ATE166358T1 - Quinolin-carboxylsäurester von 21-hydroxypregnan derivaten und antibakterielle und entzüdungshemmende präparate davon - Google Patents

Quinolin-carboxylsäurester von 21-hydroxypregnan derivaten und antibakterielle und entzüdungshemmende präparate davon

Info

Publication number: ATE166358T1
Authority: AT; Austria
Prior art keywords: hydroxypregnan; antibacterial; derivatives; carboxylic acid; acid esters
Prior art date: 1993-12-22

Application number

AT94120195T

Other languages

English (en)

Inventor

Kazumi Ogata

Takahiro Sakaue

Yuuichi Isowaki

Hidetoshi Nakao

Kazuhiko Ito

Original Assignee

Senju Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-22

Filing date

1994-12-20

Publication date

1998-06-15

1994-12-20 Application filed by Senju Pharma Co filed Critical Senju Pharma Co

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166358T1 publication Critical patent/ATE166358T1/de

Links

230000000844 anti-bacterial effect Effects 0.000 title abstract 2
230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
DBMUNIJZUYVPCQ-XFNFOBRPSA-N pregnan-21-ol Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCO)[C@@H]4[C@@H]3CCC21 DBMUNIJZUYVPCQ-XFNFOBRPSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
-1 steroid compound Chemical class 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94120195T 1993-12-22 1994-12-20 Quinolin-carboxylsäurester von 21-hydroxypregnan derivaten und antibakterielle und entzüdungshemmende präparate davon ATE166358T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP32440593		1993-12-22

Publications (1)

Publication Number	Publication Date
ATE166358T1 true ATE166358T1 (de)	1998-06-15

Family

ID=18165437

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94120195T ATE166358T1 (de)	1993-12-22	1994-12-20	Quinolin-carboxylsäurester von 21-hydroxypregnan derivaten und antibakterielle und entzüdungshemmende präparate davon

Country Status (7)

Country	Link
US (1)	US5599807A (de)
EP (1)	EP0659763B1 (de)
KR (1)	KR950018036A (de)
AT (1)	ATE166358T1 (de)
CA (1)	CA2136803A1 (de)
DE (1)	DE69410419T2 (de)
ES (1)	ES2115854T3 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE247984T1 (de) *	1997-02-11	2003-09-15	Univ Manchester	Bioreduktive konjugate zur gezielten wirkstoffzufuhr
AU4093799A (en)	1998-05-22	1999-12-13	Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
GB0114672D0 (en) *	2001-06-15	2001-08-08	Orthogenics As	Pharmaceutical formulations and methods of medical treatment
EP1562627A4 (de) *	2002-08-23	2006-11-02	Mclean Hospital Corp	Corticosteroid-konjugate und ihre verwendungen
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP1945240B1 (de)	2005-09-16	2016-12-28	Raptor Pharmaceutical Inc	Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CU20110244A7 (es)	2011-12-27	2013-08-29	Ct De Investigación Y Desarrollo De Medicamentos Cidem	Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
BR112015021388A2 (pt)	2013-03-08	2017-07-18	Allergan Inc	conjugados esteroides de ciclosporina a
RU2015138891A (ru)	2013-03-08	2017-04-11	Аллерган, Инк.	Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH421957A (de) *	1962-03-23	1966-10-15	Thomae Gmbh Dr K	Verfahren zur Herstellung von Steroidestern
JPS4925279A (de) *	1972-06-29	1974-03-06
IT1036870B (it) *	1975-02-13	1979-10-30	Acraf	Derivati steroidei dell acido bendazolico
GB1565680A (en) *	1976-12-31	1980-04-23	Leo Ab	Method for the preparation of carboxylic acid esters
US5382661A (en) *	1985-09-12	1995-01-17	The Upjohn Company	Pyrazinylpiperazinyl steroids
WO1990001933A1 (en) *	1988-08-26	1990-03-08	Alcon Laboratories, Inc.	Combination of quinolone antibiotics and steroids for topical ophthalmic use

1994
- 1994-11-28 CA CA002136803A patent/CA2136803A1/en not_active Abandoned
- 1994-12-16 US US08/356,962 patent/US5599807A/en not_active Expired - Fee Related
- 1994-12-20 DE DE69410419T patent/DE69410419T2/de not_active Expired - Fee Related
- 1994-12-20 ES ES94120195T patent/ES2115854T3/es not_active Expired - Lifetime
- 1994-12-20 EP EP94120195A patent/EP0659763B1/de not_active Expired - Lifetime
- 1994-12-20 AT AT94120195T patent/ATE166358T1/de not_active IP Right Cessation
- 1994-12-21 KR KR1019940035684A patent/KR950018036A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
EP0659763B1 (de)	1998-05-20
DE69410419D1 (de)	1998-06-25
CA2136803A1 (en)	1995-06-23
ES2115854T3 (es)	1998-07-01
DE69410419T2 (de)	1998-09-17
KR950018036A (ko)	1995-07-22
EP0659763A2 (de)	1995-06-28
EP0659763A3 (de)	1995-12-20
US5599807A (en)	1997-02-04

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Legal Events

Date	Code	Title	Description
1998-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties