IL104437A - 4)-deoxyerythromycin derivatives - Google Patents

4)-deoxyerythromycin derivatives

Info

Publication number: IL104437A
Authority: IL; Israel
Prior art keywords: group; loweralkyl; hydrogen; hydroxy; methyl
Prior art date: 1992-01-21

Application number

IL104437A

Other languages

English (en)

Other versions

IL104437A0 (en

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1993-01-19

Publication date

1997-03-18

1993-01-19 Application filed by Abbott Lab filed Critical Abbott Lab

1993-05-13 Publication of IL104437A0 publication Critical patent/IL104437A0/xx

1997-03-18 Publication of IL104437A publication Critical patent/IL104437A/xx

Links

239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000005676 cyclic carbonates Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Oncology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL104437A 1992-01-21 1993-01-19 4)-deoxyerythromycin derivatives IL104437A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82349092A	1992-01-21	1992-01-21
US94415092A	1992-09-11	1992-09-11

Publications (2)

Publication Number	Publication Date
IL104437A0 IL104437A0 (en)	1993-05-13
IL104437A true IL104437A (en)	1997-03-18

Family

ID=27124738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL104437A IL104437A (en)	1992-01-21	1993-01-19	4)-deoxyerythromycin derivatives

Country Status (16)

Country	Link
US (3)	US5578579A (de)
EP (1)	EP0623021B1 (de)
JP (1)	JP2662094B2 (de)
KR (1)	KR0179379B1 (de)
AT (1)	ATE164848T1 (de)
AU (1)	AU656462B2 (de)
CA (1)	CA2125478A1 (de)
DE (1)	DE69317877T2 (de)
DK (1)	DK0623021T3 (de)
ES (1)	ES2115760T3 (de)
HK (1)	HK1010054A1 (de)
HU (1)	HU211337A9 (de)
IL (1)	IL104437A (de)
MX (1)	MX9300278A (de)
PH (1)	PH31561A (de)
WO (1)	WO1993013780A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY113693A (en) *	1992-05-26	2002-05-31	Chugai Pharmaceutical Co Ltd	Erythromycin derivatives having an enterokinesis stimulating action
US5922849A (en) *	1996-11-22	1999-07-13	Abbott Laboratories	Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US5760198A (en) *	1997-01-17	1998-06-02	Abbott Laboratories	Process for preparation of 4"-deoxyerythromycins A and B
US7910548B2 (en) *	1997-06-06	2011-03-22	Amylin Pharmaceuticals, Inc.	Methods for treating obesity
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
US5883236A (en) *	1997-11-19	1999-03-16	Abbott Laboratories	Process for N-desmethylating erythromycins and derivatives thereof
US5932710A (en) *	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
US6040440A (en) *	1998-03-06	2000-03-21	Abbott Laboratories	Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
US6084079A (en) *	1998-05-15	2000-07-04	Keyes; Robert F.	Process for preparing N-demethyl-N-alkyl erythromycin derivatives
WO2001060833A2 (en) *	2000-02-18	2001-08-23	Kosan Biosciences, Inc.	Motilide compounds
EP1365726A2 (de)	2001-02-15	2003-12-03	Kosan Biosciences, Inc.	Verfahern zur beurteilung der therapeutischen wirksamkeit
SI1532131T1 (sl) *	2002-08-29	2009-04-30	Pfizer	Motilidne spojine
WO2004037273A1 (ja) *	2002-10-25	2004-05-06	Chugai Seiyaku Kabushiki Kaisha	排便機能障害の治療及び／又は予防剤
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
JP2009518396A (ja) *	2005-12-08	2009-05-07	ファイザー・インク	エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
EP2431380A3 (de)	2006-09-11	2013-07-03	Tranzyme Pharma, Inc.	Makrozyklischer Antagonist des Motilinrezeptors zur Behandlung von Magen-Darm-Motilitätsstörungen
CA2670482C (en) *	2006-12-05	2011-10-11	Pfizer Inc.	Motilide polymorphs
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5849396A (ja) *	1981-09-07	1983-03-23	Toyo Jozo Co Ltd	４″−デオキシ−１４員環マクロライド抗生物質
JPS6187625A (ja) *	1984-10-05	1986-05-06	Satoshi Omura	消化管収縮運動促進剤
US5175150A (en) *	1985-08-31	1992-12-29	Kitasato, Kenkyusho	Erythromycin derivative
DE3689758T2 (de) *	1985-08-31	1994-08-18	Kitasato Inst	Erythromycinderivat und Verfahren zu dessen Herstellung.
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
US4640910A (en) *	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
US4681872A (en) *	1985-11-12	1987-07-21	Abbott Laboratories	Erythromycin A 11,12-carbonate and method of use
US4833236A (en) *	1986-05-02	1989-05-23	Taisho Pharmaceutical Co., Ltd.	Erythromycin derivatives
MY103197A (en) *	1987-02-20	1993-05-29	Kitasato Inst	A growth promoting composition and production thereof
US4920102A (en) *	1988-04-18	1990-04-24	Eli Lilly And Company	Method for treating gastrointestinal disorders

1993
- 1993-01-19 DK DK93904533T patent/DK0623021T3/da active
- 1993-01-19 IL IL104437A patent/IL104437A/xx not_active IP Right Cessation
- 1993-01-19 DE DE69317877T patent/DE69317877T2/de not_active Expired - Fee Related
- 1993-01-19 AU AU35861/93A patent/AU656462B2/en not_active Ceased
- 1993-01-19 AT AT93904533T patent/ATE164848T1/de not_active IP Right Cessation
- 1993-01-19 JP JP5512713A patent/JP2662094B2/ja not_active Expired - Lifetime
- 1993-01-19 KR KR1019940702489A patent/KR0179379B1/ko not_active Expired - Fee Related
- 1993-01-19 ES ES93904533T patent/ES2115760T3/es not_active Expired - Lifetime
- 1993-01-19 MX MX9300278A patent/MX9300278A/es not_active IP Right Cessation
- 1993-01-19 CA CA002125478A patent/CA2125478A1/en not_active Abandoned
- 1993-01-19 WO PCT/US1993/000468 patent/WO1993013780A1/en not_active Ceased
- 1993-01-19 HK HK98110890A patent/HK1010054A1/en not_active IP Right Cessation
- 1993-01-19 EP EP93904533A patent/EP0623021B1/de not_active Expired - Lifetime
- 1993-01-21 PH PH45597A patent/PH31561A/en unknown
1994
- 1994-08-02 US US08/284,730 patent/US5578579A/en not_active Expired - Fee Related
1995
- 1995-05-04 US US08/435,903 patent/US5834438A/en not_active Expired - Fee Related
- 1995-05-04 US US08/435,900 patent/US5654411A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00662P patent/HU211337A9/hu unknown

Also Published As

Publication number	Publication date
JPH06511257A (ja)	1994-12-15
MX9300278A (es)	1993-12-31
HU211337A9 (en)	1995-11-28
EP0623021A1 (de)	1994-11-09
JP2662094B2 (ja)	1997-10-08
AU656462B2 (en)	1995-02-02
DE69317877D1 (en)	1998-05-14
KR0179379B1 (ko)	1999-04-01
ATE164848T1 (de)	1998-04-15
IL104437A0 (en)	1993-05-13
PH31561A (en)	1998-11-03
CA2125478A1 (en)	1993-07-22
ES2115760T3 (es)	1998-07-01
HK1010054A1 (en)	1999-06-11
DE69317877T2 (de)	1998-10-29
WO1993013780A1 (en)	1993-07-22
US5578579A (en)	1996-11-26
US5654411A (en)	1997-08-05
AU3586193A (en)	1993-08-03
US5834438A (en)	1998-11-10
EP0623021B1 (de)	1998-04-08
EP0623021A4 (en)	1994-12-14
DK0623021T3 (da)	1999-02-08

Legal Events

Date	Code	Title
1997-09-30	FF	Patent granted
1998-02-08	KB	Patent renewed
1999-06-20	KB	Patent renewed
2003-10-31	RH1	Patent not in force

Publication	Publication Date	Title
IL104437A (en)	1997-03-18	4)-deoxyerythromycin derivatives
GR3032083T3 (en)	2000-03-31	Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
KR950003271A (ko)	1995-02-16	1-벤젠술포닐-1, 3-디히드로-인돌-2-온 유도체, 그의 제조방법 및 이를 함유한 약학적 조성물
NO943093L (no)	1994-12-09	Fremgangsmåte for fremstilling av clavulansyre
HU9401256D0 (en)	1994-08-29	Trisubstituted tetrahydrofuran derivatives and antifungal compositions compositions containing them as active components
ES2124545T3 (es)	1999-02-01	Azolidindionas como agentes antihiperglucemicos.
ATE207922T1 (de)	2001-11-15	Carbapenem-derivate
IE43496L (en)	1977-01-21	1-(benzazolylalkyl) piperidine derivatives.
MX9501622A (es)	1997-03-29	Derivados de milbemicina 13-sustituidos, su preparacion y su uso.
SE8101323L (sv)	1981-09-04	7-oxo-1-azabicyklo(3.2.0)-hept-2-en-2-karboxylsyra-derivat
CA2030051A1 (en)	1991-05-18	Indole derivatives
PT87025A (pt)	1988-04-01	Process for the preparation of imidazol derivatives and of pharmaceutical compositions containing the same
IE822917L (en)	1983-06-11	Optically active penems
ATE25689T1 (de)	1987-03-15	5-0-mycaminosyl-tylonolide derivate, modifiziert an position c-23.
GB1525351A (en)	1978-09-20	Benzazepine derivatives and their acid addition salts processes for preparing them and pharmaceutical compositions containing them
ATE42295T1 (de)	1989-05-15	Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen.
AU560621B2 (en)	1987-04-09	Polymethylene imine substituted triazines
JPS5283380A (en)	1977-07-12	Synthesis of thiocarbostyril derivatives
CA2072575A1 (en)	1991-07-07	Anticholinergic agents
TW334428B (en)	1998-06-21	Novel benzodiazepine derivatives
KR850007067A (ko)	1985-10-30	옥스아자포스포린 유도체의 염의 제조방법
KR920014809A (ko)	1992-08-25	트리플루오로메틸 1-카바 (1-데티아)세펨
EP0630893A4 (de)	1995-04-05	N,n'-disubstituierte amidderivate.
KR880008999A (ko)	1988-09-13	3-아릴-5-알킬티오-4h-1,2,4-트리아졸
ES8301933A1 (es)	1983-02-01	"procedimiento para la preparacion de derivados de 4-(5)-alcohil-mercaptoimidazoles".