NO943187L - Indolderivater som steroid 5-alfa-reduktasehemmere - Google Patents

Indolderivater som steroid 5-alfa-reduktasehemmere

Info

Publication number: NO943187L
Authority: NO; Norway
Prior art keywords: alkyl; alkynylene; alkenylene; alkylene; steroid
Prior art date: 1992-02-28

Application number

NO943187A

Other languages

English (en)

Norwegian (no)

Other versions

NO943187D0 (no

Inventor

Julian Blagg

Paul William Finn

Colin William Greengrass

Graham Nigel Maw

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-28

Filing date

1994-08-29

Publication date

1994-09-13

1994-08-29 Application filed by Pfizer filed Critical Pfizer

1994-08-29 Publication of NO943187D0 publication Critical patent/NO943187D0/no

1994-09-13 Publication of NO943187L publication Critical patent/NO943187L/no

Links

239000002677 5-alpha reductase inhibitor Substances 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000004419 alkynylene group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO943187A 1992-02-28 1994-08-29 Indolderivater som steroid 5-alfa-reduktasehemmere NO943187L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929204365A GB9204365D0 (en)	1992-02-28	1992-02-28	Indoles
PCT/EP1993/000380 WO1993017014A1 (en)	1992-02-28	1993-02-16	Indole derivatives as steroid 5 alpha-reductase inhibitors

Publications (2)

Publication Number	Publication Date
NO943187D0 NO943187D0 (no)	1994-08-29
NO943187L true NO943187L (no)	1994-09-13

Family

ID=10711259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO943187A NO943187L (no)	1992-02-28	1994-08-29	Indolderivater som steroid 5-alfa-reduktasehemmere

Country Status (24)

Country	Link
US (1)	US5767139A (de)
EP (1)	EP0628040B1 (de)
JP (1)	JP2540016B2 (de)
KR (1)	KR950700287A (de)
CN (1)	CN1079465A (de)
AT (1)	ATE164376T1 (de)
AU (1)	AU3497793A (de)
BR (1)	BR9305991A (de)
CA (1)	CA2117610C (de)
CZ (1)	CZ207794A3 (de)
DE (1)	DE69317651T2 (de)
DK (1)	DK0628040T3 (de)
ES (1)	ES2115053T3 (de)
FI (2)	FI943931A7 (de)
GB (1)	GB9204365D0 (de)
HR (1)	HRP930227A2 (de)
HU (1)	HUT71126A (de)
IL (1)	IL104816A0 (de)
MX (1)	MX9301112A (de)
NO (1)	NO943187L (de)
RU (1)	RU94042391A (de)
SK (1)	SK100894A3 (de)
WO (1)	WO1993017014A1 (de)
ZA (1)	ZA931383B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL109728A0 (en)	1993-05-28	1994-08-26	Pfizer Res & Dev	Indoles
ES2099007B1 (es) *	1993-07-16	1997-12-01	Pfizer Res & Dev	Derivados de indol.
GB9317096D0 (en) *	1993-08-17	1993-09-29	Pfizer Ltd	Indoles
GB9403516D0 (en) *	1994-02-24	1994-04-13	Pfizer Ltd	Indoles
GB9409583D0 (en) *	1994-05-13	1994-07-06	Pfizer Ltd	Indoles
KR100430059B1 (ko) *	1995-04-10	2004-09-24	후지사와 야꾸힝 고교 가부시키가이샤	cGMP-PDE억제제로서의인돌유도체
DE69931496T2 (de)	1998-08-03	2006-11-23	Eli Lilly And Co., Indianapolis	INDOLVERBINDUNGEN ALS sPLA2 INHIBITOREN
FR2796274B1 (fr) *	1999-07-16	2001-09-21	Oreal	Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
FR2796279B1 (fr) *	1999-07-16	2001-09-21	Oreal	Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour le traitement de la seborrhee
UA79504C2 (en) *	2002-11-07	2007-06-25	Organon Nv	Indols for treating diseases associated with androgen receptors
MXPA05004929A (es) *	2002-11-07	2005-08-18	Akzo Nobel Nv	Indoles utiles en el tratamiento de enfermedades relacionadas a receptor de androgeno.
TW200602317A (en)	2004-04-23	2006-01-16	Akzo Nobel Nv	Novel androgens
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3557142A (en) *	1968-02-20	1971-01-19	Sterling Drug Inc	4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
PH23498A (en) *	1984-08-06	1989-08-16	Sterling Drug Inc	3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
CA2036307C (en) *	1990-03-08	2002-07-09	Susan Jean Ward	3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions and method
GB9011335D0 (en) *	1990-05-21	1990-07-11	Fujisawa Pharmaceutical Co	Indolebutyric acid derivatives and process for preparation thereof
IL109728A0 (en) *	1993-05-28	1994-08-26	Pfizer Res & Dev	Indoles

1992
- 1992-02-28 GB GB929204365A patent/GB9204365D0/en active Pending
1993
- 1993-02-16 US US08/256,734 patent/US5767139A/en not_active Expired - Fee Related
- 1993-02-16 EP EP93903984A patent/EP0628040B1/de not_active Expired - Lifetime
- 1993-02-16 RU RU94042391/04A patent/RU94042391A/ru unknown
- 1993-02-16 DE DE69317651T patent/DE69317651T2/de not_active Expired - Fee Related
- 1993-02-16 BR BR9305991A patent/BR9305991A/pt not_active Application Discontinuation
- 1993-02-16 JP JP5514517A patent/JP2540016B2/ja not_active Expired - Fee Related
- 1993-02-16 DK DK93903984.8T patent/DK0628040T3/da active
- 1993-02-16 HU HU9402466A patent/HUT71126A/hu unknown
- 1993-02-16 ES ES93903984T patent/ES2115053T3/es not_active Expired - Lifetime
- 1993-02-16 FI FI943931A patent/FI943931A7/fi not_active IP Right Cessation
- 1993-02-16 WO PCT/EP1993/000380 patent/WO1993017014A1/en not_active Ceased
- 1993-02-16 AT AT93903984T patent/ATE164376T1/de not_active IP Right Cessation
- 1993-02-16 CZ CZ942077A patent/CZ207794A3/cs unknown
- 1993-02-16 CA CA002117610A patent/CA2117610C/en not_active Expired - Fee Related
- 1993-02-16 AU AU34977/93A patent/AU3497793A/en not_active Abandoned
- 1993-02-22 IL IL104816A patent/IL104816A0/xx unknown
- 1993-02-24 HR HR9204365.2A patent/HRP930227A2/hr not_active Application Discontinuation
- 1993-02-26 ZA ZA931383A patent/ZA931383B/xx unknown
- 1993-02-26 MX MX9301112A patent/MX9301112A/es unknown
- 1993-02-27 CN CN93103673A patent/CN1079465A/zh active Pending
1994
- 1994-08-24 SK SK1008-94A patent/SK100894A3/sk unknown
- 1994-08-27 KR KR1019940703018A patent/KR950700287A/ko not_active Ceased
- 1994-08-29 NO NO943187A patent/NO943187L/no unknown
2000
- 2000-08-09 FI FI20001771A patent/FI20001771A7/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU94042391A (ru)	1996-08-10
FI943931A0 (fi)	1994-08-26
DE69317651D1 (en)	1998-04-30
CZ207794A3 (en)	1995-01-18
MX9301112A (es)	1994-07-29
AU3497793A (en)	1993-09-13
HUT71126A (en)	1995-11-28
JP2540016B2 (ja)	1996-10-02
WO1993017014A1 (en)	1993-09-02
ES2115053T3 (es)	1998-06-16
HRP930227A2 (en)	1996-10-31
CA2117610C (en)	2000-07-18
CN1079465A (zh)	1993-12-15
DE69317651T2 (de)	1998-07-09
HU9402466D0 (en)	1994-10-28
SK100894A3 (en)	1995-04-12
EP0628040B1 (de)	1998-03-25
NO943187D0 (no)	1994-08-29
DK0628040T3 (da)	1998-04-27
ATE164376T1 (de)	1998-04-15
ZA931383B (en)	1994-08-26
FI20001771A7 (fi)	2000-08-09
CA2117610A1 (en)	1993-09-02
BR9305991A (pt)	1997-10-21
KR950700287A (ko)	1995-01-16
JPH07500347A (ja)	1995-01-12
GB9204365D0 (en)	1992-04-08
US5767139A (en)	1998-06-16
IL104816A0 (en)	1993-06-10
FI943931A7 (fi)	1994-08-26
EP0628040A1 (de)	1994-12-14

Publication	Publication Date	Title
NO943187L (no)	1994-09-13	Indolderivater som steroid 5-alfa-reduktasehemmere
NO932004L (no)	1993-12-06	Angiotensin-II-antagonister
AU4437896A (en)	1996-07-31	Piperidine derivatives having tachykinin antagonist activity
WO1999033858A3 (en)	1999-09-16	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
EE200100528A (et)	2003-02-17	Asendatud bitsükliline heteroarüülühend, seda sisaldav farmatseutiline kompositsioon ning nende raviotstarbeline kasutamine
UA41251C2 (uk)	2001-09-17	Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
BG103984A (en)	2000-09-29	Gastrokinetic monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
MX9700675A (es)	1997-04-30	Compuestos utiles como agentes antiproliferativos e inhibidores de la glicinamida ribonucleotido formil transferasa.
NZ332658A (en)	2000-05-26	Halo-substituted bis-indolylmaleimide derivatives and pharmaceutical compositions
NO20053730L (no)	2005-10-07	Pyridinderivater anvendelig for hemming av natrium/kalsium-utbyttingssystem
BG104933A (en)	2001-10-31	Water soluble azoles and broad-spectrum antifungals
MY132062A (en)	2007-09-28	Apolipoprotein-b synthesis inhibitors
MX9306310A (es)	1994-04-29	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU1250295A (en)	1995-07-17	Novel antiviral 2,4-pyrimidinedione derivatives and processes for the preparation thereof
ATE176232T1 (de)	1999-02-15	Verwendung dimethylbenzofuran und dimethylbenzopyran derivate als 5-ht3 antagoniste
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
TW350838B (en)	1999-01-21	Quinoline derivatives
HUP9800820A2 (hu)	1998-07-28	Halogén-alk(en)il-tio-szubsztituenseket tartalmazó szulfonil-amino-karbonil-triazolinon-származékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket hatóanyagként tartalmazó herbicid vagy fungicid készítmények
AU5399896A (en)	1996-11-07	Novel triazolones as apolipoprotein-b synthesis inhibitors
ATE159255T1 (de)	1997-11-15	Chinuclidine derivate als squalen synthase inhibitoren
ATE211140T1 (de)	2002-01-15	Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel
DE69712325D1 (de)	2002-06-06	Verwendung von 4-phenyl-3,6-dihydro-2h-pyridyl derivaten als nmda rezeptor subtyp blocker
ATE40140T1 (de)	1989-02-15	Aromatase inhibierende steroide.
NO934791L (no)	1994-06-27	Cefalosporinsalter og fremgangsmåte for fremstilling derav
DK0714395T3 (da)	1999-10-11	Substituerede dihydropyranopyridiner med vasokonstriktoraktivitet