ATE162385T1 - Wasserentzug bei hydrogel - Google Patents

Wasserentzug bei hydrogel

Info

Publication number
ATE162385T1
ATE162385T1 AT94919808T AT94919808T ATE162385T1 AT E162385 T1 ATE162385 T1 AT E162385T1 AT 94919808 T AT94919808 T AT 94919808T AT 94919808 T AT94919808 T AT 94919808T AT E162385 T1 ATE162385 T1 AT E162385T1
Authority
AT
Austria
Prior art keywords
hydrogel
implants
water withdrawal
hydrated
discs
Prior art date
Application number
AT94919808T
Other languages
English (en)
Inventor
Qi-Bin Bao
Original Assignee
Howmedica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howmedica filed Critical Howmedica
Application granted granted Critical
Publication of ATE162385T1 publication Critical patent/ATE162385T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30112Rounded shapes, e.g. with rounded corners
    • A61F2002/30133Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0015Kidney-shaped, e.g. bean-shaped
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/02Homopolymers or copolymers of unsaturated alcohols
    • C08J2329/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S264/00Plastic and nonmetallic article shaping or treating: processes
    • Y10S264/90Direct application of fluid pressure differential to shape, reshape, i.e. distort, or sustain an article or preform and heat-setting, i.e. crystallizing of stretched or molecularly oriented portion thereof
    • Y10S264/901Heat-setting of stretched or molecularly oriented article formed from planar preform, e.g. sheet, film

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT94919808T 1993-09-16 1994-07-18 Wasserentzug bei hydrogel ATE162385T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/122,110 US5522898A (en) 1993-09-16 1993-09-16 Dehydration of hydrogels

Publications (1)

Publication Number Publication Date
ATE162385T1 true ATE162385T1 (de) 1998-02-15

Family

ID=22400676

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94919808T ATE162385T1 (de) 1993-09-16 1994-07-18 Wasserentzug bei hydrogel

Country Status (7)

Country Link
US (1) US5522898A (de)
EP (1) EP0719117B1 (de)
JP (1) JP2935572B2 (de)
AT (1) ATE162385T1 (de)
CA (1) CA2170037C (de)
DE (2) DE69408153T2 (de)
WO (1) WO1995007668A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008396A1 (en) * 1999-03-17 2003-01-09 Ku David N. Poly(vinyl alcohol) hydrogel
GB9713330D0 (en) * 1997-06-25 1997-08-27 Bridport Gundry Plc Surgical implant
DE29720022U1 (de) * 1997-11-12 1998-01-15 SCHÄFER micomed GmbH, 73035 Göppingen Zwischenwirbelimplantat
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6520996B1 (en) * 1999-06-04 2003-02-18 Depuy Acromed, Incorporated Orthopedic implant
FR2897259B1 (fr) 2006-02-15 2008-05-09 Ldr Medical Soc Par Actions Si Cage intersomatique transforaminale a greffon de fusion intervetebrale et instrument d'implantation de la cage
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US7553329B2 (en) 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
WO2009033100A1 (en) 2007-09-07 2009-03-12 Intrinsic Therapeutics, Inc. Bone anchoring systems
WO2004100841A1 (en) 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
US7998213B2 (en) 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US20040010317A1 (en) 1999-08-18 2004-01-15 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7258700B2 (en) 1999-08-18 2007-08-21 Intrinsic Therapeutics, Inc. Devices and method for nucleus pulposus augmentation and retention
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
US6883520B2 (en) 1999-08-18 2005-04-26 Intrinsic Therapeutics, Inc. Methods and apparatus for dynamically stable spinal implant
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6264695B1 (en) * 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
CA2392721C (en) * 1999-12-06 2009-01-20 Sdgi Holdings, Inc. Intervertebral disc treatment devices and methods
WO2004028401A2 (en) * 2002-09-24 2004-04-08 Bogomir Gorensek Stabilizing device for intervertebral disc, and methods thereof
JP2007515988A (ja) 2003-06-20 2007-06-21 イントリンジック セラピューティックス インコーポレイテッド 椎間板の環状欠損からインプラントを送出する装置および方法
US20040260300A1 (en) 2003-06-20 2004-12-23 Bogomir Gorensek Method of delivering an implant through an annular defect in an intervertebral disc
EP1786485A4 (de) 2004-02-06 2012-05-30 Georgia Tech Res Inst Oberflächengerichtete zellulare anbringung
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
AU2005225205B9 (en) * 2004-03-26 2009-11-19 Nuvasive, Inc. Prosthetic spinal disc
US20080306595A1 (en) * 2004-03-26 2008-12-11 Pearsalls Limited Porous Implant For Spinal Disc Nucleus Replacement
WO2005112833A1 (en) * 2004-05-20 2005-12-01 Pearsalls Limited Improvements in and relating to surgical implants
US20050277921A1 (en) * 2004-05-28 2005-12-15 Sdgi Holdings, Inc. Prosthetic joint and nucleus supplement
US20070255417A1 (en) * 2004-09-10 2007-11-01 Stichting Dutch Polymer Institute Radiopaque Prosthetic Intervertebral Disc Nucleus
EP1895946A4 (de) * 2005-06-03 2012-11-21 Nuvasive Inc Verbesserungen von und im zusammenhang mit chirurgischen implantaten
GB0514891D0 (en) * 2005-07-20 2005-08-24 Pearsalls Ltd Improvements in and relating to implants
JP2008542518A (ja) 2005-06-06 2008-11-27 ザ ジェネラル ホスピタル コーポレイション ディー ビー エイ マサチューセッツ ジェネラル ホスピタル 靱性ヒドロゲル
US20070093906A1 (en) * 2005-10-26 2007-04-26 Zimmer Spine, Inc. Nucleus implant and method
US8038920B2 (en) * 2006-01-25 2011-10-18 Carticept Medical, Inc. Methods of producing PVA hydrogel implants and related devices
US8603171B2 (en) * 2006-01-25 2013-12-10 Mimedx Group, Inc. Spinal disc implants with flexible keels and methods of fabricating implants
US20070179618A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US7918889B2 (en) * 2006-02-27 2011-04-05 Warsaw Orthopedic, Inc. Expandable spinal prosthetic devices and associated methods
US7942104B2 (en) * 2007-01-22 2011-05-17 Nuvasive, Inc. 3-dimensional embroidery structures via tension shaping
US7946236B2 (en) * 2007-01-31 2011-05-24 Nuvasive, Inc. Using zigzags to create three-dimensional embroidered structures
US20100320639A1 (en) * 2007-02-08 2010-12-23 Christopher Reah Medical Implants with Pre-Settled Cores and Related Methods
US20100210752A1 (en) 2007-04-23 2010-08-19 The General Hospital Corporation Pva hydrogels having improved creep resistance, lubricity, and toughness
EP2166991A4 (de) * 2007-04-24 2013-12-18 Gen Hospital Corp Pva-paa-hydrogele
US8282681B2 (en) * 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
CA2837303C (en) 2011-05-26 2019-08-20 Cartiva, Inc. Tapered joint implant and related tools
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
EP3636226A1 (de) 2015-03-31 2020-04-15 Cartiva, Inc. Daumensattelgelenkimplantate
AU2017214566A1 (en) 2016-02-05 2018-08-23 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234659A (en) * 1961-05-08 1966-02-15 Fan Air Systems Inc Low temperature, high humidity method of lumber drying in a kiln
US3760045A (en) * 1967-12-12 1973-09-18 H Thiele Process of preparing shaped optical bodies useful as aids to vision
JPS5956446A (ja) * 1982-09-24 1984-03-31 Nippon Oil Co Ltd ポリビニルアルコ−ル凍結ゲルの柔軟性低下法
JPH0678460B2 (ja) * 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース 多孔質透明ポリビニルアルユールゲル
JPH0611290B2 (ja) * 1986-11-05 1994-02-16 住友ベークライト株式会社 ポリビニルアルコ−ルゲルのγ線滅菌法
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP3007903B2 (ja) * 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板

Also Published As

Publication number Publication date
DE9490462U1 (de) 1996-05-30
EP0719117A1 (de) 1996-07-03
DE69408153D1 (de) 1998-02-26
US5522898A (en) 1996-06-04
JP2935572B2 (ja) 1999-08-16
JPH08509891A (ja) 1996-10-22
CA2170037A1 (en) 1995-03-23
EP0719117B1 (de) 1998-01-21
DE69408153T2 (de) 1998-05-07
CA2170037C (en) 2000-05-30
WO1995007668A1 (en) 1995-03-23

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