMBFGLXSA-N Leu-Arg-Pro Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(O)=O IBMVEYRWAWIOTN-RWMBFGLXSA-N 0.000 abstract 1
YKNBJXOJTURHCU-DCAQKATOSA-N Leu-Asp-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCCN=C(N)N YKNBJXOJTURHCU-DCAQKATOSA-N 0.000 abstract 1
QJUWBDPGGYVRHY-YUMQZZPRSA-N Leu-Gly-Cys Chemical compound CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CS)C(=O)O)N QJUWBDPGGYVRHY-YUMQZZPRSA-N 0.000 abstract 1
KYIIALJHAOIAHF-KKUMJFAQSA-N Leu-Leu-His Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 KYIIALJHAOIAHF-KKUMJFAQSA-N 0.000 abstract 1
RXGLHDWAZQECBI-SRVKXCTJSA-N Leu-Leu-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O RXGLHDWAZQECBI-SRVKXCTJSA-N 0.000 abstract 1
IEWBEPKLKUXQBU-VOAKCMCISA-N Leu-Leu-Thr Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O IEWBEPKLKUXQBU-VOAKCMCISA-N 0.000 abstract 1
AMSSKPUHBUQBOQ-SRVKXCTJSA-N Leu-Ser-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)N AMSSKPUHBUQBOQ-SRVKXCTJSA-N 0.000 abstract 1
PDIDTSZKKFEDMB-UWVGGRQHSA-N Lys-Pro-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O PDIDTSZKKFEDMB-UWVGGRQHSA-N 0.000 abstract 1
WQDKIVRHTQYJSN-DCAQKATOSA-N Lys-Ser-Arg Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N WQDKIVRHTQYJSN-DCAQKATOSA-N 0.000 abstract 1
WINFHLHJTRGLCV-BZSNNMDCSA-N Lys-Tyr-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CC=C(O)C=C1 WINFHLHJTRGLCV-BZSNNMDCSA-N 0.000 abstract 1
OZVXDDFYCQOPFD-XQQFMLRXSA-N Lys-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCCN)N OZVXDDFYCQOPFD-XQQFMLRXSA-N 0.000 abstract 1
TZHFJXDKXGZHEN-IHRRRGAJSA-N Met-His-Leu Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(O)=O TZHFJXDKXGZHEN-IHRRRGAJSA-N 0.000 abstract 1
LXCSZPUQKMTXNW-BQBZGAKWSA-N Met-Ser-Gly Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O LXCSZPUQKMTXNW-BQBZGAKWSA-N 0.000 abstract 1
108010079364 N-glycylalanine Proteins 0.000 abstract 1
VYWNORHENYEQDW-YUMQZZPRSA-N Pro-Gly-Glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1 VYWNORHENYEQDW-YUMQZZPRSA-N 0.000 abstract 1
HAAQQNHQZBOWFO-LURJTMIESA-N Pro-Gly-Gly Chemical compound OC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1 HAAQQNHQZBOWFO-LURJTMIESA-N 0.000 abstract 1
WDXYVIIVDIDOSX-DCAQKATOSA-N Ser-Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)CCCN=C(N)N WDXYVIIVDIDOSX-DCAQKATOSA-N 0.000 abstract 1
OJPHFSOMBZKQKQ-GUBZILKMSA-N Ser-Gln-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO OJPHFSOMBZKQKQ-GUBZILKMSA-N 0.000 abstract 1
SMIDBHKWSYUBRZ-ACZMJKKPSA-N Ser-Glu-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O SMIDBHKWSYUBRZ-ACZMJKKPSA-N 0.000 abstract 1
OVLIFGQSBSNGHY-KKHAAJSZSA-N Val-Asp-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)N)O OVLIFGQSBSNGHY-KKHAAJSZSA-N 0.000 abstract 1
108010076324 alanyl-glycyl-glycine Proteins 0.000 abstract 1
108010078114 alanyl-tryptophyl-alanine Proteins 0.000 abstract 1
108010005233 alanylglutamic acid Proteins 0.000 abstract 1
KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
108010062796 arginyllysine Proteins 0.000 abstract 1
239000002299 complementary DNA Substances 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
108010055341 glutamyl-glutamic acid Proteins 0.000 abstract 1
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
108010064235 lysylglycine Proteins 0.000 abstract 1
230000001452 natriuretic effect Effects 0.000 abstract 1
108010020755 prolyl-glycyl-glycine Proteins 0.000 abstract 1
108010087846 prolyl-prolyl-glycine Proteins 0.000 abstract 1
108010004914 prolylarginine Proteins 0.000 abstract 1
108010071207 serylmethionine Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cardiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT91111630T 1990-07-13 1991-07-12 Cnp-gen und vorläuferprotein aus schwein ATE162201T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2186583A JP3026351B2 (ja)	1990-07-13	1990-07-13	ブタｃｎｐ遺伝子及び前駆体蛋白

Publications (1)

Publication Number	Publication Date
ATE162201T1 true ATE162201T1 (de)	1998-01-15

Family

ID=16191085

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT91111630T ATE162201T1 (de)	1990-07-13	1991-07-12	Cnp-gen und vorläuferprotein aus schwein
AT96117857T ATE386118T1 (de)	1990-07-13	1991-07-12	Cnp-gen und vorläuferprotein aus schwein

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT96117857T ATE386118T1 (de)	1990-07-13	1991-07-12	Cnp-gen und vorläuferprotein aus schwein

Country Status (8)

Country	Link
US (1)	US6020168A (de)
EP (2)	EP0466175B1 (de)
JP (1)	JP3026351B2 (de)
AT (2)	ATE162201T1 (de)
DE (2)	DE69133591T2 (de)
DK (1)	DK0466175T3 (de)
ES (2)	ES2112258T3 (de)
GR (1)	GR3026553T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3026352B2 (ja) *	1990-09-11	2000-03-27	壽之松尾	ラットＣＮＰｃＤＮＡ及び前駆体蛋白
AU3749293A (en) *	1992-03-18	1993-10-21	Wolf-Georg Forssmann	DNA coding for aphrodisin
IL142118A0 (en) *	2001-03-20	2002-03-10	Prochon Biotech Ltd	Method and composition for treatment of skeletal dysplasias
CA2559228C (en)	2004-04-21	2016-06-21	Enobia Pharma Inc.	Bone delivery conjugates and method of using same to target proteins to bone
EP2217620A2 (de)	2007-11-21	2010-08-18	BioMarin Pharmaceutical Inc.	Varianten des natriuretischen peptids typ c
PT2432489T (pt)	2009-05-20	2016-12-07	Biomarin Pharm Inc	Variantes do péptido natriurético de tipo c
WO2012088608A1 (en)	2010-12-27	2012-07-05	Enobia Canada Limited Partnership	Compositions comprising natriuretic peptides and methods of use thereof
KR20140084201A (ko)	2011-10-19	2014-07-04	알렉시온 파마 홀딩	알칼리성 포스파타제 및/또는 나트륨이뇨 펩티드를 포함하는 조성물 및 그의 사용 방법
WO2013095759A1 (en) *	2011-12-23	2013-06-27	Mayo Foundation For Medical Education And Research	Assessing renal structural alterations and outcomes
US10052366B2 (en)	2012-05-21	2018-08-21	Alexion Pharmaceuticsl, Inc.	Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
WO2016007873A1 (en)	2014-07-11	2016-01-14	The Regents Of The University Of Michigan	Compositions and methods for treating craniosynostosis
MX389350B (es)	2014-12-05	2025-03-19	Alexion Pharma Inc	Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones.
JP6868561B2 (ja)	2015-01-28	2021-05-12	アレクシオンファーマシューティカルズ，インコーポレイテッド	アルカリホスファターゼ欠損を有する被験者を治療する方法
WO2016157250A1 (ja) *	2015-03-30	2016-10-06	国立大学法人神戸大学	動物種鑑別方法及び装置
CN108350440A (zh)	2015-08-17	2018-07-31	阿雷克森制药公司	碱性磷酸酯的制造
JP6868617B2 (ja)	2015-09-28	2021-05-12	アレクシオンファーマシューティカルズ，インコーポレイテッド	低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定
JP2018533571A (ja)	2015-10-30	2018-11-15	アレクシオンファーマシューティカルズ，インコーポレイテッド	患者の頭蓋縫合早期癒合症を治療するための方法
WO2017155569A1 (en)	2016-03-08	2017-09-14	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in children
JP7613826B2 (ja)	2016-04-01	2025-01-15	アレクシオンファーマシューティカルズ，インコーポレイテッド	アルカリホスファターゼによって筋力低下を治療すること
US10898549B2 (en)	2016-04-01	2021-01-26	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in adolescents and adults
US10988744B2 (en)	2016-06-06	2021-04-27	Alexion Pharmaceuticals, Inc.	Method of producing alkaline phosphatase
EP3500289B1 (de)	2016-08-18	2024-10-09	Alexion Pharmaceuticals, Inc.	Asfotase alfa zur behandlung von tracheobronchomalazie
EP3600383A4 (de)	2017-03-31	2020-10-28	Alexion Pharmaceuticals, Inc.	Verfahren zur behandlung von hypophosphatasie (hpp) bei erwachsenen und jugendlichen
US11913039B2 (en)	2018-03-30	2024-02-27	Alexion Pharmaceuticals, Inc.	Method for producing recombinant alkaline phosphatase
US12268733B2 (en)	2018-08-10	2025-04-08	Alexion Pharmaceuticals, Inc.	Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
CA3161266A1 (en)	2019-12-09	2021-06-17	Alexion Pharmaceuticals, Inc.	Alkaline phosphatase polypeptides and methods of use thereof
AU2021337652B2 (en)	2020-09-04	2025-01-30	Alexion Pharmaceuticals, Inc.	Methods for treating bone mineralization disorders
BR112023016048A2 (pt)	2021-02-12	2023-11-14	Alexion Pharma Inc	Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60136596A (ja)	1983-12-26	1985-07-20	Suntory Ltd	ペプチド及びこれを有効成分とする利尿剤
JPS60184098A (ja)	1984-03-02	1985-09-19	Suntory Ltd	新規なペプチド及びこれを有効成分とする利尿剤
JPH0794473B2 (ja)	1984-03-02	1995-10-11	サントリー株式会社	新規なペプチド及びこれを有効成分とする利尿剤
JPS60260596A (ja)	1984-06-08	1985-12-23	Toshiyuki Matsuo	新規なペプチド及びこれを有効成分とする医薬
JPS617298A (ja)	1984-06-22	1986-01-13	Toshiyuki Matsuo	新規なペプチド及びこれを有効成分とする医薬

1990
- 1990-07-13 JP JP2186583A patent/JP3026351B2/ja not_active Expired - Lifetime
1991
- 1991-07-12 EP EP91111630A patent/EP0466175B1/de not_active Expired - Lifetime
- 1991-07-12 DE DE69133591T patent/DE69133591T2/de not_active Expired - Lifetime
- 1991-07-12 ES ES91111630T patent/ES2112258T3/es not_active Expired - Lifetime
- 1991-07-12 AT AT91111630T patent/ATE162201T1/de not_active IP Right Cessation
- 1991-07-12 DK DK91111630T patent/DK0466175T3/da active
- 1991-07-12 US US07/728,220 patent/US6020168A/en not_active Expired - Lifetime
- 1991-07-12 ES ES96117857T patent/ES2303336T3/es not_active Expired - Lifetime
- 1991-07-12 EP EP96117857A patent/EP0771875B1/de not_active Expired - Lifetime
- 1991-07-12 DE DE69128664T patent/DE69128664T2/de not_active Expired - Lifetime
- 1991-07-12 AT AT96117857T patent/ATE386118T1/de not_active IP Right Cessation
1998
- 1998-04-06 GR GR980400740T patent/GR3026553T3/el unknown

Also Published As

Publication number	Publication date
JP3026351B2 (ja)	2000-03-27
US6020168A (en)	2000-02-01
EP0466175A1 (de)	1992-01-15
ES2112258T3 (es)	1998-04-01
EP0771875B1 (de)	2008-02-13
EP0466175B1 (de)	1998-01-14
DK0466175T3 (da)	1998-09-07
DE69128664D1 (de)	1998-02-19
ES2303336T3 (es)	2008-08-01
GR3026553T3 (en)	1998-07-31
ATE386118T1 (de)	2008-03-15
DE69133591D1 (de)	2008-03-27
DE69128664T2 (de)	1998-06-04
JPH0474199A (ja)	1992-03-09
EP0771875A1 (de)	1997-05-07
DE69133591T2 (de)	2009-02-05

Legal Events

Date	Code	Title	Description
1999-03-15	UEP	Publication of translation of european patent specification
2009-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE386118T1 (de)	2008-03-15	Cnp-gen und vorläuferprotein aus schwein
NL300013I1 (nl)	2000-10-02	Nieuwe protein met TNF-remmende werking en hun ber
ATE528014T1 (de)	2011-10-15	Polypeptid mit modifizierten kunitz domains
MD1652F2 (en)	2001-04-30	Protein possessing the cytokin - type activity, recombinant DNA-codifyer for such protein, transformed cells and microorganism, expression vector, process for protein obtaining and remedy containing such a protein
DE3486154D1 (de)	1993-07-01	Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung.
NO942553D0 (no)	1994-07-06	Ny humanproteaseinhibitor av Kunitz-type og varianter derav
DE69126487D1 (de)	1997-07-17	cDNA für Ratten C-Typ natriuretisches Peptid und Vorläuferprotein
CA2002924A1 (en)	1990-05-11	Anti-Thrombins
DE69201438D1 (en)	1995-03-23	Als therapeutika geeignete peptide.
YU29596A (sh)	1998-07-10	Genski proizvodi koji regulišu gojaznost
EP0292257A3 (de)	1990-06-06	Peptide mit ANF-Wirksamkeit
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
ATE84042T1 (de)	1993-01-15	Peptide.
EP0687685A4 (de)	1998-07-01	Physiologisch-aktive peptide
ES8605987A1 (es)	1986-04-01	Procedimiento para preparar polipeptidos inmunoterapeuticos
IT1177963B (it)	1987-09-03	Agenti polipeptidici immunoterapeutici e procedimento di preparazione
CA2311684A1 (en)	1990-06-22	Chemically-modified g-csf