ATE164376T1 - Indol derivate als steroid 5 alpha-reductase inhibitoren - Google Patents

Indol derivate als steroid 5 alpha-reductase inhibitoren

Info

Publication number
ATE164376T1
ATE164376T1 AT93903984T AT93903984T ATE164376T1 AT E164376 T1 ATE164376 T1 AT E164376T1 AT 93903984 T AT93903984 T AT 93903984T AT 93903984 T AT93903984 T AT 93903984T AT E164376 T1 ATE164376 T1 AT E164376T1
Authority
AT
Austria
Prior art keywords
pct
steroid
alpha
reductase inhibitors
indole derivatives
Prior art date
Application number
AT93903984T
Other languages
English (en)
Inventor
Julian Blagg
Paul William Finn
Colin William Greengrass
Graham Nigel Maw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE164376T1 publication Critical patent/ATE164376T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93903984T 1992-02-28 1993-02-16 Indol derivate als steroid 5 alpha-reductase inhibitoren ATE164376T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929204365A GB9204365D0 (en) 1992-02-28 1992-02-28 Indoles

Publications (1)

Publication Number Publication Date
ATE164376T1 true ATE164376T1 (de) 1998-04-15

Family

ID=10711259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93903984T ATE164376T1 (de) 1992-02-28 1993-02-16 Indol derivate als steroid 5 alpha-reductase inhibitoren

Country Status (24)

Country Link
US (1) US5767139A (de)
EP (1) EP0628040B1 (de)
JP (1) JP2540016B2 (de)
KR (1) KR950700287A (de)
CN (1) CN1079465A (de)
AT (1) ATE164376T1 (de)
AU (1) AU3497793A (de)
BR (1) BR9305991A (de)
CA (1) CA2117610C (de)
CZ (1) CZ207794A3 (de)
DE (1) DE69317651T2 (de)
DK (1) DK0628040T3 (de)
ES (1) ES2115053T3 (de)
FI (2) FI943931A7 (de)
GB (1) GB9204365D0 (de)
HR (1) HRP930227A2 (de)
HU (1) HUT71126A (de)
IL (1) IL104816A0 (de)
MX (1) MX9301112A (de)
NO (1) NO943187L (de)
RU (1) RU94042391A (de)
SK (1) SK100894A3 (de)
WO (1) WO1993017014A1 (de)
ZA (1) ZA931383B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109728A0 (en) 1993-05-28 1994-08-26 Pfizer Res & Dev Indoles
ES2099007B1 (es) * 1993-07-16 1997-12-01 Pfizer Res & Dev Derivados de indol.
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles
GB9403516D0 (en) * 1994-02-24 1994-04-13 Pfizer Ltd Indoles
GB9409583D0 (en) * 1994-05-13 1994-07-06 Pfizer Ltd Indoles
KR100430059B1 (ko) * 1995-04-10 2004-09-24 후지사와 야꾸힝 고교 가부시키가이샤 cGMP-PDE억제제로서의인돌유도체
DE69931496T2 (de) 1998-08-03 2006-11-23 Eli Lilly And Co., Indianapolis INDOLVERBINDUNGEN ALS sPLA2 INHIBITOREN
FR2796274B1 (fr) * 1999-07-16 2001-09-21 Oreal Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
FR2796279B1 (fr) * 1999-07-16 2001-09-21 Oreal Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour le traitement de la seborrhee
UA79504C2 (en) * 2002-11-07 2007-06-25 Organon Nv Indols for treating diseases associated with androgen receptors
MXPA05004929A (es) * 2002-11-07 2005-08-18 Akzo Nobel Nv Indoles utiles en el tratamiento de enfermedades relacionadas a receptor de androgeno.
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557142A (en) * 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
CA2036307C (en) * 1990-03-08 2002-07-09 Susan Jean Ward 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions and method
GB9011335D0 (en) * 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof
IL109728A0 (en) * 1993-05-28 1994-08-26 Pfizer Res & Dev Indoles

Also Published As

Publication number Publication date
RU94042391A (ru) 1996-08-10
FI943931A0 (fi) 1994-08-26
DE69317651D1 (en) 1998-04-30
CZ207794A3 (en) 1995-01-18
MX9301112A (es) 1994-07-29
AU3497793A (en) 1993-09-13
HUT71126A (en) 1995-11-28
JP2540016B2 (ja) 1996-10-02
WO1993017014A1 (en) 1993-09-02
ES2115053T3 (es) 1998-06-16
HRP930227A2 (en) 1996-10-31
CA2117610C (en) 2000-07-18
CN1079465A (zh) 1993-12-15
DE69317651T2 (de) 1998-07-09
HU9402466D0 (en) 1994-10-28
SK100894A3 (en) 1995-04-12
EP0628040B1 (de) 1998-03-25
NO943187D0 (no) 1994-08-29
NO943187L (no) 1994-09-13
DK0628040T3 (da) 1998-04-27
ZA931383B (en) 1994-08-26
FI20001771A7 (fi) 2000-08-09
CA2117610A1 (en) 1993-09-02
BR9305991A (pt) 1997-10-21
KR950700287A (ko) 1995-01-16
JPH07500347A (ja) 1995-01-12
GB9204365D0 (en) 1992-04-08
US5767139A (en) 1998-06-16
IL104816A0 (en) 1993-06-10
FI943931A7 (fi) 1994-08-26
EP0628040A1 (de) 1994-12-14

Similar Documents

Publication Publication Date Title
DE69331190D1 (de) Überbrückte azabicyclische derivate als substanz p antagonisten
DK0687251T3 (da) 1,3-dihydroindol-2-on-derivater, der er substitueret i 3-stillingen med en nitrogengruppe, til anvendelse som vasopressin- og/eller ocytocin-agonister og/eller -antagonister
ATE171445T1 (de) Perhydroisoindolderivate als substanz p antagonisten
DE69932173D1 (de) Adenine-derivate
ATE164376T1 (de) Indol derivate als steroid 5 alpha-reductase inhibitoren
ATE275545T1 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
DE69323322D1 (de) Verwendung dimethylbenzofuran und dimethylbenzopyran derivate als 5-ht3 antagoniste
ATE144497T1 (de) N-substituierte 3-azabicyclo(3.2.0>heptan- derivate als neuroleptika
TW221993B (de)
MX9303607A (es) Derivados de azabicicloheptano sustituidos, su obtencion y uso.
ATE154352T1 (de) Indolderivate als steroid 5-alpha-reduktase inhibitoren

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee