ATE162796T1 - 4-a-substutierte avermectinderivate - Google Patents

4-a-substutierte avermectinderivate

Info

Publication number: ATE162796T1
Authority: AT; Austria
Prior art keywords: derivatives; substuated; avermectine; alkyl; substituted
Prior art date: 1991-06-20

Application number

AT92305633T

Other languages

English (en)

Inventor

Lin Chu

Todd K Jones

Helmut Mrozik

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-20

Filing date

1992-06-19

Publication date

1998-02-15

1992-06-19 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1998-02-15 Application granted granted Critical

1998-02-15 Publication of ATE162796T1 publication Critical patent/ATE162796T1/de

Links

125000000217 alkyl group Chemical group 0.000 abstract 2
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
239000000921 anthelmintic agent Substances 0.000 abstract 1
229940124339 anthelmintic agent Drugs 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
229940125687 antiparasitic agent Drugs 0.000 abstract 1
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT92305633T 1991-06-20 1992-06-19 4-a-substutierte avermectinderivate ATE162796T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US71795391A	1991-06-20	1991-06-20
US81099991A	1991-12-20	1991-12-20
US07/882,809 US5262400A (en)	1991-06-20	1992-05-19	4α-substituted avermectin derivatives

Publications (1)

Publication Number	Publication Date
ATE162796T1 true ATE162796T1 (de)	1998-02-15

Family

ID=27418973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92305633T ATE162796T1 (de)	1991-06-20	1992-06-19	4-a-substutierte avermectinderivate

Country Status (10)

Country	Link
US (1)	US5262400A (de)
EP (1)	EP0519731B1 (de)
JP (1)	JPH089623B2 (de)
AT (1)	ATE162796T1 (de)
AU (1)	AU650143B2 (de)
CA (1)	CA2071803A1 (de)
DE (1)	DE69224234T2 (de)
ES (1)	ES2112300T3 (de)
IE (1)	IE922005A1 (de)
NZ (1)	NZ243153A (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5229415A (en) *	1992-03-24	1993-07-20	Merck & Co., Inc.	Alkylthio alkyl avermectins are active antiparasitic agents
GB9300883D0 (en) *	1993-01-18	1993-03-10	Pfizer Ltd	Antiparasitic agents
US5362862A (en) *	1993-09-29	1994-11-08	Merck & Co., Inc.	Process for 4"-EPI-acetylamino-4"-deoxy-5-oximinoavermectin-B1
US5420260A (en) *	1993-09-29	1995-05-30	Merck & Co., Inc.	Process for 4"-epi-acetylamino-4"-deoxy-5-oximinoavermectin B1
SI9420059A (en) *	1993-10-05	1997-02-28	Pfizer	Process and antiparasitic intermediates for doramectin
US5981500A (en) *	1994-01-12	1999-11-09	Pfizer Inc.	Antiparasitic agents related to the milbemycins and avermectins
PT750907E (pt) *	1995-06-30	2002-08-30	American Cyanamid Co	Formulacoes de vacinas estaveis para administracao parenterica metodo para a sua utilizacao e processo para a sua preparacao
CA2259469A1 (en)	1996-06-05	1997-12-11	Ashmont Holdings Limited	Injectable compositions
CR6574A (es)	2001-02-27	2004-10-28	Syngenta Participations Ag	Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
EG23124A (en)	2001-02-27	2004-04-28	Syngenta Participations Ag	Avermectins substituted in the 4-position having pesticidal properties
AR036486A1 (es)	2001-08-28	2004-09-15	Syngenta Participations Ag	Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
AR040073A1 (es)	2002-05-07	2005-03-16	Syngenta Participations Ag	Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0229804D0 (en) *	2002-12-20	2003-01-29	Syngenta Participations Ag	Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
JP4373080B2 (ja) *	2002-12-24	2009-11-25	三井化学アグロ株式会社	ミルベマイシン類の精製法
GB0302310D0 (en)	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302308D0 (en)	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0320176D0 (en)	2003-08-28	2003-10-01	Syngenta Participations Ag	Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
US8901163B2 (en)	2007-01-03	2014-12-02	Galderma S.A.	Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
US8425925B2 (en) *	2007-06-29	2013-04-23	Y-Tex Corporation	Pesticidal tag
AU2007251891B8 (en) *	2007-06-29	2014-03-06	Y-Tex Corporation	Pesticidal ear tag
JP5595412B2 (ja)	2008-12-04	2014-09-24	メリアルリミテッド	二量体アベルメクチン及びミルベマイシン誘導体
NZ600845A (en)	2009-12-17	2014-08-29	Merial Ltd	Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
US8912151B2 (en)	2010-10-20	2014-12-16	Galderma S.A.	Method of treating hemorrhoids using macrocyclic lactone compound
US8901090B2 (en)	2010-10-20	2014-12-02	Galderma S.A.	Method of treating otitis externa using macrocyclic lactone compound
EP3351546B9 (de)	2011-12-02	2024-07-10	Boehringer Ingelheim Vetmedica GmbH	Langwirkende injizierbare moxidectinformulierungen
CN105017358B (zh) *	2015-07-31	2018-07-10	内蒙古嘉宝仕生物科技股份有限公司	一种合成甲胺基阿维菌素苯甲酸盐的方法
CN107188915B (zh) *	2017-07-19	2019-08-02	苏州正永生物医药有限公司	一种塞拉菌素中间体的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950360A (en) *	1972-06-08	1976-04-13	Sankyo Company Limited	Antibiotic substances
SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
NZ201681A (en) *	1981-09-03	1985-11-08	Merck & Co Inc	Avermectin derivatives and parasiticidal compositions
US4457920A (en) *	1981-09-03	1984-07-03	Merck & Co., Inc.	4a-Substituted avermectin compounds
DE3519834C2 (de) *	1984-06-05	1993-12-16	American Cyanamid Co	Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
PL152148B1 (en) *	1984-09-14	1990-11-30	Glaxo Group Ltd	Antibiotic compounds and their preparation
GB8606123D0 (en) *	1986-03-12	1986-04-16	Glaxo Group Ltd	Chemical compounds
JPS6429379A (en) *	1987-07-23	1989-01-31	Kumiai Chemical Industry Co	Physiologically active substance and production thereof
JPS6431776A (en) *	1987-07-28	1989-02-02	Sankyo Co	Novel macrolide compound and production thereof
DE3727648A1 (de) *	1987-08-19	1989-03-02	Bayer Ag	Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung
JPH01272587A (ja) *	1987-10-09	1989-10-31	Microbial Chem Res Found	マクロライド抗生物質ｍｉ１９８物質及びその製造法、並びに線形動物又は節足動物の殺滅剤
DE3888936T2 (de) *	1987-11-03	1994-07-21	Beecham Group Plc	Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
JPH078871B2 (ja) *	1987-12-28	1995-02-01	三共株式会社	抗生物質ミルベマイシン化合物
IL90337A0 (en) *	1988-05-24	1989-12-15	Pfizer	Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
JP2849389B2 (ja) *	1988-07-05	1999-01-20	三共株式会社	新規マクロライド化合物
JP2844214B2 (ja) *	1989-06-13	1999-01-06	クミアイ化学工業株式会社	４ａ―ヒドロキシミルベマイシンα類の製造法
US5290804A (en) *	1991-05-01	1994-03-01	Merck & Co., Inc.	Anthelmintic milbemycin analogs of novel microorganisms

1992
- 1992-05-19 US US07/882,809 patent/US5262400A/en not_active Expired - Fee Related
- 1992-06-16 NZ NZ243153A patent/NZ243153A/xx unknown
- 1992-06-19 ES ES92305633T patent/ES2112300T3/es not_active Expired - Lifetime
- 1992-06-19 AU AU18448/92A patent/AU650143B2/en not_active Ceased
- 1992-06-19 EP EP92305633A patent/EP0519731B1/de not_active Expired - Lifetime
- 1992-06-19 CA CA002071803A patent/CA2071803A1/en not_active Abandoned
- 1992-06-19 DE DE69224234T patent/DE69224234T2/de not_active Expired - Lifetime
- 1992-06-19 AT AT92305633T patent/ATE162796T1/de active
- 1992-06-22 JP JP4204212A patent/JPH089623B2/ja not_active Expired - Lifetime
- 1992-07-01 IE IE200592A patent/IE922005A1/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH089623B2 (ja)	1996-01-31
DE69224234T2 (de)	1998-08-20
EP0519731A1 (de)	1992-12-23
JPH05255342A (ja)	1993-10-05
ES2112300T3 (es)	1998-04-01
EP0519731B1 (de)	1998-01-28
US5262400A (en)	1993-11-16
NZ243153A (en)	1994-08-26
AU1844892A (en)	1992-12-24
AU650143B2 (en)	1994-06-09
IE922005A1 (en)	1992-12-30
DE69224234D1 (de)	1998-03-05
CA2071803A1 (en)	1992-12-21

Publication	Publication Date	Title
DE69224234D1 (de)	1998-03-05	4-a-Substutierte Avermectinderivate
MX9203633A (es)	1992-07-01	Derivados de leucina y composiciones farmaceuticas que los contienen.
MX9200817A (es)	1992-08-01	Derivados de piranil cianoguanidina y proceso para su preparacion.
ES2069137T3 (es)	1995-05-01	Derivados de imidazopiridina y su uso.
DK0778277T3 (da)	2003-10-27	Substituerede heterocycliske derivater som CRF antagonister
ATE157368T1 (de)	1997-09-15	6-0-methylerythromycin a-derivat
BR1100987A (pt)	1999-12-07	Composto, composição farmacêutica da matéria, e, composição veterinária
ATE370148T1 (de)	2007-09-15	Halbsynthetische ectein-ascidine
AR010307A1 (es)	2000-06-07	Derivado de la eritromicina a, composicion farmaceutica y preparacion antibacteriana que lo contienen.
IL123776A0 (en)	1998-10-30	Novel derivatives of cyclodepsipeptide PF 1022
FI101376B1 (fi)	1998-06-15	Menetelmä 3-bentsyyliamino-2-fenyylipiperidiinijohdannaisten valmistamiseksi
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
FI930974A0 (fi)	1993-03-04	Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
FI913769A0 (fi)	1991-08-08	Nya tricykliska foereningar eller deras salter, foerfarande foer deras framstaellning och dessa innehaollande antimikrobiellt medel.
DK1197215T3 (da)	2006-07-10	Anthelmintiske sammensætninger
HUT70761A (en)	1995-10-30	Alkyl derivatives of trazodone having action for central nervous system, pharmaceutical compositions for preparing thereof
DK0637244T3 (da)	2001-01-29	En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser
PT96564A (pt)	1991-10-15	Processo para a preparacao de um novo antibiotico, desoximulundocandina, e de composicoes farmaceuticas que o contem
ATE87926T1 (de)	1993-04-15	Ethylierte avermectine.
ES2068947T3 (es)	1995-05-01	Derivados de angolamicina.
DE69528984D1 (de)	2003-01-09	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use
ECSP951417A (es)	1996-07-16	Nuevos derivados de la eritromicina, su procedimiento de preparacion y su aplicación como medicamentos
ES2140804T3 (es)	2000-03-01	Derivados de los alquilos-3-oxo-alcanoatos y su procedimiento de preparacion.
SE8600411L (sv)	1987-07-31	Isokinolinderivat, deras framstellning och anvendning