ATE118213T1 - Neue 4-aminobuttersäurederivate, verfahren zu ihrer herstellung und diese enthaltende arzneizubereitungen. - Google Patents
Neue 4-aminobuttersäurederivate, verfahren zu ihrer herstellung und diese enthaltende arzneizubereitungen.Info
- Publication number
- ATE118213T1 ATE118213T1 AT91401739T AT91401739T ATE118213T1 AT E118213 T1 ATE118213 T1 AT E118213T1 AT 91401739 T AT91401739 T AT 91401739T AT 91401739 T AT91401739 T AT 91401739T AT E118213 T1 ATE118213 T1 AT E118213T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- optionally substituted
- atom
- nitrogen
- carbon
- Prior art date
Links
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9008093A FR2663934B1 (fr) | 1990-06-27 | 1990-06-27 | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE118213T1 true ATE118213T1 (de) | 1995-02-15 |
Family
ID=9398069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91401739T ATE118213T1 (de) | 1990-06-27 | 1991-06-27 | Neue 4-aminobuttersäurederivate, verfahren zu ihrer herstellung und diese enthaltende arzneizubereitungen. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5162364A (de) |
| EP (1) | EP0463969B1 (de) |
| JP (1) | JPH04243853A (de) |
| AT (1) | ATE118213T1 (de) |
| AU (1) | AU637242B2 (de) |
| CA (1) | CA2045445A1 (de) |
| DE (1) | DE69107250T2 (de) |
| DK (1) | DK0463969T3 (de) |
| ES (1) | ES2071250T3 (de) |
| FR (1) | FR2663934B1 (de) |
| GR (1) | GR3015796T3 (de) |
| IE (1) | IE65593B1 (de) |
| OA (1) | OA09373A (de) |
| PT (1) | PT98100A (de) |
| ZA (1) | ZA914969B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2153842T3 (es) * | 1992-08-19 | 2001-03-16 | Mcneilab Inc | Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central. |
| US6489355B2 (en) * | 1993-12-01 | 2002-12-03 | Eli Lilly And Company | Methods of inhibiting the effects of amyloidogenic proteins |
| FR2722192A1 (fr) * | 1994-07-06 | 1996-01-12 | Adir | Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9906882D0 (en) * | 1999-03-25 | 1999-05-19 | Novartis Ag | Organic compounds |
| US7319095B2 (en) | 1999-12-09 | 2008-01-15 | Astrazeneca Ab | Use of GABAB receptor agonists |
| SE9904508D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| SE9904507D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| AR033779A1 (es) * | 2001-06-08 | 2004-01-07 | Astrazeneca Ab | Compuestos utiles en la enfermedad de reflujo |
| EP2354120A1 (de) | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon |
| KR20110097942A (ko) | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| WO2005060968A1 (en) | 2003-12-11 | 2005-07-07 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| EP1966150A4 (de) * | 2005-12-23 | 2011-07-20 | Astrazeneca Ab | Pyrazole zur behandlung von gerd und ibs |
| BRPI0620372A2 (pt) * | 2005-12-23 | 2011-11-08 | Astrazeneca Ab | composto, composição farmaceutica, e, uso de um composto |
| CN101374824A (zh) * | 2005-12-23 | 2009-02-25 | 阿斯利康(瑞典)有限公司 | 杂环gaba-b调节剂 |
| CN101341131A (zh) * | 2005-12-23 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 作为gaba-b受体调节剂的咪唑 |
| BRPI0620464A2 (pt) | 2005-12-23 | 2011-11-16 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, método para o tratamento de uma doença |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| MX2009010893A (es) * | 2007-04-18 | 2009-10-26 | Astrazeneca Ab | Compuestos de xantina que tienen un efecto modulador del receptor gabab alosterico positivo. |
| US20080262064A1 (en) * | 2007-04-18 | 2008-10-23 | Astrazeneca Ab | Novel Compounds For The Treatment Of GI Disorders 682 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011113904A1 (en) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
| EP3753410A3 (de) | 2010-09-28 | 2021-04-28 | The Regents Of The University Of California | Kombinationen enthaltend gaba agonisten zur behandlung von hyperglyzemie |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4940460B1 (de) * | 1971-08-28 | 1974-11-02 | ||
| US4328214A (en) * | 1979-07-04 | 1982-05-04 | Ciba-Geigy Corporation | Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture |
| ZA804008B (en) * | 1979-07-04 | 1981-06-24 | Ciba Geigy | New cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture |
| US4581167A (en) * | 1982-01-19 | 1986-04-08 | Research Corporation | Peptide synthesis and amino acid blocking agents |
| DE3241512A1 (de) * | 1982-11-10 | 1984-05-10 | Bayer Ag, 5090 Leverkusen | Substituierte malonsaeurediamide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| JP2561478B2 (ja) * | 1986-07-22 | 1996-12-11 | 武田薬品工業株式会社 | グリセリン誘導体 |
| GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
| US5047540A (en) * | 1987-12-17 | 1991-09-10 | Shionogi & Co., Ltd. | Lipid derivatives |
-
1990
- 1990-06-27 FR FR9008093A patent/FR2663934B1/fr not_active Expired - Fee Related
-
1991
- 1991-06-11 US US07/713,760 patent/US5162364A/en not_active Expired - Fee Related
- 1991-06-25 CA CA002045445A patent/CA2045445A1/fr not_active Abandoned
- 1991-06-26 JP JP3154760A patent/JPH04243853A/ja active Pending
- 1991-06-26 IE IE222491A patent/IE65593B1/en not_active IP Right Cessation
- 1991-06-26 AU AU79294/91A patent/AU637242B2/en not_active Ceased
- 1991-06-26 PT PT98100A patent/PT98100A/pt not_active Application Discontinuation
- 1991-06-27 ZA ZA914969A patent/ZA914969B/xx unknown
- 1991-06-27 DK DK91401739.7T patent/DK0463969T3/da active
- 1991-06-27 OA OA60029A patent/OA09373A/xx unknown
- 1991-06-27 ES ES91401739T patent/ES2071250T3/es not_active Expired - Lifetime
- 1991-06-27 DE DE69107250T patent/DE69107250T2/de not_active Expired - Fee Related
- 1991-06-27 EP EP91401739A patent/EP0463969B1/de not_active Expired - Lifetime
- 1991-06-27 AT AT91401739T patent/ATE118213T1/de not_active IP Right Cessation
-
1992
- 1992-07-28 US US07/920,786 patent/US5278166A/en not_active Expired - Fee Related
-
1995
- 1995-04-17 GR GR950400926T patent/GR3015796T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2045445A1 (fr) | 1991-12-28 |
| PT98100A (pt) | 1992-03-31 |
| AU7929491A (en) | 1992-01-02 |
| US5278166A (en) | 1994-01-11 |
| US5162364A (en) | 1992-11-10 |
| IE912224A1 (en) | 1992-01-01 |
| DE69107250D1 (de) | 1995-03-23 |
| OA09373A (fr) | 1992-09-15 |
| JPH04243853A (ja) | 1992-08-31 |
| FR2663934B1 (fr) | 1994-06-03 |
| DE69107250T2 (de) | 1995-09-21 |
| GR3015796T3 (en) | 1995-07-31 |
| EP0463969B1 (de) | 1995-02-08 |
| IE65593B1 (en) | 1995-11-01 |
| AU637242B2 (en) | 1993-05-20 |
| FR2663934A1 (fr) | 1992-01-03 |
| DK0463969T3 (da) | 1995-07-10 |
| EP0463969A1 (de) | 1992-01-02 |
| ZA914969B (en) | 1992-04-29 |
| ES2071250T3 (es) | 1995-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |