ATE164848T1 - 4''-deoxyerythromycinderivate - Google Patents

4''-deoxyerythromycinderivate

Info

Publication number: ATE164848T1
Authority: AT; Austria
Prior art keywords: derivatives; deoxyerythromycin; deoxyerythromycin derivatives; erythromycin; enhancers
Prior art date: 1992-01-21

Application number

AT93904533T

Other languages

English (en)

Inventor

Paul A Lartey

Hugh N Nellans

Larry L Klein

Ramin Faghih

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1993-01-19

Publication date

1998-04-15

1993-01-19 Application filed by Abbott Lab filed Critical Abbott Lab

1998-04-15 Application granted granted Critical

1998-04-15 Publication of ATE164848T1 publication Critical patent/ATE164848T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
230000030135 gastric motility Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT93904533T 1992-01-21 1993-01-19 4''-deoxyerythromycinderivate ATE164848T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82349092A	1992-01-21	1992-01-21
US94415092A	1992-09-11	1992-09-11

Publications (1)

Publication Number	Publication Date
ATE164848T1 true ATE164848T1 (de)	1998-04-15

Family

ID=27124738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93904533T ATE164848T1 (de)	1992-01-21	1993-01-19	4''-deoxyerythromycinderivate

Country Status (16)

Country	Link
US (3)	US5578579A (de)
EP (1)	EP0623021B1 (de)
JP (1)	JP2662094B2 (de)
KR (1)	KR0179379B1 (de)
AT (1)	ATE164848T1 (de)
AU (1)	AU656462B2 (de)
CA (1)	CA2125478A1 (de)
DE (1)	DE69317877T2 (de)
DK (1)	DK0623021T3 (de)
ES (1)	ES2115760T3 (de)
HK (1)	HK1010054A1 (de)
HU (1)	HU211337A9 (de)
IL (1)	IL104437A (de)
MX (1)	MX9300278A (de)
PH (1)	PH31561A (de)
WO (1)	WO1993013780A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY113693A (en) *	1992-05-26	2002-05-31	Chugai Pharmaceutical Co Ltd	Erythromycin derivatives having an enterokinesis stimulating action
US5922849A (en) *	1996-11-22	1999-07-13	Abbott Laboratories	Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US5760198A (en) *	1997-01-17	1998-06-02	Abbott Laboratories	Process for preparation of 4"-deoxyerythromycins A and B
US7910548B2 (en) *	1997-06-06	2011-03-22	Amylin Pharmaceuticals, Inc.	Methods for treating obesity
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
US5883236A (en) *	1997-11-19	1999-03-16	Abbott Laboratories	Process for N-desmethylating erythromycins and derivatives thereof
US5932710A (en) *	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
US6040440A (en) *	1998-03-06	2000-03-21	Abbott Laboratories	Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
US6084079A (en) *	1998-05-15	2000-07-04	Keyes; Robert F.	Process for preparing N-demethyl-N-alkyl erythromycin derivatives
AU2001238476A1 (en)	2000-02-18	2001-08-27	Kosan Biosciences, Inc.	Motocide compounds
EP1365726A2 (de)	2001-02-15	2003-12-03	Kosan Biosciences, Inc.	Verfahern zur beurteilung der therapeutischen wirksamkeit
CN100363359C (zh) *	2002-08-29	2008-01-23	菲塞股份有限公司	运动内酯化合物
WO2004037273A1 (ja) *	2002-10-25	2004-05-06	Chugai Seiyaku Kabushiki Kaisha	排便機能障害の治療及び／又は予防剤
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
US20070135362A1 (en) *	2005-12-08	2007-06-14	Yaoquan Liu	Method for demethylating the 3'-dimethylamino group of erythromycin compounds
EP2431380A3 (de)	2006-09-11	2013-07-03	Tranzyme Pharma, Inc.	Makrozyklischer Antagonist des Motilinrezeptors zur Behandlung von Magen-Darm-Motilitätsstörungen
RU2422453C2 (ru)	2006-12-05	2011-06-27	Пфайзер Инк.	Полиморфы мотилида
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5849396A (ja) *	1981-09-07	1983-03-23	Toyo Jozo Co Ltd	４″−デオキシ−１４員環マクロライド抗生物質
JPS6187625A (ja) *	1984-10-05	1986-05-06	Satoshi Omura	消化管収縮運動促進剤
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
DE3689758T2 (de) *	1985-08-31	1994-08-18	Kitasato Inst	Erythromycinderivat und Verfahren zu dessen Herstellung.
US5175150A (en) *	1985-08-31	1992-12-29	Kitasato, Kenkyusho	Erythromycin derivative
US4640910A (en) *	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
US4681872A (en) *	1985-11-12	1987-07-21	Abbott Laboratories	Erythromycin A 11,12-carbonate and method of use
JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
MY103197A (en) *	1987-02-20	1993-05-29	Kitasato Inst	A growth promoting composition and production thereof
US4920102A (en) *	1988-04-18	1990-04-24	Eli Lilly And Company	Method for treating gastrointestinal disorders

1993
- 1993-01-19 CA CA002125478A patent/CA2125478A1/en not_active Abandoned
- 1993-01-19 AU AU35861/93A patent/AU656462B2/en not_active Ceased
- 1993-01-19 ES ES93904533T patent/ES2115760T3/es not_active Expired - Lifetime
- 1993-01-19 IL IL104437A patent/IL104437A/xx not_active IP Right Cessation
- 1993-01-19 MX MX9300278A patent/MX9300278A/es not_active IP Right Cessation
- 1993-01-19 DE DE69317877T patent/DE69317877T2/de not_active Expired - Fee Related
- 1993-01-19 WO PCT/US1993/000468 patent/WO1993013780A1/en not_active Ceased
- 1993-01-19 EP EP93904533A patent/EP0623021B1/de not_active Expired - Lifetime
- 1993-01-19 KR KR1019940702489A patent/KR0179379B1/ko not_active Expired - Fee Related
- 1993-01-19 AT AT93904533T patent/ATE164848T1/de not_active IP Right Cessation
- 1993-01-19 JP JP5512713A patent/JP2662094B2/ja not_active Expired - Lifetime
- 1993-01-19 HK HK98110890A patent/HK1010054A1/en not_active IP Right Cessation
- 1993-01-19 DK DK93904533T patent/DK0623021T3/da active
- 1993-01-21 PH PH45597A patent/PH31561A/en unknown
1994
- 1994-08-02 US US08/284,730 patent/US5578579A/en not_active Expired - Fee Related
1995
- 1995-05-04 US US08/435,903 patent/US5834438A/en not_active Expired - Fee Related
- 1995-05-04 US US08/435,900 patent/US5654411A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00662P patent/HU211337A9/hu unknown

Also Published As

Publication number	Publication date
EP0623021B1 (de)	1998-04-08
IL104437A0 (en)	1993-05-13
AU656462B2 (en)	1995-02-02
US5834438A (en)	1998-11-10
KR0179379B1 (ko)	1999-04-01
CA2125478A1 (en)	1993-07-22
HK1010054A1 (en)	1999-06-11
DE69317877D1 (en)	1998-05-14
ES2115760T3 (es)	1998-07-01
US5578579A (en)	1996-11-26
EP0623021A1 (de)	1994-11-09
US5654411A (en)	1997-08-05
IL104437A (en)	1997-03-18
JP2662094B2 (ja)	1997-10-08
DE69317877T2 (de)	1998-10-29
DK0623021T3 (da)	1999-02-08
WO1993013780A1 (en)	1993-07-22
JPH06511257A (ja)	1994-12-15
EP0623021A4 (en)	1994-12-14
HU211337A9 (en)	1995-11-28
PH31561A (en)	1998-11-03
AU3586193A (en)	1993-08-03
MX9300278A (es)	1993-12-31

Legal Events

Date	Code	Title	Description
1998-12-15	UEP	Publication of translation of european patent specification
2003-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0623021T3 (da)	1999-02-08	4"-deoxyerythromycinderivater
ATE202337T1 (de)	2001-07-15	Cyclopropylalkansäurederivate
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
DE69705829D1 (de)	2001-08-30	Meta-substituierte phenylsulphonamidderivate
NZ244021A (en)	1995-01-27	Benzylthiazolidinedione derivatives, preparation and pharmaceutical compositions thereof
DK0894084T3 (da)	2002-10-14	Kanelsyrederivater og deres anvendelse som integrinantagonister
TR199902995T2 (xx)	2000-02-21	9-Oksim eritromisin t�revleri
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
NZ247201A (en)	1996-05-28	Substituted sulphonylamido- or sulphonamidocarbonyl-pyridine-2-carboxamide derivatives and pharmaceutical compositions
PT1021456E (pt)	2003-08-29	Derivados macrociclicos de eritromicinas a e b de anel de 13 membros
PT876388E (pt)	2004-07-30	Derivados de eritromicina triciclica
NZ217650A (en)	1989-09-27	Quinoline derivatives and pharmaceutical compositions
KR960703863A (ko)	1996-08-31	암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
TR27833A (tr)	1995-08-31	Antelmintik'lerin uygulanmasina mahsus ''pour-on'' formülasyonu.
DE69318715D1 (de)	1998-06-25	Pharmakologisch aktive alpha-(tertiär-aminoethyl)-phenylmethanol-derivate
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
EP0641346A1 (de)	1995-03-08	Antibiotische 7-aminonaphthazarinderivate.
ES2133567T3 (es)	1999-09-16	Derivados de eritromicina.
ATE42305T1 (de)	1989-05-15	Antibiotika, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
IT1261994B (it)	1996-06-11	Derivati guanidinici ad uso terapeutico.
IT1255696B (it)	1995-11-10	Composto con attivita' vasodilatatrice procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono