ATE528014T1 - Polypeptid mit modifizierten kunitz domains - Google Patents

Polypeptid mit modifizierten kunitz domains

Info

Publication number: ATE528014T1
Authority: AT; Austria
Prior art keywords: phe; cys; glu; ala; polypeptide
Prior art date: 2002-06-07

Application number

AT07023364T

Other languages

English (en)

Inventor

Robert C Ladner

Arthur Ley

Original Assignee

Dyax Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-07

Filing date

2003-06-06

Publication date

2011-10-15

2003-06-06 Application filed by Dyax Corp filed Critical Dyax Corp

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE528014T1 publication Critical patent/ATE528014T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
150000001413 amino acids Chemical group 0.000 abstract 2
WQVFQXXBNHHPLX-ZKWXMUAHSA-N Ala-Ala-His Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O WQVFQXXBNHHPLX-ZKWXMUAHSA-N 0.000 abstract 1
BGDILZXXDJCKPF-CIUDSAMLSA-N Arg-Gln-Cys Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(O)=O BGDILZXXDJCKPF-CIUDSAMLSA-N 0.000 abstract 1
HUZGPXBILPMCHM-IHRRRGAJSA-N Asn-Arg-Phe Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O HUZGPXBILPMCHM-IHRRRGAJSA-N 0.000 abstract 1
FANQWNCPNFEPGZ-WHFBIAKZSA-N Asp-Asp-Gly Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O FANQWNCPNFEPGZ-WHFBIAKZSA-N 0.000 abstract 1
YWEHYKGJWHPGPY-XGEHTFHBSA-N Cys-Thr-Arg Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CS)N)O YWEHYKGJWHPGPY-XGEHTFHBSA-N 0.000 abstract 1
NUSWUSKZRCGFEX-FXQIFTODSA-N Glu-Glu-Cys Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(O)=O NUSWUSKZRCGFEX-FXQIFTODSA-N 0.000 abstract 1
YLJHCWNDBKKOEB-IHRRRGAJSA-N Glu-Glu-Phe Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O YLJHCWNDBKKOEB-IHRRRGAJSA-N 0.000 abstract 1
IDEODOAVGCMUQV-GUBZILKMSA-N Glu-Ser-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O IDEODOAVGCMUQV-GUBZILKMSA-N 0.000 abstract 1
XXGQRGQPGFYECI-WDSKDSINSA-N Gly-Cys-Glu Chemical compound NCC(=O)N[C@@H](CS)C(=O)N[C@H](C(O)=O)CCC(O)=O XXGQRGQPGFYECI-WDSKDSINSA-N 0.000 abstract 1
VEPIBPGLTLPBDW-URLPEUOOSA-N Ile-Phe-Thr Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)N VEPIBPGLTLPBDW-URLPEUOOSA-N 0.000 abstract 1
PRTZQMBYUZFSFA-XEGUGMAKSA-N Ile-Tyr-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)O)N PRTZQMBYUZFSFA-XEGUGMAKSA-N 0.000 abstract 1
102000001399 Kallikrein Human genes 0.000 abstract 1
108060005987 Kallikrein Proteins 0.000 abstract 1
KJIXWRWPOCKYLD-IHRRRGAJSA-N Lys-Lys-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N KJIXWRWPOCKYLD-IHRRRGAJSA-N 0.000 abstract 1
BKIFWLQFOOKUCA-DCAQKATOSA-N Met-His-Ser Chemical compound CSCC[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)O)N BKIFWLQFOOKUCA-DCAQKATOSA-N 0.000 abstract 1
KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 abstract 1
UEHNWRNADDPYNK-DLOVCJGASA-N Phe-Cys-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=CC=C1)N UEHNWRNADDPYNK-DLOVCJGASA-N 0.000 abstract 1
DNAXXTQSTKOHFO-QEJZJMRPSA-N Phe-Lys-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC1=CC=CC=C1 DNAXXTQSTKOHFO-QEJZJMRPSA-N 0.000 abstract 1
OWSLLRKCHLTUND-BZSNNMDCSA-N Phe-Phe-Asn Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC(=O)N)C(=O)O)N OWSLLRKCHLTUND-BZSNNMDCSA-N 0.000 abstract 1
NUZHSNLQJDYSRW-BZSNNMDCSA-N Pro-Arg-Trp Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O NUZHSNLQJDYSRW-BZSNNMDCSA-N 0.000 abstract 1
AIZVVCMAFRREQS-GUBZILKMSA-N Pro-Cys-Arg Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O AIZVVCMAFRREQS-GUBZILKMSA-N 0.000 abstract 1
108010041407 alanylaspartic acid Proteins 0.000 abstract 1
108010084264 glycyl-glycyl-cysteine Proteins 0.000 abstract 1
108010012581 phenylalanylglutamate Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurology (AREA)
Surgery (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)

AT07023364T 2002-06-07 2003-06-06 Polypeptid mit modifizierten kunitz domains ATE528014T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38723902P	2002-06-07	2002-06-07
US40700302P	2002-08-28	2002-08-28

Publications (1)

Publication Number	Publication Date
ATE528014T1 true ATE528014T1 (de)	2011-10-15

Family

ID=29739936

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03757339T ATE477020T1 (de)	2002-06-07	2003-06-06	Prevention und verringerung von ischemia
AT07023364T ATE528014T1 (de)	2002-06-07	2003-06-06	Polypeptid mit modifizierten kunitz domains

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03757339T ATE477020T1 (de)	2002-06-07	2003-06-06	Prevention und verringerung von ischemia

Country Status (12)

Country	Link
US (13)	US7064107B2 (de)
EP (4)	EP1531791B1 (de)
JP (3)	JP2005534647A (de)
AT (2)	ATE477020T1 (de)
AU (3)	AU2003243394B2 (de)
CA (1)	CA2488558C (de)
CY (1)	CY1112228T1 (de)
DE (1)	DE60333758D1 (de)
DK (4)	DK1941867T3 (de)
ES (4)	ES2348230T3 (de)
PT (4)	PT2298278E (de)
WO (1)	WO2003103475A2 (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
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AU2006214371A1 (en)	2005-02-15	2006-08-24	Virginia Commonwealth University	Mineral technologies (MT) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
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US9345457B2 (en)	2006-12-13	2016-05-24	Devicor Medical Products, Inc.	Presentation of biopsy sample by biopsy device
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WO2009026539A1 (en) *	2007-08-23	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
US20090162406A1 (en) *	2007-09-05	2009-06-25	Z-Medica Corporation	Wound healing with zeolite-based hemostatic devices
US8637454B2 (en)	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
SMT201800552T1 (it)	2010-01-06	2018-11-09	Dyax Corp	Proteine che legano la callicreina plasmatica
EP2347778A1 (de)	2010-01-25	2011-07-27	ECP Entwicklungsgesellschaft mbH	Fluidpumpe mit einem radial komprimierbaren Rotor
US8858969B2 (en)	2010-09-22	2014-10-14	Z-Medica, Llc	Hemostatic compositions, devices, and methods
KR102320178B1 (ko)	2011-01-06	2021-11-02	다케다 파머수티컬 컴패니 리미티드	혈장 칼리크레인 결합 단백질
EP3320922A1 (de)	2011-06-10	2018-05-16	Ionis Pharmaceuticals, Inc.	Verfahren zur modulierung der kallikrein (klkb1)-expression
US9322021B2 (en)	2011-06-29	2016-04-26	Ionis Pharmaceuticals, Inc.	Methods for modulating kallikrein (KLKB1) expression
HRP20170427T1 (hr)	2011-11-16	2017-06-16	Sphingotec Gmbh	Testovi na adrenomedulin i postupci određivanja zrelog adrenomedulina
PT2780371T (pt)	2011-11-16	2019-01-30	Adrenomed Ag	Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou uma estrutura não ig anti-adm para a regulação do equilíbrio de fluidos num doente com uma doença aguda ou crónica
EP2780370B1 (de)	2011-11-16	2019-09-25	AdrenoMed AG	Anti-adrenomedullin (adm)-antikörper oder anti-adm-antikörperfragment oder anti-adm-non-ig-gerüst zur verwendung in der therapie einer akuten erkrankung bei einem patienten zur stabilisierung des kreislaufs
LT3553084T (lt)	2011-11-16	2023-03-10	Adrenomed Ag	Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme
IL283215B2 (en)	2011-11-16	2024-05-01	Adrenomed Ag	Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment and pharmaceutical compostions comprising the same
ES2494190T3 (es)	2011-11-16	2014-09-15	Adrenomed Ag	Anticuerpo anti-adrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o andamiaje proteico sin Ig anti-ADM para reducir el riesgo de mortalidad en un paciente que padece una enfermedad crónica o aguda o un estado agudo
CN103308673B (zh)	2012-03-08	2017-05-31	思芬构技术有限公司	用于预测雌性对象中发生心血管事件的风险的方法
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EP4234583A3 (de)	2013-01-20	2024-01-24	Takeda Pharmaceutical Company Limited	Untersuchung und behandlung von bradykininvermittelten erkrankungen
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EA038532B1 (ru)	2014-01-21	2021-09-10	Такеда Фармасьютикал Компани Лимитед	Способ лечения наследственного ангионевротического отека (hae)
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HUE052709T2 (hu)	2014-05-01	2021-05-28	Ionis Pharmaceuticals Inc	Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására
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Publication number	Publication date
PT1941867E (pt)	2012-02-16
PT2298278E (pt)	2016-02-25
US20140349940A1 (en)	2014-11-27
EP1941867A1 (de)	2008-07-09
US10245307B2 (en)	2019-04-02
EP1531791A4 (de)	2008-05-21
US20090082267A1 (en)	2009-03-26
US20080131426A1 (en)	2008-06-05
US7811991B2 (en)	2010-10-12
AU2011201811A1 (en)	2011-05-19
US20080200646A1 (en)	2008-08-21
US20080076712A1 (en)	2008-03-27
JP2010155842A (ja)	2010-07-15
EP2298278B1 (de)	2015-11-11
US20080152656A1 (en)	2008-06-26
DK1531791T3 (da)	2010-11-01
JP5249251B2 (ja)	2013-07-31
ES2528254T3 (es)	2015-02-05
DE60333758D1 (de)	2010-09-23
US9480733B2 (en)	2016-11-01
PT2311432E (pt)	2015-02-09
US20080260752A1 (en)	2008-10-23
CA2488558A1 (en)	2003-12-18
AU2008202377A1 (en)	2008-06-19
ES2559927T3 (es)	2016-02-16
WO2003103475A3 (en)	2005-03-10
EP2311432A1 (de)	2011-04-20
ES2372978T3 (es)	2012-01-30
HK1154211A1 (en)	2012-04-13
US11344610B2 (en)	2022-05-31
CY1112228T1 (el)	2015-12-09
WO2003103475A2 (en)	2003-12-18
HK1154513A1 (en)	2012-04-27
US20110086801A1 (en)	2011-04-14
EP1531791B1 (de)	2010-08-11
PT1531791E (pt)	2010-12-16
AU2003243394A1 (en)	2003-12-22
US7851442B2 (en)	2010-12-14
JP2013049698A (ja)	2013-03-14
EP2311432B1 (de)	2014-12-24
AU2003243394B2 (en)	2008-06-12
ES2348230T3 (es)	2010-12-01
ATE477020T1 (de)	2010-08-15
US20040038893A1 (en)	2004-02-26
US7064107B2 (en)	2006-06-20
HK1119955A1 (en)	2009-03-20
EP1531791A2 (de)	2005-05-25
DK2311432T3 (en)	2015-02-02
JP2005534647A (ja)	2005-11-17
DK2298278T3 (en)	2016-02-01
US20080064637A1 (en)	2008-03-13
US8710007B2 (en)	2014-04-29
US20160361395A1 (en)	2016-12-15
US20060194727A1 (en)	2006-08-31
US20190247477A1 (en)	2019-08-15
US8124586B2 (en)	2012-02-28
DK1941867T3 (da)	2012-01-02
EP1941867B1 (de)	2011-10-12
CA2488558C (en)	2013-08-20
EP2298278A1 (de)	2011-03-23
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