ATE165095T1 - Heterocyclische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

Heterocyclische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number
ATE165095T1
ATE165095T1 AT89310406T AT89310406T ATE165095T1 AT E165095 T1 ATE165095 T1 AT E165095T1 AT 89310406 T AT89310406 T AT 89310406T AT 89310406 T AT89310406 T AT 89310406T AT E165095 T1 ATE165095 T1 AT E165095T1
Authority
AT
Austria
Prior art keywords
sulphur
nitrogen
chem
oxygen
group
Prior art date
Application number
AT89310406T
Other languages
English (en)
Inventor
Barry Sidney Orlek
Richard Eric Faulkner
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888824071A external-priority patent/GB8824071D0/en
Priority claimed from GB888830223A external-priority patent/GB8830223D0/en
Priority claimed from GB898920660A external-priority patent/GB8920660D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of ATE165095T1 publication Critical patent/ATE165095T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT89310406T 1988-10-13 1989-10-11 Heterocyclische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen ATE165095T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888824071A GB8824071D0 (en) 1988-10-13 1988-10-13 Novel compounds
GB888830223A GB8830223D0 (en) 1988-12-23 1988-12-23 Novel compounds
GB898920660A GB8920660D0 (en) 1989-09-18 1989-09-18 Novel compounds

Publications (1)

Publication Number Publication Date
ATE165095T1 true ATE165095T1 (de) 1998-05-15

Family

ID=27264121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89310406T ATE165095T1 (de) 1988-10-13 1989-10-11 Heterocyclische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (9)

Country Link
US (1) US5166357A (de)
EP (1) EP0366304B1 (de)
JP (1) JP2934743B2 (de)
AT (1) ATE165095T1 (de)
AU (1) AU4278289A (de)
CA (1) CA2000041A1 (de)
DE (1) DE68928644T2 (de)
DK (1) DK504889A (de)
PT (1) PT91956B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
EP0402056A3 (de) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
ATE153024T1 (de) * 1989-08-16 1997-05-15 Beecham Group Plc Azabicyclische verbindungen
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
WO1992011261A1 (en) * 1990-12-21 1992-07-09 Merck Sharp & Dohme Limited 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
JPH11512444A (ja) * 1995-09-22 1999-10-26 ノボ ノルディスク アクティーゼルスカブ 新規置換アザ環式またはアザ二環式化合物
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
DE60015944T2 (de) * 1999-03-30 2005-11-03 E.I. Du Pont De Nemours And Co., Wilmington Verfahren zur herstellung von alpha-methylenelactonen und alpha-substitutierten hydrocarbyliden-lactonen
EP1165536B1 (de) 1999-03-30 2003-09-17 E.I. Du Pont De Nemours And Company Verfahren zur herstellung von alpha-methylenlactonen
US6362346B1 (en) 1999-11-12 2002-03-26 E. I. Du Pont De Nemours And Company Process for the preparation of α-methylene-γ-butyrolactone and α-acetoxymethyl-γ-butyrolactone
US6642346B2 (en) 2000-02-28 2003-11-04 E. I. Du Pont De Nemours And Company Coating compositions containing substituted and unsubstituted exomethylene lactone or lactam monomers
US6531616B2 (en) 2000-12-22 2003-03-11 E. I. Du Pont De Nemours And Company Process for the preparation of a-methylenelactones and a-substituted hydrocarbylidene lactones
KR100428408B1 (ko) * 2001-12-14 2004-04-28 학교법인 성균관대학 α-메틸렌-γ-부티로락톤의 제조방법
WO2003057686A1 (en) 2002-01-07 2003-07-17 E.I. Du Pont De Nemours And Company Alpha-methylenelactone synthesis in supercritical fluids
US6649776B2 (en) 2002-01-07 2003-11-18 E. I. Du Pont De Nemours And Company Methylenelactone synthesis in supercritical fluids
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP1928437A2 (de) * 2005-08-26 2008-06-11 Braincells, Inc. Neurogenese mittels muscarinrezeptormodulation
EP2068872A1 (de) * 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
CN102276559B (zh) * 2011-08-12 2014-05-28 河北威远生化农药有限公司 3-羟甲基四氢呋喃的合成方法
JP2025507371A (ja) 2022-02-11 2025-03-18 ヘンケル・アクチェンゲゼルシャフト・ウント・コムパニー・コマンディットゲゼルシャフト・アウフ・アクチェン α－メチレン－γ－ブチロラクトンを合成する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
EP0287356B1 (de) * 1987-04-15 1996-01-24 Beecham Group Plc Am Brückenkopf substituierte Azabicyclenderivate
EP0307141B1 (de) * 1987-09-10 1993-01-13 MERCK SHARP & DOHME LTD. Oxazole und Thiazole zur Behandlung seniler Demenz
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Also Published As

Publication number Publication date
EP0366304A2 (de) 1990-05-02
US5166357A (en) 1992-11-24
PT91956A (pt) 1990-04-30
DE68928644T2 (de) 1998-08-27
JP2934743B2 (ja) 1999-08-16
JPH02134380A (ja) 1990-05-23
PT91956B (pt) 1995-05-31
EP0366304B1 (de) 1998-04-15
DK504889D0 (da) 1989-10-11
DK504889A (da) 1990-04-14
EP0366304A3 (de) 1991-09-11
AU4278289A (en) 1990-04-26
DE68928644D1 (de) 1998-05-20
CA2000041A1 (en) 1990-04-13

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties